Lista de obras - Cecilia Pozzi - Dominio Público Uruguay

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives

artículo científico publicado en 2013

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

scientific article published on 01 March 2019

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam

artículo científico publicado en 2018

Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster

artículo científico publicado en 2017

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

artículo científico publicado en 2017

Cover Feature: Iron Biomineral Growth from the Initial Nucleation Seed in L‐Ferritin (Chem. Eur. J. 26/2020)

artículo científico publicado en 2020

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and Imipenem

artículo científico publicado en 2016

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

scientific article published on 16 December 2019

Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin

scientific article published on 07 May 2019

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

scientific article published on 09 April 2019

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.

artículo científico publicado en 2019

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D -lactamase OXA-10 by rational protein design

artículo científico publicado en 2011

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

artículo científico publicado en 2017

Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity

artículo científico publicado en 2016

Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini

artículo científico publicado en 2019

High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor

scientific article published on 29 May 2020

Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

artículo científico publicado en 2015

Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.

artículo científico publicado en 2018

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction

artículo científico publicado en 2020

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening

artículo científico publicado en 2011

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.

artículo científico publicado en 2017

Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin

artículo científico publicado en 2020

Iron binding to human heavy-chain ferritin

artículo científico publicado en 2015

Loop electrostatics modulates the intersubunit interactions in ferritin

artículo científico publicado en 2014

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart

scientific article published on 21 September 2018

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

artículo científico publicado en 2016

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

artículo científico publicado en 2011

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

scientific article published on 30 November 2018

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

artículo científico publicado en 2019

Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors

artículo científico publicado en 2019

Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes

artículo científico publicado en 2012

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

article

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

artículo científico publicado en 2014

Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS)

artículo científico publicado en 2019

The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease

artículo científico publicado en 2015

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism

artículo científico publicado en 2012

The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders

artículo científico publicado en 2018

Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites

artículo científico publicado en 2015

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

artículo científico publicado en 2020

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors

artículo científico publicado en 2016

Lista de obras de Cecilia Pozzi

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam

Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

Cover Feature: Iron Biomineral Growth from the Initial Nucleation Seed in L‐Ferritin (Chem. Eur. J. 26/2020)

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and Imipenem

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D -lactamase OXA-10 by rational protein design

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity

Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini

High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor

Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.

Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.

Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin

Iron binding to human heavy-chain ferritin

Loop electrostatics modulates the intersubunit interactions in ferritin

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors

Structural Insights into the Ferroxidase Site of Ferritins from Higher Eukaryotes

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS)

The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism

The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders

Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors