Lista de obras - Tom Brown - Dominio Público Uruguay

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

artículo científico publicado en 2020

5-Formylcytosine does not change the global structure of DNA.

artículo científico publicado en 2017

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

artículo científico publicado en 2021

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

artículo científico publicado en 2019

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

artículo científico publicado en 2019

An autonomous molecular assembler for programmable chemical synthesis

artículo científico publicado en 2016

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

artículo científico publicado en 2017

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

artículo científico publicado en 2017

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

scientific article published on 15 April 2020

DNA Structural Changes Induced by Intermolecular Triple Helix Formation

artículo científico publicado en 2020

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals

artículo científico publicado en 2018

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting

scientific article published on 03 June 2019

Dynamics of the 4D genome during in vivo lineage specification and differentiation

artículo científico publicado en 2020

Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes.

artículo científico publicado en 2016

Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA.

artículo científico publicado en 2014

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

scientific article published on 24 August 2018

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures.

artículo científico publicado en 2018

Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer's Disease and Prostate Cancer

artículo científico publicado en 2016

Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

artículo científico publicado en 2018

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

artículo científico publicado en 2021

Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments.

artículo científico publicado en 2017

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

artículo científico publicado en 2017

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

artículo científico publicado en 2019

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4

scientific article published on 01 February 2020

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

artículo científico publicado en 2017

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

artículo científico publicado en 2017

Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers.

artículo científico publicado en 2018

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

artículo científico publicado en 2018

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

artículo científico

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

scientific article published on 01 September 2019

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

artículo científico publicado en 2018

Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells

scientific article published on 16 July 2019

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

artículo científico publicado en 2018

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

artículo científico publicado en 2017

Shining Light on CRISPR Gene Editing

artículo científico publicado en 2020

Single tube gene synthesis by phosphoramidate chemical ligation

artículo científico publicado en 2017

Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

artículo científico publicado en 2018

Stable end-sealed DNA as robust nano-rulers for single-molecule fluorescence

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

artículo científico publicado en 2019

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

artículo científico publicado en 2018

Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

artículo científico publicado en 2018

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET.

artículo científico publicado en 2017

Lista de obras de Tom Brown

2'-Alkynyl spin-labelling is a minimally perturbing tool for DNA structural analysis

5-Formylcytosine does not change the global structure of DNA.

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA

An autonomous molecular assembler for programmable chemical synthesis

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation

CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response

DNA Structural Changes Induced by Intermolecular Triple Helix Formation

DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals

Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting

Dynamics of the 4D genome during in vivo lineage specification and differentiation

Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes.

Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA.

Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation

Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above

Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures.

Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer's Disease and Prostate Cancer

Graphene Oxide–Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments.

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices

Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4

Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation

Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers.

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue

Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells

Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

Shining Light on CRISPR Gene Editing

Single tube gene synthesis by phosphoramidate chemical ligation

Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF

Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence

Stable end-sealed DNA as robust nano-rulers for single-molecule fluorescence

Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs).

Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET.