Lista de obras - Michael Groll - Dominio Público Uruguay

20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A

artículo científico publicado en 2010

A Minimal β-Lactone Fragment for Selective β5c or β5i Proteasome Inhibitors

artículo científico publicado en 2015

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

artículo científico publicado en 2008

Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells

artículo científico publicado en 2012

Alternative bacterial two-component small heat shock protein systems

artículo científico publicado en 2012

Applied techniques for mining natural proteasome inhibitors

artículo científico publicado en 2014

Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation

artículo científico publicado en 2012

Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG

artículo científico publicado en 2010

Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5Å resolution

artículo científico publicado en 2012

Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914

artículo científico publicado en 2015

Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential

artículo científico publicado en 2016

Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis ⬇️

artículo científico publicado el 16 de noviembre de 2011

Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis

artículo científico publicado en 2012

DNA minor groove sensing and widening by the CCAAT-binding complex

artículo científico publicado en 2012

Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding

artículo científico publicado en 2014

Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome

artículo científico publicado en 2013

Discovery of acetylene hydratase activity of the iron–sulphur protein IspH

artículo científico publicado en 2012

Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition

artículo científico publicado en 2014

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

artículo científico publicado el 10 de enero de 2011

Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner

artículo científico publicado en 2010

Flavoenzyme-catalyzed formation of disulfide bonds in natural products

artículo científico publicado en 2014

Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family

artículo científico publicado en 2006

Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions

artículo científico publicado en 2014

Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism

artículo científico publicado en 2014

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

artículo científico publicado en 2013

Hydroxyureas as Noncovalent Proteasome Inhibitors ⬇️

artículo científico publicado el 21 de noviembre de 2011

Identification of a β1/β2-specific sulfonamide proteasome ligand by crystallographic screening

artículo científico publicado en 2015

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity

artículo científico publicado en 2012

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

artículo científico publicado en 2013

Indolo-phakellins as β5-specific noncovalent proteasome inhibitors

artículo científico publicado en 2015

Induced-fit mechanism in class I terpene cyclases

artículo científico publicado en 2014

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

artículo científico publicado en 2012

Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

artículo científico publicado en 2014

Interactions of the natural product kendomycin and the 20S proteasome

artículo científico publicado en 2014

Investigations on the maturation and regulation of archaebacterial proteasomes

artículo científico publicado en 2003

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

artículo científico publicado en 2013

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

artículo científico publicado en 2015

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum

artículo científico publicado en 2002

Omuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferences

artículo científico publicado en 2014

One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor

artículo científico publicado en 2012

Probing the reaction mechanism of IspH protein by x-ray structure analysis

artículo científico publicado en 2010

Proteasome inhibition by fellutamide B induces nerve growth factor synthesis

artículo científico publicado en 2008

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

artículo científico publicado en 2014

Quinone reductase acts as a redox switch of the 20S yeast proteasome

artículo científico publicado en 2009

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

artículo científico publicado en 2011

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

artículo científico publicado en 2015

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism

artículo científico publicado en 2015

Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA

artículo científico publicado en 2016

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

artículo científico publicado en 2009

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

artículo científico publicado en 2008

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad

artículo científico publicado en 2013

Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor

artículo científico publicado en 2006

Structure and reaction mechanism of pyrrolysine synthase (PylD)

artículo científico publicado en 2013

Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

artículo científico publicado en 2009

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

artículo científico publicado en 2016

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

artículo científico publicado en 2016

Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes

artículo científico publicado en 2014

Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH

artículo científico publicado en 2013

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism

artículo científico publicado en 2002

Synthesis and biological activity of optimized belactosin C congeners

artículo científico publicado en 2011

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

artículo científico publicado en 2009

Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors

artículo científico publicado en 2015

Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif

artículo científico publicado en 2014

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation

artículo científico publicado en 2015

The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes

artículo científico publicado en 2015

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

artículo científico publicado en 2012

The formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD)

artículo científico publicado en 2014

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

artículo científico publicado en 2014

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

scientific journal article

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

artículo científico publicado en 2008

Versatile C(3)-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

artículo científico publicado en 2014

α-Keto phenylamides as P1'-extended proteasome inhibitors

artículo científico publicado en 2014

Lista de obras de Michael Groll

20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A

A Minimal β-Lactone Fragment for Selective β5c or β5i Proteasome Inhibitors

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cells

Alternative bacterial two-component small heat shock protein systems

Applied techniques for mining natural proteasome inhibitors

Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation

Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG

Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5Å resolution

Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914

Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential

Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis ⬇️

Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis

DNA minor groove sensing and widening by the CCAAT-binding complex

Differential global structural changes in the core particle of yeast and mouse proteasome induced by ligand binding

Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome

Discovery of acetylene hydratase activity of the iron–sulphur protein IspH

Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner

Flavoenzyme-catalyzed formation of disulfide bonds in natural products

Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family

Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions

Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism

High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

Hydroxyureas as Noncovalent Proteasome Inhibitors ⬇️

Identification of a β1/β2-specific sulfonamide proteasome ligand by crystallographic screening

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

Indolo-phakellins as β5-specific noncovalent proteasome inhibitors

Induced-fit mechanism in class I terpene cyclases

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

Interactions of the natural product kendomycin and the 20S proteasome

Investigations on the maturation and regulation of archaebacterial proteasomes

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome

Navigation inside a protease: substrate selection and product exit in the tricorn protease from Thermoplasma acidophilum

Omuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferences

One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor

Probing the reaction mechanism of IspH protein by x-ray structure analysis

Proteasome inhibition by fellutamide B induces nerve growth factor synthesis

Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD

Quinone reductase acts as a redox switch of the 20S yeast proteasome

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism

Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad

Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor

Structure and reaction mechanism of pyrrolysine synthase (PylD)

Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes

Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH

Structures of the tricorn-interacting aminopeptidase F1 with different ligands explain its catalytic mechanism

Synthesis and biological activity of optimized belactosin C congeners

Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition

Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors

Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation

The Chaperone Activity of the Developmental Small Heat Shock Protein Sip1 Is Regulated by pH-Dependent Conformational Changes

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

The formation of pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD)

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

Thiazolopyrimidine inhibitors of 2-methylerythritol 2,4-cyclodiphosphate synthase (IspF) from Mycobacterium tuberculosis and Plasmodium falciparum

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

Versatile C(3)-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

α-Keto phenylamides as P1'-extended proteasome inhibitors