Lista de obras - Maria Deak - Dominio Público Uruguay

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

artículo científico publicado en 2010

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

artículo científico publicado en 2005

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

artículo científico publicado en 2002

ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster

artículo científico publicado en 2002

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

artículo científico publicado en 2009

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

scientific article published on 30 August 2016

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

artículo científico publicado en 2003

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

artículo científico publicado en 2008

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

artículo científico publicado en 2004

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

artículo científico publicado en 2005

Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.

artículo científico publicado en 2015

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

artículo científico publicado en 2002

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

artículo científico publicado en 2006

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

artículo científico publicado en 2003

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

artículo científico publicado en 2002

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

artículo científico publicado en 2002

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

artículo científico publicado en 2007

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.

artículo científico publicado en 2007

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

artículo científico publicado en 2005

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

artículo científico publicado en 2003

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

artículo científico publicado en 2005

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

artículo científico publicado en 2010

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

artículo científico publicado en 2003

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

artículo científico publicado en 2003

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

artículo científico publicado en 2004

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

artículo científico publicado en 2014

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

scientific journal article

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

artículo científico publicado en 2012

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

artículo científico publicado en 2004

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

artículo científico publicado en 2011

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

artículo científico publicado en 2003

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

artículo científico publicado en 2002

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate

artículo científico publicado en 2015

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

artículo científico publicado en 2010

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

artículo científico publicado en 2010

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

artículo científico publicado en 2006

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

artículo científico publicado en 2006

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

artículo científico publicado en 2005

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

artículo científico publicado en 2012

Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts

artículo científico publicado en 2016

Structural basis for the recruitment of glycogen synthase by glycogenin

artículo científico publicado en 2014

Structural insights into the recognition of substrates and activators by the OSR1 kinase

artículo científico publicado en 2007

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

artículo científico publicado en 2009

Structure of the OSR1 kinase, a hypertension drug target

artículo científico publicado en 2008

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

artículo científico publicado en 2009

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

artículo científico publicado en 2011

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells

artículo científico publicado en 2010

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

artículo científico publicado en 2014

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

artículo científico publicado en 2014

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

scientific journal article

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

artículo científico publicado en 2006

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

artículo científico publicado en 2004

Lista de obras de Maria Deak

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts

Structural basis for the recruitment of glycogen synthase by glycogenin

Structural insights into the recognition of substrates and activators by the OSR1 kinase

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Structure of the OSR1 kinase, a hypertension drug target

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate