Lista de obras - Markku Laakso - Dominio Público Uruguay

35th Annual Meeting of the European Association for the Study of Diabetes

artículo científico

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

article

A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients

artículo científico publicado en 2005

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.

artículo científico publicado en 2018

A Follow‐Up Study of Age‐Associated Memory Impairment: Neuropsychological Predictors of Dementia ⬇️

artículo científico publicado el 1 de septiembre de 1995

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

artículo científico publicado en 2017

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

artículo científico publicado en 2018

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

artículo científico publicado en 2017

A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

artículo científico publicado en 2017

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

artículo científico publicado en 1998

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

artículo científico publicado en 2018

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus

artículo científico publicado en 2017

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

artículo científico publicado en 2007

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell

artículo científico publicado en 2014

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

artículo científico publicado en 2007

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

artículo científico publicado en 2011

A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity

artículo científico publicado en 2003

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

artículo científico publicado en 2012

A genome-wide association search for type 2 diabetes genes in African Americans

artículo científico publicado en 2012

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

artículo científico publicado en 2016

A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

artículo científico publicado en 2017

A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia

artículo científico publicado en 2001

A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.

artículo científico publicado en 2013

A nationwide study on parathyroid carcinoma.

artículo científico publicado en 2017

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

artículo científico publicado en 2003

A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy

artículo científico publicado en 2004

A novel surrogate index for hepatic insulin resistance

artículo científico publicado en 2010

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

artículo científico publicado en 1988

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

artículo científico publicado en 2016

APOE-epsilon4 is associated with weight loss in women with AD: a population-based study

artículo científico publicado en 2001

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

artículo científico publicado en 2002

Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data

artículo científico publicado en 2004

Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial

artículo científico publicado en 2003

Acoustic-reflex responses in patients with insulin-dependent diabetes mellitus

artículo científico publicado en 1994

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

artículo científico publicado en 2009

Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.

artículo científico publicado en 2017

Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism

artículo científico publicado en 2002

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose

artículo científico publicado en 2009

Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women

artículo científico publicado en 1998

Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia

artículo científico publicado en 1998

Adiponectin gene haplotype is associated with preeclampsia.

artículo científico publicado en 2006

Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes

artículo científico publicado en 2012

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

artículo científico publicado en 2013

Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

artículo científico publicado en 2012

Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes

scientific article published on 01 February 1990

Age of onset and type of diabetes

artículo científico publicado en 1985

Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis

artículo científico publicado en 2004

Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes

artículo científico publicado en 2004

Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes

artículo científico publicado en 2004

Alpha-synuclein pathology is highly dependent on the case selection.

artículo científico publicado en 2001

Amino acid substitutions in hexokinase II among patients with NIDDM.

artículo científico

An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance

artículo científico publicado en 2005

An association between a subset of Finnish late-onset Alzheimer's disease and alpha2-macroglobulin.

artículo científico publicado en 2001

Analysis of protein-coding genetic variation in 60,706 humans

artículo científico publicado en 2016

Antihypertensive drugs as predictors of type 2 diabetes among subjects with impaired glucose tolerance

artículo científico publicado en 2000

Antiplatelet therapy is effective in the prevention of stroke or death in women: subgroup analysis of the European Stroke Prevention Study (ESPS)

artículo científico publicado en 1991

Antiplatelet treatment in elderly people with transient ischaemic attacks or ischaemic strokes

artículo científico publicado en 1995

Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease

artículo científico publicado en 2001

Apolipoprotein E4 Phenotype Is Not an Important Risk Factor for Coronary Heart Disease or Stroke in Elderly Subjects ⬇️

artículo científico publicado el 1 de septiembre de 1995

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

artículo científico publicado en 2010

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

artículo científico publicado en 2015

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population

artículo científico publicado en 2006

Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients

artículo científico publicado en 2002

Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study

artículo científico publicado en 2004

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study ⬇️

artículo científico publicado el 25 de octubre de 1997

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

artículo científico publicado en 2009

Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome

artículo científico publicado en 2007

Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland

artículo científico publicado en 1996

Association of Common Genetic Variation in The FOXO1 Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, And Type 2 Diabetes

artículo científico publicado en 2009

Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels

Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients

artículo científico publicado en 2005

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease

artículo científico publicado en 2001

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes

artículo científico publicado en 2009

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes.

artículo científico publicado en 2013

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.

artículo científico publicado en 2010

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

scientific article published on 04 April 2013

Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease

artículo científico publicado en 2002

Association of metabolic syndrome with Alzheimer disease: a population-based study.

artículo científico publicado en 2006

Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly

artículo científico publicado el 1 de septiembre de 1992

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes

artículo científico publicado en 2013

Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study

artículo científico publicado en 2006

Association of serum lipids and lipoproteins with plasma C-peptide concentration in non-insulin-dependent diabetic and non-diabetic subjects

artículo científico publicado en 1987

Association of the Leu72Met polymorphism of the ghrelin gene with the risk of Type 2 diabetes in subjects with impaired glucose tolerance in the Finnish Diabetes Prevention Study

artículo científico publicado en 2006

Association of the PRO12ALA polymorphism of the PPAR-gamma2 gene with oxidized low-density lipoprotein and cardiolipin autoantibodies in nondiabetic and type 2 diabetic subjects

artículo científico publicado en 2003

Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study

artículo científico publicado en 2002

Associations between two single nucleotide polymorphisms in the adiponectin gene and polycystic ovary syndrome.

artículo científico publicado en 2005

Associations of blood pressure with carotid intima-media thickness in elderly Finns with diabetes mellitus or impaired glucose tolerance ⬇️

artículo científico publicado el 1 de octubre de 2003

Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men.

artículo científico publicado en 2015

Astrogliosis and the ApoE genotype. an immunohistochemical study of postmortem human brain tissue

artículo científico publicado en 1999

Asymptomatic atherosclerosis and insulin resistance

artículo científico publicado en 1991

Asymptomatic hyperglycemia and atherosclerotic vascular disease in the elderly

artículo científico publicado el 1 de agosto de 1992

Asymptomatic hyperglycemia and cardiovascular risk factors in the elderly

artículo científico publicado en 1991

Atherosclerosis and cardiovascular risk reduction with PPAR agonists

artículo científico publicado en 2007

Atherosclerotic Vascular Disease and Its Risk Factors in Non-Insulin-Dependent Diabetic and Nondiabetic Subjects in Finland ⬇️

artículo científico publicado el 1 de junio de 1988

Atherosclerotic vascular disease in middle-aged, insulin-treated, diabetic patients. Association with endogenous insulin secretion capacity

artículo científico publicado en 1988

Auditory brainstem latencies in type I (insulin-dependent) diabetic patients

artículo científico publicado en 1993

Author Correction: Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

artículo científico publicado en 2018

Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

article

Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease

artículo científico publicado en 2005

Autonomic nervous function and its relationship to cardiac performance in middle-aged diabetic patients without clinically evident cardiovascular disease ⬇️

artículo científico publicado el 1 de julio de 1992

Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation

artículo científico publicado en 2013

Baroreflex sensitivity in essential and secondary hypertension

artículo científico publicado en 2002

Blood pressure and atherosclerotic plaques in carotid, aortic and femoral arteries in elderly Finns with diabetes mellitus or impaired glucose tolerance

artículo científico publicado en 2005

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish men

artículo científico publicado en 2015

Cardiac adrenergic activity is associated with left ventricular hypertrophy in genetically homogeneous subjects with hypertrophic cardiomyopathy

artículo científico publicado en 2003

Cardiac adrenergic innervation is affected in asymptomatic subjects with very early stage of coronary artery disease

artículo científico publicado en 2002

Cardiovascular disease risk factors as predictors of type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects

artículo científico publicado en 1993

Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease

artículo científico publicado en 2001

Cardiovascular risk factors clustering with endogenous hyperinsulinaemia predict death from coronary heart disease in patients with Type II diabetes

artículo científico publicado en 2000

Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion

artículo científico publicado en 2002

Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty

artículo científico publicado en 2000

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects

artículo científico publicado en 2009

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

scientific article published on 17 February 2009

Changes in the prevalence and incidence of diabetes mellitus in Finnish adults, 1970-1987.

artículo científico publicado en 1991

Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population

artículo científico publicado en 2003

Chlorpropamide-alcohol flushing and coronary heart disease in non-insulin dependent diabetics

artículo científico publicado en 1983

Cholinergic deficit in Alzheimer's disease: A study based on CSF and autopsy data ⬇️

artículo científico publicado el 1 de febrero de 1988

Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels

artículo científico publicado el 1 de julio de 1992

Cine MR imaging of myocardial contractile impairment in patients with hypertrophic cardiomyopathy attributable to Asp175Asn mutation in the alpha-tropomyosin gene

artículo científico publicado en 2005

Circulating RNAs as predictive markers for the progression of type 2 diabetes

Circulating metabolite predictors of glycemia in middle-aged men and women

artículo científico publicado en 2012

Clinical characteristics in the discrimination between patients with low or high C-peptide level among middle-aged insulin-treated diabetics

artículo científico publicado en 1987

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

artículo científico publicado en 2016

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia

artículo científico publicado en 1997

Cognitive function in an elderly population with persistent impaired glucose tolerance

artículo científico publicado en 1998

Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q

artículo científico publicado en 2003

Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response

scientific article published on 20 May 2009

Common polymorphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men.

artículo científico publicado en 2005

Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.

artículo científico publicado en 2005

Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study

artículo científico publicado en 2004

Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial

artículo científico publicado en 2004

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects

artículo científico publicado en 2009

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

artículo científico publicado en 2008

Common variants associated with plasma triglycerides and risk for coronary artery disease

artículo científico publicado en 2013

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

artículo científico publicado en 2010

Common variants at 30 loci contribute to polygenic dyslipidemia

artículo científico publicado en 2009

Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention Study

artículo científico publicado en 2004

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

artículo científico publicado en 2017

Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass

artículo científico publicado en 2012

Contribution of genetic and dietary insulin resistance to Alzheimer phenotype in APP/PS1 transgenic mice

artículo científico publicado en 2012

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scholarly article published in Nature Genetics

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

artículo científico publicado en 1990

Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease

artículo científico publicado en 1987

Decreased plasma C-reactive protein levels in 4 allele carriers

Decreased plasma β-amyloid in the Alzheimer's disease APP A673T variant carriers

artículo científico publicado en 2017

Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited. Metabolic studies on offspring of diabetic probands

artículo científico publicado en 1998

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid

scientific article published on 01 January 1991

Desmosterol in human nonalcoholic steatohepatitis

artículo científico publicado en 2013

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

artículo científico publicado en 2010

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort

artículo científico publicado en 2016

Determination of C-peptide in the choice of treatment for diabetics

artículo científico publicado el 1 de enero de 1983

Diabetes Secondary to Treatment with Statins

artículo científico publicado en 2017

Diabetes and atherosclerosis: an epidemiologic view

artículo científico publicado en 1987

Diabetes mellitus and brain atrophy: a computed tomography study in an elderly population

artículo científico publicado el 1 de noviembre de 1992

Dietary fat in relation to erythrocyte fatty acid composition in men

artículo científico publicado en 2013

Dietary fat predicts coronary heart disease events in subjects with type 2 diabetes

artículo científico publicado en 2003

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

artículo científico publicado en 2015

Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia

artículo científico publicado en 1998

Differential Associations of Inflammatory Markers With Insulin Sensitivity and Secretion: The Prospective METSIM Study

artículo científico publicado en 2017

Directional dominance on stature and cognition in diverse human populations

artículo científico publicado en 2015

Discovery and refinement of loci associated with lipid levels

artículo científico publicado en 2013

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium

artículo científico publicado en 2014

Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis.

artículo científico publicado en 2011

Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models

artículo científico publicado en 2013

Distribution and medical impact of loss-of-function variants in the Finnish founder population

artículo científico publicado en 2014

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.

artículo científico publicado en 2000

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

artículo científico publicado en 2008

Dyslipidemia and Hyperglycemia Predict Coronary Heart Disease Events in Middle-Aged Patients With NIDDM ⬇️

artículo científico publicado el 1 de agosto de 1997

ERPs reveal deficits in automatic cerebral stimulus processing in patients with NIDDM.

artículo científico publicado en 1996

Early abnormalities in coronary heart disease risk factors in relatives of subjects with non-insulin-dependent diabetes

artículo científico publicado el 1 de junio de 1992

Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data

artículo científico publicado en 2008

Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial

artículo científico publicado en 2009

Effect of genotype on success of lifestyle intervention in subjects at risk for type 2 diabetes

artículo científico publicado en 2006

Effect of nateglinide on the incidence of diabetes and cardiovascular events

artículo científico publicado en 2010

Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial

artículo científico publicado en 2006

Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects

artículo científico publicado en 2003

Effect of the Pro12Ala polymorphism of the PPAR-gamma2 gene on long-term weight change in Finnish non-diabetic subjects

artículo científico publicado en 2001

Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin sensitivity

artículo científico publicado en 2005

Effect of valsartan on the incidence of diabetes and cardiovascular events

artículo científico publicado en 2010

Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men.

artículo científico publicado en 2011

Effects of a very-low-calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics

artículo científico publicado en 1990

Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia

artículo científico publicado el 1 de diciembre de 1992

Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow

artículo científico publicado el 1 de agosto de 1992

Effects of euglycaemic and hypoglycaemic hyperinsulinaemia on sympathetic and parasympathetic regulation of haemodynamics in healthy subjects

artículo científico publicado en 2003

Effects of hypocaloric diet and insulin therapy on metabolic control and mechanisms of hyperglycemia in obese non-insulin-dependent diabetic subjects

artículo científico publicado en 1988

Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial

artículo científico publicado en 2005

Effects of losartan on insulin sensitivity in hypertensive subjects

scientific article published on 01 September 1996

Efficient estimation and applications of cross-validated genetic predictions

Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects.

artículo científico publicado en 2008

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

artículo científico publicado en 2017

Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus

artículo científico publicado en 2004

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

artículo científico publicado en 2007

Eosinophilic fasciitis

artículo científico publicado en 1987

Epidemiological evidence for the association of hyperglycaemia and atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus

artículo científico publicado en 1996

Epigenetic regulation of glucose-stimulated osteopontin (OPN) expression in diabetic kidney

artículo científico publicado en 2015

Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney

artículo científico publicado en 2016

Epigenome-wide association in adipose tissue from the METSIM cohort.

artículo científico publicado en 2018

Epigenome-wide association in adipose tissue from the METSIM cohort.

artículo científico publicado en 2018

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

artículo científico publicado en 2017

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2011

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2018

Essential hypertension and cognitive function. The role of hyperinsulinemia

artículo científico publicado en 1993

Essential hypertension and insulin resistance in non-insulin-dependent diabetes

artículo científico publicado en 1989

European Stroke Prevention Study (ESPS): antithrombotic therapy is also effective in the elderly

scientific article published on 01 February 1993

European stroke prevention study: effectiveness of antiplatelet therapy in diabetic patients in secondary prevention of stroke

artículo científico publicado el 1 de junio de 1992

Evaluation of Heart Size and Pulmonary Vasculature

Evaluation of heart size and pulmonary vasculature. Conventional chest roentgenography and image intensifier photofluorography compared

artículo científico publicado el 1 de mayo de 1991

Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow

artículo científico publicado en 2000

Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles

artículo científico publicado en 2011

Exercise during military training improves cardiovascular risk factors in young men ⬇️

artículo científico publicado el 24 de febrero de 2011

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

artículo científico publicado en 2012

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

article by Jason Flannick et al published 22 May 2019 in Nature

Exome-wide association study of plasma lipids in >300,000 individuals

artículo científico publicado en 2017

Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis

artículo científico publicado en 2011

Factors associated with fasting and postglucagon plasma C-peptide levels in middle-aged insulin-treated diabetic patients

artículo científico publicado en 1989

Familial aggregation of non-insulin dependent diabetes and coronary heart disease are accompanied by different effects on serum lipids, lipoproteins and apolipoproteins

artículo científico publicado en 1991

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

artículo científico publicado en 2004

Family history of coronary heart disease is a stronger predictor of coronary heart disease morbidity and mortality than family history of non-insulin dependent diabetes mellitus

artículo científico publicado en 1996

Family-specific aggregation of lipid GWAS variants confers the susceptibility to familial hypercholesterolemia in a large Austrian family

artículo científico publicado en 2017

Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic Finnish offspring of type 2 diabetic individuals

artículo científico publicado en 2014

Fasting, postprandial and postprandial plus glucagon-stimulated plasma C-peptide levels in non-insulin-dependent diabetics and in control subjects.

artículo científico publicado en 1987

Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity

artículo científico publicado en 2016

Femoral atherosclerosis in middle-aged subjects: association with cardiovascular risk factors and insulin resistance

artículo científico publicado en 1996

Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability

artículo científico publicado en 2011

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort

artículo científico publicado en 2016

First-pass MR imaging in the assessment of perfusion impairment in patients with hypertrophic cardiomyopathy and the Asp175Asn mutation of the alpha-tropomyosin gene

artículo científico publicado en 2003

Fragile-X: neuropsychological test performance, CGG triplet repeat lengths, and hippocampal volumes

artículo científico publicado en 1997

Frontal dysfunction blocks the therapeutic effect of THA on attention in Alzheimer's disease

artículo científico publicado en 1997

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia

artículo científico publicado en 2018

Functional consequences of naturally occurring variants of human hexokinase II.

artículo científico publicado en 1998

G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia

artículo científico publicado en 2000

Galanin preproprotein is associated with elevated plasma triglycerides

artículo científico publicado en 2008

Gastrointestinal symptoms in middle-aged diabetic patients

artículo científico publicado en 1993

Gender difference in the impact of type 2 diabetes on coronary heart disease risk

artículo científico publicado en 2004

Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study

artículo científico publicado en 2008

Gender differences relating to metabolic syndrome and proinflammation in Finnish subjects with elevated blood pressure ⬇️

artículo científico publicado en 2009

Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease.

artículo científico publicado en 2006

Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes

artículo científico publicado en 2000

Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry

artículo científico publicado en 2013

Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits

artículo científico publicado en 2017

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

Genetic evidence of assortative mating in humans

article

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

artículo científico publicado en 2009

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

artículo científico publicado en 2015

Genetic influences contributing to LDL particle size in familial combined hyperlipidaemia

artículo científico publicado en 2002

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

artículo científico publicado en 2013

Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study

artículo científico publicado en 2017

Genetic screening for the risk of type 2 diabetes: worthless or valuable?

artículo científico publicado en 2013

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease.

artículo científico publicado en 2008

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

artículo científico publicado en 2013

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

artículo científico publicado en 2011

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study

artículo científico publicado en 2005

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

artículo científico publicado en 2011

Genetic variation of FTO and TCF7L2 in premature adrenarche.

artículo científico publicado en 2009

Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns

artículo científico publicado en 2005

Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes

artículo científico publicado en 2004

Genetics of metabolic syndrome

artículo científico publicado en 2014

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

artículo científico publicado en 2016

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

artículo científico publicado en 2011

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

artículo científico publicado en 2009

Genome-wide association study identifies eight loci associated with blood pressure

artículo científico publicado en 2009

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

artículo científico publicado en 2017

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

artículo científico publicado en 2017

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

scientific journal article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

artículo científico publicado en 2014

Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels

artículo científico publicado en 1999

Genomewide search and association studies in a Finnish celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci

article

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

artículo científico publicado en 2017

Glucokinase gene islet promoter region variant (G-->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns

artículo científico publicado en 1998

Glucokinase gene variants in subjects with late-onset NIDDM and impaired glucose tolerance

scientific article published on 01 March 1995

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

artículo científico publicado en 2011

Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

artículo científico publicado en 2015

Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes

artículo científico publicado en 2015

Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men

artículo científico publicado en 2013

Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)

article published 13 June 2006 in European Heart Journal

Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)

article published 1 June 2007 in European Heart Journal Supplements

Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes

artículo científico publicado en 2005

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance

artículo científico publicado en 2017

Heterozygous RFX6 protein truncating variants cause Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance

Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production

scientific journal article

Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice

artículo científico publicado en 2003

Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse

artículo científico publicado en 2005

Hexokinase II-deficient mice. Prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes

scientific journal article

High amount of visceral fat mass is associated with multiple metabolic changes in offspring of type 2 diabetic patients

artículo científico publicado en 2005

High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects

artículo científico publicado en 2008

High fasting plasma insulin is an indicator of coronary heart disease in non-insulin-dependent diabetic patients and nondiabetic subjects

artículo científico publicado en 1991

High plasma insulin level associated with coronary heart disease in the elderly

artículo científico publicado en 1993

High serum levels of advanced glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a population-based 18-year follow-up study

artículo científico publicado en 2005

High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive

artículo científico publicado en 2011

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status

artículo científico publicado en 2014

Hippocampal atrophy, acute THA treatment and memory in Alzheimer's disease.

artículo científico publicado en 1995

Human hexokinase II: sequence and homology to other hexokinases

artículo científico publicado en 1993

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men

artículo científico publicado en 2012

Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study

artículo científico publicado en 1998

Hyperinsulinemia predicts multiple atherogenic changes in lipoproteins in elderly subjects

artículo científico publicado en 1994

Hyperinsulinemic microalbuminuria. A new risk indicator for coronary heart disease

artículo científico publicado en 1995

Hyperproinsulinemia is not a characteristic feature in the offspring of patients with different phenotypes of type II diabetes

artículo científico publicado en 2000

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

artículo científico publicado en 2017

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

artículo científico publicado en 2015

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

artículo científico publicado en 2015

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

artículo científico publicado en 2016

Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects

artículo científico publicado en 1999

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.

artículo científico publicado en 2018

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

artículo científico publicado en 2009

Identification of undiagnosed type 2 diabetic individuals by the finnish diabetes risk score and biochemical and genetic markers: a population-based study of 7232 Finnish men.

artículo científico publicado en 2010

Imaging diagnostics in early dementia

artículo científico publicado en 2000

Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study ⬇️

artículo científico publicado en 2010

Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementation

artículo científico publicado en 2003

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

artículo científico publicado en 2013

Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

artículo científico publicado en 2010

Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients.

artículo científico publicado en 2000

Impaired insulin-stimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemia?

artículo científico publicado en 1998

Impaired left ventricular systolic function during exercise in middle-aged insulin-dependent and noninsulin-dependent diabetic subjects without clinically evident cardiovascular disease

artículo científico publicado en 1988

Impairment of diastolic function in middle-aged type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients free of cardiovascular disease

scientific article published on 01 November 1988

Improvement of left ventricular function after starting insulin treatment in patients with non-insulin-dependent diabetes

artículo científico publicado en 1988

Improvement of metabolic control does not normalize auditory brainstem latencies in subjects with insulin-dependent diabetes mellitus ⬇️

artículo científico publicado el 1 de mayo de 1995

Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study

artículo científico publicado en 2009

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

artículo científico publicado en 2015

Increased risk of non-insulin-dependent diabetes mellitus in elderly hypertensive subjects.

artículo científico publicado en 1994

Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes: a population-based 18 year follow-up study

artículo científico publicado en 2007

Increased serum levels of methylglyoxal-derived hydroimidazolone-AGE are associated with increased cardiovascular disease mortality in nondiabetic women

artículo científico publicado en 2009

Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance

artículo científico publicado en 1999

Inducibility of life-threatening ventricular arrhythmias is related to maximum left ventricular thickness and clinical markers of sudden cardiac death in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-t

artículo científico publicado en 2004

Influence of endogenous NEFA on beta cell function in humans

artículo científico publicado en 2015

Insulin action and age. European Group for the Study of Insulin Resistance (EGIR).

artículo científico publicado en 1996

Insulin receptor substrate-1 variants in non-insulin-dependent diabetes

artículo científico publicado en 1994

Insulin resistance and depression: Authors' reply.

artículo científico publicado en 2005

Insulin resistance and hyperglycaemia in cardiovascular disease development

artículo científico

Insulin resistance in familial and nonfamilial hypercholesterolemia.

artículo científico publicado en 1993

Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men.

artículo científico publicado en 2003

Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance

artículo científico publicado en 1990

Insulin resistance is related to albuminuria in patients with type II (non-insulin-dependent) diabetes mellitus

artículo científico publicado en 1993

Insulin resistance is related to left ventricular hypertrophy in patients with polycystic kidney disease type 1.

artículo científico publicado en 2003

Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.

artículo científico publicado en 1999

Insulin resistance syndrome predicts coronary heart disease events in elderly type 2 diabetic men.

artículo científico publicado en 2001

Insulin resistance, body fat distribution, and sex hormones in men.

artículo científico publicado en 1994

Insulin resistant phenotype is associated with high serum leptin levels in offspring of patients with non-insulin-dependent diabetes mellitus

artículo científico publicado en 1998

Insulin secretion and its determinants in the progression of impaired glucose tolerance to type 2 diabetes in impaired glucose-tolerant individuals: the Finnish Diabetes Prevention Study

artículo científico publicado en 2011

Insulin sensitivity and Lp(a) concentrations in normoglycemic men.

artículo científico publicado en 1995

Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study

artículo científico publicado en 2013

Insulin sensitivity is not an independent determinant of plasma plasminogen activator inhibitor-1 activity

artículo científico publicado en 1994

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study

artículo científico publicado en 2010

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study

artículo científico publicado en 2007

Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS.

artículo científico publicado en 2018

Integrative approaches for large-scale transcriptome-wide association studies

artículo científico publicado en 2016

Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity

artículo científico publicado en 2005

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes

artículo científico publicado en 2009

Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Preve

artículo científico publicado en 2008

Interaction of the -308G/A promoter polymorphism of the tumor necrosis factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population

artículo científico publicado en 2005

Interactions between genetic variation and cellular environment in skeletal muscle gene expression

article

Interactions between peroxisome proliferator-activated receptor-gamma 2 gene polymorphisms and size at birth on blood pressure and the use of antihypertensive medication

artículo científico publicado en 2004

Interleukin 1 alpha gene polymorphism as a susceptibility factor in Alzheimer's disease and its influence on the extent of histopathological hallmark lesions of Alzheimer's disease.

artículo científico publicado en 2002

Inverse relationship of serum HDL and HDL2 cholesterol to C-peptide level in middle-aged insulin-treated diabetics

artículo científico publicado en 1985

Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?

artículo científico publicado en 1999

Is there a sex difference in the association of plasma insulin level and insulin sensitivity with serum lipids and lipoproteins?

artículo científico publicado en 1994

Isolated low HDL cholesterol. An insulin-resistant state

artículo científico publicado en 1994

K121Q PC‐1 Gene Polymorphism Is Not Associated with Insulin Resistance in a Spanish Population ⬇️

artículo científico publicado el 1 de mayo de 2003

Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans.

artículo científico publicado en 2015

LDL size and risk of coronary heart disease in elderly men and women

artículo científico publicado en 1999

Lack of association between sex hormones and Lp(a) concentrations in American and Finnish men.

artículo científico publicado en 1994

Lack of effect of hepatic enzyme induction on metabolic control in patients with type 2 (non-insulin-dependent) diabetes

artículo científico publicado en 1987

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

artículo científico publicado en 2017

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

artículo científico publicado en 2012

Large-scale association analysis identifies new risk loci for coronary artery disease

artículo científico publicado en 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

artículo científico publicado en 2012

Left ventricular dysfunction in diabetes: evidence for the impact of metabolic factors

scientific article published on 01 March 1987

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

artículo científico publicado en 2011

Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy

artículo científico publicado en 2016

Leptin concentrations, sex hormones, and cortisol in nondiabetic men.

artículo científico

Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance

artículo científico publicado en 2005

Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes

artículo científico publicado en 2000

Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: a population-based study

artículo científico publicado en 2008

Link between GIP and osteopontin in adipose tissue and insulin resistance

artículo científico publicado en 2013

Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23

artículo científico publicado en 1998

Lipid and lipoprotein abnormalities associated with coronary heart disease in patients with insulin-dependent diabetes mellitus

artículo científico publicado en 1986

Lipid and lipoprotein abnormalities in diabetic patients with peripheral vascular disease

scientific article published on 01 November 1988

Lipids and lipoproteins predicting coronary heart disease mortality and morbidity in patients with non-insulin-dependent diabetes

artículo científico publicado en 1993

Lipoprotein subclass profiles in individuals with varying degrees of glucose tolerance: a population-based study of 9399 Finnish men.

artículo científico publicado en 2012

Long term effects of a very low calorie diet on metabolic control and cardiovascular risk factors in the treatment of obese non-insulin-dependent diabetics

artículo científico publicado en 1989

Long-term consumption of plant stanol and sterol esters, vascular function and genetic regulation

artículo científico publicado en 2008

Long-term effects of pioglitazone and metformin on insulin sensitivity in patients with Type 2 diabetes mellitus

artículo científico publicado en 2005

Long-term effects of placental growth on overweight and body composition

artículo científico publicado en 2012

Longitudinal EEG spectral analysis in early stage of Alzheimer's disease

artículo científico publicado en 1989

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

artículo científico publicado en 2014

Low Insulin Sensitivity is Associated with Clustering of Cardiovascular Disease Risk Factors ⬇️

artículo científico publicado el 15 de agosto de 1997

Low levels of sex hormone-binding globulin and testosterone are associated with smaller, denser low density lipoprotein in normoglycemic men.

artículo científico publicado en 1996

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

artículo científico publicado en 2015

Low-grade inflammation and the phenotypic expression of myocardial fibrosis in hypertrophic cardiomyopathy

artículo científico publicado en 2012

Lower-extremity amputations in diabetic and nondiabetic patients. A population-based study in eastern Finland

scientific article published on 01 January 1993

Macrovascular complications in relation to hyperinsulinaemia in non-insulin-dependent diabetes mellitus

artículo científico publicado en 1987

Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease

artículo científico publicado en 2014

Measurement of the mass and width of the Z0-particle from multihadronic final states produced in e+e− annihilations

article

Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus

artículo científico publicado en 1996

Memory functions in human subjects with different apolipoprotein E phenotypes during a 3-year population-based follow-up study

artículo científico

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

artículo científico publicado en 2013

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

artículo científico publicado en 2010

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

artículo científico publicado en 2008

Metabolic control by means of insulin in patients with type 2 diabetes and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity--secondary publication

artículo científico publicado en 2006

Metabolic defects in persistent impaired glucose tolerance are related to the family history of non—insulin-dependent diabetes mellitus ⬇️

artículo científico publicado el 1 de agosto de 1995

Metabolic syndrome and incident end-stage peripheral vascular disease: a 14-year follow-up study in elderly Finns

artículo científico publicado en 2007

Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

artículo científico publicado en 2006

Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans

artículo científico publicado en 2013

Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1.

artículo científico publicado en 2001

Molecular Characterization of the Lipid Genome-Wide Association Study Signal on Chromosome 18q11.2 Implicates HNF4A-Mediated Regulation of the TMEM241 Gene

artículo científico publicado en 2016

Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction

artículo científico publicado en 1998

Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern

artículo científico publicado en 2000

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

artículo científico publicado en 2019

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

artículo científico publicado en 2015

Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome

artículo científico publicado en 2004

Myocardial infarct size and mortality in patients with non-insulin-dependent diabetes mellitus

artículo científico publicado en 1994

Myocardial late gadolinium enhancement is associated with raised serum amino-terminal propeptide of type III collagen concentrations in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha tropomyosin gene: m

artículo científico publicado en 2006

Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study ⬇️

artículo científico publicado el 22 de marzo de 2011

New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes

artículo científico publicado en 2001

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

artículo científico publicado en 2010

New genetic loci link adipose and insulin biology to body fat distribution

artículo científico publicado en 2015

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

artículo científico publicado en 2016

New variants in the glycogen synthase gene (Gln71His, Met416Val) in patients with NIDDM from eastern Finland.

artículo científico publicado en 1997

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

artículo científico publicado en 2012

Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men

artículo científico publicado en 2013

Non-insulin-dependent diabetes and its metabolic control are important predictors of stroke in elderly subjects

artículo científico publicado en 1994

Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography.

artículo científico publicado en 2006

Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns

artículo científico publicado en 2017

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

artículo científico publicado en 2018

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy

artículo científico publicado en 2006

Obese men with type IIB hyperlipidemia are insulin resistant

artículo científico publicado en 1993

Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

artículo científico publicado en 2017

Oxidised LDL and progression of atherosclerosis

artículo científico publicado en 1992

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Partial hexokinase II knockout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

artículo científico publicado en 2010

Pathogenesis and treatment of diabetic vascular disease - illustrated by two cases

artículo científico publicado en 2006

Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II

scientific journal article

Physical activity and insulin sensitivity: the RISC study

artículo científico publicado en 2008

Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children

artículo científico publicado en 2011

Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes

article

Physical activity, high-sensitivity C-reactive protein, and total and cardiovascular disease mortality in type 2 diabetes

artículo científico publicado en 2011

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

artículo científico publicado en 2017

Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia

artículo científico publicado en 2005

Plasma fatty acids as predictors of glycaemia and type 2 diabetes

artículo científico publicado en 2015

Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects

artículo científico publicado en 1987

Plasma insulin, serum lipids and lipoproteins in gall stone disease in non-insulin dependent diabetic subjects: a case control study

artículo científico publicado en 1990

Pleiotropic effects of GIP on islet function involve osteopontin

artículo científico publicado en 2011

Polymorphism Pro12Ala of PPARG in prepubertal children with premature adrenarche and its association with growth in healthy children

artículo científico publicado en 2010

Polymorphism in the peroxisome proliferator-activated receptor-gamma gene in women with polycystic ovary syndrome

artículo científico publicado en 2003

Polymorphism of the beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns

artículo científico publicado en 1997

Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity

artículo científico publicado en 2004

Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study

artículo científico publicado en 2005

Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study

artículo científico publicado en 2004

Polymorphisms of the human hexokinase II gene: lack of association with NIDDM and insulin resistance.

artículo científico publicado en 1995

Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity

artículo científico publicado en 2001

Population-based dementia screening program in Kuopio: the effect of education, age, and sex on brief neuropsychological tests

artículo científico publicado el 1 de julio de 1992

Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene

artículo científico publicado en 1998

Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene

artículo científico publicado en 2001

Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects

artículo científico publicado en 1999

Prandial glucose regulation and cardiovascular disease in type 2 diabetes

artículo científico publicado en 1999

Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study

artículo científico publicado en 2017

Predictors of stroke in middle-aged patients with non-insulin-dependent diabetes

artículo científico publicado en 1996

Prevalence and associated factors of restless legs in a 57-year-old urban population in northern Finland

artículo científico publicado en 2009

Prevalence of age-associated memory impairment in a randomly selected population from eastern Finland

artículo científico publicado en 1995

Prevalence of ageing-associated cognitive decline in an elderly population.

artículo científico publicado en 1996

Prevalence of diabetes and impaired glucose tolerance in elderly subjects and their association with obesity and family history of diabetes

artículo científico publicado en 1990

Prevalence of diabetes mellitus in elderly subjects in east Finland

artículo científico publicado en 1987

Prevalence of insulin deficiency among initially non-insulin-dependent middle-aged diabetic individuals

scientific article published on 01 May 1986

Prevalence of retinopathy in people with diabetes, impaired glucose tolerance, and normal glucose tolerance

artículo científico publicado en 1998

Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme

artículo científico publicado en 1999

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

artículo científico publicado en 2001

Progression of kidney disease varies between families with defects in the polycystic kidney disease type 1 gene in eastern Finland

artículo científico publicado en 2003

Prolongation of the Q-T interval caused by sotalol-Possible association with ventricular tachyarhythmias ⬇️

artículo científico publicado el 1 de agosto de 1981

Prolonged P wave duration predicts stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease

artículo científico publicado en 2014

Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects

artículo científico publicado en 2003

Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study

artículo científico publicado en 2003

Prospective Study of Small LDLs as a Risk Factor for Non–Insulin Dependent Diabetes Mellitus in Elderly Men and Women ⬇️

artículo científico publicado el 1 de octubre de 1995

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

artículo científico publicado en 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Proteinuria modifies the effect of systolic blood pressure on total and cardiovascular disease mortality in patients with type 2 diabetes

artículo científico publicado en 2012

Proteinuria predicts stroke and other atherosclerotic vascular disease events in nondiabetic and non-insulin-dependent diabetic subjects

scientific article published on 01 November 1996

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

artículo científico publicado en 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

artículo científico publicado en 2018

Quantifying prion disease penetrance using large population control cohorts

artículo científico publicado en 2016

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

Rare and low-frequency coding variants alter human adult height

artículo científico publicado en 2017

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue

artículo científico publicado en 1999

Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy

artículo científico publicado en 1991

Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis.

artículo científico publicado en 2012

Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury

artículo científico publicado en 2010

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

artículo científico publicado en 2018

Regulation of alternative splicing in human obesity loci

artículo científico publicado en 2016

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.

artículo científico publicado en 2018

Relation of coronary heart disease and apolipoprotein E phenotype in patients with non-insulin dependent diabetes ⬇️

artículo científico publicado el 9 de noviembre de 1991

Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic finnish offspring of type 2 diabetic individuals

artículo científico publicado en 2010

Relationship between postheparin plasma lipases and high-density lipoprotein cholesterol in different types of diabetes

artículo científico publicado en 1987

Relationship of LDL Size to Insulin Sensitivity in Normoglycemic Men ⬇️

artículo científico publicado el 1 de julio de 1997

Relationship of plasma insulin concentration and insulin sensitivity to blood pressure. Is it modified by obesity?

artículo científico publicado en 1996

Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort

artículo científico publicado en 2017

Repeatability of C-peptide response in glucagon stimulation test

artículo científico publicado en 1987

Response to Brosch et al

artículo científico publicado en 2012

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

artículo científico publicado en 2006

Retinopathy predicts coronary heart disease events in NIDDM patients

artículo científico publicado en 1996

Reverse GWAS: Using genetics to identify and model phenotypic subtypes

article

Risk factors predicting lower extremity amputations in patients with NIDDM.

artículo científico publicado en 1996

Role of osteopontin and its regulation in pancreatic islet

artículo científico publicado en 2017

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

artículo científico publicado en 2010

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

artículo científico publicado en 2011

SNPs in PPARG associate with type 2 diabetes and interact with physical activity

artículo científico publicado en 2008

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

artículo científico publicado en 2016

Safety and Feasibility of Catheter-Based Local Intracoronary Vascular Endothelial Growth Factor Gene Transfer in the Prevention of Postangioplasty and In-Stent Restenosis and in the Treatment of Chronic Myocardial Ischemia ⬇️

artículo científico publicado el 12 de mayo de 2003

Screening for Down syndrome in the fetus using maternal blood samples

artículo científico publicado el 1 de enero de 1990

Second European Stroke Prevention Study: antiplatelet therapy is effective regardless of age. ESPS2 Working Group

artículo científico publicado en 1999

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

artículo científico publicado en 2005

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2017

Serine/threonine protein kinase 25 (STK25): a novel negative regulator of lipid and glucose metabolism in rodent and human skeletal muscle

artículo científico publicado en 2012

Serum homocysteine, creatinine, and glucose as predictors of the severity and extent of coronary artery disease in asymptomatic members of high-risk families

artículo científico publicado en 2002

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans.

artículo científico publicado en 2011

Serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetics

artículo científico publicado en 1985

Serum lipids, lipoproteins, and apolipoproteins and the excessive occurrence of coronary heart disease in non-insulin-dependent diabetic patients

scientific article published on 01 October 1989

Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects

artículo científico publicado en 1995

Serum zinc level and coronary heart disease events in patients with type 2 diabetes

artículo científico publicado en 2007

Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation

artículo científico publicado en 2004

Severity of hippocampal atrophy correlates with the prolongation of MRI T2 relaxation time in temporal lobe epilepsy but not in Alzheimer's disease.

artículo científico publicado en 1996

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

artículo científico publicado en 2013

Short Adult Stature Predicts Impaired β-Cell Function, Insulin Resistance, Glycemia, and Type 2 Diabetes in Finnish Men.

artículo científico publicado en 2016

Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects

artículo científico publicado en 2007

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

artículo científico publicado en 2015

Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake

artículo científico publicado en 2005

Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.

artículo científico publicado en 2006

Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial.

artículo científico publicado en 2006

Single nucleotide polymorphisms of the MCHR1 gene do not affect metabolism in humans

artículo científico publicado en 2007

Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects

artículo científico publicado en 2006

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance

artículo científico publicado en 2008

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

artículo científico publicado en 2009

Smoking is independently associated with high plasma insulin levels in nondiabetic men.

artículo científico publicado en 1996

Somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with Parkinson's disease and its relation to dementia

artículo científico publicado en 1986

Sotalol, prolonged Q-T interval, and ventricular tachyarrhythmias

artículo científico publicado en 1981

Stability of age-associated memory impairment during a longitudinal population-based study.

artículo científico publicado en 1997

Status of the DELPHI vertex detector: Alignment methods and geometrical resolution

Stopping insulin treatment in middle-aged diabetic patients with high postglucagon plasma C-peptide. Effect on glycaemic control, serum lipids and lipoproteins

artículo científico publicado en 1988

Structure and costs of health care of diabetic patients in Finland

artículo científico publicado en 1996

Structure of the human hexokinase II gene

artículo científico publicado en 1994

Subjective memory complaints and personality traits in normal elderly subjects

artículo científico publicado en 1994

Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults

artículo científico publicado en 2005

Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns

artículo científico publicado en 1998

Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

article

THA disrupts mismatch negativity in Alzheimer disease

artículo científico publicado en 1997

Tetrahydroaminoacridine improves the recency effect in Alzheimer's disease

artículo científico publicado en 1998

The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels

artículo científico publicado en 2009

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function ⬇️

artículo científico publicado el 1 de febrero de 2011

The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity

artículo científico publicado en 2003

The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects

artículo científico publicado en 2005

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies

artículo científico publicado en 2010

The European Stroke Prevention Study (ESPS): results by arterial distribution

scientific article published on 01 June 1991

The European Stroke Prevention Study: Results according to sex ⬇️

artículo científico publicado el 1 de agosto de 1991

The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study

artículo científico publicado en 2004

The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial

artículo científico publicado en 2005

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia

artículo científico publicado en 2003

The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism

artículo científico publicado en 2003

The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases

artículo científico publicado en 2017

The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy

artículo científico publicado en 2015

The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia

artículo científico publicado en 2000

The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

artículo científico publicado en 2009

The Pro12Ala polymorphism of the PPAR gamma 2 gene influences sex hormone-binding globulin level and its relationship to the development of the metabolic syndrome in young Finnish men.

artículo científico publicado en 2006

The Pro12Ala polymorphism of the PPAR gamma 2 gene regulates weight from birth to adulthood

artículo científico publicado en 2004

The Pro12Ala polymorphism of the PPARgamma2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus

artículo científico publicado en 2009

The Relation of Proinsulin, Insulin, and Proinsulin-to-Insulin Ratio to Insulin Sensitivity and Acute Insulin Response in Normoglycemic Subjects ⬇️

artículo científico publicado el 1 de diciembre de 1997

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

artículo científico publicado en 2017

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.

artículo científico publicado en 2017

The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain

artículo científico publicado en 2004

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis.

artículo científico publicado en 2011

The association of apolipoprotein E polymorphism with memory: a population based study ⬇️

artículo científico publicado el 26 de mayo de 1995

The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth

artículo científico publicado en 2004

The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge

artículo científico publicado en 2011

The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes

retracted scientific article published on June 2013

The cardiac beta-myosin heavy chain gene is not the predominant gene for hypertrophic cardiomyopathy in the Finnish population.

artículo científico publicado en 1998

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study

artículo científico publicado en 2008

The common polymorphisms (single nucleotide polymorphism [SNP] +45 and SNP +276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial

artículo científico publicado en 2005

The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study

artículo científico publicado en 2009

The effect of standard chow and reduced hexokinase II on growth, cardiac and skeletal muscle hexokinase and low-flow cardiac ischaemia-reperfusion injury.

artículo científico publicado en 2011

The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity

artículo científico publicado en 2003

The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-gamma2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study

artículo científico publicado en 2005

The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth

artículo científico publicado en 2003

The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth

artículo científico publicado en 2002

The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects

artículo científico publicado en 1996

The genetic and metabolic determinants of cardiovascular complications in type 2 diabetes: recent insights from animal models and clinical investigations

artículo científico publicado en 2013

The genetic architecture of type 2 diabetes

artículo científico publicado en 2016

The genetic regulatory signature of type 2 diabetes in human skeletal muscle

scientific article published on 29 June 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

artículo científico publicado en 2016

The hormone sensitive lipase gene in familial combined hyperlipidemia and insulin resistance

artículo científico publicado en 2001

The human hexokinase II gene promoter: functional characterization and detection of variants among patients with NIDDM.

artículo científico publicado en 1997

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology

artículo científico publicado en 2017

The interuncal distance in Alzheimer disease and age-associated memory impairment.

artículo científico publicado en 1995

The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns

artículo científico publicado en 2007

The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns

artículo científico publicado en 2009

The metabolic syndrome predicts incident stroke: a 14-year follow-up study in elderly people in Finland

artículo científico publicado en 2008

The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease

artículo científico publicado en 2009

The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study

artículo científico publicado en 2010

Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects: 18-year follow-up study

artículo científico publicado en 2009

Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus

artículo científico publicado en 2017

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

artículo científico publicado en 2016

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained

artículo científico publicado en 2013

Trauma, renal vein thrombosis and subsequent nephrotic syndrome

artículo científico publicado en 1982

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

artículo científico publicado en 2010

Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population

artículo científico publicado en 2012

Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland

artículo científico publicado en 2000

Two novel mutations in the beta-myosin heavy chain gene associated with dilated cardiomyopathy

artículo científico publicado en 2004

Type-2 diabetes and cognitive function in a non-demented population.

artículo científico publicado en 1999

Underlying genetic models of inheritance in established type 2 diabetes associations

artículo científico publicado en 2009

Update on Current Care Guideline. Diabetes

artículo científico publicado en 2016

Update on type 2 diabetes as a cardiovascular disease risk equivalent

artículo científico publicado en 2013

Variable effects of statins on glucose homeostasis parameters and their diabetogenic role. Reply to Kostapanos MS, Agouridis AP and Elisaf MS [letter].

artículo científico publicado en 2015

Variance of the SGK1 gene is associated with insulin secretion in different European populations: results from the TUEF, EUGENE2, and METSIM studies

artículo científico publicado en 2008

Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study

artículo científico publicado en 2009

Variants in MTNR1B influence fasting glucose levels

artículo científico publicado en 2008

Variants in the Human Intestinal Fatty Acid Binding Protein 2 Gene in Obese Subjects ⬇️

artículo científico publicado el 1 de agosto de 1997

Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes

artículo científico publicado en 2000

Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM.

artículo científico publicado en 1998

Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion

article

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study

artículo científico publicado en 2009

Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study.

artículo científico publicado en 2000

Visfatin is an adipokine, but it is not regulated by thiazolidinediones

artículo científico publicado en 2006

WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4.

artículo científico publicado en 2013

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels

artículo científico publicado en 2008

[Chlorpropamide and the alcohol flush reaction and coronary artery disease in adult diabetics]

artículo científico publicado en 1984

[Congenital hyperinsulinism].

artículo científico publicado en 2005

[Prolonged QT(U) interval: association with disease and use of drugs]

artículo científico publicado en 1986

40 EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004 ⬇️

artículo

Lista de obras de Markku Laakso

35th Annual Meeting of the European Association for the Study of Diabetes

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

A 100-kDa urinary protein is associated with insulin resistance in offspring of type 2 diabetic patients

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.

A Follow‐Up Study of Age‐Associated Memory Impairment: Neuropsychological Predictors of Dementia ⬇️

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism.

A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus

A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study

A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis

A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes

A deletion in the alpha2B-adrenergic receptor gene and autonomic nervous function in central obesity

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

A genome-wide association search for type 2 diabetes genes in African Americans

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

A major gene effect on fasting insulin and insulin sensitivity in familial combined hyperlipidemia

A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.

A nationwide study on parathyroid carcinoma.

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

A novel mutation, Ser143Pro, in the lamin A/C gene is common in finnish patients with familial dilated cardiomyopathy

A novel surrogate index for hepatic insulin resistance

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

APOE-epsilon4 is associated with weight loss in women with AD: a population-based study

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

Acarbose for the prevention of Type 2 diabetes, hypertension and cardiovascular disease in subjects with impaired glucose tolerance: facts and interpretations concerning the critical analysis of the STOP-NIDDM Trial data

Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial

Acoustic-reflex responses in patients with insulin-dependent diabetes mellitus

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.

Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose

Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women

Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia

Adiponectin gene haplotype is associated with preeclampsia.

Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

Adverse effects of obesity on lipid and lipoprotein levels in insulin-dependent and non-insulin-dependent diabetes

Age of onset and type of diabetes

Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis

Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes

Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes

Alpha-synuclein pathology is highly dependent on the case selection.

Amino acid substitutions in hexokinase II among patients with NIDDM.

An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance

An association between a subset of Finnish late-onset Alzheimer's disease and alpha2-macroglobulin.

Analysis of protein-coding genetic variation in 60,706 humans

Antihypertensive drugs as predictors of type 2 diabetes among subjects with impaired glucose tolerance

Antiplatelet therapy is effective in the prevention of stroke or death in women: subgroup analysis of the European Stroke Prevention Study (ESPS)

Antiplatelet treatment in elderly people with transient ischaemic attacks or ischaemic strokes

Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease

Apolipoprotein E4 Phenotype Is Not an Important Risk Factor for Coronary Heart Disease or Stroke in Elderly Subjects ⬇️

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population

Association between Chlamydia pneumoniae antibodies and intimal calcification in femoral arteries of nondiabetic patients

Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study ⬇️

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome

Association of Chlamydia pneumoniae and acute coronary heart disease events in non-insulin dependent diabetic and non-diabetic subjects in Finland

Association of Common Genetic Variation in The FOXO1 Gene with β-Cell Dysfunction, Impaired Glucose Tolerance, And Type 2 Diabetes

Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels

Association of adiponectin level and variants in the adiponectin gene with glucose metabolism, energy expenditure, and cytokines in offspring of type 2 diabetic patients

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease

Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes.

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

Association of leucine 7 to proline 7 polymorphism in the preproneuropeptide Y with serum lipids in patients with coronary heart disease

Association of metabolic syndrome with Alzheimer disease: a population-based study.

Association of obesity and distribution of obesity with glucose tolerance and cardiovascular risk factors in the elderly