"Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource.
artículo científico publicado en 2017
10th Biennial Helene Harris Memorial Trust Meeting
scientific article published on 01 March 2006
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma
artículo científico publicado en 2009
A Bayesian hierarchical model for inference across related reverse phase protein arrays experiments
artículo científico publicado en 2014
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
artículo científico publicado en 2018
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
artículo científico publicado en 2017
A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas
artículo científico publicado en 2021
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.
artículo científico publicado en 2017
A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors
artículo científico publicado en 2017
A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells
artículo científico publicado en 2005
A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers
artículo científico publicado en 2010
A Time‐Series DDP for Functional Proteomics Profiles
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artículo científico publicado el 5 de enero de 2012
A comprehensive comparison of normalization methods for loading control and variance stabilization of reverse-phase protein array data
artículo científico publicado en 2014
A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma
artículo científico publicado en 2014
A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.
artículo científico publicado en 2014
A decision support framework for genomically informed investigational cancer therapy
artículo científico publicado en 2015
A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity
artículo científico publicado en 2017
A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory.
artículo científico publicado en 2017
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
artículo científico publicado en 2007
A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer
artículo científico publicado en 2014
A functional genomic approach to actionable gene fusions for precision oncology
artículo científico publicado en 2022
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
artículo científico publicado en 2014
A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance
artículo científico publicado en 2011
A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition
artículo científico publicado en 2013
A genetically defined model for human ovarian cancer
artículo científico publicado en 2004
A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer
artículo científico publicado en 2011
A module of negative feedback regulators defines growth factor signaling
artículo científico publicado en 2007
A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis
artículo científico publicado en 2022
A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses
artículo científico publicado en 2022
A murine preclinical syngeneic transplantation model for breast cancer precision medicine.
artículo científico publicado en 2017
A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes
artículo científico publicado en 2012
A new mutational AKTivation in the PI3K pathway
artículo científico publicado en 2007
A novel AKT3 mutation in melanoma tumours and cell lines
artículo científico publicado en 2008
A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy
artículo científico publicado en 2008
A pan-cancer proteomic perspective on The Cancer Genome Atlas.
artículo científico publicado en 2014
A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers
artículo científico publicado en 2017
A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase
artículo científico publicado en 2007
A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.
artículo científico publicado en 2015
A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models
artículo científico publicado en 2013
A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners
artículo científico publicado en 2006
A sequence-based survey of the complex structural organization of tumor genomes
artículo científico publicado en 2008
A systems approach to analysis of molecular complexity in breast cancer
artículo científico publicado en 2009
A unified approach to targeting the lysosome's degradative and growth signaling roles.
artículo científico publicado en 2017
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
artículo científico publicado en 2008
A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer
artículo científico publicado en 2018
A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis
artículo científico publicado en 2019
AKT isoform-specific expression and activation across cancer lineages
artículo científico publicado en 2018
AKT pathway genes define 5 prognostic subgroups in glioblastoma
artículo científico publicado en 2014
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis
artículo científico publicado en 2012
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53stability and cell apoptosis.
artículo científico publicado en 2014
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
artículo científico publicado en 2009
ALK: a tyrosine kinase target for cancer therapy
artículo científico publicado en 2017
AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
artículo científico publicado en 2008
AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability
artículo científico publicado en 2010
AMPK: a contextual oncogene or tumor suppressor?
artículo científico
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers
artículo científico publicado en 2003
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
artículo científico publicado en 2015
ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
artículo científico publicado en 2018
ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma
artículo científico publicado en 2017
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
artículo científico publicado en 2010
ATX-LPA receptor axis in inflammation and cancer
artículo científico publicado en 2009
AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies
artículo científico publicado en 2016
Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer
artículo científico publicado en 2012
Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes
artículo científico publicado en 2015
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells.
artículo científico publicado en 2012
Abstract 3299: Maternal embryonic leucine zipper kinase is critical for the growth and migration of triple negative breast cancer cells
Abstract 4265: Derivation and characterization of endometrial cancer cells resistant to phosphatidylinositol-3-kinase (PI3K) pathway inhibitors
Abstract 82: Novel role of DAPK-1 in growth regulation of ER-negative breast cancer
Abstract LB010: SMMART Program: A multi-omics tumor board with a focus on breast cancer
artículo científico publicado en 2021
Abstract OT3-05-01: Adaptive Multi-Drug Treatment of Evolving Cancers (AMTEC): A Phase II, Open-Label, Study of Olaparib in Combination with either Durvalumab, Selumetinib or Capivasertib, or Ceralasertib Monotherapy in Patients with Metastatic TNBC
artículo científico publicado en 2023
Acquired Uniparental Disomy Regions Are Associated with Disease Outcome in Patients with Oral Cavity and Oropharynx But Not Larynx Cancers
scientific article published on 15 April 2020
Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
artículo científico publicado en 2007
Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers
artículo científico publicado en 2003
Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer
artículo científico publicado en 2014
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells
artículo científico publicado en 2007
Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis.
artículo científico publicado en 2010
Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis
artículo científico publicado en 2010
Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines
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artículo científico publicado el 15 de mayo de 1998
Active Disclosure of Secondary Germline Findings to Deceased Research Participants' Personal Representatives: Process and Outcomes
scientific article published on 31 October 2017
Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates
artículo científico publicado en 2009
Adaptive responses in a PARP inhibitor window of opportunity trial illustrate limited functional interlesional heterogeneity and potential combination therapy options
scientific article published on 28 May 2019
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
artículo científico publicado en 1998
Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
artículo científico publicado en 2011
Advancing Drug Development in Gynecologic Malignancies
scientific article published on 24 May 2019
Agents That Stabilize Mutated von Hippel–Lindau (VHL) Protein: Results of a High-Throughput Screen to Identify Compounds That Modulate VHL Proteostasis
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artículo científico publicado el 21 de febrero de 2012
Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57 Kip2
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artículo científico publicado el 6 de marzo de 2012
Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy
artículo científico publicado en 2007
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression
artículo científico publicado en 2009
Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells
artículo científico publicado en 2009
Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor
artículo científico publicado en 2007
Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer
artículo científico publicado en 2007
Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.
artículo científico publicado en 2007
An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.
artículo científico publicado en 2015
An efficient procedure for protein extraction from formalin-fixed, paraffin-embedded tissues for reverse phase protein arrays
artículo científico publicado en 2012
An emerging toolkit for targeted cancer therapies
artículo científico publicado en 2012
An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
artículo científico publicado en 2012
An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation.
artículo científico publicado en 2013
An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration.
artículo científico publicado en 2006
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
scientific article published on August 2008
An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer
artículo científico publicado en 2022
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes
artículo científico publicado en 2020
Analysis of molecular aberrations in ovarian cancer allows novel target identification
artículo científico publicado en 2004
Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA
scientific article published on 07 October 2020
Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion
artículo científico publicado en 2016
Analysis of the EDG2 receptor based on the structure/activity relationship of LPA.
artículo científico publicado en 2000
Androgen Regulation of 5α-Reductase Isoenzymes in Prostate Cancer: Implications for Prostate Cancer Prevention
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artículo científico publicado el 14 de diciembre de 2011
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer
artículo científico publicado en 2009
Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
artículo científico publicado en 2007
Are oncogenes sufficient to cause human cancer?
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artículo científico publicado el 17 de noviembre de 2010
Assay of Rab25 function in ovarian and breast cancers
artículo científico
Assessing BRCA carrier probabilities in extended families.
artículo científico publicado en 2006
Assessing the clinical utility of cancer genomic and proteomic data across tumor types.
artículo científico publicado en 2014
Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival
artículo científico publicado en 2014
Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma
artículo científico publicado en 2015
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy
artículo científico publicado en 2011
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
artículo científico publicado en 2005
Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
artículo científico publicado en 2010
Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer
artículo científico publicado en 2018
Author Correction: Loss of Phd2 cooperates with BRAF to drive melanomagenesis
artículo científico publicado en 2019
Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
artículo científico publicado en 2019
Author Correction: Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin
artículo científico publicado en 2018
Author response
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.
artículo científico publicado en 2014
Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model.
artículo científico publicado en 2008
Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity
artículo científico publicado en 2006
Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice
artículo científico publicado en 2012
Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p
scientific article published on 31 May 2018
Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis
artículo científico publicado en 2012
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
artículo científico publicado en 2002
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate
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artículo científico publicado el 1 de septiembre de 2003
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression
artículo científico publicado en 2015
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis
artículo científico publicado en 2009
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis.
artículo científico publicado en 2009
BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators
artículo científico publicado en 2021
BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System
artículo científico
BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis
artículo científico publicado en 2020
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation
artículo científico publicado en 2013
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
artículo científico publicado en 2018
BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors
artículo científico publicado en 2018
BRD4 facilitates replication stress-induced DNA damage response.
artículo científico publicado en 2018
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
artículo científico publicado en 2006
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation
artículo científico publicado en 2013
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
artículo científico publicado en 2009
Bayesian inference of signaling network topology in a cancer cell line
artículo científico publicado en 2012
Bayesian models based on test statistics for multiple hypothesis testing problems
artículo científico publicado en 2008
Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity
artículo científico publicado en 2011
Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells.
artículo científico publicado en 2009
Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma
artículo científico publicado en 2014
Bias from removing read duplication in ultra-deep sequencing experiments
artículo científico publicado en 2014
Bioinformatics and systems biology
artículo científico publicado en 2012
Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer
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artículo científico publicado el 29 de agosto de 2012
Breast cancer quantitative proteome and proteogenomic landscape
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR
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artículo científico publicado el 9 de enero de 2012
Building a personalized medicine infrastructure at a major cancer center
artículo científico publicado en 2013
CA 125: the past and the future
artículo científico publicado en 1998
COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms
scientific article published on 15 July 2019
CSIG-08NITROSOUREAS IMPROVE SURVIVAL IN THE SECONDARY-LIKE AKT SUBTYPE OF GLIOBLASTOMA.
artículo científico publicado en 2015
CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence.
artículo científico publicado en 2017
CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis
artículo científico publicado en 2010
CanDrA: cancer-specific driver missense mutation annotation with optimized features
artículo científico publicado en 2013
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance
artículo científico publicado en 2018
Cancer Systems Biology: a peek into the future of patient care?
artículo científico
Cancer driver mutation prediction through Bayesian integration of multi-omic data.
artículo científico publicado en 2018
Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
artículo científico publicado en 2008
Candidate biomarker assessment for pharmacological response
artículo científico publicado en 2020
Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis
artículo científico publicado en 2006
Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.
artículo científico publicado en 2016
Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors
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artículo científico publicado en 2014
Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.
artículo científico publicado en 2009
Characteristics of percutaneous core biopsies adequate for next generation genomic sequencing.
artículo científico publicado en 2017
Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays
artículo científico publicado en 2017
Characterization of Hypoxia-associated Molecular Features to Aid Hypoxia-Targeted Therapy
artículo científico publicado en 2019
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
artículo científico publicado en 2009
Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance
artículo científico publicado en 2015
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours
artículo científico publicado en 2015
Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer
artículo científico publicado en 2017
Clinical Use of Precision Oncology Decision Support
artículo científico publicado en 2017
Clinical actionability enhanced through deep targeted sequencing of solid tumors
artículo científico publicado en 2015
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
artículo científico publicado en 2018
Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing
artículo científico publicado en 2012
Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer
artículo científico publicado en 2013
Clinical next generation sequencing to identify actionable aberrations in a phase I program
artículo científico publicado en 2015
Clinical outcomes based on multigene profiling in metastatic breast cancer patients
artículo científico publicado en 2016
Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers
artículo científico publicado en 2019
Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma
artículo científico publicado en 2014
Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma
artículo científico publicado en 2015
Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities
artículo científico publicado en 2015
Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma
artículo científico publicado en 2018
Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness
artículo científico publicado en 2019
Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors
artículo científico publicado en 2009
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
scientific article published on 24 July 2020
Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas
artículo científico publicado en 2017
Comparison of Real-Time Fluorescence Confocal Digital Microscopy With Hematoxylin-Eosin-Stained Sections of Core-Needle Biopsy Specimens
artículo científico publicado en 2020
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients
artículo científico
Comprehensive Characterization of Alternative Polyadenylation in Human Cancer
artículo científico publicado en 2017
Comprehensive Characterization of Cancer Driver Genes and Mutations
artículo científico publicado en 2018
Comprehensive Characterization of Cancer Driver Genes and Mutations
article
Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients
artículo científico publicado en 2016
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
artículo científico publicado en 2015
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
artículo científico publicado en 2017
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
artículo científico publicado en 2018
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma
artículo científico publicado en 2015
Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
artículo científico publicado en 2018
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
artículo científico publicado en 2015
Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
article
Comprehensive assessment of computational algorithms in predicting cancer driver mutations
artículo científico publicado en 2020
Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines
artículo científico publicado en 2019
Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer
artículo científico publicado en 2014
Concordance of genomic alterations between primary and recurrent breast cancer.
artículo científico publicado en 2014
Confocal Fluorescence Microscopy Platform Suitable for Rapid Evaluation of Small Fragments of Tissue in Surgical Pathology Practice
artículo científico publicado en 2018
Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.
artículo científico publicado en 2000
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
artículo científico publicado en 2016
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway
artículo científico publicado en 2002
Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer
artículo científico publicado en 2018
Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules
artículo científico publicado en 2013
Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
artículo científico publicado en 2014
Correction: A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory
scientific article published on 27 August 2019
Correction: Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes
artículo científico publicado en 2016
Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer
artículo científico publicado en 2017
Correction: Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer
scientific article published on 01 May 2019
Correction: RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin
scientific article published on 01 May 2019
Correction: Systematic Identification of Combinatorial Drivers and Targets in Cancer Cell Lines
Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis
artículo científico publicado en 2020
Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas
scientific article published on 28 January 2015
Credentialing Individual Samples for Proteogenomic Analysis
artículo científico publicado en 2018
Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference
article
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
artículo científico publicado en 2002
Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis
artículo científico publicado en 2011
Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.
artículo científico publicado en 2014
Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells.
artículo científico publicado en 2016
Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma.
artículo científico publicado en 2006
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers
artículo científico publicado en 2006
DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
artículo científico publicado en 2011
Data integration gets 'Sloppy'
artículo científico publicado en 2006
Death-associated protein kinase 1 promotes growth of p53-mutant cancers
artículo científico publicado en 2015
Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis
artículo científico publicado en 2010
Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer
artículo científico publicado en 2015
Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype
artículo científico publicado en 2018
Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer
artículo científico publicado en 2014
Derailed endocytosis: an emerging feature of cancer
artículo científico publicado en 2008
Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
artículo científico publicado en 2019
Detection algorithm for the validation of human cell lines
artículo científico publicado en 2012
Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases
artículo científico publicado en 2019
Determinants of rapamycin sensitivity in breast cancer cells
artículo científico publicado en 2004
Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.
artículo científico publicado en 2011
Development and Validation of a Prognostic Gene-Expression Signature for Lung Adenocarcinoma
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artículo científico publicado el 7 de septiembre de 2012
Development and validation of an ultra-deep next-generation sequencing assay for testing of plasma cell-free DNA from patients with advanced cancer
artículo científico publicado en 2017
Development of a robust classifier for quality control of reverse-phase protein arrays
artículo científico publicado en 2014
Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma
scientific article published on 10 February 2020
Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes
artículo científico publicado en 2013
Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression
scientific article published on 09 April 2020
Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine
artículo científico publicado en 2006
Differential signaling by an anti-p185(HER2) antibody and heregulin
artículo científico publicado en 2000
Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer
artículo científico publicado en 2016
Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer
artículo científico publicado en 2012
Distinct histone modifications denote early stress-induced drug tolerance in cancer
artículo científico publicado en 2017
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
artículo científico publicado en 2010
Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.
artículo científico publicado en 2012
Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors
artículo científico publicado en 2020
Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells
artículo científico publicado en 2018
Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models
artículo científico publicado en 2011
Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor
artículo científico publicado en 2009
Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion
artículo científico publicado en 2019
EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol
artículo científico publicado en 2012
EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation.
artículo científico publicado en 2018
EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.
artículo científico publicado en 2011
ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.
artículo científico publicado en 2016
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
artículo científico publicado en 2008
ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
artículo científico publicado en 2011
EVI1 splice variants modulate functional responses in ovarian cancer cells
artículo científico publicado en 2013
Early detection of ovarian cancer: promise and reality
artículo científico publicado en 2002
Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck
artículo científico publicado en 2007
Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK
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artículo científico publicado el 15 de marzo de 1998
Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.
artículo científico publicado en 2014
Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer
artículo científico publicado en 2013
Emerging role of RAB GTPases in cancer and human disease
artículo científico publicado en 2005
Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity
artículo científico publicado en 2003
Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts
artículo científico publicado en 2013
Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.
artículo científico publicado en 2017
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab
scientific article published on 01 September 2007
Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.
artículo científico publicado en 2017
Erratum to: Modeling precision treatment of breast cancer
artículo científico publicado en 2015
Erratum: Corrigendum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
article
Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo
artículo científico publicado en 2017
Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.
artículo científico publicado en 2016
Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
artículo científico publicado en 2018
Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2.
artículo científico publicado en 2002
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival
scientific article published on 24 April 2003
Ex Vivo Confocal Fluorescence Microscopy for Rapid Evaluation of Tissues in Surgical Pathology Practice
artículo científico publicado en 2017
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
scientific article published in Nature
Expanded analysis of secondary germline findings from matched tumor/normal sequencing identifies additional clinically significant mutations
scientific article published on 11 April 2019
Exploratory analysis of the copy number alterations in glioblastoma multiforme
artículo científico publicado en 2008
Explore, Visualize, and Analyze Functional Cancer Proteomic Data Using the Cancer Proteome Atlas.
artículo científico publicado en 2017
Exposing the cancer genome atlas as a SPARQL endpoint
artículo científico publicado en 2010
Expression of Concern: Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer
scientific article published on 11 September 2020
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
artículo científico publicado en 1992
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
artículo científico publicado en 2009
Expression of endogenous granzyme B in a subset of human primary breast carcinomas
artículo científico publicado en 2003
Expression of p16 induces transcriptional downregulation of the RB gene
artículo científico publicado en 1998
Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV)
scientific article published on 01 March 1999
Extracellular lactate cooperates with limited glucose and glutamine to sustain breast cancer cell survival by providing ATP, NADPH, amino acids, and glutathione
Favorable modulation of benign breast tissue and serum risk biomarkers is associated with > 10 % weight loss in postmenopausal women
artículo científico publicado en 2013
Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials
artículo científico publicado en 2015
Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways
scientific article published on 29 June 2020
Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer
artículo científico publicado en 2012
Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes.
artículo científico publicado en 2012
Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals
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artículo científico publicado el 6 de diciembre de 2012
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer
artículo científico publicado en 2014
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
artículo científico publicado en 2013
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
artículo científico publicado en 2016
Functional annotation of rare gene aberration drivers of pancreatic cancer
artículo científico publicado en 2016
Functional consequence of the MET-T1010I polymorphism in breast cancer
artículo científico publicado en 2015
Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer
artículo científico publicado en 2000
Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy
artículo científico publicado en 2010
Functional proteomic characterization of cancer cell lines
artículo científico publicado en 2017
Functional proteomic profiling of AML predicts response and survival
artículo científico publicado en 2008
Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer
artículo científico publicado en 2011
Functional proteomics characterization of residual breast cancer after neoadjuvant systemic chemotherapy.
artículo científico publicado en 2012
Functional proteomics characterization of residual triple-negative breast cancer after standard neoadjuvant chemotherapy
scientific article published on 07 August 2013
Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer
artículo científico publicado en 2016
Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.
artículo científico publicado en 2015
Functional variomics and network perturbation: connecting genotype to phenotype in cancer.
artículo científico publicado en 2017
Future for ovarian cancer screening: novel markers from emerging technologies of transcriptional profiling and proteomics
artículo científico publicado en 2001
Future of personalized medicine in oncology: a systems biology approach
artículo científico publicado en 2010
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth
artículo científico publicado en 2005
GENE-29. DEEP PANEL SEQUENCING OF A PROSPECTIVELY COLLECTED GLIOMA COHORT
GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and β-catenin activity
scientific article published on 26 March 2019
Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.
artículo científico publicado en 2014
Gene Expression, Molecular Class Changes, and Pathway Analysis after Neoadjuvant Systemic Therapy for Breast Cancer
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artículo científico publicado el 10 de enero de 2012
Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation
artículo científico publicado en 2018
Gene and protein expression markers of response to combined antiangiogenic and epidermal growth factor targeted therapy in renal cell carcinoma
artículo científico publicado en 2010
Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer
artículo científico publicado en 2011
General keynote: molecular therapeutics and pharmocogenomics
artículo científico publicado en 2003
General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer
artículo científico publicado en 2003
Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling
artículo científico publicado en 2005
Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer
scientific article published on 01 November 2020
Genetic alterations in the PI3K/AKT pathway and baseline AKT activity define AKT inhibitor sensitivity in breast cancer patient-derived xenografts
scientific article published on 27 March 2020
Genetic analysis of early- versus late-stage ovarian tumors.
artículo científico publicado en 2001
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein
artículo científico publicado en 2014
Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer
artículo científico publicado en 2015
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer
artículo científico publicado en 2009
Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations
Genome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma
scientific article published on 14 November 2019
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
scientific journal article
Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers
artículo científico publicado en 2015
Genome-wide transcriptome profiling of homologous recombination DNA repair
artículo científico publicado en 2014
Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma
artículo científico publicado en 2015
Genomic amplicons target vesicle recycling in breast cancer
artículo científico publicado en 2009
Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature
artículo científico publicado en 2017
Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
artículo científico publicado en 2018
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
artículo científico publicado en 2013
Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines
artículo científico publicado en 2015
Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models
artículo científico publicado en 2021
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase
artículo científico publicado en 2004
Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer
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artículo científico publicado en 2016
Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.
artículo científico publicado en 2013
HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.
artículo científico publicado en 2011
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.
artículo científico publicado en 2003
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
artículo científico publicado en 2016
Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis
artículo científico publicado en 1997
Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity
artículo científico publicado en 2001
High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype
artículo científico publicado en 2016
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability
artículo científico publicado en 2011
High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays
artículo científico publicado en 2009
High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients
artículo científico publicado en 2013
Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.
artículo científico publicado en 2015
Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.
artículo científico publicado en 2015
Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.
artículo científico publicado en 2016
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts
artículo científico publicado en 2008
Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types
artículo científico publicado en 2016
Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer
artículo científico publicado en 2010
Identification and validation of a prognostic proteomic signature for cervical cancer
artículo científico publicado en 2019
Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations
artículo científico publicado en 2015
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor
artículo científico publicado en 2003
Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment naïve gBRCA+ breast cancers
artículo científico publicado en 2022
Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis
artículo científico publicado en 2010
Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer
artículo científico publicado en 2006
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
artículo científico publicado en 1995
Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets
artículo científico publicado en 2017
Immuno-genomic landscape of osteosarcoma
scientific article published on 21 February 2020
Impact of Cold Ischemic Time and Freeze-Thaw Cycles on RNA, DNA and Protein Quality in Colorectal Cancer Tissues Biobanking
artículo científico publicado en 2019
Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies.
artículo científico publicado en 2018
Implementation of biomarker-driven cancer therapy: existing tools and remaining gaps
artículo científico publicado en 2014
Implementing a comprehensive translational oncology platform: from molecular testing to actionability
artículo científico publicado en 2018
Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm
artículo científico publicado en 2017
In silico prediction of physical protein interactions and characterization of interactome orphans
artículo científico publicado en 2015
In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).
artículo científico publicado en 2000
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
artículo científico publicado en 2018
Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer
artículo científico publicado en 2011
Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol
artículo científico publicado en 2016
Individualized molecular medicine: linking functional proteomics to select therapeutics targeting the PI3K pathway for specific patients
artículo científico publicado en 2008
Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma
artículo científico publicado en 2018
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling
artículo científico publicado en 2002
Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment
artículo científico publicado en 2010
Inferring causal molecular networks: empirical assessment through a community-based effort
artículo científico publicado en 2016
Inferring tumour purity and stromal and immune cell admixture from expression data
artículo científico publicado en 2013
Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
artículo científico publicado en 2013
Influence of biospecimen variables on proteomic biomarkers in breast cancer
artículo científico publicado en 2014
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma
artículo científico publicado en 2006
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells
artículo científico publicado en 2012
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells
artículo científico publicado en 2000
Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma
artículo científico publicado en 2014
Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.
artículo científico publicado en 2002
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors
artículo científico publicado en 2020
Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
artículo científico publicado en 2002
Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
artículo científico publicado en 2006
Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity i
artículo científico publicado en 2003
Integrated Genomic Characterization of the Human Immunome in Cancer
scientific article published on 27 August 2020
Integrated Molecular Characterization of Uterine Carcinosarcoma
artículo científico publicado en 2017
Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma
artículo científico publicado en 2009
Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer
artículo científico publicado en 2016
Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D.
artículo científico publicado en 2014
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer
artículo científico publicado en 2015
Integrated genomic characterization of endometrial carcinoma
artículo científico publicado en 2013
Integrated transcriptomic-genomic tool Texomer profiles cancer tissues
scientific article published on 15 April 2019
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
artículo científico publicado en 2017
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
artículo científico publicado en 2018
Integrative Protein-Based Prognostic Model for Early-Stage Endometrioid Endometrial Cancer
artículo científico publicado en 2015
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
artículo científico publicado en 2009
Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set
artículo científico publicado en 2010
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
artículo científico publicado en 2017
Integrative epidemiology: from risk assessment to outcome prediction
artículo científico publicado en 2005
Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.
artículo científico publicado en 2010
Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
artículo científico publicado en 2005
Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells
artículo científico publicado en 2007
Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy
artículo científico publicado en 2012
Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms
artículo científico publicado en 2009
Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells.
artículo científico publicado en 2001
Involvement of the SHP-1 tyrosine phosphatase in regulating B lymphocyte antigen receptor signaling, proliferation and transformation
artículo científico publicado en 1999
Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels
artículo científico publicado en 2014
Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling
artículo científico
Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells
artículo científico publicado en 2006
LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer
artículo científico publicado en 2013
LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients
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artículo científico publicado el 29 de marzo de 2012
LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer
artículo científico publicado en 2014
Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer
artículo científico publicado en 2013
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response
artículo científico publicado en 2021
Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines
artículo científico publicado en 2020
Large-Scale Drug Screens Support Precision Medicine
artículo científico publicado en 2015
Levels of soluble interleukin-2 receptor-α are elevated in serum and ascitic fluid from epithelial ovarian cancer patients
artículo científico publicado en 1994
Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line
artículo científico publicado en 2004
Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer
artículo científico publicado en 2003
Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo
artículo científico publicado en 2001
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis
artículo científico publicado en 2007
Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors
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artículo científico publicado el 1 de febrero de 2011
Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis
artículo científico publicado en 2015
Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.
artículo científico publicado en 2016
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
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artículo científico publicado el 8 de mayo de 2003
Loss of Phd2 cooperates with BRAF to drive melanomagenesis
scientific article published in Nature Communications
Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer
artículo científico publicado en 2009
Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.
artículo científico publicado en 2014
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers
artículo científico publicado en 2008
Loss-of-function screens of druggable targetome against cancer stem-like cells.
artículo científico publicado en 2016
Lysophosphatidic Acid Induces Lymphangiogenesis and IL-8 Production in Vitro in Human Lymphatic Endothelial Cells
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artículo científico publicado el 30 de marzo de 2012
Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling
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artículo científico publicado el 20 de octubre de 2011
Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells
artículo científico publicado en 2008
Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management.
artículo científico publicado en 2001
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression
artículo científico publicado en 2011
Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells
artículo científico publicado en 1999
Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
artículo científico publicado en 2007
Lysophosphatidic acid is a bioactive mediator in ovarian cancer
artículo científico publicado en 2002
Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer
artículo científico publicado en 2006
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase
artículo científico publicado en 2000
Lysophosphatidic acid production and action: validated targets in cancer?
artículo científico publicado en 2004
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells
artículo científico publicado en 2008
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis
artículo científico publicado en 2009
Lysophosphatidylcholine Stimulates Activator Protein 1 and the c-Jun N-terminal Kinase Activity
artículo científico publicado en 1997
Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
artículo científico publicado en 2000
MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer
artículo científico publicado en 2015
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling
scientific article published on 07 May 2020
MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis
scientific article published on 08 November 2019
MEK Inhibition Remodels the Immune Landscape of Mutant <i>KRAS</i> Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
artículo científico publicado en 2021
MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology
scientific article published on 19 January 2019
MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition
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artículo científico publicado el 16 de enero de 2012
MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY.
artículo científico publicado en 2011
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
artículo científico publicado en 2012
Mammalian target of rapamycin
artículo científico publicado en 2004
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
artículo científico publicado en 2010
Mask is required for the activity of the Hippo pathway effector Yki/YAP.
artículo científico publicado en 2013
Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II
artículo científico publicado en 2022
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells
artículo científico publicado en 2003
Mechanisms underlying chemoprevention of ovarian cancer
artículo científico publicado en 2002
Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
artículo científico publicado en 2008
Mechanistic basis for overcoming platinum resistance using copper chelating agents
artículo científico publicado en 2012
Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance
artículo científico publicado en 2014
Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis
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artículo científico publicado el 1 de enero de 2010
Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes
artículo científico publicado en 2016
Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
artículo científico publicado en 2005
Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.
artículo científico publicado en 2018
Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation
artículo científico publicado en 2014
Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance
artículo científico publicado en 2020
Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance
Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.
artículo científico publicado en 2011
Modeling precision treatment of breast cancer
artículo científico publicado en 2013
Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women
artículo científico publicado en 2015
Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women
artículo científico publicado en 2015
Modulation of the Hippo pathway and organ growth by RNA processing proteins
artículo científico publicado en 2018
Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer
scientific article published on 01 April 2020
Molecular characterization of gallbladder cancer using somatic mutation profiling
artículo científico publicado en 2013
Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation
artículo científico publicado en 1994
Molecular determinants of post-mastectomy breast cancer recurrence
artículo científico publicado en 2018
Molecular heterogeneity at the network level: high-dimensional testing, clustering and a TCGA case study
artículo científico publicado en 2017
Molecular mechanisms and pathobiology of oncogenic fusion transcripts in epithelial tumors
Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients
artículo científico publicado en 2015
Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein
artículo científico publicado en 2006
Molecular therapeutics: promise and challenges
artículo científico publicado en 2004
Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3.
artículo científico publicado en 2008
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity
artículo científico publicado en 2002
Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy
artículo científico publicado en 2015
Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo.
artículo científico publicado en 2018
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.
artículo científico publicado en 2018
Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy
scientific article published on 02 October 2020
Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing.
artículo científico publicado en 2015
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma
artículo científico publicado en 2016
Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies
artículo científico publicado en 2021
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
artículo científico publicado en 2014
Multiplatform-based molecular subtypes of non-small-cell lung cancer
artículo científico publicado en 2016
Multiplex digital spatial profiling of proteins and RNA in fixed tissue
scientific article published on 11 May 2020
Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.
artículo científico publicado en 2016
Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1
scientific article published on 03 January 2020
Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications
artículo científico publicado en 2014
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
artículo científico publicado en 2009
Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
artículo científico publicado en 2015
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas
artículo científico publicado en 1999
Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors
artículo científico publicado en 2014
Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
artículo científico publicado en 2018
Neomorphic mutations create therapeutic challenges in cancer.
artículo científico publicado en 2016
Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis
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artículo científico publicado el 11 de septiembre de 2012
Network inference using steady-state data and Goldbeter-Koshland kinetics. [corrected]
artículo científico publicado en 2012
Network inference using steady-state data and Goldbeter–Koshland kinetics
artículo científico publicado en 2013
Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.
artículo científico publicado en 2008
New era of integrated cancer biomarker discovery using reverse-phase protein arrays
artículo científico publicado en 2016
Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent®) a VEGFR2/PDGFRβ/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial
artículo científico publicado en 2014
Next-Generation Sequencing and Result Interpretation in Clinical Oncology: Challenges of Personalized Cancer Therapy.
artículo científico publicado en 2016
Next-generation characterization of the Cancer Cell Line Encyclopedia
artículo científico publicado en 2019
Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.
artículo científico publicado en 2017
Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
artículo científico publicado en 2010
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models
artículo científico publicado en 2019
Non-parametric quantification of protein lysate arrays
artículo científico publicado en 2007
Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
artículo científico publicado en 2016
Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer
artículo científico publicado en 2016
Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure
artículo científico publicado en 2015
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer
artículo científico publicado en 2006
Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial
scientific article published on 14 March 2019
Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms
artículo científico publicado en 2011
Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer
artículo científico publicado en 2017
Open-label randomized clinical trial of standard neoadjuvant chemotherapy with paclitaxel followed by FEC versus the combination of paclitaxel and everolimus followed by FEC in women with triple receptor-negative breast cancer†.
artículo científico publicado en 2014
Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007.
artículo científico publicado en 2007
OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets.
artículo científico publicado en 2014
Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead
artículo científico publicado en 2008
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
artículo científico publicado en 2014
Overcoming implementation challenges of personalized cancer therapy
artículo científico publicado en 2012
Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis
artículo científico publicado en 2008
Overexpression of kallikrein 10 in epithelial ovarian carcinomas
artículo científico publicado en 2003
Oxygen sensor boosts growth factor signaling
artículo científico publicado en 2009
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.
artículo científico publicado en 2014
P5-21-01: A Renewable Tissue Resource of Phenotypically Stable Human Breast Cancer Xenografts for Preclinical Studies.
artículo científico publicado en 2011
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
artículo científico publicado en 2017
PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness
artículo científico publicado en 2019
PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer.
artículo científico publicado en 2011
PI3K pathway-directed therapeutic strategies in cancer.
artículo científico publicado en 2010
PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma
scientific article published on 15 November 2018
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer
artículo científico
PIK3CA is implicated as an oncogene in ovarian cancer.
artículo científico publicado en 1999
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
artículo científico publicado en 2010
PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors
artículo científico publicado en 2014
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
scientific article published on 29 January 2020
PIK3CA/PTEN Mutations and Akt Activation As Markers of Sensitivity to Allosteric mTOR Inhibitors
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artículo científico publicado el 15 de marzo de 2012
PKCiota promotes ovarian tumor progression through deregulation of cyclin E.
artículo científico publicado en 2015
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
artículo científico publicado en 2013
PRECISION ONCOLOGY DECISION SUPPORT: CURRENT APPROACHES AND STRATEGIES FOR THE FUTURE.
artículo científico publicado en 2018
PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth
artículo científico publicado en 2009
PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients
artículo científico publicado en 2015
PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival
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artículo científico publicado el 23 de julio de 2010
Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis
artículo científico publicado en 2003
Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway
artículo científico publicado en 2016
Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
artículo científico publicado en 2005
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
artículo científico publicado en 2012
Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer
artículo científico publicado en 2012
Peritoneal Spread of Ovarian Cancer harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling
artículo científico publicado en 2020
Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer
artículo científico publicado en 2014
Personalized Integrated Network Modeling of the Cancer Proteome Atlas
scientific article published in Scientific Reports
Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies
artículo científico publicado en 2015
Personalizing therapy for ovarian cancer: BRCAness and beyond
artículo científico publicado en 2010
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
artículo científico publicado en 2018
Perturbation biology: inferring signaling networks in cellular systems
artículo científico publicado en 2013
Pharmacodynamic markers of perifosine efficacy
artículo científico publicado en 2007
Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer
artículo científico publicado en 2020
Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer.
artículo científico publicado en 2016
Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation
artículo científico publicado en 2019
Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer
artículo científico publicado en 2019
Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival
artículo científico publicado en 2016
Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.
artículo científico publicado en 2011
Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists
artículo científico publicado en 2006
Phosphorylated 4E-BP1 is associated with poor survival in melanoma
scientific article published on 31 March 2009
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
artículo científico publicado en 2000
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor
artículo científico publicado en 2014
Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
artículo científico publicado en 2006
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
artículo científico publicado en 2007
Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function
artículo científico publicado en 2016
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase
artículo científico publicado en 2010
Physician interpretation of genomic test results and treatment selection.
artículo científico publicado en 2017
Physiologic and pathologic drug resistance in ovarian carcinoma--a hypothesis based on a clonal progression model
artículo científico publicado en 1998
Point mutations of protein kinases and individualised cancer therapy
artículo científico publicado en 2006
Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer
artículo científico publicado en 2011
Polymorphisms in the survivin promoter are associated with age of onset of ovarian cancer
artículo científico publicado en 2009
Precision oncology: neither a silver bullet nor a dream
artículo científico publicado en 2017
Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro.
artículo científico publicado en 2018
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.
artículo científico publicado en 2007
Predicting Cancer Cell Line Dependencies From the Protein Expression Data of Reverse-Phase Protein Arrays
scientific article published on 01 April 2020
Predicting high-risk endometrioid carcinomas using proteins.
artículo científico publicado en 2018
Predicting time to ovarian carcinoma recurrence using protein markers.
artículo científico publicado en 2013
Predicting time to ovarian carcinoma recurrence using protein markers.
artículo científico publicado en 2013
Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the computer model BRCAPRO
artículo científico publicado en 2002
Prevention and early detection of ovarian cancer: mission impossible?
artículo científico publicado en 2007
Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance
artículo científico publicado en 2012
Prognostic relevance of acquired uniparental disomy in serous ovarian cancer
artículo científico publicado en 2015
Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors.
artículo científico publicado en 1999
Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward
artículo científico publicado en 2006
Promising rationally derived combination therapy with PI3K and CDK4/6 inhibitors.
artículo científico publicado en 2014
Prospective Clinical Sequencing of Adult Glioma
scientific article published on 29 March 2019
Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer
scientific article published on 20 March 2019
Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
scientific article published on 27 February 2020
Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts
artículo científico publicado en 2015
Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.
artículo científico publicado en 2017
Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response
artículo científico publicado en 2020
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
artículo científico publicado en 2010
Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations
artículo científico publicado en 2013
Proteomic classification of breast cancer.
artículo científico publicado en 2012
Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer
artículo científico publicado en 2013
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
artículo científico publicado en 2012
Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence
artículo científico publicado en 2010
Proteomic profiling of endometrioid endometrial cancer reveals differential expression of hormone receptors and MAPK signaling proteins in obese versus non-obese patients
artículo científico publicado en 2017
Proteomics advances for precision therapy in ovarian cancer
artículo científico publicado en 2019
Quantitative proteomic analysis in breast cancer
artículo científico publicado en 2011
Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells
artículo científico publicado en 2013
RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?
artículo científico publicado en 2014
RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin
artículo científico publicado en 2016
RET fusion as a novel driver of medullary thyroid carcinoma
artículo científico publicado en 2014
RNA editing derived epitopes function as cancer antigens to elicit immune responses
scientific article published in Nature Communications
RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC
artículo científico publicado en 2020
RPPAML/RIMS: a metadata format and an information management system for reverse phase protein arrays
artículo científico publicado en 2008
Rab GTPases implicated in inherited and acquired disorders
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artículo científico publicado el 13 de diciembre de 2010
Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression
scientific article published on March 2016
Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.
artículo científico publicado en 2016
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
artículo científico publicado en 2007
Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.
artículo científico publicado en 2018
Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress
artículo científico publicado en 2012
Rak functions as a tumor suppressor by regulating PTEN protein stability and function
artículo científico publicado en 2009
Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer
artículo científico publicado en 2017
Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer
artículo científico publicado en 2010
Ras-superfamily GTP-ases in ovarian cancer
artículo científico publicado en 2009
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
artículo científico publicado en 2017
Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society
artículo científico publicado en 2014
Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer
artículo científico publicado en 2009
Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation
artículo científico publicado en 2010
Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer
scientific journal article
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
artículo científico publicado en 1997
Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
artículo científico publicado en 1999
Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies
artículo científico publicado en 2015
Regulation of mRNA expression in breast cancer - a cis-tematic trans-action
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artículo científico publicado el 29 de octubre de 2012
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
artículo científico publicado en 2012
Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium
artículo científico publicado en 2015
Relationship Between Response and Dose in Published, Contemporary Phase I Oncology Trials
scientific article published on 01 April 2020
Reply to M.P. Decatris et al
artículo científico publicado en 2016
Repurposing the Pap smear: one step closer to gynecologic cancer screening
artículo científico publicado en 2013
Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils
artículo científico publicado en 1996
Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents
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artículo científico publicado el 18 de diciembre de 2012
Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035)
artículo científico publicado en 2020
Rethinking ovarian cancer: recommendations for improving outcomes
artículo científico publicado en 2011
Retrospective Review of MET Gene Mutations
artículo científico publicado en 2015
Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.
artículo científico publicado en 2009
Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells
artículo científico publicado en 2006
Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer
artículo científico publicado en 2014
Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers
artículo científico publicado en 2015
Role of RPL39 in Metaplastic Breast Cancer.
artículo científico publicado en 2016
Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer
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artículo científico publicado el 1 de septiembre de 2003
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity
artículo científico publicado en 2005
Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
artículo científico publicado en 2011
SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity
artículo científico publicado en 1999
SU2C phase Ib study of paclitaxel and MK-2206 in advanced solid tumors and metastatic breast cancer
artículo científico publicado en 2015
Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study
artículo científico publicado en 2019
Sarcomatoid renal cell carcinoma has a distinct molecular pathogenesis, driver mutation profile and transcriptional landscape
artículo científico
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis
artículo científico publicado en 2004
Selective Genomic Copy Number Imbalances and Probability of Recurrence in Early-Stage Breast Cancer
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artículo científico publicado el 12 de agosto de 2011
Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer
artículo científico publicado en 2013
Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy
scientific article published on 01 June 2019
Serial dilution curve: a new method for analysis of reverse phase protein array data
artículo científico publicado en 2009
Sex-associated molecular differences for cancer immunotherapy
artículo científico publicado en 2020
Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation
artículo científico publicado en 2008
Shrewd AKT regulation to survive
artículo científico publicado en 2014
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia
artículo científico publicado en 2006
Site-specific activation of AKT protects cells from death induced by glucose deprivation
artículo científico publicado en 2013
Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia
artículo científico publicado en 2013
Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha
artículo científico publicado en 2008
Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy
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artículo científico publicado el 5 de diciembre de 2012
Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer
scientific article published on 01 November 1995
Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer
artículo científico publicado en 2010
Somatic mutations of PIK3R1 promote gliomagenesis
artículo científico publicado en 2012
Sparse Bayesian Graphical Models for RPPA Time Course Data
artículo científico publicado en 2012
Spatial normalization of reverse phase protein array data
artículo científico publicado en 2014
Spatially Interacting Phosphorylation Sites and Mutations in Cancer
artículo científico publicado en 2021
Spatially interacting phosphorylation sites and mutations in cancer
artículo científico publicado en 2021
Specific keynote: genome copy number abnormalities in ovarian cancer
artículo científico publicado en 2003
Specific keynote: molecular therapeutics in ovarian cancer
artículo científico publicado en 2003
Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo
artículo científico publicado en 2012
Src Kinase Activity Is Regulated by the SHP-1 Protein-tyrosine Phosphatase
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artículo científico publicado el 22 de agosto de 1997
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades
artículo científico publicado en 2003
Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer
artículo científico publicado en 2007
Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer.
artículo científico publicado en 2017
State-of-the-art strategies for targeting the DNA damage response in cancer
article
Stem cell-ness: a "magic marker" for cancer
artículo científico publicado en 2005
Stem cell-ness: a “magic marker” for cancer.
artículo científico publicado en 2005
Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation
artículo científico publicado en 2010
Structure-activity relationships of fluorinated lysophosphatidic acid analogues
artículo científico publicado en 2005
Subtype and pathway specific responses to anticancer compounds in breast cancer
artículo científico publicado en 2011
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
scientific article published on 01 August 2019
Survival Outcomes by TP53 Mutation Status in Metastatic Breast Cancer
artículo científico publicado en 2018
Survival of cancer stem-like cells under metabolic stress via CaMK2α-mediated upregulation of sarco/endoplasmic reticulum calcium ATPase expression
artículo científico publicado en 2017
Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML
artículo científico publicado en 2012
Surviving ovarian cancer: an affair between defective DNA repair and RB1.
artículo científico publicado en 2017
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
artículo científico publicado en 2003
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.
artículo científico publicado en 2005
Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid
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artículo científico publicado el 8 de octubre de 2010
Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis
scientific article published on 21 August 2020
Systematic Functional Annotation of Somatic Mutations in Cancer.
artículo científico publicado en 2018
Systematic analysis of genotype-specific drug responses in cancer
artículo científico publicado en 2012
Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers
artículo científico publicado en 2017
Systematic identification of combinatorial drivers and targets in cancer cell lines
artículo científico publicado en 2013
Systems Biology Approaches to Decoding the Genome of Liver Cancer
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artículo científico publicado el 27 de diciembre de 2011
Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.
artículo científico
Systems approach to rational combination therapy: PARP inhibitors
artículo científico publicado en 2020
Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
artículo científico publicado en 2018
TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data
scientific article published on 14 June 2019
TCPA: a resource for cancer functional proteomics data
artículo científico publicado en 2013
Targeting Extracellular Matrix Remodeling restores BRAF Inhibitor Sensitivity in BRAFi Resistant Melanoma
artículo científico publicado en 2020
Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p
artículo científico publicado en 2016
Targeting PI3K-AKT pathway for cancer therapy
artículo científico publicado en 2003
Targeting gamma secretase: has progress moved up a Notch?
artículo científico publicado en 2018
Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma
artículo científico publicado en 2005
Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells
artículo científico publicado en 2004
Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid
artículo científico publicado en 2010
Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity
artículo científico publicado en 2019
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
artículo científico publicado en 2016
Targeting ncRNAs in the 3q26.2 amplicon
artículo científico publicado en 2015
Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis
artículo científico publicado en 2016
Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy
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artículo científico publicado el 6 de agosto de 2012
Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges.
artículo científico publicado en 2009
Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression
artículo científico publicado en 2007
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy
artículo científico publicado en 2003
Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment.
artículo científico publicado en 2016
Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer
artículo científico publicado en 2014
Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.
artículo científico publicado en 2013
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells
artículo científico publicado en 2007
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
artículo científico publicado en 2006
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
artículo científico publicado en 2018
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
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The Cancer Genome Atlas Pan-Cancer analysis project
artículo científico publicado en 2013
The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer
artículo científico publicado en 2019
The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment
artículo científico publicado en 2016
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers
artículo científico publicado en 2015
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.
artículo científico publicado en 2018
The Impact of Tumor Heterogeneity on Patient Treatment Decisions
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artículo científico publicado el 9 de noviembre de 2012
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
artículo científico publicado en 2017
The PI3K/AKT Pathway and Renal Cell Carcinoma
artículo científico publicado en 2015
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
artículo científico publicado en 1999
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers
artículo científico publicado en 2004
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF
artículo científico publicado en 2014
The Somatic Genomic Landscape of Glioblastoma
article
The biology of ovarian cancer: new opportunities for translation
artículo científico publicado en 2009
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
artículo científico publicado en 2006
The degree of intratumor mutational heterogeneity varies by primary tumor sub-site.
artículo científico publicado en 2016
The emerging role of lysophosphatidic acid in cancer
artículo científico publicado en 2003
The emerging role of the RAB25 small GTPase in cancer
artículo científico publicado en 2009
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
artículo científico publicado en 2003
The management of malignant ascites and impact on quality of life outcomes in women with ovarian cancer
scientific article published on 27 May 2016
The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression
artículo científico publicado en 1999
The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression
artículo científico publicado en 2019
The rebirth of a phoenix: ovarian cancers are addicted to ErbB-3.
artículo científico publicado en 2010
The right drugs at the right time for the right patient: the MD Anderson precision oncology decision support platform
artículo científico publicado en 2015
The rise of genomic profiling in ovarian cancer
artículo científico publicado en 2016
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
artículo científico publicado en 2001
The somatic genomic landscape of glioblastoma
artículo científico publicado en 2013
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
artículo científico publicado en 2008
The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer
artículo científico publicado en 2018
The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin
artículo científico publicado en 1994
Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers
article
TransVar: a multilevel variant annotator for precision genomics
artículo científico publicado en 2015
Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells
artículo científico publicado en 2002
Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer
scientific article published on 08 October 2019
Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression
artículo científico publicado en 1996
Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development
artículo científico publicado en 2016
Transient commensal clonal interactions can drive tumor metastasis
artículo científico publicado en 2020
Translational research--traffic on the bridge.
artículo científico publicado en 2001
Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers
artículo científico publicado en 2011
Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.
artículo científico publicado en 2012
Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals
artículo científico publicado en 2011
Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium
artículo científico publicado en 2019
Uniparental disomy in cancer
artículo científico publicado en 2009
Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening
artículo científico publicado en 2017
Unraveling the regulatory connections between two controllers of breast cancer cell fate
artículo científico publicado en 2014
Upregulation of Cell Surface GD3 Ganglioside Phenotype is Associated with Human Melanoma Brain Metastasis
scientific article published on 02 May 2020
Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer
scientific article published on 25 January 2019
Use of proteomic patterns in serum to identify ovarian cancer
artículo científico publicado en 2002
Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma.
artículo científico publicado en 2005
Using Reverse Phase Protein Array (RPPA) to Identify and Target Adaptive Resistance
scientific article published on 01 January 2019
Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer
artículo científico publicado en 2016
Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials.
artículo científico publicado en 2016
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
artículo científico publicado en 2006
Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer
artículo científico publicado en 2008
Verteporfin inhibits PD-L1 through autophagy and the STAT1-IRF1-TRIM28 signaling axis, exerting antitumor efficacy
scientific article published on 07 April 2020
Verteporfin inhibits YAP function through up-regulating 14-3-3σ sequestering YAP in the cytoplasm
artículo científico publicado en 2015
Vimentin is a novel AKT1 target mediating motility and invasion
artículo científico publicado en 2011
WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome
artículo científico publicado en 2005
Which path to follow? Utilizing proteomics to improve therapy choices for breast cancer patients
scientific article published on 20 April 2020
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
artículo científico publicado en 2012
YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway
artículo científico publicado en 2017
YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer
artículo científico publicado en 2014
Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma
artículo científico publicado en 2015
ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction
artículo científico publicado en 2005
ZNF668 Functions as a Tumor Suppressor by Regulating p53 Stability and Function in Breast Cancer
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artículo científico publicado el 18 de agosto de 2011
cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer
artículo científico publicado en 2014
cMET and phospho-cMET protein levels in breast cancers and survival outcomes
artículo científico publicado en 2012
hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.
artículo científico publicado en 2014
mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer
artículo científico publicado en 2015
miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
artículo científico publicado en 2019
p202 self-associates through a sequence conserved among the members of the 200-family proteins
scientific article published on 01 October 1998
p85α neomorphic mutants: splitting away from the canonical path.
artículo científico publicado en 2015
p85β regulates autophagic degradation of AXL to activate oncogenic signaling
scientific article published on 08 May 2020
α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration
artículo científico publicado en 2014
β-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer
scientific article published on 12 June 2018
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
artículo científico publicado en 2016
Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
artículo científico publicado en 2002