Lista de obras - Justin Yerbury - Dominio Público Uruguay

ANS binding reveals common features of cytotoxic amyloid species

artículo científico publicado en 2010

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation

artículo científico publicado en 2017

Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue

artículo científico publicado en 2018

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.

artículo científico publicado en 2018

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

artículo científico publicado en 2016

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.

artículo científico publicado en 2017

Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding

scientific article published on January 2009

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

artículo científico publicado en 2011

Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer

artículo científico publicado en 2008

Clusterin protects neurons against intracellular proteotoxicity

artículo científico publicado en 2017

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

artículo científico publicado en 2019

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding

scientific article published on 07 December 2018

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

artículo científico publicado en 2016

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

artículo científico publicado en 2015

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

artículo científico publicado en 2019

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice.

artículo científico publicado en 2017

Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.

artículo científico publicado en 2015

Extracellular Chaperones

artículo científico publicado en 2010

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.

artículo científico publicado en 2012

Extracellular chaperones

artículo científico

Extracellular chaperones and proteostasis.

artículo científico

Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake

artículo científico publicado en 2009

Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.

artículo científico publicado en 2013

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

artículo científico publicado en 2017

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

artículo científico publicado en 2013

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.

artículo científico publicado en 2017

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

artículo científico publicado en 2014

Longitudinal assessment of metal concentrations and copper isotope ratios in the G93A SOD1 mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2017

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

scientific article published on 14 January 2014

Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans.

artículo científico publicado en 2016

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

artículo científico publicado en 2020

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A ) mouse model of amyotrophic lateral sclerosis include sex-dependent phenotypes

scientific article published on 10 September 2019

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

artículo científico publicado en 2018

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice.

scientific article published on March 2017

P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia

artículo científico publicado en 2013

P2X7 receptor antagonism in amyotrophic lateral sclerosis.

artículo científico publicado en 2017

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

artículo científico publicado en 2017

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.

artículo científico publicado en 2007

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

artículo científico publicado en 2019

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

artículo científico publicado en 2008

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

artículo científico publicado en 2013

Protein aggregates stimulate macropinocytosis facilitating their propagation

artículo científico publicado en 2016

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis

scientific article published on 14 April 2020

Quality control of protein folding in extracellular space

artículo científico publicado en 2005

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.

artículo científico publicado en 2016

Roles of Extracellular Chaperones in Amyloidosis ⬇️

artículo científico publicado el 10 de enero de 2012

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

artículo científico publicado en 2015

SOD1A4Vaggregation alters ubiquitin homeostasis in a cell model of ALS

artículo científico publicado en 2018

Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis

artículo científico publicado en 2020

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

artículo científico publicado en 2015

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

artículo científico publicado en 2017

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

artículo científico publicado en 2019

Structural characterization of clusterin-chaperone client protein complexes

artículo científico publicado en 2009

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.

artículo científico publicado en 2016

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

scientific article published on 13 March 2020

The Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase Through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt-Bridge Formation

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

artículo científico publicado en 2019

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin

scientific article published on 01 August 2005

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

artículo científico publicado en 2018

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

artículo científico publicado en 2007

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species

scientific article published on 07 March 2007

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.

artículo científico publicado en 2017

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS

artículo científico publicado en 2019

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

artículo científico publicado en 2019

The pivotal role of Ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration

artículo científico publicado en 2020

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

artículo científico publicado en 2017

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases

artículo científico publicado en 2015

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

artículo científico publicado en 2012

Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation

artículo científico publicado en 2020

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

scientific article published in Scientific Reports

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

scientific article published on 30 January 2020

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

artículo científico publicado en 2020

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

scientific article published on 18 September 2019

Walking the tightrope: proteostasis and neurodegenerative disease

artículo científico publicado en 2016

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

scientific article published on 11 December 2008

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death

artículo científico publicado en 2021

Lista de obras de Justin Yerbury

ANS binding reveals common features of cytotoxic amyloid species

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation

Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle tissue

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.

Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer

Clusterin protects neurons against intracellular proteotoxicity

Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice.

Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.

Extracellular Chaperones

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.

Extracellular chaperones

Extracellular chaperones and proteostasis.

Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake

Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis

Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles.

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

Longitudinal assessment of metal concentrations and copper isotope ratios in the G93A SOD1 mouse model of amyotrophic lateral sclerosis.

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans.

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A ) mouse model of amyotrophic lateral sclerosis include sex-dependent phenotypes

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice.

P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia

P2X7 receptor antagonism in amyotrophic lateral sclerosis.

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

Protein aggregates stimulate macropinocytosis facilitating their propagation

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis

Quality control of protein folding in extracellular space

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.

Roles of Extracellular Chaperones in Amyloidosis ⬇️

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

SOD1A4Vaggregation alters ubiquitin homeostasis in a cell model of ALS

Selenium-based compounds: Emerging players in the ever-unfolding story of SOD1 in amyotrophic lateral sclerosis

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

Structural characterization of clusterin-chaperone client protein complexes

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity.

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice

The Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase Through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt-Bridge Formation

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.

The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

The pivotal role of Ubiquitin-activating enzyme E1 (UBA1) in neuronal health and neurodegeneration

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

Walking the tightrope: proteostasis and neurodegenerative disease

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death