Lista de obras - Daniel Durocher - Dominio Público Uruguay

A Pif1-dependent threshold separates DNA double-strand breaks and telomeres

A Strategy for Modulation of Enzymes in the Ubiquitin System

artículo científico publicado en 2013

A Web Resource for Improved Analysis of AP-MS Protein Interaction Data

artículo científico publicado en 2013

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

artículo científico publicado en 2013

A consensus set of genetic vulnerabilities to ATR inhibition

artículo científico publicado en 2019

A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator

artículo científico publicado en 2006

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.

artículo científico publicado en 2008

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

artículo científico publicado en 2006

A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions

artículo científico publicado en 2007

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

artículo científico publicado en 2017

A siRNA-based screen for genes involved in chromosome end protection

artículo científico publicado en 2011

A substrate binding model for the KEOPS tRNA modifying complex

artículo científico publicado en 2020

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

scientific journal article

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

artículo científico publicado en 2008

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

artículo científico publicado en 2017

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

artículo científico publicado en 2011

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

artículo científico publicado en 2008

Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction

artículo científico publicado en 2003

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

artículo científico publicado en 2022

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation

artículo científico publicado en 2010

Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length

artículo científico publicado en 2006

Chromatin and DNA repair: the benefits of relaxation

Combinatorial interactions regulating cardiac transcription

artículo científico publicado en 1998

Combinatorial interactions regulating cardiac transcription

Control of homologous recombination by the HROB-MCM8-MCM9 pathway

scientific article published on 29 August 2019

DNA Repair Has a New FAN1 Club

DNA Repair: DNA Polymerase ζ and Rev1 Break in

DNA damage signalling targets the kinetochore to promote chromatin mobility

artículo científico publicado en 2016

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

artículo científico publicado en 2001

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks

artículo científico publicado en 2010

Dun1 Counts on Rad53 to Be Turned On

Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability

artículo científico publicado en 2003

Engineering a DNA damage response without DNA damage

scientific article published on 28 July 2008

Erratum: Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

artículo científico publicado en 2006

Functional characterization of a PROTAC directed against BRAF mutant V600E

artículo científico publicado en 2020

Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library

artículo científico publicado en 2021

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

artículo científico publicado en 2011

HELB Is a Feedback Inhibitor of DNA End Resection

scientific journal article

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

artículo científico publicado en 2017

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture

artículo científico publicado en 2012

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

artículo científico publicado en 2021

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

artículo científico publicado en 2010

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

artículo científico publicado en 2012

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

artículo científico publicado en 2007

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

scientific journal article

PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint.

artículo científico publicado en 2008

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

artículo científico publicado en 2015

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease ⬇️

artículo científico publicado el 8 de febrero de 2011

RMI1 promotes DNA replication fork progression and recovery from replication fork stress

artículo científico publicado en 2012

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

artículo científico publicado en 2009

Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.

artículo científico publicado en 2008

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

artículo científico publicado en 2013

Regulation of DNA Damage Responses by Ubiquitin and SUMO ⬇️

artículo científico publicado el 14 de febrero de 2013

Regulatory ubiquitylation in response to DNA double-strand breaks

artículo científico publicado en 2009

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

artículo científico publicado en 2010

SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus

artículo científico publicado en 2020

Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation

artículo científico publicado en 2005

Shieldin – the protector of DNA ends

artículo científico publicado en 2019

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

artículo científico publicado en 2008

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin

artículo científico publicado en 2011

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis

artículo científico publicado en 2016

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

artículo científico publicado en 2002

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange

artículo científico publicado en 2014

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

artículo científico publicado en 2014

Synthetic Lethality in Cancer Therapeutics: The Next Generation

artículo científico publicado en 2021

Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.

artículo científico publicado en 2010

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

artículo científico publicado en 2002

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

artículo científico publicado en 2012

Telomere Protection: An Act of God

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

artículo científico publicado en 2013

The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.

artículo científico publicado en 2006

The FHA domain

artículo científico publicado en 2002

The FHA domain is a modular phosphopeptide recognition motif.

artículo científico publicado en 1999

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

artículo científico publicado en 2010

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

artículo científico publicado en 2009

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

artículo científico publicado en 2017

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

scientific journal article

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

artículo científico publicado en 1997

The control of DNA repair by the cell cycle

artículo científico publicado en 2016

The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

artículo científico publicado en 2005

The structural basis of modified nucleosome recognition by 53BP1

artículo científico publicado en 2016

The ubiquitous role of ubiquitin in the DNA damage response

artículo científico publicado en 2010

Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer

artículo científico publicado en 2011

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

artículo científico publicado en 2004

gammaH2AX as a checkpoint maintenance signal

artículo científico publicado en 2006

Lista de obras de Daniel Durocher

A Pif1-dependent threshold separates DNA double-strand breaks and telomeres

A Strategy for Modulation of Enzymes in the Ubiquitin System

A Web Resource for Improved Analysis of AP-MS Protein Interaction Data

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

A consensus set of genetic vulnerabilities to ATR inhibition

A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions

A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres

A siRNA-based screen for genes involved in chromosome end protection

A substrate binding model for the KEOPS tRNA modifying complex

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction

CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition

CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation

Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length

Chromatin and DNA repair: the benefits of relaxation

Combinatorial interactions regulating cardiac transcription

Combinatorial interactions regulating cardiac transcription

Control of homologous recombination by the HROB-MCM8-MCM9 pathway

DNA Repair Has a New FAN1 Club

DNA Repair: DNA Polymerase ζ and Rev1 Break in

DNA damage signalling targets the kinetochore to promote chromatin mobility

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks

Dun1 Counts on Rad53 to Be Turned On

Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability

Engineering a DNA damage response without DNA damage

Erratum: Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

Functional characterization of a PROTAC directed against BRAF mutant V600E

Genome-scale chemogenomic CRISPR screens in human cells using the TKOv3 library

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

HELB Is a Feedback Inhibitor of DNA End Resection

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint.

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease ⬇️

RMI1 promotes DNA replication fork progression and recovery from replication fork stress

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

Regulation of DNA Damage Responses by Ubiquitin and SUMO ⬇️

Regulatory ubiquitylation in response to DNA double-strand breaks

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus

Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation

Shieldin – the protector of DNA ends

Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes

Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

Structural basis of Rad53 kinase activation by dimerization and activation segment exchange

Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

Synthetic Lethality in Cancer Therapeutics: The Next Generation

Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

Telomere Protection: An Act of God

The CRAPome: a contaminant repository for affinity purification-mass spectrometry data

The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.

The FHA domain

The FHA domain is a modular phosphopeptide recognition motif.

The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors