Lista de obras - Leemor Joshua-Tor - Dominio Público Uruguay

A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis

artículo científico publicado el 1 de octubre de 1992

A structural snapshot of base-pair opening in DNA

artículo científico publicado en 1999

A structural view of the initiators for chromosome replication

scientific article published on 12 September 2018

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails

artículo científico publicado en 2012

Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi

artículo científico publicado en 2006

Ancestral roles of small RNAs: an Ago-centric perspective

scientific article published on October 2011

Argonaute MID domain takes centre stage

artículo científico publicado en 2010

Argonaute and RNA--getting into the groove

artículo científico publicado en 2006

Argonaute slicing is required for heterochromatic silencing and spreading

artículo científico publicado en 2006

Argonaute2 is the catalytic engine of mammalian RNAi

artículo científico publicado en 2004

Argonautes confront new small RNAs

artículo científico publicado en 2007

CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing

artículo científico publicado en 2014

Chd5 requires PHD-mediated histone 3 binding for tumor suppression

scientific journal article

Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein ⬇️

artículo científico publicado el 1 de noviembre de 1992

Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum

artículo científico publicado en 1998

Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling

artículo científico publicado en 1999

Crystal structure of Argonaute and its implications for RISC slicer activity

artículo científico publicado en 2004

Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes

artículo científico publicado en 2000

Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease

artículo científico publicado en 1999

Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex

artículo científico publicado en 2002

Decoding the 5' nucleotide bias of PIWI-interacting RNAs

article

Dynamic look at DNA unwinding by a replicative helicase.

artículo científico publicado en 2014

Engineering photocycle dynamics. Crystal structures and kinetics of three photoactive yellow protein hinge-bending mutants

artículo científico publicado en 2002

Essential Dynamics from NMR Clusters: Dynamic Properties of the Myb DNA-Binding Domain and a Hinge-Bending Enhancing Variant ⬇️

artículo científico publicado el 1 de marzo de 1998

Eukaryotic Argonautes come into focus

artículo científico

Evolution of DNA replication origin specification and gene silencing mechanisms

artículo científico publicado en 2020

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.

artículo científico publicado en 2018

From guide to target: molecular insights into eukaryotic RNA-interference machinery.

artículo científico publicado en 2015

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

artículo científico publicado en 2018

High-Affinity Binding of Chp1 Chromodomain to K9 Methylated Histone H3 Is Required to Establish Centromeric Heterochromatin

artículo científico publicado en 2009

High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations

scientific article published on 10 June 2019

Mechanism of DNA translocation in a replicative hexameric helicase

artículo científico

Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway

scientific journal article

Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis

artículo científico publicado en 2017

Multivalent Recruitment of Human Argonaute by GW182.

artículo científico publicado en 2017

Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure

artículo científico publicado en 2007

NADP Regulates the Yeast GAL Induction System

artículo científico publicado en 2008

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

artículo científico publicado en 2015

Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster

artículo científico publicado en 2002

On helicases and other motor proteins

artículo científico publicado en 2008

On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme

artículo científico publicado en 2015

PTEN functions by recruitment to cytoplasmic vesicles

artículo científico publicado en 2015

Purified Argonaute2 and an siRNA form recombinant human RISC

artículo científico publicado en 2005

Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.

artículo científico publicado en 2017

Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases

artículo científico publicado en 2001

Slicer and the argonautes

artículo científico publicado en 2007

Strategies for protein coexpression in Escherichia coli

artículo científico publicado en 2006

Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum

artículo científico publicado en 2005

Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference

artículo científico publicado en 2018

Structure of the active form of human origin recognition complex and its ATPase motor module

artículo científico publicado en 2017

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution

artículo científico publicado en 2002

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 Å resolution

article by Daan M. F. van Aalten et al published 22 March 2002 in Acta Crystallographica Section D: Biological Crystallography

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

scientific article published on 31 May 2022

The Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITS

artículo científico publicado en 2011

The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding

artículo científico publicado en 2004

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation

artículo científico publicado en 2012

The Making of a Slicer: Activation of Human Argonaute-1

artículo científico publicado en 2013

The Structure of Human Argonaute-2 in Complex with miR-20a

artículo científico publicado en 2012

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

artículo científico publicado en 2003

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

artículo científico publicado en 2012

The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase

artículo científico publicado en 1998

Three-dimensional structures of bulge-containing DNA fragments

artículo científico publicado en 1992

X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus ⬇️

artículo científico publicado el 1 de noviembre de 1992

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

artículo científico publicado en 2016

siRNAs at RISC.

artículo científico publicado en 2004

Lista de obras de Leemor Joshua-Tor

A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis

A structural snapshot of base-pair opening in DNA

A structural view of the initiators for chromosome replication

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails

Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi

Ancestral roles of small RNAs: an Ago-centric perspective

Argonaute MID domain takes centre stage

Argonaute and RNA--getting into the groove

Argonaute slicing is required for heterochromatic silencing and spreading

Argonaute2 is the catalytic engine of mammalian RNAi

Argonautes confront new small RNAs

CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing

Chd5 requires PHD-mediated histone 3 binding for tumor suppression

Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein ⬇️

Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum

Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling

Crystal structure of Argonaute and its implications for RISC slicer activity

Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes

Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease

Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex

Decoding the 5' nucleotide bias of PIWI-interacting RNAs

Dynamic look at DNA unwinding by a replicative helicase.

Engineering photocycle dynamics. Crystal structures and kinetics of three photoactive yellow protein hinge-bending mutants

Essential Dynamics from NMR Clusters: Dynamic Properties of the Myb DNA-Binding Domain and a Hinge-Bending Enhancing Variant ⬇️

Eukaryotic Argonautes come into focus

Evolution of DNA replication origin specification and gene silencing mechanisms

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.

From guide to target: molecular insights into eukaryotic RNA-interference machinery.

Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development

High-Affinity Binding of Chp1 Chromodomain to K9 Methylated Histone H3 Is Required to Establish Centromeric Heterochromatin

High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations

Mechanism of DNA translocation in a replicative hexameric helicase

Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway

Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis

Multivalent Recruitment of Human Argonaute by GW182.

Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure

NADP Regulates the Yeast GAL Induction System

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster

On helicases and other motor proteins

On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme

PTEN functions by recruitment to cytoplasmic vesicles

Purified Argonaute2 and an siRNA form recombinant human RISC

Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.

Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases

Slicer and the argonautes

Strategies for protein coexpression in Escherichia coli

Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum

Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference

Structure of the active form of human origin recognition complex and its ATPase motor module

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 Å resolution

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

The Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITS

The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation

The Making of a Slicer: Activation of Human Argonaute-1

The Structure of Human Argonaute-2 in Complex with miR-20a

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase

Three-dimensional structures of bulge-containing DNA fragments

X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus ⬇️

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

siRNAs at RISC.