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Lista de obras de Ilpo Huhtaniemi

15th European Workshop on Molecular and Cellular Endocrinology of the Testis. Introduction

scientific article published on 06 April 2009

A Novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.

artículo científico publicado en 2002

A common polymorphism in the human relaxin-like factor (RLF) gene: no relationship with cryptorchidism

artículo científico publicado en 2000

A hormonal contraceptive for men: how close are we?

artículo científico publicado en 2010

A multicenter phase IIb study of a novel combination of intramuscular androgen (testosterone decanoate) and oral progestogen (etonogestrel) for male hormonal contraception.

artículo científico publicado en 2005

A new FSHbeta mutation in a 29-year-old woman with primary amenorrhea and isolated FSH deficiency: functional characterization and ovarian response to human recombinant FSH.

artículo científico publicado en 2009

A novel Ala(-3)Thr mutation in the signal peptide of human luteinizing hormone beta-subunit: potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathway by recombinant variant hormone

artículo científico publicado en 2002

A novel approach of targeted ablation of mammary carcinoma cells through luteinizing hormone receptors using Hecate-CGbeta conjugate.

artículo científico publicado en 2003

A novel inactivating mutation of the LH/chorionic gonadotrophin receptor with impaired membrane trafficking leading to Leydig cell hypoplasia type 1.

artículo científico publicado en 2015

A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice.

artículo científico publicado en 2005

A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3 ⬇️

artículo científico publicado el 5 de octubre de 2011

A short evolutionary history of FSH-stimulated spermatogenesis

artículo científico publicado en 2015

A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation.

artículo científico publicado en 2016

Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations

artículo científico publicado en 2004

Adaptation to acute coronary syndrome-induced stress with lowering of testosterone: a possible survival factor

artículo científico publicado en 2016

Adenosine triphosphate induces Ca2+ signal in epithelial cells of the mouse caput epididymis through activation of P2X and P2Y purinergic receptors

artículo científico publicado en 2002

Adrenal hyperplasia and tumours in mice in connection with aberrant pituitary-gonadal function.

scientific article published on 19 October 2008

Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4.

artículo científico publicado en 2004

Advances in the Molecular Pathophysiology, Genetics, and Treatment of Primary Ovarian Insufficiency.

artículo científico publicado en 2018

Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS).

artículo científico publicado en 2009

Aging and the Male Reproductive System

scientific article published on 01 August 2019

Aging of the human ovary and testis

artículo científico publicado en 2008

Androgen Replacement Therapy in Late-Onset Hypogonadism: Current Concepts and Controversies – A Mini-Review ⬇️

artículo científico publicado el 2 de agosto de 2010

Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium.

artículo científico publicado en 2006

Are gonadotrophins tumorigenic--a critical review of clinical and experimental data

artículo científico publicado en 2010

Assisted large fragment insertion by Red/ET-recombination (ALFIRE)--an alternative and enhanced method for large fragment recombineering.

artículo científico publicado en 2007

Association between cognitive performance and the metabolic syndrome in middle-aged and older European men

Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization

scientific journal article

Both testosterone and follicle-stimulating hormone independently inhibit spermatogonial differentiation in irradiated rats.

artículo científico publicado en 2005

CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures.

artículo científico publicado en 2014

Cell-based evidence regarding the role of FSH in prostate cancer

scientific article published on 02 January 2019

Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men.

artículo científico publicado en 2013

Complete Sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: evidence from genetic models of isolated FSH action.

artículo científico publicado en 2004

Compound heterozygous mutations in the luteinizing hormone receptor signal peptide causing 46,XY disorder of sex development

scientific article published on 01 August 2019

Constitutive activity in gonadotropin receptors

artículo científico publicado en 2014

Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta

artículo científico publicado en 2007

Di/Oligomerization of GPCRs—Mechanisms and Functional Significance

artículo científico publicado el 1 de enero de 2013

Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling

scientific journal article

Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat ⬇️

artículo científico publicado el 21 de noviembre de 2012

Discovery and characterization of new epididymis-specific beta-defensins in mice

artículo científico publicado en 2005

Discovery in Silico and Characterization in Vitro of Novel Genes Exclusively Expressed in the Mouse Epididymis

article

Does the andropause exist?

artículo científico publicado en 2007

Does variant luteinizing hormone (V-LH) predispose to improper testicular position in late pregnancy?

scientific article published on 01 September 2005

EVALUATION OF 25-HYDROXYVITAMIN D AND 1,25-DIHYDROXYVITAMIN D AND COGNITIVE DECLINE IN THE EUROPEAN MALE AGEING STUDY

artículo científico publicado en 2016

Editorial

Editorial: Follicle-Stimulating Hormone: Fertility and Beyond

scientific article published on 06 September 2019

Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor

artículo científico publicado en 2002

Effects of medroxyprogesterone and estradiol on the recovery of spermatogenesis in irradiated rats

artículo científico publicado en 2004

Effects of resistance training on testosterone metabolism in younger and older men

artículo científico publicado en 2015

Electroacupuncture mimics exercise in affecting gene expression of skeletal muscle

artículo científico publicado en 2020

Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin

artículo científico publicado en 2003

Endogenous testosterone and brachial artery endothelial function in middle-aged men with symptoms of late-onset hypogonadism ⬇️

artículo científico publicado el 11 de agosto de 2011

Endogenous testosterone and serum lipids in middle-aged men

artículo científico publicado en 2007

Enhanced LH action in transgenic female mice expressing hCGbeta-subunit induces pituitary prolactinomas; the role of high progesterone levels

artículo científico publicado en 2010

Epididymal dysfunction initiated by the expression of simian virus 40 T-antigen leads to angulated sperm flagella and infertility in transgenic mice

artículo científico publicado en 2002

Epididymal protein Rnase10 is required for post‐testicular sperm maturation and male fertility ⬇️

artículo científico publicado el 29 de junio de 2012

Epididymis-specific promoter-driven gene targeting: a new approach to control epididymal function?

artículo científico publicado en 2004

Estrogen enhances recovery from radiation-induced spermatogonial arrest in rat testes

artículo científico publicado en 2009

Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation.

artículo científico publicado en 2011

European Academy of Andrology (EAA) guidelines* on investigation, treatment and monitoring of functional hypogonadism in males

artículo científico publicado en 2020

Extragonadal FSHR Expression and Function-Is It Real?

scientific article published on 04 February 2019

Extragonadal LH/hCG action--not yet time to rewrite textbooks

artículo científico publicado en 2007

Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action

artículo científico publicado en 2005

Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal Testis

artículo científico publicado en 2015

Focus on gonadotrophin signalling

artículo científico publicado en 2005

Functional Expression of FSH Receptor in Endometriotic Lesions.

artículo científico publicado en 2016

Functional Implications of LH/hCG Receptors in Pregnancy-Induced Cushing Syndrome.

artículo científico publicado en 2017

Functional characterization of the human FSH receptor with an inactivating Ala189Val mutation

artículo científico publicado en 2002

Functional study of a recombinant form of human LHbeta-subunit variant carrying the Gly(102)Ser mutation found in Asian populations

artículo científico publicado en 2002

GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors

artículo científico publicado en 2008

Genetic Determinants of Circulating Estrogen Levels, and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

artículo científico publicado en 2018

Genetic determinants of serum testosterone concentrations in men.

artículo científico publicado en 2011

Genetically modified mouse models in studies of luteinising hormone action

artículo científico publicado en 2006

GnRH antagonist treatment of malignant adrenocortical tumors

scholarly article by Milena Doroszko et al published 1 January 2019 in Endocrine-related cancer

Gonadotrophin actions on the testis--genotypes and phenotypes of gonadotrophin and gonadotrophin receptor mutations

artículo científico publicado en 2003

Gonadotrophin resistance

artículo científico publicado en 2006

Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter

artículo científico publicado en 2009

High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-alpha-subunit promoter/Simian virus 40 T-antigen fusion gene

artículo científico publicado en 2003

Human FSH beta subunit gene is highly conserved

scientific article published on 12 August 2005

Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation

artículo científico publicado en 2007

Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone.

artículo científico publicado en 2006

Hyperglycosylated human chorionic gonadotropin stimulates angiogenesis through TGF-β receptor activation

artículo científico publicado en 2012

Identification of novel epididymal genes by expression profiling and in silico gene discovery

artículo científico publicado en 2006

Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane

artículo científico publicado en 2014

Immortalization by large T-antigen of the adult epididymal duct epithelium.

artículo científico publicado en 2004

Increased carotid atherosclerosis in andropausal middle-aged men.

artículo científico publicado en 2005

Indirect Sertoli cell-mediated ablation of germ cells in mice expressing the inhibin-alpha promoter/herpes simplex virus thymidine kinase transgene

artículo científico publicado en 2004

Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary

artículo científico publicado en 2004

Inhibition of recovery of spermatogenesis in irradiated rats by different androgens.

artículo científico publicado en 2002

Inhibition of small ubiquitin-related modifier-1 expression by luteinizing hormone receptor stimulation is linked to induction of progesterone receptor during ovulation in mouse granulosa cells

artículo científico publicado en 2003

Interactions of the GnRH receptor with heterotrimeric G proteins ⬇️

artículo científico publicado el 27 de noviembre de 2012

Is the adrenal cortex a target for gonadotropins?

artículo científico publicado en 2008

Knockout of luteinizing hormone receptor abolishes the effects of follicle-stimulating hormone on preovulatory maturation and ovulation of mouse graafian follicles

artículo científico publicado en 2005

Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS).

artículo científico publicado en 2008

Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment

artículo científico publicado en 2014

Leydig cell-specific expression of DAX1 improves fertility of the Dax1-deficient mouse.

artículo científico publicado en 2003

Life expectancy of humans is increasing

artículo científico publicado en 2013

Loss of Bmyc results in increased apoptosis associated with upregulation of Myc expression in juvenile murine testis

artículo científico publicado en 2012

Loss of cysteine-rich secretory protein 4 (Crisp4) leads to deficiency in sperm-zona pellucida interaction in mice

scientific journal article

Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone levels: results from the European Male Ageing Study.

artículo científico publicado en 2015

Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS).

artículo científico publicado en 2013

Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice

artículo científico publicado en 2017

MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms

scientific article published on 29 June 2018

Male contraception--quo vadis?

artículo científico publicado en 2004

Male hormonal contraception: a double-blind, placebo-controlled study

artículo científico publicado en 2008

Male late-onset hypogonadism: pathogenesis, diagnosis and treatment ⬇️

artículo científico publicado el 19 de abril de 2011

Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior

artículo científico publicado en 2007

Male reproductive endocrinology. Preface

artículo científico publicado en 2011

Measurements of salivary progesterone throughout the menstrual cycle in women suffering from unexplained infertility reveal high frequency of luteal phase defects**Supported by research contracts from The Finnish Life and Pension Insurance Companies

article

Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein

artículo científico publicado en 2013

Members of the murine Pate family are predominantly expressed in the epididymis in a segment-specific fashion and regulated by androgens and other testicular factors

artículo científico publicado en 2011

Molecular Mechanisms of Bladder Outlet Obstruction in Transgenic Male Mice Overexpressing Aromatase (Cyp19a1) ⬇️

artículo científico publicado el 1 de marzo de 2011

Molecular characterization of postnatal development of testicular steroidogenesis in luteinizing hormone receptor knockout mice

artículo científico publicado en 2003

Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner

artículo científico publicado en 2005

Mouse models of infertility due to swollen spermatozoa

artículo científico publicado en 2004

Multiple sites of tumorigenesis in transgenic mice overproducing hCG.

artículo científico publicado en 2005

Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor.

artículo científico publicado en 2004

Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1.

artículo científico publicado en 2002

Mutations affecting gonadotropin secretion and action

artículo científico publicado en 2003

Mutations along the hypothalamic-pituitary-gonadal axis affecting male reproduction

artículo científico publicado en 2007

Mutations along the pituitary-gonadal axis affecting sexual maturation: novel information from transgenic and knockout mice

artículo científico publicado en 2006

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

artículo científico publicado en 2015

Novel concepts of human chorionic gonadotropin: reproductive system interactions and potential in the management of infertility

artículo científico publicado en 2005

Novel epididymal protease inhibitors with Kazal or WAP family domain

scientific journal article

Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice

artículo científico publicado en 2017

Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.

artículo científico publicado en 2008

PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.

artículo científico publicado en 2009

Pharmacogenetics of FSH Action in the Female

scientific article published on 26 June 2019

Phenotypic characterisation of mice with exaggerated and missing LH/hCG action

artículo científico publicado en 2006

Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice

scientific journal article

Polymorphisms in androgen and estrogen receptor genes: effects on male aging

artículo científico publicado en 2004

REPLACR-mutagenesis, a one-step method for site-directed mutagenesis by recombineering

artículo científico publicado en 2016

Regional expression of androgen receptor coregulators and androgen action in the mouse epididymis

artículo científico publicado en 2011

Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin

artículo científico publicado en 2002

Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation.

artículo científico publicado en 2010

Restoration of Spermatogenesis in Dibromochloropropane (DBCP)-Treated Rats by Hormone Suppression ⬇️

artículo científico publicado el 26 de septiembre de 2003

Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells

artículo científico publicado en 2016

Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse

artículo científico publicado en 2007

SUN-213 Hsd17b3 Knockout Mice Serve As A Model To Define Mechanisms Behind The Altered Endocrine Phenotype Of Patients With Hsd17b3 Mutations

Sequestration of connexin43 in the early endosomes: An early event of Leydig cell tumor progression

scholarly article by Dominique Segretain published in November 2003

Serum testosterone but not leptin predicts mortality in elderly men.

artículo científico publicado en 2008

Sex differences in the development of prolactinoma in mice overexpressing hCGβ: role of TGFβ1.

artículo científico publicado en 2017

Sexual dimorphism in superantigen shock involves elevated TNF-alpha and TNF-alpha induced hepatic apoptosis

artículo científico publicado en 2007

Sexual symptoms in aging men indicate poor life satisfaction and increased health service consumption

artículo científico publicado en 2007

Single-molecule resolution of G protein-coupled receptor (GPCR) complexes.

artículo científico publicado en 2015

Smoking and low serum testosterone associates with high concentration of oxidized LDL.

artículo científico publicado en 2008

Spatiotemporal expression of androgen receptors in the female rat brain during the oestrous cycle and the impact of exogenous androgen administration: a comparison with gonadally intact males

artículo científico publicado en 2010

Sperm volume regulation: maturational changes in fertile and infertile transgenic mice and association with kinematics and tail angulation

artículo científico publicado en 2002

Structure-function relationships of glycoprotein hormones; lessons from mutations and polymorphisms of the thyrotrophin and gonadotrophin subunit genes

artículo científico publicado en 2002

Synergistic Activation of Innate and Adaptive Immune Mechanisms in the Treatment of Gonadotropin-Sensitive Tumors ⬇️

artículo científico publicado el 8 de abril de 2013

TGF-beta1 system in Leydig cells. Part I: effect of hCG and progesterone

artículo científico publicado en 2010

Targeted ablation of prostate carcinoma cells through LH receptor using Hecate-CGbeta conjugate: functional characteristic and molecular mechanism of cell death pathway.

artículo científico publicado en 2005

Targeted expression of human FSH receptor Asp567Gly mutant mRNA in testis of transgenic mice: role of human FSH receptor promoter

artículo científico publicado en 2003

Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia ⬇️

scientific journal article

Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding

artículo científico publicado en 2016

Targeted therapy for adrenocortical tumors in transgenic mice through their LH receptor by Hecate-human chorionic gonadotropin beta conjugate

artículo científico publicado en 2008

Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice

artículo científico publicado en 2004

The adrenal gland may be a target of LH action in postmenopausal women

artículo científico publicado en 2006

The effects of chemicals on mammalian fertility. The report and recommendations of ECVAM Workshop 53--the first strategic workshop of the EU ReProTect Project.

artículo científico publicado en 2005

The gonadotropin receptors FSH-R and LH-R of Atlantic halibut (Hippoglossus hippoglossus)--2. Differential follicle expression and asynchronous oogenesis

artículo científico publicado en 2008

The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis ⬇️

artículo científico publicado el 29 de octubre de 2003

The permissive role of prolactin as a regulator of luteinizing hormone action in the female mouse ovary and extragonadal tumorigenesis

artículo científico publicado en 2013

The polymorphic androgen receptor gene CAG repeat, pituitary-testicular function and andropausal symptoms in ageing men.

artículo científico publicado en 2003

The transgenic expression of the β-subunit of human chorionic gonadotropin influences the growth of implanted tumor cells

Trafficking of the follitropin receptor

artículo científico publicado en 2013

Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization ⬇️

artículo científico publicado el 30 de noviembre de 2012

Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice ⬇️

artículo científico publicado el 26 de febrero de 2013

Transgenic and knockout mouse models for aberrant pituitary-testicular function: relevance to the pathogenesis of cryptorchidism

artículo científico publicado en 2004

Transgenic and knockout mouse models for the study of luteinizing hormone and luteinizing hormone receptor function.

artículo científico publicado en 2002

Transgenic mice expressing inhibin α-subunit promoter (inhα)/Simian Virus 40 T-antigen (Tag) transgene as a model for the therapy of granulosa cell-derived ovarian cancer.

artículo científico publicado en 2013

Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis

artículo científico publicado en 2005

Transgenic mice harboring murine luteinizing hormone receptor promoter/beta-galactosidase fusion genes: different structural and hormonal requirements of expression in the testis, ovary, and adrenal gland.

artículo científico publicado en 2002

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

artículo científico publicado en 2009

Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging.

artículo científico publicado en 2015

What have gonadotrophin overexpressing transgenic mice taught us about gonadal function?

artículo científico publicado en 2005

Will GnRH antagonists improve prostate cancer treatment?

artículo científico publicado en 2008

Zika virus infection-do they also endanger male fertility?

artículo científico publicado en 2017

[Diagnosis and therapy of male hormonal changes related to aging].

artículo científico publicado en 2009

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