Lista de obras - Ralf Ficner - Dominio Público Uruguay

A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme

artículo científico publicado en 2009

Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore

artículo científico publicado en 2020

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence

artículo científico publicado en 2018

Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor

artículo científico publicado en 2007

Crystal Structure of the Borna Disease Virus Nucleoprotein ⬇️

artículo científico publicado el 1 de octubre de 2003

Crystal Structure of the RNA Recognition Motif of Yeast Translation Initiation Factor eIF3b Reveals Differences to Human eIF3b ⬇️

artículo científico publicado el 16 de septiembre de 2010

Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity

artículo científico publicado en 2012

Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA

artículo científico publicado en 2010

Crystal structure analysis of a fatty acid double-bond hydratase from Lactobacillus acidophilus

artículo científico publicado en 2013

Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification

artículo científico publicado en 2014

Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide

artículo científico publicado en 2003

Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding

artículo científico publicado en 2010

Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP

artículo científico publicado en 2021

Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode

artículo científico publicado en 2008

Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP

artículo científico publicado en 2009

Crystal structures of the c-di-AMP-synthesizing enzyme CdaA

artículo científico publicado en 2019

Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP

artículo científico publicado en 2014

Crystal structures of two tetrameric β-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora

artículo científico publicado en 2014

De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse

artículo científico publicado en 2009

Impact of the crystallization condition on importin-β conformation

artículo científico publicado en 2016

Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography

artículo científico publicado en 2009

Mapping protein interactions in the active TOM-TIM23 supercomplex

artículo científico publicado en 2021

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

artículo científico publicado en 2010

Observation of a stable carbene at the active site of a thiamin enzyme

artículo científico publicado en 2013

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)

artículo científico publicado en 2008

Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase from Leishmania major ⬇️

artículo científico publicado el 10 de noviembre de 2010

Structural Basis of Targeting the Exportin CRM1 in Cancer

artículo científico publicado en 2015

Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22

artículo científico publicado en 2012

Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2

artículo científico publicado en 2020

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

artículo científico publicado en 2015

Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28

artículo científico publicado en 2014

Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus

artículo científico publicado en 2007

Structural basis for cooperativity of CRM1 export complex formation

artículo científico publicado en 2013

Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1

artículo científico publicado en 2005

Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1

artículo científico publicado en 2009

Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)

artículo científico publicado en 2007

Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF

artículo científico publicado en 2010

Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

artículo científico publicado en 2017

Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.

artículo científico publicado en 2018

Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes

artículo científico publicado en 2014

Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA

artículo científico publicado en 2021

Structure analysis of Entamoeba histolytica enolase

artículo científico publicado en 2011

Structure analysis of endosialidase NF at 0.98 A resolution

artículo científico publicado en 2010

Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1

artículo científico publicado en 2009

Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM

artículo científico publicado en 2015

Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate

artículo científico publicado en 2013

The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB

artículo científico publicado en 2013

The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region

artículo científico publicado en 2011

The structure of Prp2 bound to RNA and ADP-BeF<sub>3</sub><sup>-</sup> reveals structural features important for RNA unwinding by DEAH-box ATPases

artículo científico publicado en 2021

Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunit

artículo científico publicado en 2014

Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot

artículo científico publicado en 2015

Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism ⬇️

artículo científico publicado el 21 de agosto de 2011

Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH

artículo científico publicado en 2003

Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin ⬇️

artículo científico publicado el 22 de junio de 2012

eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining

artículo científico publicado en 2014

Lista de obras de Ralf Ficner

A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme

Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence

Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor

Crystal Structure of the Borna Disease Virus Nucleoprotein ⬇️

Crystal Structure of the RNA Recognition Motif of Yeast Translation Initiation Factor eIF3b Reveals Differences to Human eIF3b ⬇️

Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity

Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA

Crystal structure analysis of a fatty acid double-bond hydratase from Lactobacillus acidophilus

Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification

Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide

Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding

Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP

Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode

Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP

Crystal structures of the c-di-AMP-synthesizing enzyme CdaA

Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP

Crystal structures of two tetrameric β-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora

De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse

Impact of the crystallization condition on importin-β conformation

Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography

Mapping protein interactions in the active TOM-TIM23 supercomplex

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

Observation of a stable carbene at the active site of a thiamin enzyme

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)

Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase from Leishmania major ⬇️

Structural Basis of Targeting the Exportin CRM1 in Cancer

Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22

Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28

Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus

Structural basis for cooperativity of CRM1 export complex formation

Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1

Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1

Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)

Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF

Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.

Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes

Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA

Structure analysis of Entamoeba histolytica enolase

Structure analysis of endosialidase NF at 0.98 A resolution

Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1

Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM

Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate

The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB

The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region

The structure of Prp2 bound to RNA and ADP-BeF<sub>3</sub><sup>-</sup> reveals structural features important for RNA unwinding by DEAH-box ATPases

Translation initiation factor eIF3b contains a nine-bladed β-propeller and interacts with the 40S ribosomal subunit

Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot

Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism ⬇️

Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH

Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin ⬇️

eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining