Lista de obras - David Komander - Dominio Público Uruguay

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation

scholarly article by Jonathan N Pruneda et al published 5 November 2018 in Nature Microbiology

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

artículo científico publicado en 2017

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

artículo científico publicado en 2016

A further case of Dop‐ing in bacterial pupylation ⬇️

artículo científico publicado el 17 de septiembre de 2010

Activation mechanism of PINK1

artículo científico publicado en 2021

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

scientific article published on 28 August 2013

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins

artículo científico publicado en 2018

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

artículo científico publicado en 2008

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

artículo científico publicado en 2011

An essential role for the ATG8 ortholog LC3C in antibacterial autophagy

artículo científico publicado en 2013

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.

artículo científico publicado en 2017

Analysis of the LKB1-STRAD-MO25 complex

artículo científico publicado en 2004

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

artículo científico publicado en 2009

Assembly and specific recognition of k29- and k33-linked polyubiquitin.

artículo científico publicado en 2015

Assembly, analysis and architecture of atypical ubiquitin chains

artículo científico publicado en 2013

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages ⬇️

artículo científico publicado el 23 de julio de 2012

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

artículo científico publicado en 2011

Biochemistry. Details of destruction, one molecule at a time

artículo científico publicado en 2015

Breaking the chains: deubiquitylating enzyme specificity begets function

artículo científico publicado en 2019

Breaking the chains: structure and function of the deubiquitinases

artículo científico publicado en 2009

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

scientific journal article

CYLD tidies up dishevelled signaling

artículo científico publicado en 2010

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

artículo científico publicado en 2014

Cezanne regulates E2F1-dependent HIF2α expression

artículo científico publicado en 2015

Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest).

artículo científico publicado en 2015

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

artículo científico publicado en 2016

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

artículo científico publicado en 2020

Dissection of USP catalytic domains reveals five common insertion points

artículo científico publicado en 2009

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

artículo científico publicado en 2019

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages

artículo científico publicado en 2015

Emerging roles for Lys11-linked polyubiquitin in cellular regulation.

artículo científico publicado en 2011

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

artículo científico publicado en 2010

Enzymatic Assembly of Ubiquitin Chains

artículo científico publicado en 2018

Erratum: Mechanism of phospho-ubiquitin-induced PARKIN activation

artículo científico publicado en 2015

Evaluating enzyme activities and structures of DUBs

artículo científico publicado en 2019

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

artículo científico publicado en 2020

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

artículo científico publicado en 2016

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

artículo científico publicado en 2002

Identification and characterization of diverse OTU deubiquitinases in bacteria

scientific article published on 22 June 2020

Insights into ubiquitin chain architecture using Ub-clipping

scientific article published on 15 August 2019

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

artículo científico publicado en 2004

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

artículo científico publicado en 2018

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

artículo científico publicado en 2012

LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB.

artículo científico publicado en 2017

Lining the pockets of kinases and phosphatases.

artículo científico publicado en 2006

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

artículo científico publicado en 2010

Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase

artículo científico publicado en 2014

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

scientific article published on 26 August 2020

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

artículo científico publicado en 2017

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

artículo científico publicado en 2008

Mechanism of parkin activation by PINK1

scientific article published in Nature

Mechanism of phospho-ubiquitin-induced PARKIN activation

artículo científico publicado en 2015

Mechanism, Specificity and Structure of the Deubiquitinases ⬇️

artículo científico publicado el 1 de enero de 2010

Mechanisms of Deubiquitinase Specificity and Regulation.

artículo científico publicado en 2017

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential

artículo científico publicado en 2018

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

artículo científico publicado en 2014

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

artículo científico publicado en 2011

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

artículo científico publicado en 2016

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

artículo científico publicado en 2017

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

artículo científico publicado en 2009

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

artículo científico publicado en 2009

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

artículo científico publicado en 2008

New tools for ubiquitin signaling

artículo científico publicado en 2012

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

artículo científico publicado en 2016

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha

artículo científico publicado en 2007

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

artículo científico publicado en 2013

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

artículo científico publicado en 2013

OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death

artículo científico publicado en 2019

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

scientific article published on 30 March 2020

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

artículo científico publicado en 2013

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

artículo científico publicado en 2013

PDK1, the master regulator of AGC kinase signal transduction

artículo científico publicado en 2004

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

artículo científico publicado en 2011

Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function

scientific article published on 01 May 2019

Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.

artículo científico publicado en 2004

Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T.

artículo científico publicado en 2008

Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy

artículo científico publicado en 2016

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

artículo científico publicado en 2009

Regulation of A20 and other OTU deubiquitinases by reversible oxidation

artículo científico publicado en 2013

Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN

artículo científico publicado en 2016

Regulation of the endosomal SNX27-retromer by OTULIN

artículo científico publicado en 2019

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

artículo científico publicado en 2005

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

artículo científico publicado en 2016

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

artículo científico publicado en 2009

Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

artículo científico publicado en 2017

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

artículo científico publicado en 2003

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

artículo científico publicado en 2004

Structure of PINK1 in complex with its substrate ubiquitin.

artículo científico publicado en 2017

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

artículo científico publicado en 2008

Structure of the human Parkin ligase domain in an autoinhibited state

artículo científico publicado en 2013

Synthesis and Analysis of K11-Linked Ubiquitin Chains ⬇️

artículo científico publicado el 1 de enero de 2012

Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.

artículo científico publicado en 2017

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

scientific journal article

The E3 ubiquitin ligase SCF(Fbxo7) mediates proteasomal degradation of UXT isoform 2 (UXT-V2) to inhibit the NF-κB signaling pathway

scientific article published on 30 September 2020

The JAMM in the proteasome

scientific article published on 01 April 2014

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

scientific article published on 13 July 2016

The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence

artículo científico publicado en 2016

The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

artículo científico publicado en 2020

The emerging complexity of protein ubiquitination

artículo científico publicado en 2009

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

artículo científico publicado en 2008

The tumour suppressor CYLD regulates the p53 DNA damage response

artículo científico publicado en 2016

The ubiquitin code

artículo científico publicado en 2012

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

artículo científico publicado en 2009

USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation

artículo científico publicado en 2020

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

artículo científico publicado en 2017

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

artículo científico publicado en 2015

Ubiquitin chain conformation regulates recognition and activity of interacting proteins

artículo científico publicado en 2012

Ubiquitin modifications

artículo científico publicado en 2016

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

scientific article published on 07 January 2021

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

artículo científico publicado en 2018

Lista de obras de David Komander

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes

A further case of Dop‐ing in bacterial pupylation ⬇️

Activation mechanism of PINK1

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

An essential role for the ATG8 ortholog LC3C in antibacterial autophagy

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.

Analysis of the LKB1-STRAD-MO25 complex

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Assembly and specific recognition of k29- and k33-linked polyubiquitin.

Assembly, analysis and architecture of atypical ubiquitin chains

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages ⬇️

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

Biochemistry. Details of destruction, one molecule at a time

Breaking the chains: deubiquitylating enzyme specificity begets function

Breaking the chains: structure and function of the deubiquitinases

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

CYLD tidies up dishevelled signaling

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

Cezanne regulates E2F1-dependent HIF2α expression

Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest).

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

Dissection of USP catalytic domains reveals five common insertion points

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages

Emerging roles for Lys11-linked polyubiquitin in cellular regulation.

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

Enzymatic Assembly of Ubiquitin Chains

Erratum: Mechanism of phospho-ubiquitin-induced PARKIN activation

Evaluating enzyme activities and structures of DUBs

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

Identification and characterization of diverse OTU deubiquitinases in bacteria

Insights into ubiquitin chain architecture using Ub-clipping

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB.

Lining the pockets of kinases and phosphatases.

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure

Mechanism of parkin activation by PINK1

Mechanism of phospho-ubiquitin-induced PARKIN activation

Mechanism, Specificity and Structure of the Deubiquitinases ⬇️

Mechanisms of Deubiquitinase Specificity and Regulation.

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

New tools for ubiquitin signaling

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

PDK1, the master regulator of AGC kinase signal transduction

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function

Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.

Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T.

Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy