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Lista de obras de Udo Oppermann

---Inhibition of histone H3K27 demethylase selectively modulates inflammatory phenotypes of natural killer cells.

artículo científico publicado en 2018

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

artículo científico publicado en 2013

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

artículo científico publicado en 2016

A Chemical Probe For Tudor Domain Protein Spindlin1 to Investigate Chromatin Functions

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

artículo científico publicado en 2019

A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase

scientific article published on 01 March 2019

A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report ⬇️

artículo científico publicado en 2016

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics

artículo científico publicado en 2009

A miniaturized screen for inhibitors of Jumonji histone demethylases

artículo científico publicado en 2009

A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival

artículo científico publicado en 2010

A novel INS mutation in a family with MODY: variable insulin secretion and putative mechanisms

artículo científico publicado en 2018

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

artículo científico publicado en 2011

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

artículo científico publicado en 2012

A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency

artículo científico publicado en 2013

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation

artículo científico publicado en 2021

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

artículo científico publicado en 2019

Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons

artículo científico publicado en 2006

Advances and challenges in epigenomic single-cell sequencing applications

scientific article published on 15 April 2020

Advances and challenges in understanding histone demethylase biology.

artículo científico publicado en 2016

Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress

artículo científico publicado en 2010

Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

artículo científico publicado en 2020

Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis

artículo científico publicado en 2008

Animal Models of Epigenetic Regulation in Neuropsychiatric Disorders ⬇️

artículo científico publicado el 1 de enero de 2011

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

scientific article published on 28 October 2019

Assessing histone demethylase inhibitors in cells: lessons learned.

artículo científico publicado en 2017

Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

artículo científico publicado en 2020

Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities

artículo científico publicado en 2007

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

artículo científico publicado en 2007

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

artículo científico publicado en 2019

Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology

artículo científico publicado en 2007

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase

artículo científico publicado en 2006

Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models

artículo científico publicado en 2010

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study

artículo científico publicado en 2008

Codon optimization reveals critical factors for high level expression of two rare codon genes in Escherichia coli: RNA stability and secondary structure but not tRNA abundance.

artículo científico publicado en 2004

Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).

artículo científico publicado en 2003

Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species

artículo científico publicado en 2002

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis

artículo científico publicado en 2011

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

artículo científico publicado en 2002

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

artículo científico publicado en 2010

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

artículo científico publicado en 2013

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

scientific article published on 21 April 2011

Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing

artículo científico publicado en 2009

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

artículo científico publicado en 2010

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development

artículo científico publicado en 2012

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

artículo científico publicado en 2007

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design

artículo científico publicado en 2010

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

artículo científico publicado en 2011

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

scientific article published on 07 December 2018

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase

artículo científico publicado en 2012

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

artículo científico publicado en 2010

Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

artículo científico publicado en 2015

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

artículo científico publicado en 2018

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone

artículo científico publicado en 2008

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

artículo científico publicado en 2021

Divergent roles of prostacyclin and PGE2 in human tendinopathy

artículo científico publicado en 2019

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

artículo científico publicado en 2015

Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification

artículo científico publicado en 2007

GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome

scientific article published on 13 May 2020

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.

artículo científico publicado en 2017

Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone

scientific article published on 27 October 2020

H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.

artículo científico publicado en 2016

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships

artículo científico publicado en 2010

High-level expression and rapid purification of rare-codon genes from hyperthermophilic archaea by the GST gene fusion system

artículo científico publicado en 2003

High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2004

High‐throughput structural biology of metabolic enzymes and its impact on human diseases ⬇️

artículo científico publicado el 22 de febrero de 2011

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

artículo científico publicado en 2020

Hot spots in Tcf4 for the interaction with beta-catenin

artículo científico publicado en 2003

Human UTY(KDM6C) Is a Male-specific N -Methyl Lysyl Demethylase

artículo científico publicado en 2014

Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

artículo científico publicado en 2015

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

artículo científico publicado en 2016

Identification of the 2-Benzoxazol-2-yl-phenol Scaffold as New Hit for JMJD3 Inhibition

scientific article published on 25 February 2019

Immunophenotypic expression of UCP1 in hibernoma and other adipose/non adipose soft tissue tumours

Increased 15-PGDH expression leads to dysregulated resolution responses in stromal cells from patients with chronic tendinopathy.

artículo científico publicado en 2017

Inflammation activation and resolution in human tendon disease

artículo científico publicado en 2015

Inhibition of histone H3K27 demethylases inactivates brachyury (TBXT) and promotes chordoma cell death

scientific article published on 27 August 2020

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

artículo científico publicado en 2008

Insight into S -adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits

artículo científico publicado en 2013

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

artículo científico publicado en 2011

Interactive JIMD articles using the iSee concept: turning a new page on structural biology data

artículo científico publicado en 2011

Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

artículo científico publicado en 2011

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

artículo científico publicado en 2017

Investigating the genetic association between ERAP1 and ankylosing spondylitis

artículo científico publicado en 2009

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

artículo científico publicado en 2018

Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

artículo científico publicado en 2010

Kruidenier et al. reply

artículo científico publicado en 2014

Ligand supplementation as a method to increase soluble heterologous protein production

artículo científico publicado en 2008

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

artículo científico publicado en 2017

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

artículo científico publicado en 2012

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

artículo científico publicado en 2002

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor

artículo científico publicado en 2014

MTR-12SUV39H1 INHIBITOR AND EPIGENETIC MODIFIER DRUG CHAETOCIN SENSITIZES GBM CELLS TO TRAIL-INDUCED APOPTOSIS.

artículo científico publicado en 2015

Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study

artículo científico publicado en 2020

Mechanism and substrate recognition of human holo ACP synthase

artículo científico publicado en 2007

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

scientific article published on 01 September 2019

Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome

scientific article published on 11 July 2019

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

artículo científico publicado en 2011

Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses ⬇️

artículo científico publicado el 15 de octubre de 2003

Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq

artículo científico

Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein

artículo científico publicado en 2017

Periostin expression in neoplastic and non-neoplastic diseases of bone and joint

scientific article published on 05 September 2018

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

artículo científico publicado en 2012

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

artículo científico publicado en 2017

Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)

Protein production and purification

artículo científico publicado en 2008

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

artículo científico publicado en 2010

Quantitative analysis of histone demethylase probes using fluorescence polarization

artículo científico publicado en 2013

Quinone oxidoreductase-2-mediated prodrug cancer therapy

artículo científico publicado en 2010

Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria

artículo científico publicado en 2006

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

artículo científico publicado en 2014

Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency

artículo científico publicado en 2019

Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency

artículo científico publicado en 2007

SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy

artículo científico publicado en 2007

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation

artículo científico publicado en 2007

Sclerostin expression in bone tumours and tumour-like lesions.

artículo científico publicado en 2016

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

artículo científico publicado en 2019

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

artículo científico publicado en 2010

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

artículo científico publicado en 2016

Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes

artículo científico publicado en 2002

Short-chain dehydrogenases/reductases (SDR): the 2002 update

artículo científico publicado en 2003

Short-chain dehydrogenases/reductases (SDRs).

artículo científico publicado en 2002

Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms

artículo científico publicado en 2008

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

artículo científico publicado en 2021

Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases

artículo científico publicado en 2009

Structural analysis of human KDM5B guides histone demethylase inhibitor development

artículo científico publicado en 2016

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

artículo científico publicado en 2011

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

artículo científico publicado en 2012

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity

artículo científico publicado en 2007

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

artículo científico publicado en 2010

Structural basis for substrate specificity in human monomeric carbonyl reductases

artículo científico publicado en 2009

Structural basis of fumarate hydratase deficiency

artículo científico publicado en 2011

Structural genomics of histone tail recognition

artículo científico publicado en 2010

Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment

artículo científico publicado en 2010

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes

artículo científico publicado en 2018

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A

artículo científico publicado en 2009

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

artículo científico publicado en 2011

Structure and function of human 17beta-hydroxysteroid dehydrogenases

artículo científico publicado en 2006

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS

artículo científico publicado en 2011

Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid

artículo científico publicado en 2012

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function

artículo científico publicado en 2012

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

artículo científico publicado en 2012

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

artículo científico publicado en 2005

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

artículo científico publicado en 2008

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

artículo científico publicado en 2008

Structures of the Human GTPase MMAA and Vitamin B 12 -dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation

artículo científico publicado en 2010

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

artículo científico publicado en 2017

Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities

artículo científico publicado en 2010

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

artículo científico publicado en 2008

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

artículo científico publicado en 2009

The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions

artículo científico publicado en 2004

The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity

artículo científico publicado en 2011

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

artículo científico publicado en 2006

The first international workshop on the epigenetics of osteoarthritis

artículo científico publicado en 2016

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

artículo científico publicado en 2019

The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary

artículo científico publicado en 2008

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

artículo científico

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

artículo científico publicado en 2006

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

artículo científico publicado en 2016

The relationship between the chemistry and biological activity of the bisphosphonates.

scientific article published on 09 April 2011

The roles of Jumonji-type oxygenases in human disease

artículo científico

Thermal unfolding of the archaeal DNA and RNA binding protein Ssh10.

artículo científico publicado en 2008

Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3

artículo científico publicado en 2009

Tic32, an essential component in chloroplast biogenesis

artículo científico publicado en 2009

Tic32, an essential component in chloroplast biogenesis.

artículo científico publicado en 2004

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships

artículo científico publicado en 2014

Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications

artículo científico publicado en 2015

Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?

artículo científico publicado en 2006

UDP-glucose dehydrogenase: structure and function of a potential drug target

artículo científico publicado en 2010

Virtual fragment screening identification of a novel Quinoline-5,8-dicarboxylic acid derivative as selective JMJD3 inhibitor.

artículo científico publicado en 2018

Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases? ⬇️

artículo científico publicado el 3 de abril de 2013

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