Lista de obras - Ann-Sofie Jemth - Dominio Público Uruguay

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

artículo científico publicado en 2017

Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry.

artículo científico publicado en 2015

Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

artículo científico publicado en 2017

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

artículo científico publicado en 2017

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana

scientific article published on 16 January 2019

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

artículo científico publicado en 2016

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

artículo científico publicado en 2017

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

artículo científico publicado en 2011

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

scientific journal article

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

artículo científico publicado en 2020

CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase.

artículo científico publicado en 2010

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

artículo científico publicado en 2016

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.

artículo científico publicado en 2017

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems

artículo científico publicado en 2017

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis

article

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold

artículo científico publicado en 2018

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

artículo científico publicado en 2016

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.

artículo científico publicado en 2017

Kinetic and structural characterization of <scp>NUDT15</scp> and <scp>NUDT18</scp> as catalysts of isoprene pyrophosphate hydrolysis

artículo científico publicado en 2024

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

artículo científico publicado en 2014

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

artículo científico publicado en 2018

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

artículo científico publicado en 2020

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

artículo científico publicado en 2016

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

scientific article published on 23 July 2009

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA

artículo científico publicado en 2010

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.: FIGURE 2

scientific article published in Journal of Biological Chemistry

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

artículo científico publicado en 2017

Processing of protein ADP-ribosylation by Nudix hydrolases

artículo científico publicado en 2015

Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.

artículo científico publicado en 2015

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

artículo científico publicado en 2018

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

artículo científico publicado en 2014

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

artículo científico publicado en 2009

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

artículo científico publicado en 2018

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

artículo científico publicado en 2017

Validation and development of MTH1 inhibitors for treatment of cancer.

artículo científico publicado en 2016

dUTPase inhibition augments replication defects of 5-Fluorouracil.

artículo científico publicado en 2017

Lista de obras de Ann-Sofie Jemth

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry.

Correction to Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase.

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.

Kinetic and structural characterization of <scp>NUDT15</scp> and <scp>NUDT18</scp> as catalysts of isoprene pyrophosphate hydrolysis

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.: FIGURE 2

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors

Processing of protein ADP-ribosylation by Nudix hydrolases

Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

Validation and development of MTH1 inhibitors for treatment of cancer.

dUTPase inhibition augments replication defects of 5-Fluorouracil.