Lista de obras - Mark Ultsch - Dominio Público Uruguay

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

artículo científico publicado en 2013

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B

artículo científico publicado en 2009

A new regulatory switch in a JAK protein kinase ⬇️

artículo científico publicado el 1 de febrero de 2011

A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability

artículo científico publicado en 2008

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

artículo científico publicado en 2010

Antiparallel conformation of knob and hole aglycosylated half-antibody homodimers is mediated by a CH2-CH3 hydrophobic interaction

artículo científico publicado en 2014

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

artículo científico publicado en 2004

Development and preclinical characterization of a humanized antibody targeting CXCL12

artículo científico publicado en 2013

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

artículo científico publicado en 2012

Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors ⬇️

artículo científico publicado el 24 de octubre de 2012

Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes

artículo científico publicado en 2014

Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies ⬇️

artículo científico publicado el 28 de febrero de 2013

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

artículo científico publicado en 2013

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

artículo científico publicado en 2014

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

artículo científico publicado en 2012

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

artículo científico publicado en 2013

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

artículo científico publicado en 2014

Lead identification of novel and selective TYK2 inhibitors

artículo científico publicado en 2013

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

artículo científico publicado en 2013

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

artículo científico publicado en 2015

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta ⬇️

artículo científico publicado el 21 de agosto de 2012

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf ⬇️

artículo científico publicado el 17 de mayo de 2012

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab ⬇️

artículo científico publicado el 25 de enero de 2013

Structural and Functional Analysis of HtrA1 and Its Subdomains ⬇️

artículo científico publicado el 10 de mayo de 2012

Structural basis for high-affinity HER2 receptor binding by an engineered protein

artículo científico publicado en 2010

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479

artículo científico publicado en 2014

Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites

artículo científico publicado en 2002

Structure of the complex between HER2 and an antibody paratope formed by side chains from tryptophan and serine

artículo científico publicado en 2010

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

artículo científico publicado en 2014

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

artículo científico publicado en 2012

Lista de obras de Mark Ultsch

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B

A new regulatory switch in a JAK protein kinase ⬇️

A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

Antiparallel conformation of knob and hole aglycosylated half-antibody homodimers is mediated by a CH2-CH3 hydrophobic interaction

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

Development and preclinical characterization of a humanized antibody targeting CXCL12

Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2

Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors ⬇️

Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes

Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies ⬇️

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Lead identification of novel and selective TYK2 inhibitors

Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta ⬇️

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf ⬇️

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab ⬇️

Structural and Functional Analysis of HtrA1 and Its Subdomains ⬇️

Structural basis for high-affinity HER2 receptor binding by an engineered protein

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479

Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites

Structure of the complex between HER2 and an antibody paratope formed by side chains from tryptophan and serine

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2