Lista de obras - Florian Nachon - Dominio Público Uruguay

A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides

artículo científico publicado en 2020

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters

artículo científico publicado en 2008

A step toward the reactivation of aged cholinesterases – Crystal structure of ligands binding to aged human butyrylcholinesterase ⬇️

artículo científico publicado el 16 de agosto de 2012

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

artículo científico publicado en 2008

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

artículo científico publicado en 2007

Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.

artículo científico publicado en 2017

Binding and hydrolysis of soman by human serum albumin

artículo científico publicado en 2007

Characterization of four BCHE mutations associated with prolonged effect of suxamethonium

artículo científico publicado en 2020

Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure

scientific article published on 02 May 2020

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

artículo científico publicado en 2003

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

artículo científico publicado en 2013

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

artículo científico publicado en 2009

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos

artículo científico publicado en 2010

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

artículo científico publicado en 2020

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

artículo científico publicado en 2002

Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes

artículo científico publicado en 2011

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers ⬇️

artículo científico publicado el 24 de junio de 2011

Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase

artículo científico publicado en 2020

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

artículo científico publicado en 2013

Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel

artículo científico publicado en 2008

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates

artículo científico publicado en 2009

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase

artículo científico publicado en 2009

New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease

artículo científico publicado en 2019

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

artículo científico publicado en 2018

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

artículo científico publicado en 2019

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.

artículo científico publicado en 2017

Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration

artículo científico publicado en 2018

Purification of recombinant human butyrylcholinesterase on Hupresin®

artículo científico publicado en 2018

Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

artículo científico publicado en 2011

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

artículo científico publicado en 2011

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents

artículo científico publicado en 2012

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging

artículo científico publicado en 2005

Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents

artículo científico publicado en 2011

Structural approach to the aging of phosphylated cholinesterases

artículo científico publicado en 2010

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

artículo científico publicado en 2010

Structure, activities and biomedical applications of human butyrylcholinesterase

artículo científico publicado en 2009

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

artículo científico publicado en 2018

Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite

artículo científico publicado en 2002

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

artículo científico publicado en 2017

The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate

artículo científico publicado en 2005

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

artículo científico publicado en 2007

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

artículo científico publicado en 2011

X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates

scientific article published on 22 October 2018

Lista de obras de Florian Nachon

A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides

A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters

A step toward the reactivation of aged cholinesterases – Crystal structure of ligands binding to aged human butyrylcholinesterase ⬇️

Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation

Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry

Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.

Binding and hydrolysis of soman by human serum albumin

Characterization of four BCHE mutations associated with prolonged effect of suxamethonium

Characterization of organophosphate-induced brain injuries in a convulsive mouse model of diisopropylfluorophosphate exposure

Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization

Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers ⬇️

Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase

Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry

Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase

New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach.

Potent 3-hydroxy-2-pyridine aldoxime reactivators of organophosphate-inhibited cholinesterases with predicted blood-brain barrier penetration

Purification of recombinant human butyrylcholinesterase on Hupresin®

Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamics

Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents

Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging

Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents

Structural approach to the aging of phosphylated cholinesterases

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation

Structure, activities and biomedical applications of human butyrylcholinesterase

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

The reactant state for substrate-activated turnover of acetylthiocholine by butyrylcholinesterase is a tetrahedral intermediate

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger

X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates