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Lista de obras de Michele Vendruscolo

A Conformational Ensemble Derived Using NMR Methyl Chemical Shifts Reveals a Mechanical Clamping Transition That Gates the Binding of the HU Protein to DNA

scientific article published in 2014

A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction

artículo científico publicado en 2008

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins

artículo científico publicado en 2016

A PDZ domain recapitulates a unifying mechanism for protein folding

artículo científico publicado en 2006

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate

artículo científico publicado en 2015

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

artículo científico publicado en 2018

A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

artículo científico publicado en 2012

A Relationship between the Aggregation Rates of α-Synuclein Variants and the β-Sheet Populations in Their Monomeric Forms ⬇️

artículo científico publicado el 9 de septiembre de 2013

A clear view of polymorphism, twist, and chirality in amyloid fibril formation

artículo científico publicado en 2013

A condensation-ordering mechanism in nanoparticle-catalyzed peptide aggregation ⬇️

artículo científico publicado en 2009

A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates

artículo científico publicado en 2008

A geometrical parametrization of C1′-C5′ RNA ribose chemical shifts calculated by density functional theory ⬇️

artículo científico publicado el 21 de julio de 2013

A glimpse at the organization of the protein universe

artículo científico publicado en 2005

A method for partitioning the information contained in a protein sequence between its structure and function

artículo científico publicado en 2018

A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings

artículo científico publicado en 2013

A method of incorporating rate constants as kinetic constraints in molecular dynamics simulations

artículo científico publicado en 2021

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

artículo científico publicado en 2019

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

artículo científico publicado en 2015

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

artículo científico publicado en 2017

A protein evolution model with independent sites that reproduces site-specific amino acid distributions from the Protein Data Bank

artículo científico publicado en 2006

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease.

artículo científico publicado en 2016

A relationship between mRNA expression levels and protein solubility in E. coli

artículo científico publicado en 2009

A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein

artículo científico publicado en 2014

A simple lattice model that captures protein folding, aggregation and amyloid formation

artículo científico publicado en 2014

A stochastic method for the reconstruction of protein structures from one-dimensional structural profiles.

artículo científico publicado en 2008

A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding

artículo científico publicado en 2016

A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone

artículo científico publicado en 2019

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

scientific article published on 17 December 2018

A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings

artículo científico publicado en 2015

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation

artículo científico publicado en 2016

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

artículo científico publicado en 2012

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

ALMOST: an all atom molecular simulation toolkit for protein structure determination.

artículo científico publicado en 2014

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism

artículo científico publicado en 2011

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

artículo científico publicado en 2015

Accurate Random Coil Chemical Shifts from an Analysis of Loop Regions in Native States of Proteins

article

Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR ⬇️

artículo científico publicado en 2010

Adsorption free energy predicts amyloid protein nucleation rates

scientific article published in 2022

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

artículo científico publicado en 2017

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

artículo científico publicado en 2011

An analytical solution to the kinetics of breakable filament assembly

artículo científico publicado en 2009

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease

artículo científico publicado en 2016

An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase

artículo científico publicado en 2020

Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations

artículo científico publicado en 2009

Analysis of the Contributions of Ring Current and Electric Field Effects to the Chemical Shifts of RNA Bases ⬇️

artículo científico publicado el 11 de febrero de 2013

Analysis of the distributed computing approach applied to the folding of a small beta peptide

artículo científico publicado en 2003

Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network

artículo científico publicado en 2015

Analysis of the performance of the CHESHIRE and YAPP methods at CASD-NMR round 3.

artículo científico publicado en 2015

Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain

artículo científico publicado en 2014

Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

scientific article published on 20 May 2020

Assessment of the quality of energy functions for protein folding by using a criterion derived with the help of the noisy go model ⬇️

artículo científico publicado el 1 de junio de 2001

Assessment of the use of NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations to characterize the dynamics of proteins

artículo científico publicado en 2013

Atomic force microscopy for single molecule characterisation of protein aggregation

artículo científico publicado en 2019

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

artículo científico publicado en 2013

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

artículo científico publicado en 2020

Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

scientific article published in Scientific Reports

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

artículo científico publicado en 2018

Automated assignment of SCOP and CATH protein structure classifications from FSSP scores.

artículo científico publicado en 2002

BPPred: a Web-based computational tool for predicting biophysical parameters of proteins

artículo científico publicado en 2006

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

artículo científico publicado en 2019

Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling

artículo científico publicado en 2018

Biological function in a non-native partially folded state of a protein

artículo científico publicado en 2008

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates

artículo científico

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

artículo científico publicado en 2020

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases - ERRATUM

scientific article published on 18 November 2020

Blind testing of routine, fully automated determination of protein structures from NMR data

artículo científico publicado en 2012

Calculation of mutational free energy changes in transition states for protein folding

artículo científico publicado en 2003

Calculation of the free energy barriers in the oligomerisation of Ab

scientific article published on 01 May 2008

Can a pairwise contact potential stabilize native protein folds against decoys obtained by threading?

artículo científico publicado en 2000

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins

article

Characterisation of transition state structures for protein folding using 'high', 'medium' and 'low' {Phi}-values

artículo científico

Characterization of the conformational equilibrium between the two major substates of RNase A using NMR chemical shifts

artículo científico publicado en 2012

Characterization of the conformational fluctuations in the Josephin domain of ataxin-3.

artículo científico publicado en 2014

Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics

artículo científico publicado en 2013

Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations

artículo científico publicado en 2013

Characterization of the nucleation barriers for protein aggregation and amyloid formation

artículo científico publicado en 2007

Characterization of the residual structure in the unfolded state of the Δ131Δ fragment of staphylococcal nuclease

article

Characterizing the first steps of amyloid formation for the ccbeta peptide

artículo científico publicado en 2008

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

artículo científico publicado en 2018

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation

artículo científico publicado en 2019

Chemical biology: More charges against aggregation

artículo científico publicado en 2007

Chemical kinetics for drug discovery to combat protein aggregation diseases

artículo científico

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

artículo científico publicado en 2016

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

artículo científico publicado en 2018

Chris Dobson (1949-2019)

artículo científico publicado en 2020

Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study

artículo científico publicado en 2015

Coarse-grained model for protein folding based on structural profiles

artículo científico publicado en 2011

Comparison of sequence-based and structure-based energy functions for the reversible folding of a peptide

artículo científico publicado en 2005

Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins

artículo científico publicado en 2008

Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraints

artículo científico publicado en 2004

Comparison of the transition states for folding of two Ig-like proteins from different superfamilies

artículo científico publicado en 2004

Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin

artículo científico publicado en 2008

Competition between intramolecular and intermolecular interactions in an amyloid-forming protein

artículo científico publicado en 2009

Connectivity of Neutral Networks, Overdispersion, and Structural Conservation in Protein Evolution

article published in 2003

Cooperative Assembly of Hsp70 Subdomain Clusters

scientific article published on 29 May 2018

Correlation between mRNA expression levels and protein aggregation propensities in subcellular localisations

Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein.

artículo científico publicado en 2017

Cucurbit[8]uril and blue-box: high-energy water release overwhelms electrostatic interactions

artículo científico publicado en 2013

Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism

artículo científico publicado en 2014

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

artículo científico publicado en 2021

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

artículo científico publicado en 2017

Derivation of a solubility condition for proteins from an analysis of the competition between folding and aggregation.

artículo científico publicado en 2010

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

artículo científico publicado en 2011

Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings

artículo científico publicado en 2011

Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts

artículo científico publicado en 2012

Determination of Structural Ensembles of Proteins: Restraining vs Reweighting

scientific article published on 28 November 2018

Determination of a Structural Ensemble Representing the Dynamics of a G-Quadruplex DNA

artículo científico publicado en 2019

Determination of a transition state at atomic resolution from protein engineering data

artículo científico publicado en 2002

Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein

artículo científico publicado en 2004

Determination of an ensemble of structures representing the intermediate state of the bacterial immunity protein Im7.

artículo científico publicado en 2005

Determination of conformationally heterogeneous states of proteins

artículo científico publicado en 2007

Determination of protein structural ensembles using cryo-electron microscopy

artículo científico publicado en 2018

Determination of protein structures consistent with NMR order parameters

artículo científico publicado en 2004

Determination of protein structures in the solid state from NMR chemical shifts

artículo científico publicado en 2008

Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings

artículo científico publicado en 2012

Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach

scientific article published on 21 July 2018

Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values

artículo científico publicado en 2005

Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements

artículo científico publicado en 2009

Determination of the individual roles of the linker residues in the interdomain motions of calmodulin using NMR chemical shifts

artículo científico publicado en 2014

Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses

artículo científico publicado en 2008

Developing NMR methods for macromolecular machines: Measurement of residual dipolar couplings to probe dynamic regions of the ribosome

scholarly article published 10 May 2018

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers

scientific article published on 02 August 2019

Diffusion in disordered media as a process with memory.

artículo científico publicado en 1996

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

artículo científico publicado en 2020

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

artículo científico publicado en 2014

Disordered flat phase and phase diagram for restricted solid-on-solid models of fcc (110) surfaces

artículo científico publicado en 1996

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

artículo científico publicado en 2018

Druggability of Intrinsically Disordered Proteins

artículo científico publicado en 2015

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

artículo científico publicado en 2015

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

artículo científico publicado en 2020

Effective interactions between chaotropic agents and proteins

artículo científico publicado en 2005

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

article

Efficient identification of near-native conformations in ab initio protein structure prediction using structural profiles.

artículo científico publicado en 2010

Emergence and evolution of an interaction between intrinsically disordered proteins

artículo científico publicado en 2017

Energetics of enzyme stability ⬇️

artículo científico publicado el 1 de enero de 2002

Enzymatic activity in disordered states of proteins ⬇️

artículo científico publicado el 9 de septiembre de 2010

Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts.

artículo científico publicado en 2014

Erratum: Prediction of variable translation rate effects on cotranslational protein folding

artículo científico publicado en 2013

Excited-State Control of Protein Activity ⬇️

artículo científico publicado el 27 de julio de 2011

Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

artículo científico publicado en 2011

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding

artículo científico publicado en 2018

Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response

artículo científico publicado en 2019

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

artículo científico publicado en 2018

Factors That Affect the Degree of Twist in β-Sheet Structures: A Molecular Dynamics Simulation Study of a Cross-β Filament of the GNNQQNY Peptide

Factors that affect the degree of twist in beta-sheet structures: a molecular dynamics simulation study of a cross-beta filament of the GNNQQNY peptide

artículo científico publicado en 2009

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans

scientific article published on 27 June 2019

Fast and accurate predictions of protein NMR chemical shifts from interatomic distances.

artículo científico publicado en 2009

Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone

artículo científico publicado en 2012

Focus on physical principles of protein behavior in the cell

Folding of small proteins by Monte Carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology

artículo científico publicado en 2009

Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies

artículo científico publicado en 2005

From macroscopic measurements to microscopic mechanisms of protein aggregation

artículo científico

Functional interactions as a survival strategy against abnormal aggregation

artículo científico publicado en 2010

Geometry, energetics, and dynamics of hydrogen bonds in proteins: structural information derived from NMR scalar couplings

artículo científico publicado en 2006

Hamiltonian Dynamics of Protein Filament Formation

artículo científico publicado en 2016

Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy

artículo científico publicado en 2013

How to guarantee optimal stability for most representative structures in the Protein Data Bank.

artículo científico publicado en 2001

Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain

artículo científico publicado en 2016

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.

artículo científico publicado en 2014

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

artículo científico publicado en 2015

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

scientific article published on March 2017

Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide

artículo científico publicado en 2013

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

artículo científico publicado en 2019

Importance of metastable states in the free energy landscapes of polypeptide chains

artículo científico publicado en 2007

In support of the BMRB.

artículo científico publicado en 2012

In vitro and in silico Activity of Iridoids Against Leishmania amazonensis

artículo científico publicado en 2019

In vitro and in silico assessment of the developability of a designed monoclonal antibody library

scientific article published on 18 January 2019

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

artículo científico publicado en 2012

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells

artículo científico publicado en 2013

Influence of Harvest Season and Cultivar on the Variation of Phenolic Compounds Composition and Antioxidant Properties in Vaccinium ashei Leaves.

artículo científico publicado en 2017

Influence of the fluctuations of the alignment tensor on the analysis of the structure and dynamics of proteins using residual dipolar couplings

scientific article published on 21 November 2007

Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region

artículo científico publicado en 2008

Inhibition of protein crystallization by evolutionary negative design

artículo científico publicado en 2004

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

artículo científico publicado en 2017

Interactions in the native state of monellin, which play a protective role against aggregation

article

Interpreting Dynamically-Averaged Scalar Couplings in Proteins

article

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide

artículo científico publicado en 2010

Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in

scientific article published on 03 May 2019

Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation

artículo científico publicado en 2011

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in <i>C. elegans</i>

artículo científico publicado en 2021

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

artículo científico publicado en 2016

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

artículo científico publicado en 2020

Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates

artículo científico publicado en 2014

Lack of self-averaging in neutral evolution of proteins

artículo científico publicado en 2002

Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue

Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

artículo científico publicado en 2015

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

article

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

artículo científico publicado en 2015

Looking at structure, stability, and evolution of proteins through the principal eigenvector of contact matrices and hydrophobicity profiles.

artículo científico publicado en 2005

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

artículo científico publicado en 2004

MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions

artículo científico publicado en 2017

Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine

artículo científico publicado en 2020

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

article

Mapping of two networks of residues that exhibit structural and dynamical changes upon binding in a PDZ domain protein

artículo científico publicado en 2008

Mapping the Protein Fold Universe Using the CamTube Force Field in Molecular Dynamics Simulations

artículo científico publicado en 2015

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

artículo científico publicado en 2018

Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics

artículo científico publicado en 2016

Metainference: A Bayesian inference method for heterogeneous systems

artículo científico publicado en 2016

Metastability of Native Proteins and the Phenomenon of Amyloid Formation

article

Methods of probing the interactions between small molecules and disordered proteins

artículo científico

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

artículo científico publicado en 2015

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

artículo científico publicado en 2018

Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons

artículo científico publicado en 2019

MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.

artículo científico publicado en 2017

Model of correlated evolution

artículo científico publicado en 1996

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

artículo científico publicado en 2016

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

artículo científico publicado en 2008

Molecular determinants of the interaction of EGCG with ordered and disordered proteins

scientific article published on 30 March 2018

Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs

scientific article published on 04 July 2018

Molecular dynamics simulations from putative transition states of alpha-spectrin SH3 domain

artículo científico publicado en 2007

Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle

artículo científico publicado en 2013

Molecular dynamics studies of the process of amyloid aggregation of peptide fragments of transthyretin

artículo científico publicado en 2004

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

artículo científico publicado en 2016

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

artículo científico publicado en 2017

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase

artículo científico publicado en 2008

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

artículo científico publicado en 2016

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

artículo científico publicado en 2014

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

artículo científico publicado en 2017

Native and non-native interactions along protein folding and unfolding pathways

scientific article published on 01 May 2002

Networks of Dynamic Allostery Regulate Enzyme Function

scientific article published on 27 December 2016

Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation

artículo científico publicado en 2021

Neutral evolution of model proteins: diffusion in sequence space and overdispersion

article

New opportunities for tensor-free calculations of residual dipolar couplings for the study of protein dynamics

artículo científico

New scenarios of protein folding can occur on the ribosome

scientific article published on 04 January 2011

Nucleated polymerisation in the presence of pre-formed seed filaments

artículo científico publicado en 2011

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

artículo científico publicado en 2011

Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations

artículo científico publicado en 2011

Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations

artículo científico publicado en 2011

On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid

artículo científico publicado en 2009

Optimal Protein Design Procedure

artículo científico publicado en 1996

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

artículo científico publicado en 2017

Parapred: antibody paratope prediction using convolutional and recurrent neural networks

artículo científico publicado en 2018

Parmbsc1: a refined force field for DNA simulations ⬇️

artículo científico publicado en 2015

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication ⬇️

artículo científico publicado en 2017

Physical principles of protein behavior in the cell

artículo científico publicado en 2009

Physicochemical determinants of chaperone requirements.

artículo científico publicado en 2010

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

scholarly article

Position-dependent electrostatic protection against protein aggregation

artículo científico publicado en 2009

Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms

artículo científico publicado en 2008

Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases

artículo científico publicado en 2005

Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences

Prediction of aggregation-prone regions in structured proteins

artículo científico publicado en 2008

Prediction of site-specific amino acid distributions and limits of divergent evolutionary changes in protein sequences

artículo científico publicado en 2005

Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains

Prediction of variable translation rate effects on cotranslational protein folding

artículo científico publicado en 2012

Principal eigenvector of contact matrices and hydrophobicity profiles in proteins

Principles of protein structural ensemble determination

artículo científico publicado en 2017

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies

scientific article published on 14 May 2019

Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy

artículo científico publicado en 2015

Probing the dynamic stalk region of the ribosome using solution NMR

artículo científico publicado en 2019

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

artículo científico publicado en 2013

Protein dynamics under light control

scientific article published on 01 August 2008

Protein dynamics: Moore's law in molecular biology.

artículo científico publicado en 2011

Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biological systems

artículo científico publicado en 2003

Protein folding and the organization of the protein topology universe.

artículo científico publicado en 2005

Protein folding using contact maps.

artículo científico publicado en 2000

Protein folding: bringing theory and experiment closer together

artículo científico publicado en 2003

Protein homeostasis of a metastable subproteome associated with Alzheimer's disease

artículo científico publicado en 2017

Protein regulation: the statistical theory of allostery

artículo científico publicado en 2011

Protein solubility and protein homeostasis: a generic view of protein misfolding disorders

artículo científico publicado en 2011

Protein structure determination from NMR chemical shifts

artículo científico publicado en 2007

Protein structure validation using side-chain chemical shifts

artículo científico publicado en 2012

Proteome folding and aggregation ⬇️

artículo científico publicado el 7 de febrero de 2012

Proteome-level interplay between folding and aggregation propensities of proteins.

artículo científico publicado en 2010

Proteome-wide observation of the phenomenon of life on the edge of solubility

artículo científico publicado en 2019

Quantitative approaches to defining normal and aberrant protein homeostasis

artículo científico publicado en 2009

Quenched disorder, memory, and self-organization.

artículo científico publicado en 1996

Rapid and accurate in silico solubility screening of a monoclonal antibody library.

artículo científico publicado en 2017

Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange

artículo científico publicado en 2003

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

artículo científico publicado en 2020

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

artículo científico publicado en 2015

Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability

artículo científico publicado en 2016

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

artículo científico publicado en 2020

Reconstruction of protein structures from a vectorial representation

scientific article published in Physical Review Letters

Recovery of protein structure from contact maps ⬇️

artículo científico publicado el 1 de enero de 1997

Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation

scientific article published on 01 June 2020

Relation between native ensembles and experimental structures of proteins

artículo científico publicado en 2006

Replica-Averaged Metadynamics

artículo científico publicado en 2013

Reply to “Comment on ‘A Tensor-Free Method for the Structural and Dynamic Refinement of Proteins using Residual Dipolar Couplings’”

Reversible inhibition of the ClpP protease via an N-terminal conformational switch

article published in the Proceedings of the National Academy of Sciences of the United States of America

Role of intermolecular forces in defining material properties of protein nanofibrils

artículo científico publicado en 2007

SAR by kinetics for drug discovery in protein misfolding diseases

article published in the Proceedings of the National Academy of Sciences of the United States of America

Scaling behaviour and rate-determining steps in filamentous self-assembly

artículo científico publicado en 2017

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates

scientific article published on 17 April 2019

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

artículo científico publicado en 2017

Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain

artículo científico publicado en 2003

Self-templated nucleation in peptide and protein aggregation

artículo científico publicado en 2008

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

artículo científico publicado en 2017

Sequence-Based Prediction of Protein Behavior

Sequence-based prediction of protein binding mode landscapes

scientific article published on 26 May 2020

Sequence-based prediction of protein solubility.

artículo científico publicado en 2011

Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides

artículo científico publicado en 2007

Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy

artículo científico publicado en 2018

Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop

artículo científico publicado en 2017

Simultaneous Production of Amyloglucosidase and Exo-Polygalacturonase by Aspergillus niger in a Rotating Drum Reactor.

artículo científico publicado en 2016

Simultaneous determination of protein structure and dynamics.

artículo científico publicado en 2005

Simultaneous quantification of protein order and disorder

artículo científico publicado en 2017

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy

artículo científico publicado en 2020

Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.

artículo científico publicado en 2013

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

artículo científico publicado en 2020

Small-world view of the amino acids that play a key role in protein folding

artículo científico publicado en 2002

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

artículo científico publicado en 2014

Spatial Propagation of Protein Polymerization

scientific article published in Physical Review Letters

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

artículo científico publicado en 2017

Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic

artículo científico publicado en 2022

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions

artículo científico publicado en 2018

Statistical mechanics of the denatured state of a protein using replica-averaged metadynamics

artículo científico publicado en 2014

Statistical properties of contact vectors

scientific article published on 18 March 2002

Statistical properties of neutral evolution

artículo científico publicado en 2003

Stochastic reconstruction of protein structures from effective connectivity profiles

artículo científico publicado en 2008

Structural Characterization of the Early Events in the Nucleation-Condensation Mechanism in a Protein Folding Process

artículo científico publicado en 2017

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein

artículo científico publicado en 2016

Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins

artículo científico publicado en 2018

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

artículo científico publicado en 2016

Structural Insights into the Calcium-Mediated Allosteric Transition in the C-Terminal Domain of Calmodulin from Nuclear Magnetic Resonance Measurements.

artículo científico publicado en 2015

Structural Interpretation of Hydrogen Exchange Protection Factors in Proteins: Characterization of the Native State Fluctuations of CI2

scientific article published on 01 January 2006

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

artículo científico publicado en 2017

Structural basis of synaptic vesicle assembly promoted by α-synuclein

artículo científico publicado en 2016

Structural biology. Dynamic visions of enzymatic reactions

artículo científico publicado en 2006

Structural biology: Protein self-assembly intermediates

artículo científico publicado en 2013

Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain

article published in 2010

Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

artículo científico publicado en 2016

Structural comparison of the two alternative transition states for folding of TI I27.

artículo científico publicado en 2006

Structural differences between toxic and nontoxic HypF-N oligomers

article

Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils

artículo científico publicado en 2007

Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures

artículo científico publicado en 2015

Structure and Dynamics of Intrinsically Disordered Proteins

artículo científico

Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation

artículo científico publicado en 2008

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

artículo científico publicado en 2015

Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex

artículo científico publicado en 2008

Structure of a Misfolded Intermediate of a PDZ Domain

Structure of a low-population binding intermediate in protein-RNA recognition

artículo científico publicado en 2016

Structure of a low-population intermediate state in the release of an enzyme product

artículo científico publicado en 2015

Structure of an intermediate state in protein folding and aggregation

artículo científico publicado en 2012

Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins

artículo científico publicado en 2015

Structure-based prediction of methyl chemical shifts in proteins

artículo científico publicado en 2011

Structures and relative free energies of partially folded states of proteins

artículo científico publicado en 2003

Structures of the Excited States of Phospholamban and Shifts in Their Populations upon Phosphorylation

artículo científico publicado en 2013

Subdomain architecture and stability of a giant repeat protein.

artículo científico publicado en 2013

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

artículo científico publicado en 2015

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

artículo científico publicado en 2017

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

artículo científico publicado en 2007

Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis

article published in the Proceedings of the National Academy of Sciences of the United States of America

Systematic mapping of the free energy landscapes of a growing immunoglobulin domain identifies a kinetic intermediate associated with co-translational proline isomerization

Targeting disordered proteins with small molecules using entropy

artículo científico

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

artículo científico publicado en 2014

The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein

artículo científico publicado en 2011

The CamSol method of rational design of protein mutants with enhanced solubility

artículo científico publicado en 2014

The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.

artículo científico publicado en 2014

The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native state ensembles of proteins

artículo científico publicado en 2007

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

scientific article published on 14 January 2020

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage.

artículo científico publicado en 2017

The Structurally Constrained Neutral Model of Protein Evolution

article

The Zyggregator method for predicting protein aggregation propensities

artículo científico publicado en 2008

The amyloid state and its association with protein misfolding diseases.

artículo científico publicado en 2014

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

artículo científico publicado en 2021

The distribution of residues in a polypeptide sequence is a determinant of aggregation optimized by evolution.

artículo científico publicado en 2007

The diversity of<i>SNCA</i>transcripts in neurons, and its impact on antisense oligonucleotide therapeutics

The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide.

artículo científico publicado en 2014

The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions

The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

artículo científico publicado en 2011

The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

artículo científico publicado en 2015

The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints

artículo científico publicado en 2009

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

artículo científico publicado en 2017

The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins

artículo científico publicado en 2014

Theoretical approaches to protein aggregation

artículo científico publicado en 2006

Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers

artículo científico publicado en 2020

Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors

scientific article published on 14 September 2020

Third generation antibody discovery methods: in silico rational design

scientific article published on 01 December 2018

Time averaging of NMR chemical shifts in the MLF peptide in the solid state

artículo científico publicado en 2010

Toward an accurate determination of free energy landscapes in solution states of proteins

artículo científico publicado en 2009

Towards a structural biology of the hydrophobic effect in protein folding

artículo científico publicado en 2016

Towards complete descriptions of the free-energy landscapes of proteins

artículo científico publicado en 2005

Towards quantitative predictions in cell biology using chemical properties of proteins

artículo científico publicado en 2008

Transient tertiary structure formation within the ribosome exit port

artículo científico publicado en 2010

Transition state contact orders correlate with protein folding rates

artículo científico publicado en 2005

Transition states for protein folding have native topologies despite high structural variability

artículo científico publicado en 2004

Translationally optimal codons associate with aggregation-prone sites in proteins

artículo científico publicado en 2010

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

artículo científico publicado en 2020

Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions.

artículo científico publicado en 2012

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

scientific article published on 13 August 2020

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

Twisting transition between crystalline and fibrillar phases of aggregated peptides

scientific article published in Physical Review Letters

Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein

artículo científico publicado en 2014

Understanding the influence of codon translation rates on cotranslational protein folding

artículo científico

Using NMR chemical shifts as structural restraints in molecular dynamics simulations of proteins

artículo científico publicado en 2010

Using Pseudocontact Shifts and Residual Dipolar Couplings as Exact NMR Restraints for the Determination of Protein Structural Ensembles

artículo científico publicado en 2015

Using Side-Chain Aromatic Proton Chemical Shifts for a Quantitative Analysis of Protein Structures

Using chemical shifts to determine structural changes in proteins upon complex formation

artículo científico publicado en 2011

Using side-chain aromatic proton chemical shifts for a quantitative analysis of protein structures.

artículo científico publicado en 2011

Validity of Gō models: comparison with a solvent-shielded empirical energy decomposition

artículo científico publicado en 2002

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

artículo científico publicado en 2015

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

artículo científico publicado en 2017

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

artículo científico publicado en 2013

Widespread occurrence of the droplet state of proteins in the human proteome

artículo científico publicado en 2020

Widespread remodeling of proteome solubility in response to different protein homeostasis stresses

scientific article published on 21 January 2020

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins

artículo científico publicado en 2014

¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase

artículo científico publicado en 2011

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

artículo científico publicado en 2016

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