Lista de obras - Gerard Drewes - Dominio Público Uruguay

2,4-Dinitrophenyl [14C]cysteinyl disulfide allows selective radioactive labeling of protein thiols under spectrophotometric control

artículo científico publicado en 1990

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

artículo científico publicado en 2004

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

artículo científico publicado en 2012

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

artículo científico publicado en 2012

Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP.

artículo científico publicado en 2013

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro ⬇️

artículo científico publicado el 1 de agosto de 1992

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

artículo científico publicado en 2017

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

artículo científico publicado en 2016

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model

artículo científico publicado en 2020

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives

artículo científico publicado en 2016

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

artículo científico publicado en 2016

Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care.

artículo científico publicado en 2008

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

artículo científico publicado en 2012

Chemical proteomics in drug discovery.

artículo científico publicado en 2012

Chemoproteomic approaches to drug target identification and drug profiling.

artículo científico publicado en 2011

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

artículo científico publicado en 2011

Chemoproteomics reveals time-dependent binding of histone deacetylase inhibitors to endogenous repressor complexes

artículo científico publicado en 2014

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

artículo científico publicado en 2010

Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

artículo científico publicado en 2017

Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator.

artículo científico publicado en 1993

Collaborative approaches for Target ID in neglected diseases: identifying new antimalarial targets.

artículo científico publicado en 2014

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

artículo científico publicado en 2004

Cooperative effects on filament stability in actin modified at the C-terminus by substitution or truncation

scientific article published on 01 February 1993

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

artículo científico publicado en 2017

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

artículo científico publicado en 2016

Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle.

artículo científico publicado en 2015

Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.

artículo científico publicado en 2017

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

artículo científico publicado en 2016

Functional interdependence of BRD4 and DOT1L in MLL leukemia

artículo científico publicado en 2016

Functional organization of the yeast proteome by systematic analysis of protein complexes

artículo científico publicado en 2002

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

artículo científico publicado en 2012

Human Proteinpedia enables sharing of human protein data

artículo científico publicado en 2008

Identification of KasA as the cellular target of an anti-tubercular scaffold

artículo científico publicado en 2016

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

artículo científico publicado en 2014

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

artículo científico publicado en 2013

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

artículo científico publicado en 2011

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

artículo científico publicado en 2015

Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles

artículo científico publicado en 2009

Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

article

Kruidenier et al. reply

artículo científico publicado en 2014

MAPs, MARKs and microtubule dynamics.

artículo científico publicado en 1998

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

artículo científico publicado en 1997

MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes

artículo científico publicado en 2004

MARKing tau for tangles and toxicity.

artículo científico publicado en 2004

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity

artículo científico publicado en 2006

Microtubule-Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study

artículo científico publicado en 2000

Microtubule-associated protein tau, paired helical filaments, and phosphorylation.

artículo científico publicado en 1993

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

artículo científico publicado en 1995

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

artículo científico publicado en 2015

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

artículo científico publicado en 2017

Pathway proteomics and chemical proteomics team up in drug discovery.

artículo científico publicado en 2007

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

artículo científico publicado en 1993

Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics

artículo científico publicado en 1996

Probing the phalloidin binding site of actin

artículo científico publicado en 1993

Proteome survey reveals modularity of the yeast cell machinery

artículo científico publicado en 2006

Proteomics-based strategies in kinase drug discovery

scientific article published on 01 January 2007

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

artículo científico publicado en 2007

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

artículo científico publicado en 2013

Running in the family

artículo científico publicado en 2014

Screening Pools of Compounds against Multiple Endogenously Expressed Targets in a Chemoproteomics Binding Assay.

artículo científico publicado en 2015

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation

artículo científico publicado en 2020

Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor

artículo científico publicado en 2013

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

artículo científico publicado en 2016

Tau domains, phosphorylation, and interactions with microtubules.

artículo científico publicado en 1995

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

artículo científico publicado en 2017

The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

artículo científico publicado en 2017

The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains

artículo científico publicado en 2014

The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.

artículo científico publicado en 2011

The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth

scientific article published on 01 November 2003

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.

artículo científico publicado en 2015

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

artículo científico publicado en 2015

Tracking cancer drugs in living cells by thermal profiling of the proteome

artículo científico publicado en 2014

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling

artículo científico publicado en 2006

Lista de obras de Gerard Drewes

2,4-Dinitrophenyl [14C]cysteinyl disulfide allows selective radioactive labeling of protein thiols under spectrophotometric control

A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP.

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro ⬇️

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives

Chemical and pathway proteomics: powerful tools for oncology drug discovery and personalized health care.

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

Chemical proteomics in drug discovery.

Chemoproteomic approaches to drug target identification and drug profiling.

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Chemoproteomics reveals time-dependent binding of histone deacetylase inhibitors to endogenous repressor complexes

Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.

Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator.

Collaborative approaches for Target ID in neglected diseases: identifying new antimalarial targets.

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

Cooperative effects on filament stability in actin modified at the C-terminus by substitution or truncation

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle.

Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

Functional interdependence of BRD4 and DOT1L in MLL leukemia

Functional organization of the yeast proteome by systematic analysis of protein complexes

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

Human Proteinpedia enables sharing of human protein data

Identification of KasA as the cellular target of an anti-tubercular scaffold

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles

Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

Kruidenier et al. reply

MAPs, MARKs and microtubule dynamics.

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes

MARKing tau for tangles and toxicity.

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity

Microtubule-Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study

Microtubule-associated protein tau, paired helical filaments, and phosphorylation.

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

Pathway proteomics and chemical proteomics team up in drug discovery.

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics

Probing the phalloidin binding site of actin

Proteome survey reveals modularity of the yeast cell machinery

Proteomics-based strategies in kinase drug discovery

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

Running in the family

Screening Pools of Compounds against Multiple Endogenously Expressed Targets in a Chemoproteomics Binding Assay.

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation

Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Tau domains, phosphorylation, and interactions with microtubules.

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains

The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.

The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

Tracking cancer drugs in living cells by thermal profiling of the proteome

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling