Lista de obras - Thorbald van Hall - Dominio Público Uruguay

A Restricted Role for FcγR in the Regulation of Adaptive Immunity.

artículo científico publicado en 2018

A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

artículo científico publicado en 2018

A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens

artículo científico publicado en 2012

Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

artículo científico publicado en 2000

Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab

artículo científico publicado en 2011

Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome

artículo científico publicado en 2015

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2

scientific article published on 13 August 2012

Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.

artículo científico publicado en 2010

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

article

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

scholarly article

Application of multicolor fluorescence in situ hybridization analysis for detection of cross-contamination and in vitro progression in commonly used murine tumor cell lines

artículo científico publicado en 2002

Arming oncolytic reovirus with GM-CSF gene to enhance immunity

article

CD3-bispecific antibody therapy turns solid tumors into inflammatory sites but does not install protective memory

artículo científico publicado en 2018

CD4+ T Cell and NK Cell Interplay Key to Regression of MHC Class Ilow Tumors upon TLR7/8 Agonist Therapy.

artículo científico publicado en 2017

CD8+ T cell responses against TAP-inhibited cells are readily detected in the human population

artículo científico publicado en 2010

Characterization of antigen-specific immune responses induced by canarypox virus vaccines

artículo científico publicado en 2007

DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells

artículo científico publicado en 2007

Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model

artículo científico publicado en 2020

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

artículo científico publicado en 2013

Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy

artículo científico publicado en 2017

Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100

artículo científico publicado en 2009

Different expression levels of the TAP peptide transporter lead to recognition of different antigenic peptides by tumor-specific CTL.

artículo científico publicado en 2011

Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28

artículo científico publicado en 2000

Digital PCR-Based T-cell Quantification-Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

artículo científico publicado en 2018

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

artículo científico publicado en 2007

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?

artículo científico publicado en 2019

Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire

artículo científico publicado en 2014

Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma

artículo científico publicado en 2012

Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope.

artículo científico publicado en 2002

Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

artículo científico publicado en 2022

Evidence for natural killer cell-mediated protection from metastasis formation in uveal melanoma patients.

artículo científico publicado en 2009

Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire

artículo científico publicado en 2005

Future Challenges in Cancer Resistance to Immunotherapy

scientific article published on 10 April 2020

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment

artículo científico publicado en 2017

HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8⁺ T lymphocytes.

artículo científico publicado en 2011

Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma

artículo científico publicado en 2015

High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy

artículo científico publicado en 2018

Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models

scientific article published on 01 September 2020

Identification of non-mutated neoantigens presented by TAP-deficient tumors.

artículo científico publicado en 2018

Immunogenicity of rat-neu+ mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment

artículo científico publicado en 2020

Importance of TAP-independent processing pathways

artículo científico publicado en 2012

In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.

artículo científico publicado en 2010

Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination

scientific article published on 01 September 2007

Infiltrating CTLs are bothered by HLA-E on tumors

artículo científico publicado en 2012

Inhibition of CSF-1R supports T-cell mediated melanoma therapy

artículo científico publicado en 2014

Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses

artículo científico publicado en 2011

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

artículo científico publicado en 2020

Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase

artículo científico publicado en 2014

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells

artículo científico publicado en 2011

Mechanisms of peptide vaccination in mouse models: tolerance, immunity, and hyperreactivity

artículo científico

New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation

artículo científico publicado en 2013

PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy

artículo científico publicado en 2017

PD-L1 immune suppression in cancer: Tumor cells or host cells?

artículo científico publicado en 2017

Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires

artículo científico publicado en 2011

Peptide vaccination after T-cell transfer causes massive clonal expansion, tumor eradication, and manageable cytokine storm

artículo científico publicado en 2010

Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

artículo científico publicado en 2020

Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides

artículo científico publicado en 2013

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells

artículo científico publicado en 2012

Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer

artículo científico publicado en 2013

Regulatory T Cell Depletion Using A CRISPR Fc-Optimized CD25 Antibody

scholarly article

Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody

scholarly article

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

artículo científico publicado en 2006

Strategies to counteract MHC-I defects in tumors ⬇️

artículo científico publicado el 4 de febrero de 2011

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes

artículo científico publicado en 2018

T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

artículo científico publicado en 2017

TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors

artículo científico publicado en 2016

TEIPP peptides: exploration of unTAPped cancer antigens

artículo científico publicado en 2019

Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation

article

The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.

artículo científico publicado en 2018

The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer

artículo científico publicado en 2016

The NKG2A - HLA-E axis as a novel checkpoint in the tumor microenvironment

artículo científico publicado en 2020

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects

scientific journal article

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects

artículo científico publicado en 2010

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

artículo científico publicado en 2010

The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma

artículo científico publicado en 2015

The prognostic benefit of tumour-infiltrating Natural Killer cells in endometrial cancer is dependent on concurrent overexpression of Human Leucocyte Antigen-E in the tumour microenvironment

artículo científico publicado en 2017

The urgent need to recover MHC class I in cancers for effective immunotherapy

artículo científico publicado en 2016

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.

artículo científico publicado en 2015

Therapeutic cancer vaccines

artículo científico publicado en 2015

Tumor eradication by wild-type p53-specific cytotoxic T lymphocytes.

artículo científico publicado en 1997

Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy

Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity

scientific article published on 21 August 2019

Upregulation of HLA Expression in Primary Uveal Melanoma by Infiltrating Leukocytes

artículo científico publicado en 2016

Vaccination against non-mutated neoantigens induced in recurrent and future tumors

scientific article published on 15 April 2020

Vaccines for established cancer: overcoming the challenges posed by immune evasion

artículo científico publicado en 2016

Lista de obras de Thorbald van Hall

A Restricted Role for FcγR in the Regulation of Adaptive Immunity.

A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement

A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens

Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab

Alternative Antigen Processing for MHC Class I: Multiple Roads Lead to Rome

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2

Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors.

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

Application of multicolor fluorescence in situ hybridization analysis for detection of cross-contamination and in vitro progression in commonly used murine tumor cell lines

Arming oncolytic reovirus with GM-CSF gene to enhance immunity

CD3-bispecific antibody therapy turns solid tumors into inflammatory sites but does not install protective memory

CD4+ T Cell and NK Cell Interplay Key to Regression of MHC Class Ilow Tumors upon TLR7/8 Agonist Therapy.

CD8+ T cell responses against TAP-inhibited cells are readily detected in the human population

Characterization of antigen-specific immune responses induced by canarypox virus vaccines

DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells

Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy

Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100

Different expression levels of the TAP peptide transporter lead to recognition of different antigenic peptides by tumor-specific CTL.

Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28

Digital PCR-Based T-cell Quantification-Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?

Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire

Effective cooperation of monoclonal antibody and peptide vaccine for the treatment of mouse melanoma

Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope.

Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S

Evidence for natural killer cell-mediated protection from metastasis formation in uveal melanoma patients.

Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire

Future Challenges in Cancer Resistance to Immunotherapy

Genetic evolution of uveal melanoma guides the development of an inflammatory microenvironment

HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8⁺ T lymphocytes.

Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma

High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy

Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models

Identification of non-mutated neoantigens presented by TAP-deficient tumors.

Immunogenicity of rat-neu+ mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment

Importance of TAP-independent processing pathways

In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages.

Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination

Infiltrating CTLs are bothered by HLA-E on tumors

Inhibition of CSF-1R supports T-cell mediated melanoma therapy

Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses

Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells

Mechanisms of peptide vaccination in mouse models: tolerance, immunity, and hyperreactivity

New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation

PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy

PD-L1 immune suppression in cancer: Tumor cells or host cells?

Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires

Peptide vaccination after T-cell transfer causes massive clonal expansion, tumor eradication, and manageable cytokine storm

Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides

Promiscuous binding of invariant chain-derived CLIP peptide to distinct HLA-I molecules revealed in leukemic cells

Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer

Regulatory T Cell Depletion Using A CRISPR Fc-Optimized CD25 Antibody

Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

Strategies to counteract MHC-I defects in tumors ⬇️

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes

T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors

TEIPP peptides: exploration of unTAPped cancer antigens

Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation

The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability.

The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer

The NKG2A - HLA-E axis as a novel checkpoint in the tumor microenvironment

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma

The prognostic benefit of tumour-infiltrating Natural Killer cells in endometrial cancer is dependent on concurrent overexpression of Human Leucocyte Antigen-E in the tumour microenvironment

The urgent need to recover MHC class I in cancers for effective immunotherapy

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.

Therapeutic cancer vaccines