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Lista de obras de Ulrich Dirnagl

5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures

artículo científico publicado en 2008

A Laboratory Critical Incident and Error Reporting System for Experimental Biomedicine

artículo científico publicado en 2016

A Semiquantitative Non-invasive Measurement of PcomA Patency in C57BL/6 Mice Explains Variance in Ischemic Brain Damage in Filament MCAo

scientific article published on 23 September 2020

A concerted appeal for international cooperation in preclinical stroke research

artículo científico publicado en 2013

A dual-labeled Annexin A5 is not suited for SPECT imaging of brain cell death in experimental murine stroke

artículo científico publicado en 2014

A flow sensitive alternating inversion recovery (FAIR)-MRI protocol to measure hemispheric cerebral blood flow in a mouse stroke model

artículo científico publicado en 2007

A fluorescence based non-radioactive electrophoretic mobility shift assay.

artículo científico

A fluorescence-based method to assess plasma protein extravasation in rat dura mater using confocal laser scanning microscopy

artículo científico publicado en 2003

A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning

artículo científico publicado en 2013

A new home for the Journal of Cerebral Blood Flow and Metabolism

artículo científico publicado en 2016

A pocket guide to electronic laboratory notebooks in the academic life sciences

artículo científico publicado en 2016

Acute pathophysiological processes after ischaemic and traumatic brain injury

artículo científico publicado en 2010

Age dependency of changes in cerebral hemoglobin oxygenation during brain activation: a near-infrared spectroscopy study

artículo científico publicado en 1995

Age-related changes of oxygen free radical production in the rat brain slice after hypoxia: on-line measurement using enhanced chemiluminescence.

artículo científico publicado en 1995

Allosteric release of nitric oxide from hemoglobin does not mediate neurovascular coupling

An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models

scientific article published on 07 February 2019

Analysis of CO2 vasomotor reactivity and vessel diameter changes by simultaneous venous and arterial Doppler recordings

artículo científico publicado en 1999

Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury

artículo científico publicado en 2005

Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury

Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis.

artículo científico publicado en 1995

Applicability of laser-Doppler flowmetry for cerebral blood flow monitoring in neurological intensive care

artículo científico publicado en 1993

Are we ready to translate T-cell transmigration in stroke?

Assessing the Organizational Climate for Translational Research with a New Survey Tool

artículo científico publicado en 2020

Assessment of Local Brain Activation

Assessment of local brain activation. A simultaneous PET and near-infrared spectroscopy study

artículo científico publicado en 1997

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models

artículo científico publicado en 2017

Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice

artículo científico publicado en 2000

Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain?

artículo científico publicado en 1999

B-waves in healthy persons

artículo científico publicado en 1989

Bench to bedside: the quest for quality in experimental stroke research

artículo científico publicado en 2006

Benchmarking university medical centres for responsible metrics. A cross sectional study on timely results dissemination across 36 German centres

article

Biomedical research: increasing value, reducing waste

artículo científico publicado en 2014

Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.

artículo científico publicado en 2015

Body weight after stroke: lessons from the obesity paradox

artículo científico publicado en 2011

Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo.

artículo científico publicado en 2003

Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition

artículo científico publicado en 2002

Brain perfusion SPECT in the mouse: normal pattern according to gender and age.

artículo científico publicado en 2012

Brain-immune interactions in acute and chronic brain disorders

artículo científico publicado en 2008

CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia

artículo científico publicado en 2010

CGRP release and c-fos expression within trigeminal nucleus caudalis of the rat following glyceryltrinitrate infusion.

artículo científico publicado en 2005

Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study.

artículo científico publicado en 1994

Catabolic signaling and muscle wasting after acute ischemic stroke in mice: indication for a stroke-specific sarcopenia

artículo científico publicado en 2014

Celebrating the 30th anniversary of our journal

artículo científico publicado en 2012

Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans.

artículo científico publicado en 2007

Central nervous system injury-induced immune deficiency syndrome

artículo científico publicado en 2005

Cerebral Blood Flow, Hemoglobin Oxygenation, and Water Diffusion Changes During Stroke: Fingerprinting with Near-Infrared Spectroscopy and MRI

Cerebral blood oxygenation changes induced by visual stimulation in humans

artículo científico publicado en 1996

Cerebral oxygenation changes during motor and somatosensory stimulation in humans, as measured by near-infrared spectroscopy.

artículo científico publicado en 1996

Cerebral oxygenation changes in response to motor stimulation.

artículo científico publicado en 1996

Cerebrovascular complications of bacterial meningitis in adults ⬇️

artículo científico publicado el 1 de agosto de 1992

Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels

artículo científico publicado en 2003

Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke

artículo científico publicado en 2013

Changing the mindset in life sciences toward translation: a consensus

artículo científico publicado en 2014

Chapter 4 Cerebral ischemia: the microcirculation as trigger and target

Checklists for Authors Improve the Reporting of Basic Science Research

scientific article published on 13 November 2019

Chemiluminescence detection of nitric oxide production from rat cerebral cortical endothelial cells in culture

artículo científico publicado en 1998

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke

artículo científico publicado en 2015

Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia

artículo científico publicado en 2005

Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers

Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers

article published in 2010

Confocal laser microscopy to study microcirculation on the rat brain surface in vivo.

artículo científico publicado en 1989

Continuous spectrum near-infrared spectroscopy approach in functional activation studies in the human adult

Correction: Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).

artículo científico publicado en 2018

Cortical hypoperfusion after global forebrain ischemia in rats is not caused by microvascular leukocyte plugging

artículo científico publicado en 1994

Cortical spreading depression-associated hyperemia in rats: involvement of serotonin.

artículo científico publicado en 1998

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

artículo científico publicado en 2009

Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide

artículo científico publicado en 1994

DNA methyltransferase contributes to delayed ischemic brain injury.

artículo científico publicado en 2000

Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)--correlation with simultaneous rCBF-PET measurements.

artículo científico publicado en 1997

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

artículo científico publicado en 2016

Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro

artículo científico publicado en 2002

Detection of brain free oxygen radical generated photons in vivo: preliminary results

artículo científico publicado en 1993

Determination of the brain-blood partition coefficient for water in mice using MRI.

artículo científico publicado en 2010

Die Bedeutung des intestinalen Mikrobioms beim ischämischen Schlaganfall

Differential mechanisms of neuroprotection by 17 beta-estradiol in apoptotic versus necrotic neurodegeneration.

artículo científico publicado en 2001

Distinct influence of the group III metabotropic glutamate receptor agonist (R,S)-4-phosphonophenylglycine [(R,S)-PPG] on different forms of neuronal damage

artículo científico publicado en 2000

Distinguishing between exploratory and confirmatory preclinical research will improve translation

artículo científico publicado en 2014

Doxorubicin induces biphasic neurotoxicity to rat cortical neurons

artículo científico publicado en 2007

Dr Smart talks to Prof Pries and Prof Dirnagl on animal experimentation in biomedical research

artículo científico publicado en 2017

Dysexecutive syndrome after mild cerebral ischemia? Mice learn normally but have deficits in strategy switching

artículo científico publicado en 2003

ESC-BRAIN: experimental and clinical stroke research--do they connect?. Meeting report of the ESC-BRAIN joint symposium held in London and Shanghai in May 2013.

artículo científico publicado en 2013

ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo

artículo científico publicado en 2003

Ecstasy-induced cell death in cortical neuronal cultures is 5-HT2A-receptor-dependent and potentiated under hyperthermia

article

Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia

scientific journal article

Editorial

Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis

artículo científico

Effect of 3,4-methylenedioxyamphetamine on dendritic spine dynamics in rat neocortical neurons--involvement of heat shock protein 27.

artículo científico publicado en 2010

Effect of catalase on regional cerebral blood flow and brain edema during the early phase of experimental pneumococcal meningitis

artículo científico publicado el 1 de diciembre de 1992

Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat.

artículo científico publicado en 2006

Effects of the PDE5-inhibitor vardenafil in a mouse stroke model

artículo científico publicado en 2009

Electrochemical failure of the brain cortex is more deleterious when it is accompanied by low perfusion

artículo científico publicado en 2013

Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment

artículo científico publicado en 2015

Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats

artículo científico publicado en 2010

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

artículo científico publicado en 2008

Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning?

artículo científico publicado en 2008

Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura?

artículo científico publicado en 2002

Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis.

artículo científico publicado en 2007

Erratum to “Induction of ischemic tolerance in rat cortical neurons by 3-nitropropionic acid: chemical preconditioning” [Neurosci. Lett. 272 (1999) 207–210]

scholarly article published in Neuroscience Letters

Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model

scientific journal article

Essential role of interleukin-6 in post-stroke angiogenesis

artículo científico publicado en 2012

Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation

artículo científico publicado en 2003

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

artículo científico publicado en 2008

Evidence of intrathecal immunoglobulin synthesis in stroke: a cohort study

artículo científico publicado en 2012

Exact replication: Foundation of science or game of chance?

artículo científico publicado en 2019

Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse

Extra- and intracellular oxygen supply during cortical spreading depression in the rat.

artículo científico publicado en 1996

Fighting publication bias: introducing the Negative Results section

artículo científico publicado en 2010

Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain

artículo científico publicado en 2008

Focal Cerebral Ischemia: The Multifaceted Role of Glial Cells

article

Focal laminar cortical MR signal abnormalities after subarachnoid hemorrhage

artículo científico publicado en 2002

Focoidin, a polysaccharide inhibiting leukocyte rolling, attenuates inflammatory responses in experimental pneumococcal meningitis in rats

article

Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes.

artículo científico publicado en 2014

Functional imaging with laser speckle contrast analysis: vascular compartment analysis and correlation with laser Doppler flowmetry and somatosensory evoked potentials

artículo científico publicado en 2006

Functional neurological recovery after spinal cord injury is impaired in patients with infections

artículo científico publicado en 2012

Glia and Stroke

Global cerebral ischemia in the rat: online monitoring of oxygen free radical production using chemiluminescence in vivo.

artículo científico publicado en 1995

Global forebrain ischaemia in the rat: controlled reduction of cerebral blood flow by hypobaric hypotension and two-vessel occlusion

artículo científico publicado en 1993

Good laboratory practice: preventing introduction of bias at the bench

artículo científico publicado en 2008

Gut microbiota impact on stroke outcome: Fad or fact?

artículo científico publicado en 2016

HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis

artículo científico publicado en 2004

Haemoglobin oxygenation changes during visual stimulation in the occipital cortex

scientific article published on 01 January 1997

Hallucinogenic amphetamines neurotoxicity in cultured hippocampal neurons

scholarly article by S. da Costa Araújo et al published August 2011 in Toxicology Letters

Health tips for research groups

scientific article published in Nature

Heparin Inhibits Leukocyte Rolling in Pial Vessels and Attenuates Inflammatory Changes in a Rat Model of Experimental Bacterial Meningitis ⬇️

artículo científico publicado el 1 de noviembre de 1997

High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types

artículo científico publicado en 2014

Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury

artículo científico publicado en 2014

Hoffnung auf Neuroprotektion

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.

artículo científico publicado en 2016

Human gestational N-methyl-d-aspartate receptor autoantibodies impair neonatal murine brain function

scientific article published on 18 September 2019

Hyperbaric oxygenation induced tolerance against focal cerebral ischemia in mice is strain dependent.

artículo científico publicado en 2000

Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen

artículo científico publicado en 2008

Hypothermia for Stroke: Call to Action 2010 ⬇️

artículo científico publicado el 1 de diciembre de 2010

Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin

artículo científico publicado en 2003

IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells

artículo científico publicado en 2011

INFECTION - AN AMENDMENT TO THE STROKE MODEL GUIDELINES

article

If you have the science, we have the journal!

artículo científico publicado en 2010

Imaging of leukocyte-endothelium interaction using in vivo confocal laser scanning microscopy during the early phase of experimental pneumococcal meningitis

artículo científico publicado en 1993

Imaging of leukocytes within the rat brain cortex in vivo

artículo científico publicado en 1991

Immune responses after acute ischemic stroke or myocardial infarction

artículo científico publicado en 2010

Immune surveillance of mouse brain perivascular spaces by blood-borne macrophages

artículo científico publicado en 2001

Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP.

artículo científico publicado en 2006

Impaired vascular reactivity of isolated rat middle cerebral artery after cortical spreading depression in vivo.

artículo científico publicado en 2004

Improved Reperfusion and Neuroprotection by Creatine in a Mouse Model of Stroke

Improved protocol for SAGE tag-to-gene allocation

artículo científico publicado en 2003

Improved reperfusion and neuroprotection by creatine in a mouse model of stroke

artículo científico publicado en 2006

Improving outcome after stroke: overcoming the translational roadblock

artículo científico publicado en 2008

Improving quality of preclinical academic research through auditing: A feasibility study

scientific article published on 15 October 2020

Improving target assessment in biomedical research: the GOT-IT recommendations

artículo científico publicado en 2020

Improving the Quality of Biomedical Research: Guidelines for Reporting Experiments Involving Animals ⬇️

artículo científico publicado el 5 de enero de 2011

Improving the quality of biomedical research: guidelines for reporting experiments involving animals.

artículo científico publicado en 2011

Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative

scientific article published on 11 February 2020

In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody

artículo científico publicado en 2008

In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia

artículo científico publicado en 2009

In-vivo confocal scanning laser microscopy of the cerebral microcirculation

artículo científico publicado en 1992

Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia

artículo científico publicado en 2005

Increased extracellular potassium concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression in human and rat brain slices

Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment

artículo científico publicado en 2017

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase

artículo científico publicado en 2004

Increasing efficiency of preclinical research by group sequential designs

artículo científico publicado en 2017

Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO).

artículo científico publicado en 2018

Inducible nitric oxide synthase does not mediate brain damage after transient focal cerebral ischemia in mice

artículo científico publicado en 2007

Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons

artículo científico publicado en 1998

Induction of ischemic tolerance in rat cortical neurons by 3-nitropropionic acid: chemical preconditioning.

artículo científico publicado en 1999

Induction of tolerance in rat cortical neurons: hypoxic preconditioning.

artículo científico publicado en 1997

Infarct Volume Prediction by Early Magnetic Resonance Imaging in a Murine Stroke Model Depends on Ischemia Duration and Time of Imaging.

artículo científico publicado en 2015

Influence of essential amino acids on muscle mass and muscle strength in patients with cerebral stroke during early rehabilitation: protocol and rationale of a randomized clinical trial (AMINO-Stroke Study)

artículo científico publicado en 2016

Inhibition of Na+,K+-ATPase activity in cultured rat cerebellar granule cells prevents the onset of apoptosis induced by low potassium

artículo científico publicado en 2000

Institutions can retool to make research more rigorous

artículo científico publicado en 2020

Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice

artículo científico publicado en 2016

International, multicenter randomized preclinical trials in translational stroke research: it's time to act.

artículo científico publicado en 2012

Intracisternal injection of inflammatory soup activates the trigeminal nerve system.

artículo científico publicado en 2009

Introduction to the EQIPD quality system

artículo científico publicado en 2021

Investigating APOE, APP-Aβ metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease

artículo científico publicado en 2020

Investigation of changes in body composition, metabolic profile and skeletal muscle functional capacity in ischemic stroke patients: the rationale and design of the Body Size in Stroke Study (BoSSS).

artículo científico publicado en 2013

Investigation of cortical spreading depression in rats by near infrared spectroscopy: Scattering and oxygenation changes

Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO.

artículo científico publicado en 2005

Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats

artículo científico publicado en 2001

Ischemia and Stroke

Ischemia and stroke

artículo científico publicado en 2002

Ischemia caused by inverse coupling between neuronal activation and cerebral blood flow in rats

Ischemia tolerance; model for research, hope for clinical practice?

artículo científico publicado en 2001

Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats

artículo científico publicado en 2002

Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space

artículo científico publicado en 2003

Ischemic Stroke: Basic Pathophysiology and Clinical Implication

Ischemic Stroke: Basic Pathophysiology and Clinical Implication

Ischemic tolerance and endogenous neuroprotection

artículo científico publicado en 2003

Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism?

artículo científico publicado en 2002

Laminar Analysis of Cerebral Blood Flow in Cortex of Rats by Laser-Doppler Flowmetry: A Pilot Study ⬇️

artículo científico publicado el 1 de diciembre de 1997

Laser-Doppler measurements of concentration and velocity of moving blood cells in rat cerebral circulation.

artículo científico publicado en 1997

Length of resting period between stimulation cycles modulates hemodynamic response to a motor stimulus.

artículo científico publicado en 1997

Long-term functional outcome in patients with acquired infections after acute spinal cord injury

artículo científico publicado en 2017

Longitudinal 19F magnetic resonance imaging of brain oxygenation in a mouse model of vascular cognitive impairment using a cryogenic radiofrequency coil

artículo científico publicado en 2018

Magnetic resoncance and optical imaging of stroke induced brain inflammation

Measurements of Microcirculatory Events in the Brain in Vivo

Mechanisms of stroke protection by physical activity

artículo científico publicado en 2003

Mechanisms of vascular reactivity during cortical spreading depression (CSD) and cortical spreading ischemia (CSI)

Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures

artículo científico publicado en 2000

Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice

artículo científico publicado en 2010

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.

artículo científico publicado en 2018

Metabolic Aspects of Neurovascular Coupling ⬇️

artículo científico publicado el 1 de enero de 1997

Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue.

artículo científico publicado en 2015

Methylprednisolone blocks interleukin 1 beta induced calcitonin gene related peptide release in trigeminal ganglia cells

artículo científico publicado en 2016

Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.

artículo científico publicado en 2001

Mitochondrial free radical production induced by glucose deprivation in cerebellar granule neurons

artículo científico publicado en 2008

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state

artículo científico publicado en 2012

Modeling immunity and inflammation in stroke: can mice be trusted?

article by Ulrich Dirnagl published September 2014 in Stroke Journal

Modeling stroke in mice - middle cerebral artery occlusion with the filament model

artículo científico

Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia

artículo científico publicado en 2009

Natural Killer (NK) Cell Functionality after human Spinal Cord Injury (SCI): protocol of a prospective, longitudinal study

artículo científico publicado en 2016

Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults

artículo científico publicado en 1993

Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice.

artículo científico publicado en 2009

Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo.

artículo científico publicado en 2001

Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment

artículo científico publicado en 2017

Neuroimmunology

artículo científico

Neuronal activation induced changes in microcirculatory haemoglobin oxygenation: to dip or not to dip

article published in 2002

Neuronal activity-induced changes of local cerebral microvascular blood oxygenation in the rat: effect of systemic hyperoxia or hypoxia

artículo científico publicado en 2003

Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization

artículo científico publicado en 2004

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

artículo científico publicado en 2016

Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones

artículo científico publicado en 2005

Neuroprotective effects of creatine in a mouse model of stroke: An experimental MRI study

Neuroprotective effects of the antifungal drug clotrimazole

artículo científico publicado en 2002

Neuroprotective effects of the beta-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures

artículo científico publicado en 2007

Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning

artículo científico publicado en 2005

Neurotoxicity mechanisms of ecstasy metabolites

scholarly article by João Paulo Capela et al published October 2007 in Toxicology Letters

Neurotoxicity mechanisms of thioether ecstasy metabolites

artículo científico publicado en 2007

Neurovascular coupling during cortical spreading depolarization and -depression

artículo científico

Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation

artículo científico publicado en 2009

Nimodipine posttreatment does not increase blood flow in rats with focal cortical ischemia

artículo científico publicado en 1990

Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons

artículo científico publicado en 2005

Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex

artículo científico publicado en 2008

Nitric oxide synthase blockade enhances vasomotion in the cerebral microcirculation of anesthetized rats

artículo científico publicado en 1993

Nitric oxide synthase inhibition does not affect somatosensory evoked potentials in the rat.

artículo científico publicado en 1996

No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation.

artículo científico publicado en 2001

Non-invasive functional mapping of the human motor cortex using near-infrared spectroscopy

artículo científico publicado en 1996

Non-invasive surface-stripping for epifluorescence small animal imaging

artículo científico publicado en 2010

Non-invasive visualization of CNS inflammation with nuclear and optical imaging

artículo científico publicado en 2008

Non-resolving aspects of acute inflammation after spinal cord injury (SCI): indices and resolution plateau

artículo científico publicado en 2011

Noninvasive assessment of cerebral hemodynamics and tissue oxygenation during activation of brain cell function in human adults using near infrared spectroscopy

artículo científico publicado en 1994

Noninvasive near infrared spectroscopy monitoring of regional cerebral blood oxygenation changes during peri-infarct depolarizations in focal cerebral ischemia in the rat.

artículo científico publicado en 1997

Noninvasive near-infrared imaging of fluorochromes within the brain of live mice: an in vivo phantom study.

artículo científico publicado en 2006

Old Dogmas, Surprising Complexities, and Novel Therapeutic Targets

Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis.

artículo científico publicado en 2016

Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis

scientific article published on 07 June 2019

Oxygen maps in the brain ⬇️

artículo científico publicado el 1 de septiembre de 2010

Partial antagonistic effect of adenosine on inverse coupling between spreading neuronal activation and cerebral blood flow in rats

artículo científico publicado en 2004

Pathobiology of injury after stroke: the neurovascular unit and beyond

artículo científico publicado en 2012

Pathobiology of ischaemic stroke: an integrated view

artículo científico publicado en 1999

Pathophysiological interference with neurovascular coupling - when imaging based on hemoglobin might go blind

artículo científico publicado en 2010

Pathophysiology of Stroke

Pathophysiology of stroke: lessons from animal models

artículo científico publicado en 2004

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

artículo científico publicado en 2010

Perivascular nerves contribute to cortical spreading depression-associated hyperemia in rats.

artículo científico publicado en 1998

Pharmacological uncoupling of activation induced increases in CBF and CMRO2.

artículo científico publicado en 2009

Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids

scientific journal article

Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow

artículo científico publicado en 2006

Physical model for the spectroscopic analysis of cortical intrinsic optical signals

article

Pneumococcal cell wall components induce nitric oxide synthase and TNF-alpha in astroglial-enriched cultures

scientific article published on 01 January 1996

Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat.

artículo científico publicado en 1990

Preclinical research: Meet patients to sharpen up research.

artículo científico publicado en 2017

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use.

artículo científico publicado en 2009

Preregistration of exploratory research: Learning from the golden age of discovery

artículo científico publicado en 2020

Presentation abstracts

article

Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial

artículo científico publicado en 2008

Preventive antibacterial treatment improves the general medical and neurological outcome in a mouse model of stroke

artículo científico publicado en 2003

Primary trigeminal afferents are the main source for stimulus-induced CGRP release into jugular vein blood and CSF.

artículo científico publicado en 2012

Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?

artículo científico publicado en 2000

Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH.

artículo científico publicado en 2007

Protective conditioning of the brain: expressway or roadblock?

artículo científico publicado en 2011

Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals

Quality Control and Standard Operating Procedures

Quality Control and Standard Operating Procedures

Quality management for academic laboratories: burden or boon?

scholarly article by Ulrich Dirnagl published in October 2018

Quality management for academic laboratories: burden or boon? Professional quality management could be very beneficial for academic research but needs to overcome specific caveats

article by Ulrich Dirnagl et al published 19 October 2018 in EMBO Reports

Quality research needs good working conditions

REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act.

artículo científico publicado en 2012

Rapid Ca2+-dependent NO-production from central nervous system cells in culture measured by NO-nitrite/ozone chemoluminescence

artículo científico publicado en 1997

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition

artículo científico publicado en 2019

Regulation of Cerebral Blood Flow by Ions

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.

artículo científico publicado en 2020

Reprint: Good Laboratory Practice: Preventing Introduction of Bias at the Bench

article

Reprint: Good laboratory practice: preventing introduction of bias at the bench

artículo científico publicado en 2008

Reprint: Good laboratory practice: preventing introduction of bias at the bench

artículo científico publicado en 2009

Resolving the Tension Between Exploration and Confirmation in Preclinical Biomedical Research

artículo científico publicado en 2020

Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete

artículo científico publicado en 2019

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

artículo científico publicado en 2015

Rethinking research reproducibility

scientific article published on 05 December 2018

Revision of the ARRIVE guidelines: rationale and scope

artículo científico publicado en 2018

Robust research: Institutions must do their part for reproducibility

artículo científico

Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo

scientific journal article

Role of glial cells in cerebral ischemia

artículo científico publicado en 2005

Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

artículo científico publicado en 1993

Role of nitric oxide in the ethylcholine aziridinium model of delayed apoptotic neurodegeneration in vivo and in vitro

article

Roller culture of free-floating retinal slices: a new system of organotypic cultures of adult rat retina

artículo científico publicado en 2006

Roller organotypic cultures of postnatal rat retina

artículo científico publicado en 2004

Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice

artículo científico publicado en 2002

Rotation of Editorial Board Members and new publication formats

artículo científico publicado en 2011

SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol

artículo científico publicado en 2016

SUMO2/3 conjugation is an endogenous neuroprotective mechanism

artículo científico publicado en 2011

Selective neuronal vulnerability following mild focal brain ischemia in the mouse.

artículo científico publicado en 2003

Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia.

artículo científico publicado en 2002

Serotonin uptake and release mechanisms in developing cultures of rat embryonic raphe neurons: age- and region-specific differences.

artículo científico publicado en 2000

Short-term block of Na+/K+-ATPase in neuro-glial cell cultures of cerebellum induces glutamate dependent damage of granule cells

artículo científico publicado en 1999

Simultaneous Assessment of Cerebral Oxygenation and Hemodynamics During a Motor Task

Simultaneous assessment of cerebral oxygenation and hemodynamics during a motor task. A combined near infrared and transcranial Doppler sonography study.

artículo científico publicado en 1997

Single-cell resolution mapping of neuronal damage in acute focal cerebral ischemia using thallium autometallography

artículo científico publicado en 2013

Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury

artículo científico publicado en 2012

SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis

artículo científico publicado en 2020

Spatiotemporal correlation of neuronal activity and cerebral blood flow of the motor cortex: Non-invasive measurement of DC-EEG and near-infrared spectroscopy in humans during a motor task

Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke

artículo científico publicado en 2013

Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level

artículo científico publicado en 2016

Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex

artículo científico publicado en 2017

Stage 1 Registered Report: Effect of deficient phagocytosis on neuronal survival and neurological outcome after temporary middle cerebral artery occlusion (tMCAo).

artículo científico publicado en 2017

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse

article by Ulrich Dirnagl & Ulrich Dirnagl published 17 August 2010 in Nature Precedings

Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing

Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing

Statistics in experimental cerebrovascular research-comparison of two groups with a continuous outcome variable

artículo científico publicado en 2010

Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable

artículo científico publicado en 2010

Stroke

article published in 2005

Stroke and the immune system: from pathophysiology to new therapeutic strategies

artículo científico publicado en 2011

Stroke induced Sarcopenia: muscle wasting and disability after stroke

artículo científico

Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia

artículo científico publicado en 2006

Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice

artículo científico publicado en 2009

Stroke research priorities for the next decade--A representative view of the European scientific community

artículo científico publicado en 2006

Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation

artículo científico publicado en 2003

Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial

artículo científico publicado en 2008

Stroke-induced immunodepression: experimental evidence and clinical relevance

artículo científico publicado en 2007

Subsurface Microscopical visualization of brain tissue in vivo: Present, problems and prospects

scholarly article by Ulrich Dirnagl et al published January 1993 in Micron

Sulfonylurea drugs do not influence initial stroke severity and in-hospital outcome in stroke patients with diabetes

artículo científico publicado en 2001

Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke

artículo científico publicado en 2007

Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: a bed to bench approach

artículo científico publicado en 2013

Superoxide dismutase inhibits brain oedema formation in experimental pneumococcal meningitis

artículo científico publicado en 1990

System for the measurement of blood flow and oxygenation in tissue applied to neurovascular coupling in brain

Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism ⬇️

artículo científico publicado en 2011

Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism.

artículo científico publicado en 2011

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.

artículo científico publicado en 2001

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

artículo científico publicado en 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

artículo científico publicado en 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

artículo científico publicado en 2020

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

artículo científico publicado en 2020

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

scientific article published on 14 July 2020

The ARRIVE guidelines 2.0: updated guidelines for reporting animal research

artículo científico publicado en 2020

The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke

artículo científico publicado en 2016

The Hong Kong Principles for assessing researchers: Fostering research integrity ⬇️

artículo científico

The Journal of Cerebral Blood Flow and Metabolism clinical, inaugural issue

artículo científico publicado en 2015

The N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801 does not block spreading ischemia in the rat

The Physiological Basis of Functional Magnetic Resonance Imaging**Supported by the Deutsche Forschungsgemeinschaft (Vi 97/7–1, Di 454/4–2), the Sander-Stiftung (90.023.2), and the Human Frontiers Science Program Organization

The SCIentinel study--prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS)--study protocol and interim feasibility data

artículo científico publicado en 2013

The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials.

artículo científico publicado en 2018

The cerebrovascular response to elevated potassium--role of nitric oxide in the in vitro model of isolated rat middle cerebral arteries

artículo científico publicado en 2001

The ischemic cascade and mediators of ischemic injury

artículo científico publicado en 2009

The microcircualtion--fantastic voyage: introduction

artículo científico publicado en 2013

The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons

artículo científico publicado en 2012

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

artículo científico publicado en 2012

The p value wars (again)

scientific article published on 01 November 2019

The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days

artículo científico publicado en 2020

Therapierelevante Pathophysiologie des akuten ischämischen Schlaganfalls: Was ist gesichert?

Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It?

artículo científico publicado en 2016

Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent

artículo científico publicado en 2002

Toward noninvasive optical human brain mapping: improvements of the spectral, temporal, and spatial resolution of near-infrared spectroscopy

Towards Brain Mapping Combining Near-Infrared Spectroscopy and High Resolution 3D MRI

artículo científico publicado en 1997

Towards imaging of cerebral blood flow and metabolism on a microscopical scale in vivo

artículo científico publicado en 1993

Towards noninvasive molecular fluorescence imaging of the human brain

artículo científico publicado en 2008

Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging

artículo científico publicado en 2006

Tracking the timely dissemination of clinical studies. Characteristics and impact of 10 tracking variables

scientific article published on 29 November 2018

Triptans reduce the inflammatory response in bacterial meningitis

artículo científico publicado en 2002

Tumour necrosis factor alpha induces only minor inflammatory changes in the central nervous system, but augments experimental meningitis

artículo científico publicado en 1998

Turnover of rat brain perivascular cells

artículo científico publicado en 2001

Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis

artículo científico publicado en 2004

Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress

artículo científico publicado en 2019

Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment

artículo científico publicado en 2014

Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation

artículo científico publicado en 1997

Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke

artículo científico publicado en 2015

Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining

artículo científico publicado en 2011

Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives

artículo científico publicado en 2011

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke

artículo científico publicado en 2016

Wisdom of the expert crowd prediction of response for 3 neurology randomized trials

artículo científico publicado en 2020

Withdrawal of statin treatment abrogates stroke protection in mice

artículo científico publicado en 2003

ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

artículo científico publicado en 1998

Zerebrale Ischämie

fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community

artículo científico publicado en 2020

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