Lista de obras - Els Pardon - Dominio Público Uruguay

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

artículo científico publicado en 2013

A general protocol for the generation of Nanobodies for structural biology

artículo científico publicado en 2014

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

artículo científico publicado en 2019

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

artículo científico publicado en 2017

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

artículo científico publicado en 2020

Activation and allosteric modulation of a muscarinic acetylcholine receptor

artículo científico publicado en 2013

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

artículo científico publicado en 2016

Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody

artículo científico publicado en 2013

Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

scientific article published on 01 April 2020

An improved yeast surface display platform for the screening of nanobody immune libraries

scientific article published in Scientific Reports

An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.

artículo científico publicado en 2010

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

artículo científico publicado en 2011

Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry.

artículo científico publicado en 2018

Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands

artículo científico publicado en 2018

Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools

scientific article published on 03 November 2018

Characterisation and structure determination of a llama-derived nanobody targeting the J-base binding protein 1

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1

Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes

artículo científico publicado en 2011

Crystal Structure of a ligand-bound LacY-Nanobody Complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

artículo científico publicado en 2009

Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation

artículo científico publicado en 2016

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport

artículo científico publicado en 2014

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

artículo científico publicado en 2012

Crystal structure of human Mediator subunit MED23

artículo científico publicado en 2018

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

artículo científico publicado en 2014

Crystal structure of the β2 adrenergic receptor-Gs protein complex

artículo científico publicado en 2011

Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins

artículo científico publicado en 2021

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.

artículo científico publicado en 2019

Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues

artículo científico publicado en 2016

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.

artículo científico publicado en 2017

Heteromeric GABAAreceptor structures in positively-modulated active states

In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters

artículo científico publicado en 2020

Interrogating dense ligand chemical space with a forward-synthetic library

artículo científico publicado en 2019

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

artículo científico publicado en 2019

Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts

artículo científico publicado en 2017

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

artículo científico publicado en 2014

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

artículo científico publicado en 2022

Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies

scientific article published on 19 November 2020

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Nanobody mediated crystallization of an archeal mechanosensitive channel.

artículo científico publicado en 2013

Nanobody mediated inhibition of attachment of F18 Fimbriae expressing Escherichia coli

artículo científico publicado en 2014

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors

artículo científico publicado en 2018

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors

scholarly article by Els Pardon et al published 30 March 2018 in Angewandte Chemie

Nanobody-aided crystallization of the transcription regulator PaaR2 from <i>Escherichia coli</i> O157:H7

artículo científico publicado en 2021

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

artículo científico publicado en 2009

Nanobody-enabled monitoring of kappa opioid receptor states

artículo científico publicado en 2020

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody

artículo científico publicado en 2014

Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein.

artículo científico publicado en 2013

Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody

artículo científico publicado en 2014

Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands.

artículo científico publicado en 2017

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

artículo científico publicado en 2013

SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization

artículo científico publicado en 2014

SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly

artículo científico publicado en 2012

Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System

artículo científico publicado en 2011

Structural basis for GABAA receptor potentiation by neurosteroids.

artículo científico publicado en 2017

Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies

artículo científico publicado en 2015

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

artículo científico publicado en 2018

Structure and Mechanism of Hedgehog Acyl Transferase

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

artículo científico publicado en 2015

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

artículo científico publicado en 2010

Structure of PINK1 in complex with its substrate ubiquitin.

artículo científico publicado en 2017

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1

scientific article published on 31 January 2019

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

scientific article published on 15 July 2019

Structure of a bacterial type IV secretion core complex at subnanometre resolution

artículo científico publicado en 2013

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

artículo científico publicado en 2011

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

artículo científico publicado en 2015

Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis

artículo científico publicado en 2013

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

artículo científico publicado en 2018

Structure, mechanism, and inhibition of Hedgehog acyltransferase

artículo científico publicado en 2021

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

artículo científico publicado en 2013

Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies

artículo científico publicado en 2011

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

scientific article published on 04 September 2019

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

scientific article published on 03 April 2019

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

artículo científico publicado en 2018

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

artículo científico publicado en 2018

The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain

artículo científico publicado en 2014

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

artículo científico publicado en 2019

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

scientific article published on 23 September 2019

The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2

artículo científico publicado en 2012

The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody

artículo científico publicado en 2013

The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools

artículo científico publicado en 2016

Thermodynamics of Nanobody Binding to Lactose Permease.

artículo científico publicado en 2016

Lista de obras de Els Pardon

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

A general protocol for the generation of Nanobodies for structural biology

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody

Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

An improved yeast surface display platform for the screening of nanobody immune libraries

An intrabody based on a llama single-domain antibody targeting the N-terminal alpha-helical multimerization domain of HIV-1 rev prevents viral production.

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic 2-microglobulin variant

Binding Specificities of Nanobody•Membrane Protein Complexes Obtained from Chemical Cross-Linking and High-Mass MALDI Mass Spectrometry.

Binding-Site Compatible Fragment Growing Applied to the Design of β2-Adrenergic Receptor Ligands

Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools

Characterisation and structure determination of a llama-derived nanobody targeting the J-base binding protein 1

Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1

Combining in-situ proteolysis and microseed matrix screening to promote crystallization of PrPc-nanobody complexes

Crystal Structure of a ligand-bound LacY-Nanobody Complex

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation

Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

Crystal structure of human Mediator subunit MED23

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins

Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.

Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.

Heteromeric GABAAreceptor structures in positively-modulated active states

In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters

Interrogating dense ligand chemical space with a forward-synthetic library

L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts

Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

Nanobody mediated crystallization of an archeal mechanosensitive channel.

Nanobody mediated inhibition of attachment of F18 Fimbriae expressing Escherichia coli

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors

Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors

Nanobody-aided crystallization of the transcription regulator PaaR2 from <i>Escherichia coli</i> O157:H7

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

Nanobody-enabled monitoring of kappa opioid receptor states

Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody

Production, crystallization and X-ray diffraction analysis of two nanobodies against the Duffy binding-like (DBL) domain DBL6ℇ-FCR3 of the Plasmodium falciparum VAR2CSA protein.

Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody

Rational Design of Nanobody80 Loop Peptidomimetics: Towards Biased β2 Adrenergic Receptor Ligands.

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization

SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly

Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System

Structural basis for GABAA receptor potentiation by neurosteroids.

Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies

Structural insights into binding specificity, efficacy and bias of a βAR partial agonist

Structure and Mechanism of Hedgehog Acyl Transferase

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

Structure of PINK1 in complex with its substrate ubiquitin.

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1

Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

Structure of a bacterial type IV secretion core complex at subnanometre resolution

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

Structure, mechanism, and inhibition of Hedgehog acyltransferase

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism

The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2