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Lista de obras de Alberto Bardelli

"Invasive-growth" signaling by the Met/HGF receptor: the hereditary renal carcinoma connection.

artículo científico publicado en 1997

A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

scientific article published on 07 March 2019

A Peptide Representing the Carboxyl-terminal Tail of the Met Receptor Inhibits Kinase Activity and Invasive Growth

artículo científico publicado en 1999

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

scientific article published on 12 December 2019

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

artículo científico publicado en 2016

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

artículo científico publicado en 2011

A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor

artículo científico publicado en 1993

A point mutation in the MET oncogene abrogates metastasis without affecting transformation.

artículo científico publicado en 1997

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.

artículo científico publicado en 2017

Absence of AKT1 mutations in glioblastoma

artículo científico publicado en 2009

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

artículo científico publicado en 2016

Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer.

artículo científico publicado en 2015

Acquired resistance to EGFR-targeted therapies in colorectal cancer

artículo científico publicado en 2014

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

artículo científico publicado en 2004

Activation of β-catenin by oncogenic PIK3CA and EGFR promotes resistance to glucose deprivation by inducing a strong antioxidant response

artículo científico publicado en 2012

Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes

artículo científico publicado en 2012

Adaptive mutability of colorectal cancers in response to targeted therapies

scientific article published on 07 November 2019

Alterations in Vascular Gene Expression in Invasive Breast Carcinoma

article

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

artículo científico publicado en 2013

Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade

scientific article published on 11 September 2018

Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab

artículo científico publicado en 2010

Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains

artículo científico publicado el 1 de octubre de 1992

BRAF V600E is a determinant of sensitivity to proteasome inhibitors

artículo científico publicado en 2013

Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction

artículo científico publicado en 1995

Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

scientific article published on 08 September 2009

Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.

artículo científico publicado en 2014

Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients

artículo científico publicado en 2015

Broccoli, PTEN deletion and prostate cancer: where is the link?

artículo científico publicado en 2010

CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

artículo científico publicado en 2016

Carcinogen-specific induction of genetic instability.

artículo científico publicado en 2001

Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases

scientific article published on 01 February 2019

Circulating pEGFR is a candidate response biomarker of cetuximab therapy in colorectal cancer

artículo científico publicado en 2014

Climbing RAS, the Everest of Oncogenes

artículo científico publicado en 2014

Clonal evolution and KRAS-MET coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer.

artículo científico publicado en 2016

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

artículo científico publicado en 2015

Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance

artículo científico publicado en 2017

Colorectal cancer: mutations in a signalling pathway

artículo científico publicado en 2005

Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis.

artículo científico publicado en 1999

Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

artículo científico publicado en 2016

Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours

artículo científico publicado en 2016

Corrigendum: Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges

artículo científico publicado en 2018

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

artículo científico publicado en 2010

Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects

artículo científico publicado en 2011

Detection of circulating tumor DNA in early- and late-stage human malignancies

artículo científico publicado en 2014

Different point mutations in the met oncogene elicit distinct biological properties.

artículo científico publicado en 2000

Digital PCR assessment of MGMT promoter methylation coupled with reduced protein expression optimises prediction of response to alkylating agents in metastatic colorectal cancer patients.

artículo científico

Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer.

artículo científico publicado en 2015

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

artículo científico publicado en 2004

Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

artículo científico publicado en 2017

Does early metastatic seeding occur in colorectal cancer?

scientific article published on 01 November 2019

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial

artículo científico publicado en 2016

Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer.

artículo científico publicado en 2017

ESMO consensus guidelines for the management of patients with metastatic colorectal cancer.

artículo científico publicado en 2016

Early-onset colorectal cancer in young individuals

artículo científico publicado en 2018

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

artículo científico publicado en 2010

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

artículo científico publicado en 2016

Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial

artículo científico publicado en 2018

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

artículo científico publicado en 2012

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

artículo científico publicado en 2017

Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.

artículo científico publicado en 2015

Erratum to: Integrated molecular dissection of the epidermal growth factor receptor (EGFR) oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer

scholarly article published in Targeted oncology

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

scientific article published on 01 July 2015

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

scientific article published on 28 June 2019

Exploiting DNA repair defects in colorectal cancer

artículo científico publicado en 2019

Exploring the links between cancer and placenta development

article

Exposure to the Tobacco Smoke Constituent 4-Aminobiphenyl Induces Chromosomal Instability in Human Cancer Cells

scientific article published on 01 August 2007

Expression and functional regulation of myoglobin in epithelial cancers

artículo científico publicado en 2009

Failure is not final: ctDNA-guided rechallenge therapy in colorectal cancer

scientific article published on 01 February 2019

Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.

artículo científico publicado en 1997

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

artículo científico publicado en 2005

Genetic analysis of the kinome and phosphatome in cancer

artículo científico publicado en 2005

Genetic targeting of the kinase activity of the Met receptor in cancer cells

artículo científico publicado en 2007

Genomic landscapes of cancers: prospects for targeted therapies

Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance

artículo científico

Genotyping tumour DNA in cerebrospinal fluid and plasma of a HER2-positive breast cancer patient with brain metastases.

artículo científico publicado en 2017

HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer

artículo científico publicado en 2019

Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene.

artículo científico publicado en 1994

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer.

artículo científico

High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib

artículo científico publicado en 2019

High frequency of mutations of the PIK3CA gene in human cancers

artículo científico publicado en 2004

High-dose vitamin C enhances cancer immunotherapy

artículo científico publicado en 2020

Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model

artículo científico publicado en 2014

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients.

artículo científico publicado en 2017

How liquid biopsies can change clinical practice in oncology

artículo científico publicado en 2019

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

artículo científico publicado en 2009

Identification of cancer genes by mutational profiling of tumor genomes

artículo científico publicado en 2005

Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells

artículo científico publicado en 2005

Identification of functional domains in the hepatocyte growth factor and its receptor by molecular engineering

artículo científico publicado en 1994

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

artículo científico publicado en 2017

Inactivation of DNA repair-prospects for boosting cancer immune surveillance

scientific article published on 28 November 2018

Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer.

artículo científico publicado en 2011

Induction of epithelial tubules by growth factor HGF depends on the STAT pathway

artículo científico publicado en 1998

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

artículo científico publicado en 2012

Integrated molecular dissection of the epidermal growth factor receptor (EGFR) [corrected] oncogenic pathway to predict response to EGFR-targeted monoclonal antibodies in metastatic colorectal cancer.

artículo científico publicado en 2010

Integrating liquid biopsies into the management of cancer

artículo científico publicado en 2017

International network of cancer genome projects

artículo científico publicado en 2010

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

artículo científico publicado en 2014

Isogenic mutant human cells: a new tool for personalized cancer medicine.

artículo científico publicado en 2010

KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy

artículo científico publicado en 2013

KRAS mutations testing in colorectal carcinoma patients in Italy: from guidelines to external quality assessment

artículo científico publicado en 2011

Kinase mutations in cancer: chinks in the enemy's armour?

artículo científico publicado en 2006

Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers

artículo científico publicado en 2007

Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies

artículo científico publicado en 2016

Liquid Biopsies for Monitoring Temporal Genomic Heterogeneity in Breast and Colon Cancers.

artículo científico publicado en 2017

Liquid Biopsies, What We Do Not Know (Yet).

artículo científico publicado en 2017

Liquid biopsies to evaluate early therapeutic response in colorectal cancer: Figure 1

article

Liquid biopsies: genotyping circulating tumor DNA

artículo científico publicado en 2014

Liquid biopsy: monitoring cancer-genetics in the blood

artículo científico publicado en 2013

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

artículo científico publicado en 2019

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

artículo científico publicado en 2017

Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET.

artículo científico publicado en 1999

MET mutations in cancers of unknown primary origin (CUPs).

artículo científico publicado en 2010

MET-Driven Resistance to Dual EGFR and BRAF Blockade May Be Overcome by Switching from EGFR to MET Inhibition in BRAF-Mutated Colorectal Cancer.

artículo científico publicado en 2016

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.

artículo científico publicado en 2016

Medical research: Personalized test tracks cancer relapse

artículo científico publicado en 2017

Minimal residual disease in breast cancer: in blood veritas

artículo científico publicado en 2014

Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis.

artículo científico publicado en 2013

Modeling tumor progression by the sequential introduction of genetic alterations into the genome of human normal cells.

artículo científico publicado en 2013

Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer

artículo científico publicado en 2015

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

artículo científico publicado en 2016

Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer

artículo científico publicado en 2010

Molecular profiling of the "plexinome" in melanoma and pancreatic cancer

artículo científico publicado en 2009

Molecularly targeted therapies for colorectal cancer: Strategies for implementing translational research in clinical trials.

scientific article published on December 2010

Monitoring tumor-derived cell-free DNA in patients with solid tumors: clinical perspectives and research opportunities

artículo científico publicado en 2013

Mouse models of Kras-mutant colorectal cancer: valuable GEMMs for drug testing?

artículo científico publicado en 2013

Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer

artículo científico publicado en 2009

Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists

artículo científico publicado en 1999

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers

artículo científico

Mutational analysis of gene families in human cancer

artículo científico publicado en 2005

Mutational analysis of the tyrosine kinome in colorectal cancers

artículo científico publicado en 2003

Mutational analysis of the tyrosine phosphatome in colorectal cancers

artículo científico publicado en 2004

Mutational profile of GNAQQ209 in human tumors.

artículo científico publicado en 2009

Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes

artículo científico publicado en 2009

Mutational profiling of kinases in glioblastoma

artículo científico publicado en 2014

Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas

artículo científico publicado en 2010

Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma

artículo científico publicado en 2007

Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

artículo científico publicado en 2016

Oncogenes and angiogenesis: a way to personalize anti-angiogenic therapy?

artículo científico

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway

artículo científico publicado en 2015

Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies.

artículo científico publicado en 2007

PIK3CA cancer mutations display gender and tissue specificity patterns.

artículo científico publicado en 2008

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

artículo científico publicado en 2010

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

artículo científico publicado en 2009

PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer

artículo científico publicado en 2008

PRL-3 expression in metastatic cancers

artículo científico publicado en 2003

PRL-3 phosphatase is implicated in ovarian cancer growth

artículo científico publicado en 2005

PRL-3: a phosphatase for metastasis?

artículo científico publicado en 2004

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

artículo científico publicado en 2015

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer

artículo científico publicado en 2017

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

artículo científico publicado en 2019

Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastro-oesophageal junction adenocarcinoma (DOCETUX study).

artículo científico publicado en 2009

Phase II study of panitumumab, oxaliplatin, 5-fluorouracil, and concurrent radiotherapy as preoperative treatment in high-risk locally advanced rectal cancer patients (StarPan/STAR-02 Study).

artículo científico publicado en 2011

Phosphatase Protein Homologue to Tensin Expression and Phosphatidylinositol-3 Phosphate Kinase Mutations in Colorectal Cancer

Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

scientific article published on 26 February 2019

Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma

artículo científico publicado en 2016

Preclinical models for precision oncology

Protein tyrosine phosphatase PTP-S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met.

artículo científico publicado en 1998

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells

artículo científico publicado en 2014

RAF/RAS oncogenes and mismatch-repair status

artículo científico publicado en 2002

RET fusions in a small subset of advanced colorectal cancers at risk of being neglected.

artículo científico publicado en 2018

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

artículo científico publicado en 2018

Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene.

artículo científico publicado en 2001

Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2.

artículo científico publicado en 1997

Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies.

artículo científico publicado en 2018

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses

artículo científico publicado en 2008

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution

artículo científico

Restoring PUMA induction overcomes KRAS-mediated resistance to anti-EGFR antibodies in colorectal cancer

scholarly article by Kyle Knickelbein published in May 2018

Retreatment with anti-EGFR monoclonal antibodies in metastatic colorectal cancer: Systematic review of different strategies

artículo científico publicado en 2018

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

artículo científico publicado en 2014

Review: Peering through a keyhole: liquid biopsy in primary and metastatic central nervous system tumours

scientific article published on 14 May 2019

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

artículo científico publicado en 2018

SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells

artículo científico publicado en 2004

Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor ⬇️

artículo científico publicado el 1 de octubre de 1991

Scatter factor receptors are key players in a unique multistep program leading to invasive growth.

artículo científico publicado en 1997

Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-Ras(G13D).

artículo científico publicado en 2009

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

artículo científico publicado en 2015

Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case.

artículo científico publicado en 2018

Somatic alterations as the basis for resistance to targeted therapies

artículo científico

Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility

artículo científico publicado en 1996

TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma

scientific article published on 20 May 2019

TGFα and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells

artículo científico publicado en 2014

TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations

artículo científico publicado en 2019

Targeted knock-in of the polymorphism rs61764370 does not affect KRAS expression but reduces let-7 levels

artículo científico publicado en 2013

Targeted therapies: how personal should we go?

artículo científico publicado en 2011

Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

artículo científico publicado en 2010

Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges

artículo científico publicado en 2017

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia

artículo científico publicado en 2011

Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer.

artículo científico publicado en 2018

The Clinical Impact of the Genomic Landscape of Mismatch Repair-Deficient Cancers

scientific article published on 15 November 2018

The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.

artículo científico publicado en 2016

The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer

artículo científico publicado en 2016

The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type.

artículo científico publicado en 2010

The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

artículo científico publicado en 1996

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

artículo científico publicado en 2015

The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

artículo científico publicado en 2010

The road to resistance: EGFR mutation and cetuximab.

artículo científico publicado en 2012

Therapeutic implications of resistance to molecular therapies in metastatic colorectal cancer.

artículo científico publicado en 2010

Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET.

artículo científico publicado en 2013

Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers

artículo científico publicado en 2011

Toward understanding and exploiting tumor heterogeneity

artículo científico publicado en 2015

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

article

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor.

artículo científico publicado en 2017

Tracking colorectal cancer evolution in time and space.

artículo científico publicado en 2017

Tracking the genomic evolution of breast cancer metastasis

artículo científico publicado en 2010

Tumor Evolution as a Therapeutic Target

artículo científico publicado en 2017

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

artículo científico publicado en 2015

Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer

artículo científico

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

artículo científico publicado en 2016

Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth

artículo científico publicado en 1998

Understanding how kinase-targeted therapies work

artículo científico publicado en 2008

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

artículo científico publicado en 2012

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

artículo científico publicado en 2015

Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

artículo científico publicado en 2008

p21(WAF1/CIP1) mediates the growth response to TGF-beta in human epithelial cells

artículo científico publicado en 2004

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