Lista de obras - Bernhard Schermer - Dominio Público Uruguay

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

artículo científico publicado en 2018

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

artículo científico publicado en 2018

A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin

artículo científico publicado en 2014

A mammalian microRNA expression atlas based on small RNA library sequencing

artículo científico publicado en 2007

A molecular mechanism explaining albuminuria in kidney disease

artículo científico publicado en 2020

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF

scientific article published on 30 July 2019

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

artículo científico publicado en 2018

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

artículo científico publicado en 2012

An approach to cystic kidney diseases: the clinician's view

artículo científico

An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes.

artículo científico publicado en 2018

Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity

artículo científico publicado en 2014

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations

artículo científico publicado en 2017

Characterization of a short isoform of the kidney protein podocin in human kidney

artículo científico publicado en 2013

Clinical spectrum and pathogenesis of nephronophthisis

artículo científico

Comparative analysis of Neph gene expression in mouse and chicken development

artículo científico publicado en 2011

Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture

artículo científico

Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT).

artículo científico publicado en 2013

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes

artículo científico publicado en 2017

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

artículo científico publicado en 2016

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

artículo científico publicado en 2014

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

artículo científico publicado en 2009

Dysregulated autophagy contributes to podocyte damage in Fabry's disease

artículo científico publicado en 2013

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

artículo científico publicado en 2012

Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms

artículo científico publicado en 2015

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis

artículo científico publicado en 2019

Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists

artículo científico publicado en 1999

Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha

artículo científico publicado en 2002

Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria

artículo científico publicado en 2012

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

artículo científico publicado en 2005

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression

artículo científico publicado en 2016

KIBRA modulates directional migration of podocytes

artículo científico publicado en 2008

Label-free quantitative proteomic analysis of the YAP/TAZ interactome

artículo científico publicado en 2014

Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions.

artículo científico publicado en 2012

Lipid-protein interactions along the slit diaphragm of podocytes

artículo científico publicado en 2009

Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response

artículo científico publicado en 2011

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation

artículo científico publicado en 2015

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia

artículo científico publicado en 2008

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner

artículo científico publicado en 2013

Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination

artículo científico publicado en 2014

Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease

artículo científico publicado en 2017

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

artículo científico publicado en 2016

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

artículo científico publicado en 2003

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

artículo científico publicado en 2011

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

artículo científico publicado en 2013

Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

artículo científico publicado en 2003

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

artículo científico publicado en 2017

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

artículo científico publicado en 2011

Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity

artículo científico publicado en 2008

Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents

scientific article published on 14 September 2018

Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia

artículo científico publicado en 2006

Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia

artículo científico publicado en 2011

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage

artículo científico publicado en 2016

PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome

artículo científico publicado en 2010

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

artículo científico publicado en 2016

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier

artículo científico publicado en 2014

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia

artículo científico publicado en 2005

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

artículo científico publicado en 2006

Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm.

artículo científico publicado en 2007

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease

artículo científico publicado en 2008

Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.

artículo científico publicado en 2018

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

artículo científico publicado en 2016

Protein half-life determines expression of proteostatic networks in podocyte differentiation

artículo científico publicado en 2018

Putting the brakes on p53-driven apoptosis

artículo científico publicado en 2012

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation

artículo científico publicado en 2016

Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay

artículo científico publicado en 2020

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

artículo científico publicado en 2011

Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

artículo científico publicado en 2016

Single nephron proteomes connect morphology and function in proteinuric kidney disease.

artículo científico publicado en 2018

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

artículo científico publicado en 2018

The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins

artículo científico publicado en 2011

The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.

artículo científico publicado en 2015

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells

artículo científico publicado en 2019

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

artículo científico publicado en 2003

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1

artículo científico publicado en 2012

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia

artículo científico publicado en 2017

The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling

scientific journal article

The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

artículo científico publicado en 2012

The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation

artículo científico publicado en 2014

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury

scientific article published on 03 December 2018

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes

artículo científico publicado en 2016

The von Hippel Lindau tumor suppressor limits longevity

artículo científico publicado en 2009

The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

artículo científico publicado en 2006

Three-layered proteomic characterization of a novel ACTN4 mutation unravels its pathogenic potential in FSGS.

artículo científico publicado en 2016

Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.

artículo científico publicado en 2013

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

artículo científico publicado en 2005

Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging

artículo científico publicado en 2013

Transition zone proteins and cilia dynamics ⬇️

artículo científico publicado el 27 de julio de 2011

Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function

artículo científico publicado en 1999

Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again

artículo científico publicado en 2014

WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals

artículo científico publicado en 2015

YAP-mediated mechanotransduction determines the podocyte's response to damage.

artículo científico publicado en 2017

[Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine?]

scientific article published on 13 February 2019

p35, the non-cyclin activator of Cdk5, protects podocytes against apoptosis in vitro and in vivo.

artículo científico publicado en 2010

Lista de obras de Bernhard Schermer

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

A Single-Cell Transcriptome Atlas of the Mouse Glomerulus

A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin

A mammalian microRNA expression atlas based on small RNA library sequencing

A molecular mechanism explaining albuminuria in kidney disease

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

An approach to cystic kidney diseases: the clinician's view

An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes.

Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity

Challenges in establishing genotype-phenotype correlations in ARPKD: case report on a toddler with two severe PKHD1 mutations

Characterization of a short isoform of the kidney protein podocin in human kidney

Clinical spectrum and pathogenesis of nephronophthisis

Comparative analysis of Neph gene expression in mouse and chicken development

Comparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture

Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT).

Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes

Cysteine S-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ).

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1

Dysregulated autophagy contributes to podocyte damage in Fabry's disease

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling

Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis

Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists

Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha

Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria

Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways

Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression

KIBRA modulates directional migration of podocytes

Label-free quantitative proteomic analysis of the YAP/TAZ interactome

Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions.

Lipid-protein interactions along the slit diaphragm of podocytes

Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response

Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation

Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia

Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner

Low-molecular weight heparin increases circulating sFlt-1 levels and enhances urinary elimination

Magnetic resonance T2 mapping and diffusion-weighted imaging for early detection of cystogenesis and response to therapy in a mouse model of polycystic kidney disease

Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression

Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton.

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity

Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents

Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia

Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia

Oral Supplementation of Glucosamine Fails to Alleviate Acute Kidney Injury in Renal Ischemia-Reperfusion Damage

PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome

Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.

Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier

Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia

Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels

Podocin organizes ion channel-lipid supercomplexes: implications for mechanosensation at the slit diaphragm.

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease

Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

Protein half-life determines expression of proteostatic networks in podocyte differentiation

Putting the brakes on p53-driven apoptosis

Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation

Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP assay

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Single and Transient Ca(2+) Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

Single nephron proteomes connect morphology and function in proteinuric kidney disease.

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins

The NF-κB essential modulator (NEMO) controls podocyte cytoskeletal dynamics independently of NF-κB.

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia

The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling

The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.

The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation

The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury