Lista de obras - Jean-Denis Docquier - Dominio Público Uruguay

1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases

artículo científico publicado en 2017

4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition

artículo científico publicado en 2020

Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

article

An update on β-lactamase inhibitor discovery and development.

artículo científico publicado en 2017

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam

artículo científico publicado en 2018

BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa

artículo científico publicado en 2009

Biochemical Characterization of CPS-1, a Subclass B3 Metallo-β-Lactamase from a Chryseobacterium piscium Soil Isolate

artículo científico publicado en 2015

Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece

artículo científico publicado en 2015

Biochemical and Structural Characterization of the Subclass B1 Metallo- -Lactamase VIM-4

artículo científico publicado en 2011

Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis

artículo científico publicado en 2014

Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea

artículo científico publicado en 2011

Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum

artículo científico publicado en 2004

Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound

artículo científico publicado en 2016

CENTA as a chromogenic substrate for studying beta-lactamases.

artículo científico publicado en 2001

Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms

artículo científico publicado en 2011

Chryseobacterium gleum in a man with prostatectomy in Senegal: a case report and review of the literature.

artículo científico publicado en 2017

Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals

artículo científico publicado en 2005

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases.

artículo científico publicado en 2017

Crystal Structure of the Narrow-Spectrum OXA-46 Class D -Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates

artículo científico publicado en 2010

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and Imipenem

artículo científico publicado en 2016

Crystal structure of a cold-adapted class C beta-lactamase

artículo científico publicado en 2008

Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

artículo científico publicado en 2009

Deciphering multifactorial resistance phenotypes in Acinetobacter baumannii by genomics and targeted label-free proteomics.

artículo científico publicado en 2017

Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol.

artículo científico publicado en 2017

Discovery of <b>ANT3310</b>, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and <i>Acinetobacter baumannii</i>

scientific article published on 11 December 2020

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

scientific article published on 16 December 2019

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae.

artículo científico publicado en 2018

Editorial overview: anti-infectives: towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need

artículo científico publicado en 2014

Effect of High N-Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens

artículo científico publicado en 2016

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D -lactamase OXA-10 by rational protein design

artículo científico publicado en 2011

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota

artículo científico publicado en 2016

FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy

artículo científico publicado en 2012

Genetic and biochemical characterisation of CTX-M-37 extended-spectrum β-lactamase from an Enterobacter cloacae clinical isolate from Mongolia.

artículo científico publicado en 2017

Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.

artículo científico publicado en 2010

High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

artículo científico publicado en 2010

IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate

artículo científico publicado en 2003

Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents.

artículo científico publicado en 2017

Intermolecular interactions of the extended recognition site of VIM-2 metallo-β-lactamase with 1,2,4-triazole-3-thione inhibitors. Validations of a polarizable molecular mechanics potential by ab initio QC

artículo científico publicado en 2020

Major enzymatic factors involved in bacterial penicillin resistance in Burkina Faso.

artículo científico publicado en 2007

Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues

artículo científico publicado en 2007

Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: a structure-guided study of OXA-24 and OXA-48

artículo científico publicado en 2015

Molecular heterogeneity of bla(VIM-2)-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase

scientific article published on 01 February 2001

Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.

artículo científico publicado en 2001

Nosocomial infections caused by multidrug-resistant isolates of pseudomonas putida producing VIM-1 metallo-beta-lactamase

artículo científico publicado en 2002

Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-beta-lactamase

artículo científico publicado en 2005

Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea

artículo científico publicado en 2005

OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant

artículo científico publicado en 2015

Occurrence of conjugative IncF-type plasmids harboring the blaCTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia

artículo científico publicado en 2014

Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases

artículo científico publicado en 2012

Postgenomic scan of metallo-beta-lactamase homologues in rhizobacteria: identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum

artículo científico publicado en 2006

Regulation of neuraminidase expression in Streptococcus pneumoniae.

artículo científico publicado en 2012

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

scientific article published on 30 November 2018

Simple microdilution test for detection of metallo-beta-lactamase production in Pseudomonas aeruginosa

artículo científico publicado en 2002

Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC -Lactamases

artículo científico publicado en 2013

Structure-Function Relationships of Class D Carbapenemases.

artículo científico publicado en 2016

Structure-based approach for identification of novel phenylboronic acids as serine-β-lactamase inhibitors.

artículo científico publicado en 2016

Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity

scientific article published on 14 October 2014

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors.

artículo científico publicado en 2016

Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily

article

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

artículo científico publicado en 2020

Lista de obras de Jean-Denis Docquier

1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases

4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition

Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

An update on β-lactamase inhibitor discovery and development.

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam

BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa

Biochemical Characterization of CPS-1, a Subclass B3 Metallo-β-Lactamase from a Chryseobacterium piscium Soil Isolate

Biochemical Characterization of VIM-39, a VIM-1-Like Metallo-β-Lactamase Variant from a Multidrug-Resistant Klebsiella pneumoniae Isolate from Greece

Biochemical and Structural Characterization of the Subclass B1 Metallo- -Lactamase VIM-4

Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis

Biochemical characterization of the TEM-107 extended-spectrum β-lactamase in a Klebsiella pneumoniae isolate from South Korea

Biochemical characterization of the THIN-B metallo-beta-lactamase of Janthinobacterium lividum

Biological Characterization and in Vivo Assessment of the Activity of a New Synthetic Macrocyclic Antifungal Compound

CENTA as a chromogenic substrate for studying beta-lactamases.

Carbapenem resistance in Pseudomonas aeruginosa isolates: an example of interaction between different mechanisms

Chryseobacterium gleum in a man with prostatectomy in Senegal: a case report and review of the literature.

Clonal relatedness and conserved integron structures in epidemiologically unrelated Pseudomonas aeruginosa strains producing the VIM-1 metallo-{beta}-lactamase from different Italian hospitals

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases.

Crystal Structure of the Narrow-Spectrum OXA-46 Class D -Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and Imipenem

Crystal structure of a cold-adapted class C beta-lactamase

Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

Deciphering multifactorial resistance phenotypes in Acinetobacter baumannii by genomics and targeted label-free proteomics.

Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol.

Discovery of <b>ANT3310</b>, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and <i>Acinetobacter baumannii</i>

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae.

Editorial overview: anti-infectives: towards novel antiviral and antibacterial drugs? Current approaches to address a growing medical need

Effect of High N-Acetylcysteine Concentrations on Antibiotic Activity against a Large Collection of Respiratory Pathogens

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D -lactamase OXA-10 by rational protein design

Expanding the Repertoire of Carbapenem-Hydrolyzing Metallo-ß-Lactamases by Functional Metagenomic Analysis of Soil Microbiota

FIM-1, a new acquired metallo-β-lactamase from a Pseudomonas aeruginosa clinical isolate from Italy

Genetic and biochemical characterisation of CTX-M-37 extended-spectrum β-lactamase from an Enterobacter cloacae clinical isolate from Mongolia.

Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States.

High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

IMP-12, a new plasmid-encoded metallo-beta-lactamase from a Pseudomonas putida clinical isolate

Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents.

Intermolecular interactions of the extended recognition site of VIM-2 metallo-β-lactamase with 1,2,4-triazole-3-thione inhibitors. Validations of a polarizable molecular mechanics potential by ab initio QC

Major enzymatic factors involved in bacterial penicillin resistance in Burkina Faso.

Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens: open issues

Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: a structure-guided study of OXA-24 and OXA-48

Molecular heterogeneity of bla(VIM-2)-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-beta-lactamase

Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.

Nosocomial infections caused by multidrug-resistant isolates of pseudomonas putida producing VIM-1 metallo-beta-lactamase

Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-beta-lactamase

Novel acquired metallo-beta-lactamase gene, bla(SIM-1), in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea

OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant

Occurrence of conjugative IncF-type plasmids harboring the blaCTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia

Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases

Postgenomic scan of metallo-beta-lactamase homologues in rhizobacteria: identification and characterization of BJP-1, a subclass B3 ortholog from Bradyrhizobium japonicum

Regulation of neuraminidase expression in Streptococcus pneumoniae.

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

Simple microdilution test for detection of metallo-beta-lactamase production in Pseudomonas aeruginosa

Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC -Lactamases

Structure-Function Relationships of Class D Carbapenemases.

Structure-based approach for identification of novel phenylboronic acids as serine-β-lactamase inhibitors.

Synthesis of linear and cyclic guazatine derivatives endowed with antibacterial activity

Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors.

Type M Resistance to Macrolides Is Due to a Two-Gene Efflux Transport System of the ATP-Binding Cassette (ABC) Superfamily

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa