Lista de obras - Hélène Munier-Lehmann - Dominio Público Uruguay

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

scientific article published on 17 June 2020

1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase

artículo científico publicado en 2001

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2003

A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

artículo científico publicado en 2007

A novel polyaminocarboxylate compound to treat murine pulmonary aspergillosis by interfering with zinc metabolism.

artículo científico publicado en 2018

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.

artículo científico publicado en 2012

A real-time cell-binding assay reveals dynamic features of STxB-Gb3 co-internalization and STxB-mediated cargo delivery into cancer cells

artículo científico publicado en 2020

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

artículo científico publicado en 2008

Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin

artículo científico publicado en 2016

AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity

artículo científico publicado en 2013

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans

artículo científico publicado en 2003

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

artículo científico publicado en 2015

Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].

artículo científico publicado en 2017

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

artículo científico publicado en 2015

Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

artículo científico publicado en 2003

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

artículo científico publicado en 2010

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2004

Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase.

artículo científico

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

artículo científico publicado en 2016

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

artículo científico publicado en 2003

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

artículo científico publicado en 2008

First-in-class allosteric inhibitors of bacterial IMPDHs

scientific article published on 02 February 2019

From sequence to structure to function: a case study

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery

artículo científico publicado en 2013

High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain

artículo científico publicado en 2004

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses

artículo científico publicado en 2014

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

artículo científico publicado en 2017

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

artículo científico publicado en 2018

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity

artículo científico publicado en 2013

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.

artículo científico publicado en 2017

Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy.

artículo científico publicado en 2004

LEA3D: a computer-aided ligand design for structure-based drug design.

artículo científico publicado en 2005

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus

artículo científico publicado en 2008

MgATP regulates allostery and fiber formation in IMPDHs

artículo científico publicado en 2013

Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols

artículo científico publicado en 2006

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

artículo científico publicado en 2017

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

artículo científico publicado en 2002

On dihydroorotate dehydrogenases and their inhibitors and uses

artículo científico publicado en 2013

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

artículo científico publicado en 2015

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

artículo científico publicado en 2015

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

artículo científico publicado en 2017

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase

artículo científico publicado en 2009

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

artículo científico publicado en 2007

Reaction of human UMP-CMP kinase with natural and analog substrates

artículo científico publicado en 2003

Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent

artículo científico publicado en 2003

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors

scientific article published on 10 April 2020

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

artículo científico publicado en 2015

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

artículo científico publicado en 2018

Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening

artículo científico publicado en 2015

Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity

artículo científico publicado en 2004

Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation

artículo científico publicado en 2010

Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase

artículo científico publicado en 2007

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

artículo científico publicado en 2018

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity

artículo científico publicado en 2008

Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme

artículo científico publicado en 2002

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

artículo científico publicado en 2013

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.

artículo científico publicado en 2006

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

artículo científico publicado en 2012

Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.

artículo científico publicado en 2012

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

artículo científico publicado en 2002

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2011

Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis

artículo científico publicado en 2018

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

artículo científico publicado en 2015

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis

artículo científico publicado en 2012

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

artículo científico publicado en 2006

The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition

artículo científico publicado en 2005

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

artículo científico publicado en 2003

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes

artículo científico publicado en 2001

Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties

artículo científico publicado en 2015

Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase

scientific journal article

Lista de obras de Hélène Munier-Lehmann

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

A novel polyaminocarboxylate compound to treat murine pulmonary aspergillosis by interfering with zinc metabolism.

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.

A real-time cell-binding assay reveals dynamic features of STxB-Gb3 co-internalization and STxB-mediated cargo delivery into cancer cells

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin

AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties

Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation

Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase.

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

First-in-class allosteric inhibitors of bacterial IMPDHs

From sequence to structure to function: a case study

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery

High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.

Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy.

LEA3D: a computer-aided ligand design for structure-based drug design.

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus

MgATP regulates allostery and fiber formation in IMPDHs

Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

On dihydroorotate dehydrogenases and their inhibitors and uses

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

Reaction of human UMP-CMP kinase with natural and analog substrates

Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening

Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity

Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation

Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity

Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes

Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties

Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase