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Lista de obras de Arlene Sharpe

4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses

artículo científico publicado en 2004

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

article

A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade

scientific article published on 09 September 2020

A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma

artículo científico publicado en 2018

A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection

artículo científico publicado en 2003

Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade

scholarly article

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

artículo científico publicado en 2019

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

scientific journal article

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

artículo científico publicado en 2016

Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo

article

Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells

artículo científico publicado en 2016

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells ⬇️

artículo científico publicado el 21 de marzo de 2012

Author Correction: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

artículo científico publicado en 2019

Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice

artículo científico publicado en 2011

B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells.

artículo científico publicado en 2017

B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].

artículo científico publicado en 2004

B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function.

artículo científico publicado en 2009

B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice

artículo científico publicado en 2004

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

artículo científico publicado en 2013

Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling

artículo científico publicado en 2016

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

artículo científico publicado en 2006

Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice

artículo científico publicado en 2013

CD160 Stimulates CD8+ T Cell Responses and Is Required for Optimal Protective Immunity to Listeria monocytogenes

scientific article published on 27 August 2018

CD28 costimulation regulates genome-wide effects on alternative splicing

artículo científico publicado en 2012

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

artículo científico publicado en 2015

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition ⬇️

artículo científico publicado el 20 de diciembre de 2010

CD48 controls T-cell and antigen-presenting cell functions in experimental colitis

artículo científico publicado en 2006

CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo.

artículo científico publicado en 2005

CTLA-4 regulates cell cycle progression during a primary immune response.

artículo científico publicado en 2002

Circulating T follicular regulatory and helper cells have memory-like properties

artículo científico publicado en 2014

Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus

artículo científico publicado en 2014

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

scientific article published on 25 November 2020

Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells

artículo científico publicado en 2018

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

scientific journal article

Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice

artículo científico publicado en 2002

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

artículo científico publicado en 2009

Cutting edge: TIGIT has T cell-intrinsic inhibitory functions

scientific journal article

Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL.

artículo científico publicado en 2002

Cutting edge: transplantation tolerance through enhanced CTLA-4 expression

artículo científico publicado en 2003

Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice

article published in the Proceedings of the National Academy of Sciences of the United States of America

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

artículo científico publicado en 2004

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

artículo científico publicado en 2018

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

artículo científico publicado en 2016

Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse

artículo científico publicado en 2013

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis ⬇️

artículo científico publicado el 1 de noviembre de 2003

Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice

artículo científico publicado en 2005

Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

artículo científico publicado en 2017

Expression of T-cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma

artículo científico publicado en 2020

GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

artículo científico publicado en 2013

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells

artículo científico publicado en 2015

Genetic background determines the requirement for B7 costimulation in induction of autoimmunity

artículo científico publicado en 2002

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

artículo científico publicado en 2009

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

artículo científico publicado en 2017

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation

artículo científico publicado en 2014

Induction of B7-1 in podocytes is associated with nephrotic syndrome

artículo científico publicado en 2004

Inhibitors of the PD-1 Pathway in Tumor Therapy

artículo científico publicado en 2018

Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1.

artículo científico publicado en 2012

Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V

artículo científico publicado en 2012

Introduction to checkpoint inhibitors and cancer immunotherapy.

artículo científico publicado en 2017

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

artículo científico publicado en 2003

Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality ⬇️

scholarly article

Mechanism of action of donor-specific transfusion in inducing tolerance: role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation

artículo científico publicado en 2004

Mechanisms of costimulation

artículo científico publicado en 2009

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.

scientific article published on July 2016

Mitochondrial metabolism in T cell activation and senescence: a mini-review

artículo científico publicado en 2014

Modulation of surgical fibrosis by microbial zwitterionic polysaccharides

artículo científico publicado en 2005

Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

artículo científico publicado en 2021

Negative co-receptors on lymphocytes

artículo científico publicado en 2002

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

artículo científico publicado en 2020

Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function

artículo científico publicado en 2022

Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity

artículo científico publicado en 2011

PD-1 Protects against Inflammation and Myocyte Damage in T Cell-Mediated Myocarditis ⬇️

artículo científico publicado el 9 de abril de 2012

PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria.

artículo científico publicado en 2013

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

artículo científico publicado en 2010

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

artículo científico publicado en 2010

Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand

artículo científico publicado en 2003

Paradoxical effect of reduced costimulation in T cell-mediated colitis

artículo científico publicado en 2007

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

artículo científico publicado en 2020

Physiologic Control of IDO Competence in Splenic Dendritic Cells ⬇️

artículo científico publicado el 3 de agosto de 2011

Prevention of CAR-T-cell dysfunction

scientific article published on 01 January 2020

Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.

artículo científico publicado en 2007

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

artículo científico publicado en 2010

Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity

artículo científico publicado en 2016

Progressive immune dysfunction with advancing disease stage in renal cell carcinoma

artículo científico publicado en 2021

Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice

artículo científico publicado en 2003

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses ⬇️

artículo científico publicado el 1 de octubre de 2003

Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions

scientific journal article

Role of PD-1/PD-L1 in Acute and Chronic Graft Versus Host Disease ⬇️

scholarly article

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins

artículo científico publicado en 2018

Role of the B7-CD28/CTLA-4 pathway in autoimmune disease

artículo científico publicado en 2002

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

scientific journal article

Small-molecule BCL6 inhibitor effectively treats mice with non-sclerodermatous chronic graft-versus-host disease

article

SnapShot: B7/CD28 costimulation

artículo científico publicado en 2009

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

scientific article published on 18 February 2019

Summary and Recommendations from the National Cancer Institute's Clinical Trials Planning Meeting on Novel Therapeutics for Non-Muscle Invasive Bladder Cancer ⬇️

artículo científico publicado en 2016

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

artículo científico publicado en 2016

Synergistic costimulation by both B7 molecules regulates colitis pathogenesis

artículo científico publicado en 2006

T Cell Activation Depends on Extracellular Alanine

artículo científico publicado en 2019

T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity

artículo científico publicado en 2020

T follicular regulatory cells

artículo científico publicado en 2016

T follicular regulatory cells in the regulation of B cell responses

artículo científico publicado en 2015

TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection

artículo científico publicado en 2008

Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells

artículo científico publicado en 2010

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

artículo científico publicado en 2017

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

artículo científico publicado en 2019

The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules

artículo científico publicado en 2002

The ICOS molecule plays a crucial role in the development of mucosal tolerance

scientific article published on 01 December 2005

The PD-1 pathway in tolerance and autoimmunity

artículo científico publicado en 2010

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells.

artículo científico publicado en 2015

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

artículo científico publicado en 2015

The effects of age and systemic metabolism on anti-tumor T cell responses

artículo científico publicado en 2020

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

artículo científico publicado en 2015

The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection

artículo científico publicado en 2017

The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus

scientific journal article

The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin

artículo científico publicado en 2003

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses

artículo científico publicado en 2014

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

artículo científico publicado en 2022

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer.

artículo científico publicado en 2017

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