Lista de obras - Alberto Podjarny - Dominio Público Uruguay

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

artículo científico publicado en 2013

A multicopy modeling of the water distribution in macromolecular crystals ⬇️

artículo científico publicado el 1 de julio de 1997

Aldose and aldehyde reductases: correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site

scientific article published on 01 November 2000

Approaches to very low resolution phasing of the ribosome 50S particle from Thermus thermophilus by the few-atoms-models and molecular-replacement methods.

artículo científico publicado en 1996

Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies

artículo científico publicado en 1999

Charge-density analysis of a protein structure at subatomic resolution: the human aldose reductase case.

artículo científico publicado en 2008

Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp)

artículo científico publicado en 1991

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

artículo científico publicado en 2006

Crystal packing modifies ligand binding affinity: The case of aldose reductase

artículo científico publicado en 2012

Crystal structure of a eukaryotic initiator tRNA ⬇️

artículo científico publicado el 8 de marzo de 1979

Crystal structure of the nucleosome core particle at 16 A resolution.

artículo científico

Crystallographic studies of protein denaturation and renaturation. 1. Effects of denaturants on volume and X-ray pattern of cross-linked triclinic lysozyme crystals

artículo científico publicado el 5 de abril de 1977

Crystallographic studies of protein denaturation and renaturation. 2. Sodium dodecyl sulfate induced structural changes in triclinic lysozyme

artículo científico publicado en 1977

Density constraints and low-resolution phasing

artículo científico publicado en 2000

Density modification in x-ray crystallography.

artículo científico publicado en 1996

Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications.

artículo científico publicado en 2004

Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

artículo científico publicado en 2005

Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.

artículo científico publicado en 2005

Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family

artículo científico publicado en 2013

Heavy-atom refinement against solvent-flattened phases.

artículo científico publicado en 1992

High resolution structure of the RNA duplex [U(U-A)6A]2.

artículo científico publicado en 1988

High-resolution crystal structure of AKR11C1 from Bacillus halodurans: an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.

artículo científico publicado en 2005

High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution

artículo científico publicado en 2016

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.

artículo científico publicado en 2005

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design

artículo científico publicado en 2014

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels

artículo científico publicado en 2016

Incorporation of methyl-protonated valine and leucine residues into deuterated ocean pout type III antifreeze protein: expression, crystallization and preliminary neutron diffraction studies.

artículo científico publicado en 2010

Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10

artículo científico publicado en 2013

Low-resolution ab initio phasing: problems and advances.

artículo científico publicado en 2000

Low-resolution data analysis for low-density lipoprotein particle.

artículo científico publicado en 2001

Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features

artículo científico publicado en 2008

Metabolic regulation of the squid nerve Na(+)/Ca (2+) exchanger: recent developments.

artículo científico

Modulation of aldose reductase inhibition by halogen bond tuning

artículo científico publicado en 2013

Neutron crystallography: opportunities, challenges, and limitations

artículo científico publicado en 2008

Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface

artículo científico publicado en 2011

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

artículo científico publicado en 2015

Novel NADPH-binding domain revealed by the crystal structure of aldose reductase ⬇️

artículo científico publicado el 30 de enero de 1992

On the ab initio solution of the phase problem for macromolecules at very low resolution: the few atoms model method.

artículo científico publicado en 1995

On the ab initio solution of the phase problem or macromolecules at very low resolution. II. Generalized likelihood based approach to cluster discrimination.

artículo científico publicado en 1998

On the solution of the molecular-replacement problem at very low resolution: application to large complexes.

artículo científico publicado en 1995

Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein.

artículo científico publicado en 2009

Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography

artículo científico publicado en 2014

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

artículo científico publicado en 2016

Probing the ultra-high resolution structure of aldose reductase with molecular modelling and noncovalent mass spectrometry.

artículo científico publicado en 2004

Production of crystals of human aldose reductase with very high resolution diffraction

artículo científico publicado en 1999

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

artículo científico publicado en 2008

Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites.

artículo científico publicado en 2007

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10

artículo científico publicado en 2015

Structural analysis of denaturant-protein interactions: comparison between the effects of bromoethanol and SDS on denaturation and renaturation of triclinic lysozyme.

artículo científico publicado en 1977

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10

artículo científico publicado en 2015

Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger

artículo científico publicado en 2012

Structural characterization of metal binding to a cold-adapted frataxin

artículo científico publicado en 2015

Structural information content at high resolution: MAD versus native

scientific article published on 01 January 2003

Structural studies of pig lens aldose reductase: reversible dimerization of the enzyme

artículo científico publicado en 1991

Structure determination of aldose reductase: joys and traps of local symmetry averaging

artículo científico publicado en 1993

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

artículo científico publicado en 2005

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.

artículo científico publicado en 2016

Subatomic and atomic crystallographic studies of aldose reductase: implications for inhibitor binding.

artículo científico publicado en 2004

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase

artículo científico publicado en 2015

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

artículo científico publicado en 2013

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

artículo científico publicado en 2015

The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop

artículo científico publicado en 2007

The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48

scientific journal article

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

artículo científico publicado en 2016

The structure of human aldose reductase bound to the inhibitor IDD384

artículo científico publicado en 2000

The structure of triclinic lysozyme at 2-5 A resolution.

artículo científico publicado en 1976

Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A

artículo científico publicado en 2004

Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat

artículo científico publicado en 2006

Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: implications for the inhibition mechanism

artículo científico publicado en 2008

Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders ⬇️

artículo científico publicado el 29 de septiembre de 2011

Virtual screening for inhibitors of human aldose reductase.

artículo científico publicado en 2004

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

artículo científico publicado en 2016

X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity

artículo científico publicado en 2013

X-ray-induced deterioration of disulfide bridges at atomic resolution

artículo científico publicado en 2010

X-ray-radiation-induced cooperative atomic movements in protein

artículo científico publicado en 2009

Yeast tRNA(Asp)-aspartyl-tRNA synthetase complex: low resolution crystal structure

artículo científico publicado en 1987

Lista de obras de Alberto Podjarny

2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors

A multicopy modeling of the water distribution in macromolecular crystals ⬇️

Aldose and aldehyde reductases: correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site

Approaches to very low resolution phasing of the ribosome 50S particle from Thermus thermophilus by the few-atoms-models and molecular-replacement methods.

Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies

Charge-density analysis of a protein structure at subatomic resolution: the human aldose reductase case.

Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp)

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

Crystal packing modifies ligand binding affinity: The case of aldose reductase

Crystal structure of a eukaryotic initiator tRNA ⬇️

Crystal structure of the nucleosome core particle at 16 A resolution.

Crystallographic studies of protein denaturation and renaturation. 1. Effects of denaturants on volume and X-ray pattern of cross-linked triclinic lysozyme crystals

Crystallographic studies of protein denaturation and renaturation. 2. Sodium dodecyl sulfate induced structural changes in triclinic lysozyme

Density constraints and low-resolution phasing

Density modification in x-ray crystallography.

Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications.

Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.

Frataxin from Psychromonas ingrahamii as a model to study stability modulation within the CyaY protein family

Heavy-atom refinement against solvent-flattened phases.

High resolution structure of the RNA duplex [U(U-A)6A]2.

High-resolution crystal structure of AKR11C1 from Bacillus halodurans: an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.

High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution

High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase.

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels

Incorporation of methyl-protonated valine and leucine residues into deuterated ocean pout type III antifreeze protein: expression, crystallization and preliminary neutron diffraction studies.

Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10

Low-resolution ab initio phasing: problems and advances.

Low-resolution data analysis for low-density lipoprotein particle.

Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features

Metabolic regulation of the squid nerve Na(+)/Ca (2+) exchanger: recent developments.

Modulation of aldose reductase inhibition by halogen bond tuning

Neutron crystallography: opportunities, challenges, and limitations

Neutron structure of type-III antifreeze protein allows the reconstruction of AFP-ice interface

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

Novel NADPH-binding domain revealed by the crystal structure of aldose reductase ⬇️

On the ab initio solution of the phase problem for macromolecules at very low resolution: the few atoms model method.

On the ab initio solution of the phase problem or macromolecules at very low resolution. II. Generalized likelihood based approach to cluster discrimination.

On the solution of the molecular-replacement problem at very low resolution: application to large complexes.

Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein.

Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

Probing the ultra-high resolution structure of aldose reductase with molecular modelling and noncovalent mass spectrometry.

Production of crystals of human aldose reductase with very high resolution diffraction

Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites.

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10

Structural analysis of denaturant-protein interactions: comparison between the effects of bromoethanol and SDS on denaturation and renaturation of triclinic lysozyme.

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10

Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger

Structural characterization of metal binding to a cold-adapted frataxin

Structural information content at high resolution: MAD versus native

Structural studies of pig lens aldose reductase: reversible dimerization of the enzyme

Structure determination of aldose reductase: joys and traps of local symmetry averaging

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.

Subatomic and atomic crystallographic studies of aldose reductase: implications for inhibitor binding.

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop

The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

The structure of human aldose reductase bound to the inhibitor IDD384

The structure of triclinic lysozyme at 2-5 A resolution.

Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A

Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat

Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: implications for the inhibition mechanism

Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders ⬇️

Virtual screening for inhibitors of human aldose reductase.

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity

X-ray-induced deterioration of disulfide bridges at atomic resolution

X-ray-radiation-induced cooperative atomic movements in protein

Yeast tRNA(Asp)-aspartyl-tRNA synthetase complex: low resolution crystal structure