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Lista de obras de Manuela Benvenuti

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam

artículo científico publicado en 2018

Crystal Structure of the Narrow-Spectrum OXA-46 Class D  -Lactamase: Relationship between Active-Site Lysine Carbamylation and Inhibition by Polycarboxylates

artículo científico publicado en 2010

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and Imipenem

artículo científico publicado en 2016

Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases

artículo científico publicado en 2009

Discovery of <b>ANT3310</b>, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and <i>Acinetobacter baumannii</i>

scientific article published on 11 December 2020

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

scientific article published on 16 December 2019

Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D  -lactamase OXA-10 by rational protein design

artículo científico publicado en 2011

High-Resolution Crystal Structure of the Subclass B3 Metallo- -Lactamase BJP-1: Rational Basis for Substrate Specificity and Interaction with Sulfonamides

artículo científico publicado en 2010

Molecular basis of selective inhibition and slow reversibility of avibactam against class D carbapenemases: a structure-guided study of OXA-24 and OXA-48

artículo científico publicado en 2015

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

scientific article published on 30 November 2018

Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC  -Lactamases

artículo científico publicado en 2013

Structural insights into the catalytic mechanism of the bacterial class B phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases

artículo científico publicado en 2008

Structure of the extended-spectrum β-lactamase TEM-72 inhibited by citrate

artículo científico publicado en 2011

The evolutionarily conserved trimeric structure of CutA1 proteins suggests a role in signal transduction

artículo científico publicado en 2003

The first structure of a bacterial class B Acid phosphatase reveals further structural heterogeneity among phosphatases of the haloacid dehalogenase fold

artículo científico publicado en 2004

The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders

artículo científico publicado en 2018

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa

artículo científico publicado en 2020