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Lista de obras de Sekar Kathiresan

A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction

artículo científico publicado en 2008

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

artículo científico publicado en 2015

A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

artículo científico publicado en 2007

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease

artículo científico publicado en 2011

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

artículo científico publicado en 2009

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

artículo científico publicado en 2016

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

artículo científico publicado en 2017

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

artículo científico publicado en 2010

A novel APOB mutation identified by exome sequencing cosegregates with steatosis, liver cancer, and hypocholesterolemia

artículo científico publicado en 2013

A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans

artículo científico publicado en 2016

A structural variation reference for medical and population genetics

artículo científico publicado en 2020

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

artículo científico publicado en 2017

APOE p.Leu167del mutation in familial hypercholesterolemia.

artículo científico publicado en 2013

Age-related clonal hematopoiesis associated with adverse outcomes

artículo científico publicado en 2014

Aggregate penetrance of genomic variants for actionable disorders in European and African Americans

artículo científico publicado en 2016

Aging syndrome genes and premature coronary artery disease

artículo científico publicado en 2005

An eMERGE Clinical Center at Partners Personalized Medicine

artículo científico publicado en 2016

An electronic cardiac rehabilitation referral system increases cardiac rehabilitation referrals.

artículo científico publicado en 2017

An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia

artículo científico publicado en 2011

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy

scientific article published on 07 May 2020

Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease

artículo científico publicado en 2015

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease.

artículo científico publicado en 2018

Analysis of protein-coding genetic variation in 60,706 humans

artículo científico publicado en 2016

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

artículo científico publicado en 2013

Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata.

artículo científico publicado en 2006

Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

artículo científico publicado en 2010

Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states

artículo científico publicado en 2008

Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study

artículo científico publicado en 2015

Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study

artículo científico publicado en 2016

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

artículo científico publicado en 2017

Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.

artículo científico publicado en 2009

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

scientific article published on 15 February 2009

Association of exome sequences with plasma C-reactive protein levels in >9000 participants

artículo científico publicado en 2014

Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies

artículo científico publicado en 2012

Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis

artículo científico publicado en 2014

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

scientific article published on April 2009

Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans

artículo científico publicado en 2014

Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls

artículo científico publicado en 2013

Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium

artículo científico publicado en 2010

Bayesian meta-analysis of genetic association studies with different sets of markers

scientific article published on April 2008

Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium

artículo científico publicado en 2013

Biological and clinical insights from genetics of insomnia symptoms

article

Biological and clinical insights from genetics of insomnia symptoms

scientific article published on 25 February 2019

Biological, clinical and population relevance of 95 loci for blood lipids

artículo científico publicado en 2010

Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality

artículo científico publicado en 2010

Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts

artículo científico publicado en 2012

CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study

artículo científico publicado en 2005

Candidate gene association resource (CARe): design, methods, and proof of concept

artículo científico publicado en 2010

Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study

artículo científico publicado en 2016

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

artículo científico publicado en 2016

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community

artículo científico publicado en 2015

Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk

artículo científico publicado en 2012

Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample.

artículo científico publicado en 2007

Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study

artículo científico publicado en 2005

Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis

artículo científico publicado en 2013

Common Genetic Variation at the Endothelial Nitric Oxide Synthase Locus and Relations to Brachial Artery Vasodilator Function in the Community

Common Genetic Variation in Five Thrombosis Genes and Relations to Plasma Hemostatic Protein Level and Cardiovascular Disease Risk

article

Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits

scientific article published on 24 March 2016

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

artículo científico publicado en 2013

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

artículo científico publicado en 2008

Common variants associated with plasma triglycerides and risk for coronary artery disease

artículo científico publicado en 2013

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

artículo científico publicado en 2010

Common variants at 30 loci contribute to polygenic dyslipidemia

artículo científico publicado en 2009

Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction

artículo científico publicado en 2011

Comprehensive Survey of Common Genetic Variation at the Plasminogen Activator Inhibitor-1 Locus and Relations to Circulating Plasminogen Activator Inhibitor-1 Levels

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

artículo científico publicado en 2016

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

artículo científico publicado en 2008

Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level

article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function

artículo científico publicado en 2006

DASH: a method for identical-by-descent haplotype mapping uncovers association with recent variation

artículo científico publicado en 2011

DNA Sequence Variation in Encoding the Activin-Receptor Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

article published in 2017

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

artículo científico publicado en 2018

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

artículo científico publicado en 2018

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

Defining the spectrum of alleles that contribute to blood lipid concentrations in humans

artículo científico publicado en 2008

Description of a large family with autosomal dominant hypercholesterolemia associated with the APOE p.Leu167del mutation

artículo científico publicado en 2012

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls

artículo científico publicado en 2010

Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia

artículo científico publicado en 2016

Discovery and refinement of loci associated with lipid levels

artículo científico publicado en 2013

Distribution and medical impact of loss-of-function variants in the Finnish founder population

artículo científico publicado en 2014

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

artículo científico publicado en 2013

Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population

artículo científico publicado en 2010

Erratum: Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

scholarly article published in Nature Genetics

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

artículo científico publicado en 2017

Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort

artículo científico publicado en 2016

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

scientific journal article

Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia

artículo científico publicado en 2011

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

artículo científico publicado en 2016

Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease.

artículo científico publicado en 2017

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia

artículo científico publicado en 2013

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

artículo científico publicado en 2014

Exome sequencing in suspected monogenic dyslipidemias

artículo científico publicado en 2015

Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia

artículo científico publicado en 2010

Exome-wide association study of plasma lipids in >300,000 individuals

artículo científico publicado en 2017

FTO genotype is associated with phenotypic variability of body mass index

artículo científico publicado en 2012

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

artículo científico publicado en 2017

Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study

artículo científico publicado en 2010

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis

artículo científico publicado en 2009

Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations

artículo científico publicado en 2012

Gene-gene Interaction Analyses for Atrial Fibrillation

artículo científico publicado en 2016

Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor

artículo científico publicado en 2017

Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure

article published in 2018

Genetic Risk Prediction of Atrial Fibrillation

artículo científico publicado en 2016

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease

artículo científico publicado en 2016

Genetic Risk, Lifestyle, and Coronary Artery Disease.

artículo científico publicado en 2017

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease

artículo científico publicado en 2017

Genetic analysis for a shared biological basis between migraine and coronary artery disease

artículo científico publicado en 2015

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic associations with valvular calcification and aortic stenosis

artículo científico publicado en 2013

Genetic determinants of plasma triglycerides ⬇️

artículo científico publicado el 1 de noviembre de 2010

Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study

artículo científico publicado en 2009

Genetic evidence of assortative mating in humans

article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

artículo científico publicado en 2015

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

artículo científico publicado en 2018

Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

artículo científico publicado en 2016

Genetic predisposition to higher blood pressure increases coronary artery disease risk

artículo científico publicado en 2013

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

artículo científico publicado en 2015

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data

artículo científico publicado en 2009

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

artículo científico publicado en 2011

Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk

artículo científico publicado en 2015

Genetically determined height and coronary artery disease

artículo científico publicado en 2015

Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease

artículo científico publicado en 2014

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

artículo científico publicado en 2018

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

artículo científico publicado en 2007

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

scientific article published on 01 November 2019

Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study

artículo científico publicado en 2007

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

artículo científico publicado en 2009

Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study

artículo científico publicado en 2007

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

artículo científico publicado en 2012

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

artículo científico publicado en 2014

Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction

artículo científico publicado en 2011

Genome-wide association study identifies eight loci associated with blood pressure

artículo científico publicado en 2009

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

artículo científico publicado en 2012

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

artículo científico publicado en 2010

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project

artículo científico publicado en 2011

Genome-wide association with select biomarker traits in the Framingham Heart Study

artículo científico publicado en 2007

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

artículo científico publicado en 2015

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

article by Amit V Khera et al published September 2018 in Nature Genetics

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

artículo científico publicado en 2014

Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus

artículo científico publicado en 2009

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

artículo científico publicado en 2014

HapMap and mapping genes for cardiovascular disease

artículo científico publicado en 2008

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

artículo científico publicado en 2012

Heritability of Atrial Fibrillation

artículo científico publicado en 2017

Heritability, Linkage, and Genetic Associations of Exercise Treadmill Test Responses

article

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

artículo científico publicado en 2017

Human knockouts in a cohort with a high rate of consanguinity

Hundreds of variants clustered in genomic loci and biological pathways affect human height

artículo científico publicado en 2010

Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction

artículo científico publicado en 2012

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

artículo científico publicado en 2011

Identification of seven loci affecting mean telomere length and their association with disease

artículo científico publicado en 2013

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates ⬇️

artículo científico publicado en 2021

Inactivating mutations in NPC1L1 and protection from coronary heart disease

artículo científico publicado en 2014

Increased burden of cardiovascular disease in carriers of APOL1 genetic variants

artículo científico publicado en 2013

Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study

artículo científico publicado en 2005

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease

artículo científico publicado en 2017

Inflammation, kidney function and albuminuria in the Framingham Offspring cohort

artículo científico publicado en 2010

Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study

artículo científico publicado en 2007

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

artículo científico publicado en 2020

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

artículo científico publicado en 2020

Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.

artículo científico publicado en 2014

Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk

scientific article published on 03 September 2009

Is Coronary Atherosclerosis One Disease or Many? Setting Realistic Expectations for Precision Medicine.

artículo científico publicado en 2017

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies

artículo científico publicado en 2010

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.

artículo científico publicado en 2017

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

artículo científico publicado en 2017

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

artículo científico publicado en 2011

Large-scale association analysis identifies new risk loci for coronary artery disease

artículo científico publicado en 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

artículo científico publicado en 2012

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

artículo científico publicado en 2012

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

artículo científico publicado en 2017

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

artículo científico publicado en 2014

Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans

artículo científico publicado en 2009

Mendelian Randomization

artículo científico publicado en 2017

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

artículo científico publicado en 2016

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

artículo científico publicado en 2012

Meta-analysis of gene-level tests for rare variant association

artículo científico publicado en 2013

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

artículo científico publicado en 2011

Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol

artículo científico publicado en 2011

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

artículo científico publicado en 2015

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Multi-ethnic analysis of lipid-associated loci: the NHLBI CARe project

artículo científico publicado en 2012

Multi-ethnic genome-wide association study for atrial fibrillation

article

Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis.

artículo científico publicado en 2016

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

artículo científico publicado en 2013

Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease

artículo científico publicado en 2014

Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community

artículo científico publicado en 2013

Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries

artículo científico publicado en 2015

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

artículo científico publicado en 2009

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis ⬇️

scientific article published on 12 October 2016

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

artículo científico publicado en 2017

Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium

artículo científico publicado en 2010

Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese

artículo científico publicado en 2014

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium.

artículo científico publicado en 2018

On the significance of linkage studies of complex traits

artículo científico publicado en 2004

PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample

artículo científico publicado en 2006

PCSK9 Inhibitors

article from 2016

Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study

artículo científico publicado en 2009

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

artículo científico publicado en 2016

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

artículo científico publicado en 2017

Phenotypic extremes in rare variant study designs

artículo científico publicado en 2015

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

artículo científico publicado en 2016

Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting

artículo científico

Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

artículo científico publicado en 2020

Polymorphisms associated with cholesterol and risk of cardiovascular events

artículo científico publicado en 2008

Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population

artículo científico publicado en 2008

Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans

artículo científico publicado en 2007

Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants

Predicting stroke through genetic risk functions: the CHARGE Risk Score Project

artículo científico publicado en 2014

Prevalence of ANGPTL3 and APOB gene mutations in subjects with combined hypolipidemia

artículo científico publicado en 2012

Prospective functional classification of all possible missense variants in PPARG.

artículo científico publicado en 2016

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

artículo científico publicado en 2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

artículo científico publicado en 2017

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

artículo científico publicado en 2018

Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

artículo científico publicado en 2020

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

artículo científico publicado en 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

artículo científico publicado en 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

artículo científico publicado en 2018

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies

artículo científico publicado en 2011

Rare and low-frequency coding variants alter human adult height

artículo científico publicado en 2017

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article

Refining The Accuracy Of Validated Target Identification Through Coding Variant Fine-Mapping In Type 2 Diabetes

article

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.

artículo científico publicado en 2018

Relation of multiple inflammatory biomarkers to incident atrial fibrillation

artículo científico publicado en 2009

Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study

artículo científico publicado en 2012

Reply: Loss-of-Function Mutations to Estimate Pharmacological ANGPTL3 Inhibition

artículo científico publicado en 2017

Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history

artículo científico publicado en 2015

SNPs and coronary heart disease – Authors' reply

artículo científico publicado en 2011

Searching for missing heritability: designing rare variant association studies

artículo científico publicado en 2014

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

artículo científico publicado en 2013

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

artículo científico publicado en 2008

Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study

artículo científico publicado en 2014

Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction

artículo científico publicado en 2010

Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis

artículo científico publicado en 2016

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

artículo científico publicado en 2017

Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction

artículo científico publicado en 2015

Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease

artículo científico publicado en 2015

Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution

artículo científico publicado en 2016

Testing for an unusual distribution of rare variants

artículo científico publicado en 2011

The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports

artículo científico publicado en 2007

The Human Cell Atlas White Paper ⬇️

artículo científico publicado en 2018

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The association of factor V Leiden with myocardial infarction is replicated in 1880 patients with premature disease

artículo científico publicado en 2010

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

artículo científico publicado en 2016

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits

artículo científico publicado en 2012

The mouse QTL map helps interpret human genome-wide association studies for HDL cholesterol

artículo científico publicado en 2011

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

artículo científico publicado en 2016

Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism

artículo científico publicado en 2011

Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke

artículo científico publicado en 2014

Ultra-rare disruptive and damaging mutations influence educational attainment in the general population

artículo científico publicado en 2016

Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study

artículo científico publicado en 2007

Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study

artículo científico publicado en 2007

Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study

artículo científico publicado en 2007

Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy.

artículo científico publicado en 2015

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

artículo científico publicado en 2014

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