Lista de obras - Jean-Philippe Julien - Dominio Público Uruguay

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

artículo científico publicado en 2017

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

artículo científico publicado en 2011

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

artículo científico publicado en 2015

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

artículo científico publicado en 2013

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

scientific article published on 09 October 2020

Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding

artículo científico publicado en 2010

Antibodies against Plasmodium falciparum malaria at the molecular level

scientific article published on 28 August 2019

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

artículo científico publicado en 2015

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

artículo científico publicado en 2018

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

artículo científico publicado en 2013

B cell targeting by molecular adjuvants for enhanced immunogenicity

artículo científico publicado en 2020

Broad neutralization coverage of HIV by multiple highly potent antibodies

artículo científico publicado en 2011

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

artículo científico publicado en 2013

CD4-induced activation in a soluble HIV-1 Env trimer

artículo científico publicado en 2014

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

artículo científico publicado en 2013

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

artículo científico publicado en 2015

Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope

artículo científico publicado en 2012

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

artículo científico publicado en 2013

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

artículo científico publicado en 2013

Crystal structure of the complex between the F(ab)' fragment of the cross-neutralizing anti-HIV-1 antibody 2F5 and the F(ab) fragment of its anti-idiotypic antibody 3H6

artículo científico publicado en 2008

Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

artículo científico publicado en 2009

De novo protein design enables the precise induction of RSV-neutralizing antibodies

artículo científico publicado en 2020

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

artículo científico publicado en 2015

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

artículo científico publicado en 2014

Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.

artículo científico publicado en 2016

Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

artículo científico publicado en 2013

EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis

artículo científico publicado en 2016

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

artículo científico publicado en 2020

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

artículo científico publicado en 2015

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

artículo científico publicado en 2016

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

artículo científico publicado en 2015

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

artículo científico publicado en 2017

Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

artículo científico publicado en 2013

Interaction of anti-HIV type 1 antibody 2F5 with phospholipid bilayers and its relevance for the mechanism of virus neutralization

artículo científico publicado en 2011

Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.

artículo científico publicado en 2016

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

artículo científico publicado en 2021

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

artículo científico publicado en 2012

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

artículo científico publicado en 2016

Molecular basis of human CD22 function and therapeutic targeting

artículo científico publicado en 2017

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

artículo científico publicado en 2017

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

artículo científico publicado en 2019

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

artículo científico publicado en 2021

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

artículo científico publicado en 2017

Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane

artículo científico publicado en 2012

Origins of a Vaccine-Induced, Human Anti-HIV-1 Antibody

artículo científico publicado en 2015

Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

artículo científico publicado en 2012

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

scientific article published on 24 September 2019

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

artículo científico publicado en 2014

Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection

artículo científico publicado en 2017

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

artículo científico publicado en 2013

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

artículo científico publicado en 2014

Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth

artículo científico publicado en 2015

Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments

artículo científico publicado en 2017

Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori

artículo científico publicado en 2006

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers

scientific article published on 03 July 2013

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

artículo científico publicado en 2020

Structural constraints imposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5

artículo científico publicado en 2009

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

artículo científico publicado en 2014

Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

artículo científico publicado en 2008

Structural evolution of glycan recognition by a family of potent HIV antibodies

artículo científico publicado en 2014

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

artículo científico publicado en 2012

Structural ordering of the <i>Plasmodium berghei</i> circumsporozoite protein repeats by inhibitory antibody 3D11

artículo científico publicado en 2020

Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

artículo científico publicado en 2014

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

artículo científico publicado en 2011

Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

artículo científico publicado en 2011

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies

artículo científico publicado en 2019

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

artículo científico publicado en 2013

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

artículo científico publicado en 2013

The structural basis of modified nucleosome recognition by 53BP1

artículo científico publicado en 2016

Toward a Carbohydrate-Based HIV-1 Vaccine

article

Lista de obras de Jean-Philippe Julien

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding

Antibodies against Plasmodium falciparum malaria at the molecular level

Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

B cell targeting by molecular adjuvants for enhanced immunogenicity

Broad neutralization coverage of HIV by multiple highly potent antibodies

Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

CD4-induced activation in a soluble HIV-1 Env trimer

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer

Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

Crystal structure of the complex between the F(ab)' fragment of the cross-neutralizing anti-HIV-1 antibody 2F5 and the F(ab) fragment of its anti-idiotypic antibody 3H6

Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming.

Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism

EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

Interaction of anti-HIV type 1 antibody 2F5 with phospholipid bilayers and its relevance for the mechanism of virus neutralization

Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.

Molecular basis of human CD22 function and therapeutic targeting

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies

Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane

Origins of a Vaccine-Induced, Human Anti-HIV-1 Antibody

Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.

Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth

Structural Basis of Enhanced Crystallizability Induced by a Molecular Chaperone for Antibody Antigen-Binding Fragments

Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of pseudaminic acid, an essential flagellar modification in Helicobacter pylori

Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

Structural constraints imposed by the conserved fusion peptide on the HIV-1 gp41 epitope recognized by the broadly neutralizing antibody 2F5

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site

Structural evolution of glycan recognition by a family of potent HIV antibodies

Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

Structural ordering of the <i>Plasmodium berghei</i> circumsporozoite protein repeats by inhibitory antibody 3D11

Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope

Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies

Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

The structural basis of modified nucleosome recognition by 53BP1

Toward a Carbohydrate-Based HIV-1 Vaccine