Lista de obras - Zdzislaw Wawrzak - Dominio Público Uruguay

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target

artículo científico publicado en 2005

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H

artículo científico publicado en 2006

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

artículo científico publicado en 2020

A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes

scientific article published on 14 August 2007

A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis

artículo científico publicado en 2020

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

artículo científico publicado en 2013

Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases

artículo científico publicado en 2012

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

scientific article published in Journal of Biological Chemistry

Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases.

artículo científico publicado en 2017

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

artículo científico publicado en 2015

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

artículo científico publicado en 2013

Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

artículo científico publicado en 2020

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants ⬇️

artículo científico publicado el 17 de mayo de 2011

Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersion

artículo científico publicado en 2002

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

artículo científico publicado en 2017

Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA

artículo científico publicado en 2002

Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif

artículo científico publicado en 2005

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

artículo científico publicado en 2016

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

artículo científico publicado en 2008

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

artículo científico publicado en 2010

Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity

artículo científico publicado en 2004

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

artículo científico publicado en 2012

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

artículo científico publicado en 2016

Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form

artículo científico publicado en 2004

Cytochrome c nitrite reductase from the bacterium Geobacter lovleyi represents a new NrfA subclass

artículo científico publicado en 2020

High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH

artículo científico publicado en 1999

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

artículo científico publicado en 2016

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.

artículo científico publicado en 2017

Kinetic and structural mechanisms of (5'S)-8,5'-cyclo-2'-deoxyguanosine-induced dna replication stalling

artículo científico publicado en 2015

Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor

artículo científico publicado en 1994

Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont

artículo científico publicado en 2016

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut.

artículo científico publicado en 2017

Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction

artículo científico publicado en 2013

Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

artículo científico publicado en 2017

Selenium-assisted nucleic acid crystallography: use of phosphoroselenoates for MAD phasing of a DNA structure

artículo científico publicado en 2002

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr

artículo científico publicado en 2018

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

artículo científico publicado en 2014

Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.

artículo científico publicado en 2016

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

artículo científico publicado en 2010

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

artículo científico publicado en 2017

Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

artículo científico publicado en 2019

Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.

artículo científico publicado en 2014

Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

artículo científico publicado en 2018

Structural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterol

artículo científico publicado en 2012

Structure and DNA binding of alkylation response protein AidB

artículo científico publicado en 2008

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

artículo científico publicado en 2013

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

artículo científico publicado en 2016

Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment

artículo científico publicado en 2019

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

artículo científico publicado en 2003

Structure of the two-subsite beta-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane

artículo científico publicado en 2008

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

artículo científico publicado en 2015

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

artículo científico publicado en 2011

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

artículo científico publicado en 2018

Supramolecular allosteric cofacial porphyrin complexes

artículo científico publicado en 2006

The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity

artículo científico publicado en 2016

Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution

artículo científico publicado en 2003

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain

artículo científico publicado en 2014

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

artículo científico publicado en 2015

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

scientific article published on 11 November 2019

Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis

artículo científico publicado en 2003

X-ray Crystal Structure of Divalent Metal-Activated β-xylosidase, RS223BX

artículo científico publicado en 2015

Lista de obras de Zdzislaw Wawrzak

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H

A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid

A convergent coordination chemistry-based approach to dissymmetric macrocyclic cofacial porphyrin complexes

A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

Basis of Miscoding of the DNA Adduct N2,3-Ethenoguanine by Human Y-family DNA Polymerases

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

Biochemical and Structural Analyses of Two Cryptic Esterases in Bacteroides intestinalis and their Synergistic Activities with Cognate Xylanases.

Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14α-Demethylases

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants ⬇️

Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle. Multiwavelength anomalous dispersion

Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

Crystal structure of a B-form DNA duplex containing (L)-alpha-threofuranosyl (3'-->2') nucleosides: a four-carbon sugar is easily accommodated into the backbone of DNA

Crystal structure of a luteoviral RNA pseudoknot and model for a minimal ribosomal frameshifting motif

Crystal structure of nonphosphorylated receiver domain of the stress response regulator RcsB from Escherichia coli

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity

Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Crystallization and preliminary crystallographic analysis of endonuclease VIII in its uncomplexed form

Cytochrome c nitrite reductase from the bacterium Geobacter lovleyi represents a new NrfA subclass

High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.

Kinetic and structural mechanisms of (5'S)-8,5'-cyclo-2'-deoxyguanosine-induced dna replication stalling

Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor

Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont

Novel carbohydrate binding modules in the surface anchored α-amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut.

Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction

Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Selenium-assisted nucleic acid crystallography: use of phosphoroselenoates for MAD phasing of a DNA structure

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr

Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.

Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress

Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress

Structural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterol

Structure and DNA binding of alkylation response protein AidB

Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

Structure of the two-subsite beta-d-xylosidase from Selenomonas ruminantium in complex with 1,3-bis[tris(hydroxymethyl)methylamino]propane

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis.

Supramolecular allosteric cofacial porphyrin complexes

The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity

Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution

Type III effector NleH2 from Escherichia coli O157:H7 str. Sakai features an atypical protein kinase domain

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis

X-ray Crystal Structure of Divalent Metal-Activated β-xylosidase, RS223BX