Lista de obras - Christian Johannes Gloeckner

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

artículo científico publicado en 2010

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

artículo científico publicado en 2017

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover ⬇️

artículo científico publicado en 2017

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

artículo científico publicado en 2007

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology

artículo científico publicado en 2015

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

artículo científico publicado en 2010

ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations

artículo científico publicado en 2009

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

artículo científico publicado en 2013

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

scientific journal article

Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons.

artículo científico publicado en 2018

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

artículo científico publicado en 2020

Applying SILAC for the differential analysis of protein complexes

artículo científico publicado en 2014

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

scientific article published on 13 November 2019

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

artículo científico publicado en 2016

Biochemical and kinetic properties of the complex Roco G-protein cycle

artículo científico publicado en 2018

Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.

artículo científico publicado en 2012

Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis

artículo científico publicado en 2006

Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice

artículo científico publicado en 2011

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein

artículo científico publicado en 2016

Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p

artículo científico publicado en 2000

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43)

scientific article published on 17 August 2018

Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach

artículo científico publicado en 2008

Improved mass spectrometric identification of gel-separated hydrophobic membrane proteins after sodium dodecyl sulfate removal by ion-pair extraction

artículo científico publicado en 2004

Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2005

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis

artículo científico publicado en 2019

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

artículo científico publicado en 2011

LRRK2 transport is regulated by its novel interacting partner Rab32

artículo científico publicado en 2014

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain

artículo científico publicado en 2014

Mass spectrometric identification of novel posttranslational modification sites in Huntingtin.

artículo científico publicado en 2012

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice

artículo científico publicado en 2020

Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells

article

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

artículo científico publicado en 2011

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3

artículo científico publicado en 2014

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

artículo científico publicado en 2010

Phosphorylation Modulates the Subcellular Localization of SOX11.

artículo científico publicado en 2018

Proteomic analysis of the porcine interphotoreceptor matrix

artículo científico publicado en 2005

Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

artículo científico publicado en 2011

Regulation of LRRK2: insights from structural and biochemical analysis.

artículo científico publicado en 2018

Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus

artículo científico publicado en 2008

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

artículo científico publicado en 2022

Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions

artículo científico publicado en 2009

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

scientific journal article

Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

artículo científico publicado en 2009

The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish

artículo científico publicado en 2011

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.

artículo científico publicado en 2017

The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant

artículo científico publicado en 2020

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

artículo científico publicado en 2018

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

artículo científico publicado en 2006

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

artículo científico publicado en 2009

The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.

artículo científico publicado en 2011

The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction

artículo científico publicado en 2014

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma

artículo científico publicado en 2016

Understanding the role of genetic variability in LRRK2 in Indian population

scientific article published on 28 November 2018

Lista de obras de Christian Johannes Gloeckner

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover ⬇️

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations

ATP-competitive LRRK2 inhibitors interfere with monoclonal antibody binding to the kinase domain of LRRK2 under native conditions. A method to directly monitor the active conformation of LRRK2?

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons.

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

Applying SILAC for the differential analysis of protein complexes

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

Biochemical and kinetic properties of the complex Roco G-protein cycle

Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.

Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis

Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein

Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43)

Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach

Improved mass spectrometric identification of gel-separated hydrophobic membrane proteins after sodium dodecyl sulfate removal by ion-pair extraction

Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1.

LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

LRRK2 transport is regulated by its novel interacting partner Rab32

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain

Mass spectrometric identification of novel posttranslational modification sites in Huntingtin.

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice

Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

Phosphorylation Modulates the Subcellular Localization of SOX11.

Proteomic analysis of the porcine interphotoreceptor matrix

Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

Regulation of LRRK2: insights from structural and biochemical analysis.

Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus

Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish

The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.

The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase.

The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B-cell lymphoma

Understanding the role of genetic variability in LRRK2 in Indian population