Lista de obras - Rolf Hilgenfeld - Dominio Público Uruguay

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

artículo científico publicado en 2013

A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex.

artículo científico publicado en 2015

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

artículo científico publicado en 2008

Accessory proteins of SARS-CoV and other coronaviruses

artículo científico

Acquisition of new protein domains by coronaviruses: analysis of overlapping genes coding for proteins N and 9b in SARS coronavirus

artículo científico publicado en 2014

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

artículo científico publicado en 2020

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

artículo científico publicado en 2006

An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules

artículo científico publicado en 2002

An unfolding/refolding step helps in the crystallization of a poorly soluble protein

artículo científico publicado en 2003

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

artículo científico publicado en 2015

Antiviral strategies to control calicivirus infections

scientific article published on 21 May 2010

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

artículo científico publicado en 2014

Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response ⬇️

artículo científico publicado el 18 de julio de 2012

Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila

artículo científico publicado en 2003

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

artículo científico publicado en 2020

Characterization of an Allosteric Pocket in Zika Virus NS2B-NS3 Protease

artículo científico publicado en 2022

Chemotherapeutic Effects of Bioassay-Guided Extracts of the American Cockroach, Periplaneta americana ⬇️

artículo científico publicado el 6 de julio de 2011

Computer-Aided Structure Based Drug Design Approaches for the Discovery of New Anti-CHIKV Agents

artículo científico publicado en 2017

Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected].

artículo científico publicado en 2004

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

artículo científico publicado en 2003

Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases

artículo científico publicado en 2005

Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights

artículo científico publicado en 2016

Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination

artículo científico publicado en 2015

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

artículo científico publicado en 2020

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

artículo científico publicado en 2016

Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus

artículo científico publicado en 2017

Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1 ⬇️

artículo científico publicado el 23 de abril de 2011

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

artículo científico publicado en 2014

Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

artículo científico publicado en 2009

Crystallization comes of age

scientific article published on 01 August 2002

Design of wide-spectrum inhibitors targeting coronavirus main proteases

artículo científico publicado en 2005

Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus NS2B–NS3 Protease ⬇️

artículo científico publicado el 10 de enero de 2013

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

artículo científico publicado en 2017

Erratum to: Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode.

artículo científico publicado en 2010

Erratum: Crystal structure of active elongation factor Tu reveals major domain rearrangements

scientific article published in Nature

Evidence for a Two-Metal-Ion Mechanism in the Cytidyltransferase KdsB, an Enzyme Involved in Lipopolysaccharide Biosynthesis ⬇️

artículo científico publicado el 3 de agosto de 2011

Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes

artículo científico publicado en 2010

Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

artículo científico publicado en 2016

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

artículo científico

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

artículo científico publicado en 2014

Functional Characterization of the Cleavage Specificity of the Sapovirus Chymotrypsin-Like Protease

artículo científico publicado en 2008

Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease ⬇️

artículo científico publicado el 26 de abril de 2013

Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA

artículo científico publicado en 2007

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

artículo científico publicado en 2009

Improved synthesis of rupintrivir

scientific article published on 04 January 2012

Improving experimental phases for strong reflections prior to density modification

artículo científico publicado en 2013

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

artículo científico publicado en 2016

Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode ⬇️

artículo científico publicado el 7 de febrero de 2010

Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold

artículo científico publicado en 2017

Modern methods of drug discovery: an introduction

artículo científico publicado en 2003

Molecular mechanisms of severe acute respiratory syndrome (SARS)

artículo científico publicado en 2005

Non structural proteins 8 and 9 of human coronavirus 229E.

artículo científico publicado en 2006

Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase Activity

artículo científico publicado en 2012

Nonstructural proteins of human coronavirus NL63.

artículo científico publicado en 2006

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

artículo científico publicado en 2017

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A.

artículo científico publicado en 2004

Optimization of Protein Crystallization: The OptiCryst Project

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

artículo científico publicado en 2011

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

artículo científico publicado en 2016

PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus genome ⬇️

artículo científico publicado el 20 de junio de 2011

Picornavirus non-structural proteins as targets for new anti-virals with broad activity

artículo científico publicado en 2011

Processing of the SARS-CoV pp1a/ab nsp7-10 region

artículo científico publicado en 2020

Processing of the SARS-CoV pp1a/ab nsp7-10 region

artículo científico publicado en 2019

Production of coronavirus nonstructural proteins in soluble form for crystallization

artículo científico publicado en 2008

Production, crystallization and X-ray diffraction analysis of the protease CT441 from Chlamydia trachomatis

artículo científico publicado en 2015

Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses

scientific article published on 31 January 2020

Purification, characterization, and crystallization of alliinase from garlic

artículo científico publicado en 2002

RNA-virus proteases counteracting host innate immunity

artículo científico publicado en 2017

Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza Drugs ⬇️

artículo científico publicado el 16 de julio de 2012

Recent advances in targeting viral proteases for the discovery of novel antivirals

artículo científico publicado en 2010

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

scientific article published on 22 October 2020

STD-NMR experiments identify a structural motif with novel second-site activity against West Nile virus NS2B-NS3 protease

artículo científico publicado en 2017

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening

scientific article published on 01 January 2008

Single-drop optimization of protein crystallization ⬇️

artículo científico publicado el 31 de julio de 2012

Sometimes intermediates. Do the job!

artículo científico publicado en 2006

Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum

artículo científico publicado en 2006

Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis

artículo científico publicado en 2012

Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin

artículo científico publicado en 2016

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium

artículo científico publicado en 2011

Structural basis of the proteolytic and chaperone activity of Chlamydia trachomatis CT441.

scientific article published on 27 October 2014

Structural biology in the fight against COVID-19

artículo científico publicado en 2021

Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

artículo científico publicado en 2009

Structure and dynamics of SARS coronavirus main proteinase (Mpro)

artículo científico publicado en 2006

Structure and functionality in flavivirus NS-proteins: perspectives for drug design

artículo científico publicado en 2010

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain

artículo científico publicado en 2002

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer

artículo científico publicado en 2006

Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila

artículo científico publicado en 2010

Structure of the X (ADRP) domain of nsp3 from feline coronavirus

artículo científico publicado en 2009

Structure-Based Antivirals for Emerging and Neglected Rna Viruses: An Emerging Field for Medicinal Chemistry in Academia ⬇️

artículo científico publicado el 1 de julio de 2010

Structures of DegQ from Legionella pneumophila Define Distinct ON and OFF States

artículo científico publicado en 2015

Substrate specificity profiling of SARS-CoV-2 Mpro protease provides basis for anti-COVID-19 drug design

scientific article (preprint)

Sugar-mediated lattice contacts in crystals of a plant glycoprotein

artículo científico publicado en 2002

Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate

artículo científico publicado en 2004

The "SARS-unique domain" (SUD) of SARS coronavirus is an oligo(G)-binding protein

artículo científico

The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies

artículo científico publicado en 2011

The PPIase active site of Legionella pneumophila Mip protein is involved in the infection of eukaryotic host cells

artículo científico publicado en 2003

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

artículo científico publicado en 2021

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

artículo científico publicado en 2009

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors

artículo científico publicado en 2011

The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation

scholarly article by Jian Lei published in April 2021

The Structure of the Zika Virus Protease, NS2B/NS3pro.

artículo científico publicado en 2018

The active principle of garlic at atomic resolution

artículo científico publicado en 2002

The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication

artículo científico publicado en 2014

The crystal structure of a Cys25 -> Ala mutant of human procathepsin S elucidates enzyme-prosequence interactions

artículo científico publicado en 2006

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor ⬇️

artículo científico publicado el 29 de octubre de 2003

The enterovirus 3C protease inhibitor SG85 efficiently blocks rhinovirus replication and is not cross-resistant with rupintrivir

artículo científico publicado en 2015

The evolution of insulin glargine and its continuing contribution to diabetes care

artículo científico publicado en 2014

The macromolecular complex of ICP and falcipain-2 fromPlasmodium: preparation, crystallization and preliminary X-ray diffraction analysis ⬇️

artículo científico publicado el 27 de octubre de 2011

The non-structural protein Nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids

artículo científico publicado en 2006

The role of protein 3D-structures in the drug discovery process.

artículo científico publicado en 2003

The structure of a glycoside hydrolase family 81 endo-β-1,3-glucanase.

artículo científico publicado en 2013

The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution

artículo científico publicado en 2010

Thiazolidone derivatives as inhibitors of chikungunya virus

artículo científico publicado en 2014

Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018

scientific article published on 28 December 2018

Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains

artículo científico publicado en 2002

Utility of homology models in the drug discovery process.

artículo científico publicado en 2004

Variable oligomerization modes in coronavirus non-structural protein 9

artículo científico publicado en 2008

Viral Entry and NS1 as Potential Antiviral Drug Targets.

artículo científico publicado en 2018

Viral enzymes

artículo científico publicado en 2006

Virus–host interactomes — antiviral drug discovery ⬇️

artículo científico publicado el 1 de octubre de 2012

WaaA of the hyperthermophilic bacterium Aquifex aeolicus is a monofunctional 3-deoxy-D-manno-oct-2-ulosonic acid transferase involved in lipopolysaccharide biosynthesis

artículo científico publicado en 2009

X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors

artículo científico publicado en 2020

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

artículo científico publicado en 2021

X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85β subunit

artículo científico publicado en 2011

Zika virus NS1, a pathogenicity factor with many faces

artículo científico publicado en 2016

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1

artículo científico publicado en 2016

pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses

artículo científico publicado en 2005

ppGpp analogues inhibit synthetase activity of Rel proteins from Gram-negative and Gram-positive bacteria

artículo científico publicado en 2010

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

artículo científico publicado en 2020

Lista de obras de Rolf Hilgenfeld

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex.

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

Accessory proteins of SARS-CoV and other coronaviruses

Acquisition of new protein domains by coronaviruses: analysis of overlapping genes coding for proteins N and 9b in SARS coronavirus

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules

An unfolding/refolding step helps in the crystallization of a poorly soluble protein

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

Antiviral strategies to control calicivirus infections

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response ⬇️

Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila

Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease

Characterization of an Allosteric Pocket in Zika Virus NS2B-NS3 Protease

Chemotherapeutic Effects of Bioassay-Guided Extracts of the American Cockroach, Periplaneta americana ⬇️

Computer-Aided Structure Based Drug Design Approaches for the Discovery of New Anti-CHIKV Agents

Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response [corrected].

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

Correction: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases

Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights

Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus

Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1 ⬇️

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property

Crystallization comes of age

Design of wide-spectrum inhibitors targeting coronavirus main proteases

Development and Characterization of New Peptidomimetic Inhibitors of the West Nile Virus NS2B–NS3 Protease ⬇️

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

Erratum to: Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode.

Erratum: Crystal structure of active elongation factor Tu reveals major domain rearrangements

Evidence for a Two-Metal-Ion Mechanism in the Cytidyltransferase KdsB, an Enzyme Involved in Lipopolysaccharide Biosynthesis ⬇️

Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes

Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design

Functional Characterization of the Cleavage Specificity of the Sapovirus Chymotrypsin-Like Protease

Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease ⬇️

Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Improved synthesis of rupintrivir

Improving experimental phases for strong reflections prior to density modification

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode ⬇️

Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold

Modern methods of drug discovery: an introduction

Molecular mechanisms of severe acute respiratory syndrome (SARS)

Non structural proteins 8 and 9 of human coronavirus 229E.

Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase Activity

Nonstructural proteins of human coronavirus NL63.

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A.

Optimization of Protein Crystallization: The OptiCryst Project

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus genome ⬇️

Picornavirus non-structural proteins as targets for new anti-virals with broad activity

Processing of the SARS-CoV pp1a/ab nsp7-10 region

Processing of the SARS-CoV pp1a/ab nsp7-10 region

Production of coronavirus nonstructural proteins in soluble form for crystallization

Production, crystallization and X-ray diffraction analysis of the protease CT441 from Chlamydia trachomatis

Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses

Purification, characterization, and crystallization of alliinase from garlic

RNA-virus proteases counteracting host innate immunity

Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza Drugs ⬇️

Recent advances in targeting viral proteases for the discovery of novel antivirals

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

STD-NMR experiments identify a structural motif with novel second-site activity against West Nile virus NS2B-NS3 protease

Sensitized detection of inhibitory fragments and iterative development of non-peptidic protease inhibitors by dynamic ligation screening

Single-drop optimization of protein crystallization ⬇️

Sometimes intermediates. Do the job!

Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum

Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis

Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium