Lista de obras - Joël Bockaert - Dominio Público Uruguay

5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders?

artículo científico publicado en 2012

5-HT(4) receptors, a place in the sun: act two.

artículo científico publicado en 2011

5-HT(4) receptors: history, molecular pharmacology and brain functions

artículo científico publicado en 2008

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

artículo científico publicado en 2012

5-HT2A receptor-dependent phosphorylation of mGlu2 receptor at Serine 843 promotes mGlu2 receptor-operated Gi/o signaling

artículo científico publicado en 2018

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

artículo científico publicado en 2012

5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling. ⬇️

artículo científico publicado en 2007

A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists.

artículo científico publicado en 2002

A model for the functioning of family 3 GPCRs

scientific article published on 01 June 2002

A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors ⬇️

artículo científico publicado el 9 de diciembre de 2002

A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

artículo científico publicado en 2002

Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis

artículo científico publicado en 1992

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes

artículo científico publicado en 1992

Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities

artículo científico publicado en 2001

Alzheimer culprits: cellular crossroads and interplay.

artículo científico publicado en 2012

Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens

artículo científico publicado en 2007

Azabicycloalkyl benzimidazolone derivatives as a novel class of potent agonists at the 5-HT4 receptor positively coupled to adenylate cyclase in braina ⬇️

artículo científico publicado el 1 de marzo de 1991

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling

artículo científico publicado en 2009

Blockade of Serotonin 5-HT Receptor Constitutive Activity Alleviates Cognitive Deficits in a Preclinical Model of Neurofibromatosis Type 1

artículo científico publicado en 2021

Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures

artículo científico publicado en 2003

Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake

artículo científico publicado en 2013

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth.

artículo científico publicado en 2014

Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites

artículo científico publicado en 2006

Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis

artículo científico publicado en 2015

Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

artículo científico publicado en 2017

Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase ⬇️

artículo científico publicado el 20 de octubre de 1997

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

artículo científico publicado en 2000

Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors

artículo científico publicado en 2009

Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants

artículo científico publicado en 2010

Constitutive secretion of protease nexin-1 by glial cells and its regulation by G-protein-coupled receptors

scientific journal article

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists

artículo científico publicado en 1996

Difference in mass analysis using labeled lysines (DIMAL-K): a new, efficient proteomic quantification method applied to the analysis of astrocytic secretomes

artículo científico publicado en 2005

Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors

artículo científico publicado en 2008

Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects.

artículo científico publicado en 2003

Donecopride, a Swiss army knife with potential against Alzheimer's disease

scientific article published on 27 December 2019

Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis

scientific article published on 11 February 2020

Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

artículo científico publicado en 2020

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease

artículo científico publicado en 2013

Effect of Glutamate and Ionomycin on the Release of Arachidonic Acid, Prostaglandins and HETEs from Cultured Neurons and Astrocytes

scientific article published on 01 January 1991

Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

artículo científico publicado en 2002

Engineering GPCR signaling pathways with RASSLs

artículo científico publicado en 2008

Enhanced detection of CNS cell secretome in plasma protein-depleted cerebrospinal fluid

artículo científico publicado en 2008

Enhancement of reference memory in aged rats by specific activation of 5-HT4 receptors using an olfactory associative discrimination task ⬇️

artículo científico publicado el 17 de junio de 2011

Epac mediates PACAP-dependent long-term depression in the hippocampus

artículo científico publicado en 2008

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

artículo científico publicado en 2007

Feeding disorders in 5-HT4 receptor knockout mice

artículo científico publicado en 2004

G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient

artículo científico publicado en 2011

G protein-coupled receptors: dominant players in cell-cell communication

artículo científico publicado en 2002

GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells

scientific journal article

GPCR interacting proteins (GIP).

artículo científico publicado en 2004

GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies

artículo científico publicado en 2010

GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?

artículo científico publicado en 2004

GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation

artículo científico publicado en 2007

Glutamate stimulates glucagon secretion via an excitatory amino acid receptor of the AMPA subtype in rat pancreas

artículo científico publicado en 1993

Glutamate stimulates inositol phosphate formation in striatal neurones

artículo científico publicado en 1985

Gαo is required for L-canavanine detection in Drosophila.

artículo científico publicado en 2013

Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons.

artículo científico publicado en 2002

Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons

artículo científico publicado en 2010

Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice

artículo científico publicado en 2010

Identification and functional roles of metabotropic glutamate receptor-interacting proteins

artículo científico publicado en 2004

Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1

artículo científico publicado en 2001

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

artículo científico publicado en 2021

Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction

artículo científico publicado en 2007

MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels

artículo científico publicado en 2006

Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice.

artículo científico publicado en 2002

Molecular and functional characterization of proteins interacting with the C-terminal domains of 5-HT2 receptors: emergence of 5-HT2 "receptosomes".

artículo científico publicado en 2004

Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy

artículo científico publicado en 2005

Molecular tinkering of G protein-coupled receptors: an evolutionary success

artículo científico publicado en 1999

Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction.

artículo científico publicado en 2008

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.

artículo científico publicado en 2006

New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting

artículo científico publicado en 2004

Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability

artículo científico publicado en 2006

PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons

artículo científico publicado en 2007

PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7

artículo científico publicado en 2002

PICK1 uncoupling from mGluR7a causes absence-like seizures

artículo científico publicado en 2008

Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor

artículo científico publicado en 2000

Pharmacological profile of engineered 5-HT4 receptors and identification of 5-HT4 receptor-biased ligands ⬇️

artículo científico publicado el 10 de noviembre de 2012

Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs.

artículo científico publicado en 2017

Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2.

artículo científico publicado en 2016

Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX

artículo científico publicado en 2009

Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

artículo científico publicado en 2016

Proteomic analysis of astrocytic secretion in the mouse. Comparison with the cerebrospinal fluid proteome

artículo científico publicado en 2003

Proteomic detection of prostate-specific antigen using a serum fractionation procedure: potential implication for new low-abundance cancer biomarkers detection

artículo científico publicado en 2005

Quantitative assessment of transcriptome differences between brain territories

artículo científico publicado en 2003

Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists

artículo científico publicado en 2014

Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis ⬇️

artículo científico publicado el 23 de septiembre de 2012

Role of p/q-Ca2+ channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses.

artículo científico publicado en 2002

S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.

artículo científico publicado en 2011

SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties

artículo científico publicado en 2002

Serotonin: A New Hope in Alzheimer's Disease?

artículo científico publicado en 2015

Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila.

artículo científico publicado en 2004

Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons.

artículo científico publicado en 2005

Sustained Activation of Postsynaptic 5-HT2A Receptors Gates Plasticity at Prefrontal Cortex Synapses

artículo científico publicado en 2019

Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach

artículo científico publicado en 2002

Techniques for Studying Inverse Agonist Activity of Antidepressants at Recombinant Nonedited 5-HT2C-INI Receptor and Native Neuronal 5-HT2C Receptors

artículo científico publicado el 1 de enero de 2010

The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks

artículo científico publicado en 2003

The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies

scientific article published on 01 November 2019

The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology.

artículo científico publicado en 2004

The mTOR pathway: a new target for treating cognitive deficits of schizophrenia?

artículo científico publicado en 2013

The promnesic effect of G-protein-coupled 5-HT4 receptors activation is mediated by a potentiation of learning-induced spine growth in the mouse hippocampus

artículo científico publicado en 2007

The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells

artículo científico publicado en 2006

The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins

artículo científico publicado en 2004

Ultrastructural localization of the GTP-binding protein Go in neurons

artículo científico publicado en 1989

Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements.

artículo científico publicado en 2005

Up-regulation in late pregnancy of both Go1 alpha and Go2 alpha isoforms in human myometrium

artículo científico publicado en 1994

VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux

artículo científico publicado en 2007

Widespread brain distribution of the Drosophila metabotropic glutamate receptor

artículo científico publicado en 2008

[When two molecules involved in the regulation of mood meet: mutual modulation of the serotonin transporter and neuronal NO-synthase]

scientific article published on 01 May 2007

Lista de obras de Joël Bockaert

5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders?

5-HT(4) receptors, a place in the sun: act two.

5-HT(4) receptors: history, molecular pharmacology and brain functions

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

5-HT2A receptor-dependent phosphorylation of mGlu2 receptor at Serine 843 promotes mGlu2 receptor-operated Gi/o signaling

5-HT4 receptors constitutively promote the non-amyloidogenic pathway of APP cleavage and interact with ADAM10.

5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling. ⬇️

A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists.

A model for the functioning of family 3 GPCRs

A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors ⬇️

A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL).

Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes

Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities

Alzheimer culprits: cellular crossroads and interplay.

Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens

Azabicycloalkyl benzimidazolone derivatives as a novel class of potent agonists at the 5-HT4 receptor positively coupled to adenylate cyclase in braina ⬇️

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling

Blockade of Serotonin 5-HT Receptor Constitutive Activity Alleviates Cognitive Deficits in a Preclinical Model of Neurofibromatosis Type 1

Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures

Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth.

Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites

Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis

Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease

Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase ⬇️

Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons

Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors

Constitutive activity of serotonin 2C receptors at G protein-independent signaling: modulation by RNA editing and antidepressants

Constitutive secretion of protease nexin-1 by glial cells and its regulation by G-protein-coupled receptors

Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists

Difference in mass analysis using labeled lysines (DIMAL-K): a new, efficient proteomic quantification method applied to the analysis of astrocytic secretomes

Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors

Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects.

Donecopride, a Swiss army knife with potential against Alzheimer's disease

Dynamic interactions of the 5-HT6 receptor with protein partners control dendritic tree morphogenesis

Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease

Effect of Glutamate and Ionomycin on the Release of Arachidonic Acid, Prostaglandins and HETEs from Cultured Neurons and Astrocytes

Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

Engineering GPCR signaling pathways with RASSLs

Enhanced detection of CNS cell secretome in plasma protein-depleted cerebrospinal fluid

Enhancement of reference memory in aged rats by specific activation of 5-HT4 receptors using an olfactory associative discrimination task ⬇️

Epac mediates PACAP-dependent long-term depression in the hippocampus

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

Feeding disorders in 5-HT4 receptor knockout mice

G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient

G protein-coupled receptors: dominant players in cell-cell communication

GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells

GPCR interacting proteins (GIP).

GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies

GPCR-GIP networks: a first step in the discovery of new therapeutic drugs?

GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation

Glutamate stimulates glucagon secretion via an excitatory amino acid receptor of the AMPA subtype in rat pancreas

Glutamate stimulates inositol phosphate formation in striatal neurones

Gαo is required for L-canavanine detection in Drosophila.

Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons.

Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons

Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice

Identification and functional roles of metabotropic glutamate receptor-interacting proteins

Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function

Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction

MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels

Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice.

Molecular and functional characterization of proteins interacting with the C-terminal domains of 5-HT2 receptors: emergence of 5-HT2 "receptosomes".

Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy

Molecular tinkering of G protein-coupled receptors: an evolutionary success

Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction.

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.

New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting

Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability

PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons

PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7

PICK1 uncoupling from mGluR7a causes absence-like seizures

Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor

Pharmacological profile of engineered 5-HT4 receptors and identification of 5-HT4 receptor-biased ligands ⬇️

Phosphorylation of β-arrestin2 at Thr383 by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs.

Physical and functional interactions between the serotonin transporter and the neutral amino acid transporter ASCT2.