Filtros de búsqueda

Lista de obras de Andrea Mozzarelli

"Muscle to meat" molecular events and technological transformations: the proteomics insight

artículo científico

A two-step process controls the formation of the bienzyme cysteine synthase complex

artículo científico publicado en 2010

ATP binding to human serine racemase is cooperative and modulated by glycine

artículo científico publicado en 2013

Academia-Industry Collaboration in Blood Substitute Development: Issues, Case Histories and a Proposal

article

Active site plasticity in D-amino acid oxidase: a crystallographic analysis

artículo científico publicado en 1997

Allosteric communication between alpha and beta subunits of tryptophan synthase: modelling the open-closed transition of the alpha subunit

artículo científico publicado en 2006

Allosteric mechanism of haemoglobin: rupture of salt-bridges raises the oxygen affinity of the T-structure 1 1Edited by D. Rees

artículo científico publicado en 1998

Anticooperative ligand binding properties of recombinant ferric Vitreoscilla homodimeric hemoglobin: a thermodynamic, kinetic and X-ray crystallographic study

artículo científico publicado en 1999

Asymmetry of the active site loop conformation between subunits of glutamate-1-semialdehyde aminomutase in solution

artículo científico publicado en 2013

Biochemistry of Hemoglobin

Bound water at protein-protein interfaces: partners, roles and hydrophobic bubbles as a conserved motif

artículo científico publicado en 2011

CO Rebinding Kinetics and Molecular Dynamics Simulations Highlight Dynamic Regulation of Internal Cavities in Human Cytoglobin

artículo científico publicado en 2013

CO Rebinding Kinetics to Myoglobin- and R-State-Hemoglobin-Doped Silica Gels in the Presence of Glycerol

artículo científico publicado en 2004

Catalytic and regulatory properties of D-glyceraldehyde-3-phosphate dehydrogenase in the crystal. Spectral properties and chemical reactivity of a chromophoric acyl-enzyme intermediate

artículo científico publicado en 1977

Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry

artículo científico publicado en 1998

Characterization of ligand migration mechanisms inside hemoglobins from the analysis of geminate rebinding kinetics

artículo científico publicado en 2008

Chemistry and Biochemistry of Oxygen Therapeutics

Chemogenomic strategies to expand the bioactive chemical space.

artículo científico publicado en 2009

Chemogenomics of pyridoxal 5'-phosphate dependent enzymes

artículo científico publicado en 2011

Circular dichroism spectroscopy of tertiary and quaternary conformations of human hemoglobin entrapped in wet silica gels

artículo científico publicado en 2006

Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action

artículo científico publicado en 2019

Complexity in modeling and understanding protonation states: computational titration of HIV-1-protease-inhibitor complexes

artículo científico publicado en 2007

Computational titration analysis of a multiprotic HIV-1 protease-ligand complex

artículo científico publicado en 2004

Confinement and crowding effects on tryptophan synthase α2β2complex

scholarly article by Barbara Pioselli published in March 2005

Conformational probes of O-acetylserine sulfhydrylase: fluorescence of tryptophans 50 and 161

Control of ionizable residues in the catalytic mechanism of tryptophan synthase from Salmonella typhimurium

artículo científico publicado en 2007

Cooperative Oxygen Binding toScapharca inaequivalvisHemoglobin in the Crystal

scientific article published in Journal of Biological Chemistry

Correlation of protein functional properties in the crystal and in solution: the case study of T-state hemoglobin

artículo científico publicado en 2002

Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro

artículo científico publicado en 2019

Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60

artículo científico publicado en 1998

Crystal structure of the beta Ser178--> Pro mutant of tryptophan synthase. A "knock-out" allosteric enzyme

artículo científico publicado en 2002

Crystal structures of a new class of allosteric effectors complexed to tryptophan synthase

artículo científico publicado en 2002

Crystals of tryptophan indole-lyase and tyrosine phenol-lyase form stable quinonoid complexes

artículo científico publicado en 2002

Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target

artículo científico publicado en 2015

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR.

artículo científico publicado en 2016

Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase

article by Laura Amori et al published 2012 in MedChemComm

Design of O -Acetylserine Sulfhydrylase Inhibitors by Mimicking Nature

artículo científico publicado en 2010

Determination of Microscopic Rate Constants for CO Binding and Migration in Myoglobin Encapsulated in Silica Gels

artículo científico publicado en 2005

Development of a novel, hemolysis-resistant reagent for assessment of α-amylase in biological fluids

artículo científico publicado en 2013

Different roles of protein dynamics and ligand migration in non-symbiotic hemoglobins AHb1 and AHb2 from Arabidopsis thaliana

article

Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria

artículo científico publicado en 2014

Drug discovery targeting amino acid racemases

artículo científico publicado en 2011

Dynamics of green fluorescent protein mutant2 in solution, on spin-coated glasses, and encapsulated in wet silica gels

artículo científico publicado en 2002

Effect of pH and Monovalent Cations on the Formation of Quinonoid Intermediates of the Tryptophan Synthase α2β2Complex in Solution and in the Crystal

artículo científico publicado en 2000

Electrophoretic analysis of PEGylated hemoglobin-based blood substitutes

scholarly article by Luca Ronda published in January 2011

Energetics of the protein-DNA-water interaction

artículo científico publicado en 2007

Energy-based prediction of amino acid-nucleotide base recognition

artículo científico publicado en 2008

Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality

artículo científico publicado en 2020

Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design

artículo científico publicado en 2016

Enhanced geminate ligand rebinding upon photo-dissociation of silica gel-embedded myoglobin–CO

artículo científico publicado en 2001

Environment effects on the oscillatory unfolding kinetics of GFP.

artículo científico publicado en 2007

Evidence for Two Geminate Rebinding States Following Laser Photolysis of R State Hemoglobin Encapsulated in Wet Silica Gels

artículo científico publicado en 2005

Evidence of discrete substates and unfolding pathways in green fluorescent protein

artículo científico publicado en 2006

Evolution of allosteric models for hemoglobin

artículo científico publicado en 2007

Expanding the chemical space of human serine racemase inhibitors

artículo científico publicado en 2015

Experimental basis for a new allosteric model for multisubunit proteins

artículo científico publicado en 2014

Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models.

artículo científico publicado en 2015

Exploring O-acetylserine sulfhydrylase-B isoenzyme from Salmonella typhimurium by fluorescence spectroscopy

artículo científico publicado en 2010

Exploring and exploiting allostery: Models, evolution, and drug targeting

artículo científico publicado en 2010

Exploring methionine γ-lyase structure-function relationship via microspectrophotometry and X-ray crystallography

artículo científico publicado en 2011

Exploring the pyridoxal 5′-phosphate-dependent enzymes

article

Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase

artículo científico publicado en 2012

From protein structure to function via single crystal optical spectroscopy

artículo científico publicado en 2015

Functional and spectroscopic characterization of half-liganded iron-zinc hybrid hemoglobin: evidence for conformational plasticity within the T state

artículo científico publicado en 2003

Functional characterization of heme proteins encapsulated in wet nanoporous silica gels.

artículo científico publicado en 2001

Functional properties of the active core of human cystathionine beta-synthase crystals.

artículo científico publicado en 2001

Geminate rebinding in R-state hemoglobin: kinetic and computational evidence for multiple hydrophobic pockets

artículo científico publicado en 2005

Getting it right: modeling of pH, solvent and "nearly" everything else in virtual screening of biological targets

artículo científico publicado en 2004

HINT predictive analysis of binding between retinol binding protein and hydrophobic ligands.

artículo científico publicado en 2000

Haemoglobin-based oxygen carriers: research and reality towards an alternative to blood transfusions

artículo científico publicado en 2010

Hemocyanin from E. californicum encapsulated in silica gels: oxygen binding and conformational states

artículo científico publicado en 2007

Hemoglobin Reactivity and Regulation

Hemoglobin, an "evergreen" red protein

artículo científico publicado en 2009

Hemoglobin-based oxygen carriers as blood substitutes

artículo científico publicado en 2008

High and low oxygen affinity conformations of T state hemoglobin

artículo científico publicado en 2001

Histidine E7 Dynamics Modulates Ligand Exchange between Distal Pocket and Solvent in AHb1 fromArabidopsis thaliana

artículo científico publicado en 2011

Human kynurenine aminotransferase II - reactivity with substrates and inhibitors

scholarly article by Elisabetta Passera published in April 2011

Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives

scholarly article by Stefano Bruno published in August 2016

Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling

artículo científico publicado en 2014

Identification of the geometric requirements for allosteric communication between the alpha- and beta-subunits of tryptophan synthase

artículo científico publicado en 2005

Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.

artículo científico publicado en 2010

Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach

artículo científico publicado en 2009

Insight into GFPmut2 pH Dependence by Single Crystal Microspectrophotometry and X-ray Crystallography

artículo científico publicado en 2018

Insight of Saffron Proteome by Gel-Electrophoresis.

artículo científico publicado en 2016

Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy

artículo científico publicado en 2005

International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids–A White Paper

article

Is cooperative oxygen binding by hemoglobin really understood?

artículo científico publicado en 1999

Is cooperative oxygen binding by hemoglobin really understood?

article

Is the protein profile of pig Longissimus dorsi affected by gender and diet?

scientific article published on 02 July 2019

Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target

artículo científico publicado en 2013

Kinetics of acid-induced spectral changes in the GFPmut2 chromophore

artículo científico publicado en 2005

Ligand migration and hexacoordination in type 1 non-symbiotic rice hemoglobin

artículo científico publicado en 2010

Ligand migration in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana

artículo científico publicado en 2007

Ligand migration through the internal hydrophobic cavities in human neuroglobin

artículo científico publicado en 2009

Ligand-induced tertiary relaxations during the T-to-R quaternary transition in hemoglobin

artículo científico publicado en 2008

Low affinity PEGylated hemoglobin from Trematomus bernacchii, a model for hemoglobin-based blood substitutes

artículo científico publicado en 2011

Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form.

artículo científico publicado en 2017

Mapping the energetics of water-protein and water-ligand interactions with the "natural" HINT forcefield: predictive tools for characterizing the roles of water in biomolecules

artículo científico publicado en 2006

MediaChrom: Discovering a Class of Pyrimidoindolone-Based Polarity-Sensitive Dyes

artículo científico publicado en 2015

Microspectrophotometry for structural enzymology

artículo científico publicado en 2004

Modulation of expression and polymerization of hemoglobin Polytaur, a potential blood substitute

scholarly article by Serena Faggiano published in January 2011

Molecular insights into dimerization inhibition of c-Maf transcription factor

scholarly article by Sara Pellegrino published in December 2014

Monovalent cations affect dynamic and functional properties of the tryptophan synthase alpha 2 beta 2 complex

artículo científico publicado en 1995

Moonlighting O-acetylserine sulfhydrylase: New functions for an old protein

artículo científico publicado en 2015

Muscle and meat: new horizons and applications for proteomics on a farm to fork perspective

artículo científico publicado en 2013

Mutational Effects at the Subunit Interfaces of Human Hemoglobin:  Evidence for a Unique Sensitivity of the T Quaternary State to Changes in the Hinge Region of the α1β2 Interface†

article

New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels

scholarly article

Novel allosteric effectors of the tryptophan synthase alpha(2)beta(2) complex identified by computer-assisted molecular modeling

artículo científico publicado en 2000

Ormosil gels doped with engineered catechol 1,2 dioxygenases for chlorocatechol bioremediation

artículo científico publicado en 2014

Oxygen and nitric oxide rebinding kinetics in nonsymbiotic hemoglobin AHb1 from Arabidopsis thaliana

artículo científico publicado en 2011

Oxygen binding and sensing proteins ⬇️

artículo científico publicado el 25 de mayo de 2013

Oxygen binding to Arabidopsis thaliana AHb2 nonsymbiotic hemoglobin: evidence for a role in oxygen transport

article

Oxygen binding to heme proteins in solution, encapsulated in silica gels, and in the crystalline state

artículo científico publicado en 2008

PEGylation promotes hemoglobin tetramer dissociation.

artículo científico publicado en 2009

Plasticity of the Tryptophan Synthase Active Site Probed by31P NMR Spectroscopy

artículo científico publicado en 1998

Polymerized and polyethylene glycol-conjugated hemoglobins: A globin-based calibration curve for dynamic light scattering analysis

scholarly article by Serena Faggiano published in June 2010

Protein crystal microspectrophotometry ⬇️

artículo científico publicado el 22 de diciembre de 2010

Proteomic analysis of pork meat in the production of cooked ham.

artículo científico publicado en 2011

Proteomics of Parma Dry-Cured Ham: Analysis of Salting Exudates

artículo científico publicado en 2017

Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents

artículo científico publicado en 2007

Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection of Staphylococcus aureus

artículo científico publicado en 2020

Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase

artículo científico publicado en 2016

Regulation of human serine racemase activity and dynamics by halides, ATP and malonate

article

Robust Classification of “Relevant” Water Molecules in Putative Protein Binding Sites

scientific article published on 31 January 2008

Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris

artículo científico publicado en 2003

Role of pyridoxal 5'-phosphate in the structural stabilization of O-acetylserine sulfhydrylase.

artículo científico publicado en 2000

Role of tertiary structures on the Root effect in fish hemoglobins

artículo científico publicado en 2013

Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases

artículo científico publicado en 2016

Serine racemase: a key player in neuron activity and in neuropathologies

artículo científico publicado en 2013

Simple, Intuitive Calculations of Free Energy of Binding for Protein−Ligand Complexes. 3. The Free Energy Contribution of Structural Water Molecules in HIV-1 Protease Complexes

article

Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 1. Models without explicit constrained water

artículo científico publicado en 2002

Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 2. Computational titration and pH effects in molecular models of neuraminidase-inhibitor complexes

artículo científico publicado en 2003

Site-directed mutations of human hemoglobin at residue 35beta: a residue at the intersection of the alpha1beta1, alpha1beta2, and alpha1alpha2 interfaces

artículo científico publicado en 2001

Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state

artículo científico publicado en 2003

Special Issue on "Cofactor-dependent proteins: Evolution, chemical diversity and bio-applications".

artículo científico publicado en 2015

Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels

artículo científico publicado en 2004

Structural insight into the interaction of O-acetylserine sulfhydrylase with competitive, peptidic inhibitors by saturation transfer difference-NMR.

artículo científico publicado en 2016

Structural plasticity and functional implications of internal cavities in distal mutants of type 1 non-symbiotic hemoglobin AHb1 from Arabidopsis thaliana.

artículo científico publicado en 2009

Structure and Oxygen Affinity of Crystalline des-His-146β Human Hemoglobin in the T State

artículo científico publicado en 1997

Structure and oxygen affinity of crystalline desArg141 alpha human hemoglobin A in the T state.

artículo científico publicado en 1995

Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes

artículo científico publicado en 2007

Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin

artículo científico publicado en 2004

Sulfur mobilization in cyanobacteria: the catalytic mechanism of L-cystine C-S lyase (C-DES) from synechocystis

artículo científico publicado en 2006

Surface-exposed tryptophan residues are essential for O-acetylserine sulfhydrylase structure, function, and stability

artículo científico publicado en 2003

T State Hemoglobin Binds Oxygen Noncooperatively with Allosteric Effects of Protons, Inositol Hexaphosphate, and Chloride ⬇️

artículo científico publicado el 19 de diciembre de 1997

Targeting cystalysin, a virulence factor of treponema denticola-supported periodontitis

artículo científico publicado en 2014

Tertiary and Quaternary Allostery in Tetrameric Hemoglobin from Scapharca inaequivalvis

artículo científico publicado en 2013

The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery.

artículo científico publicado en 2017

The consequences of scoring docked ligand conformations using free energy correlations

artículo científico publicado en 2007

The molecular pathway for the allosteric regulation of tryptophan synthase

artículo científico publicado en 2003

The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase

artículo científico publicado en 2011

The reactivity with CO of AHb1 and AHb2 from Arabidopsis thaliana is controlled by the distal HisE7 and internal hydrophobic cavities

artículo científico publicado en 2007

Time-resolved fluorescence of O-acetylserine sulfhydrylase

artículo científico publicado en 1999

Time-resolved fluorescence of O-acetylserine sulfhydrylase catalytic intermediates

artículo científico publicado en 1997

Time-resolved fluorescence of tryptophan synthase

artículo científico publicado en 1996

Time-resolved methods in Biophysics. 2. Monitoring haem proteins at work with nanosecond laser flash photolysis

artículo científico publicado en 2006

Tools for building a comprehensive modeling system for virtual screening under real biological conditions: The Computational Titration algorithm

artículo científico publicado en 2005

Towards a novel haemoglobin-based oxygen carrier: Euro-PEG-Hb, physico-chemical properties, vasoactivity and renal filtration.

artículo científico publicado en 2008

Tracking unfolding and refolding of single GFPmut2 molecules

artículo científico publicado en 2005

Trapping Hemoglobin in Rigid Matrices: Fine Tuning of Oxygen Binding Properties by Modulation of Encapsulation Protocols

scholarly article by Stefano Bruno et al published January 2007 in Artificial Cells, Blood Substitutes, and Biotechnology

Trapping of the thioacylglyceraldehyde-3-phosphate dehydrogenase intermediate from Bacillus stearothermophilus. Direct evidence for a flip-flop mechanism

artículo científico publicado en 2008

Tryptophan synthase: a mine for enzymologists

artículo científico publicado en 2009

Tyrosine phenol-lyase and tryptophan indole-lyase encapsulated in wet nanoporous silica gels: Selective stabilization of tertiary conformations

artículo científico publicado en 2004

Unfolding of Green Fluorescent Protein mut2 in wet nanoporous silica gels.

artículo científico publicado en 2005

Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence.

artículo científico publicado en 2002

Unintended consequences? Water molecules at biological and crystallographic protein-protein interfaces

artículo científico publicado en 2013

Water: How to evaluate its contribution in protein-ligand interactions

article by Pietro Cozzini et al published 2005 in International Journal of Quantum Chemistry

X-ray crystallography marries spectroscopy to unveil structure and function of biological macromolecules

artículo científico publicado en 2011

pH dependence of tryptophan synthase catalytic mechanism: I. The first stage, the beta-elimination reaction

artículo científico publicado en 2004

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda