Lista de obras - David Lloyd - Dominio Público Uruguay

'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators.

artículo científico publicado en 2010

A topological study of prodrugs of 5-fluorouracil

artículo científico publicado en 2002

Approaches to Scaffold Hopping

artículo científico publicado en 2013

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.

artículo científico publicado en 2007

Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.

artículo científico publicado en 2012

Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM?

artículo científico publicado en 2008

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

artículo científico publicado en 2009

Consensus Computational Ligand-Based Design for the Identification of Novel Modulators of Human Estrogen Receptor Alpha

artículo científico publicado en 2012

Considerations in compound database preparation--"hidden" impact on virtual screening results.

artículo científico publicado en 2005

Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold.

artículo científico publicado en 2016

Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells.

artículo científico publicado en 2016

Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.

artículo científico publicado en 2007

Guanidinium-based derivatives: searching for new kinase inhibitors.

artículo científico publicado en 2014

Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design.

artículo científico publicado en 2011

Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds

scientific article published on 24 May 2012

Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.

artículo científico publicado en 2010

Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.

artículo científico publicado en 2010

Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.

artículo científico publicado en 2011

Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer

artículo científico publicado en 2014

Molecular topology applied to the discovery of 1-benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2H-pyrrole-5-one as a non-ligand-binding-pocket antiandrogen.

artículo científico publicado en 2014

Neutral alkaline-metal and alkaline-earth-metal derivatives of imidazole and benzimidazole

artículo científico publicado en 2014

On the effects of permuted input on conformational sampling of drug-like molecules: an evaluation of stochastic proximity embedding.

artículo científico publicado en 2007

On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.

artículo científico publicado en 2004

Oncology exploration: charting cancer medicinal chemistry space

artículo científico publicado en 2006

Permuting input for more effective sampling of 3D conformer space.

artículo científico publicado en 2006

Rational Ligand-Based Virtual Screening and Structure–Activity Relationship Studies in the Ligand-Binding Domain of the Glucocorticoid Receptor-α ⬇️

artículo científico publicado el 1 de junio de 2009

Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.

artículo científico publicado en 2014

Scaffold hopping in de novo design. Ligand generation in the absence of receptor information.

artículo científico publicado en 2004

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping

artículo científico publicado en 2007

Structure-activity relationships in non-ligand binding pocket (non-LBP) diarylhydrazide antiandrogens.

artículo científico publicado en 2013

Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II.

artículo científico publicado en 2005

Study of E/Z isomerization in a series of novel non-ligand binding pocket androgen receptor antagonists.

artículo científico publicado en 2012

Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.

artículo científico publicado en 2010

Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents

artículo científico publicado en 2009

Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.

artículo científico publicado en 2011

Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.

artículo científico publicado en 2008

Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones.

artículo científico publicado en 2011

Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators.

artículo científico publicado en 2005

The effect of tightly bound water molecules on the structural interpretation of ligand-derived pharmacophore models.

artículo científico publicado en 2004

The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.

artículo científico publicado en 2010

Theoretical studies of parent 1-, 2-, 3-pyrazolines and their methylated derivatives

Unbiasing scoring functions: a new normalization and rescoring strategy

artículo científico publicado en 2007

Virtual screening of the estrogen receptor.

artículo científico publicado en 2008

Lista de obras de David Lloyd

'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators.

A topological study of prodrugs of 5-fluorouracil

Approaches to Scaffold Hopping

Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells.

Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.

Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM?

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

Consensus Computational Ligand-Based Design for the Identification of Novel Modulators of Human Estrogen Receptor Alpha

Considerations in compound database preparation--"hidden" impact on virtual screening results.

Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold.

Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells.

Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives.

Guanidinium-based derivatives: searching for new kinase inhibitors.

Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design.

Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds

Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.

Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.

Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.

Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer

Molecular topology applied to the discovery of 1-benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2H-pyrrole-5-one as a non-ligand-binding-pocket antiandrogen.

Neutral alkaline-metal and alkaline-earth-metal derivatives of imidazole and benzimidazole

On the effects of permuted input on conformational sampling of drug-like molecules: an evaluation of stochastic proximity embedding.

On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa.

Oncology exploration: charting cancer medicinal chemistry space

Permuting input for more effective sampling of 3D conformer space.

Rational Ligand-Based Virtual Screening and Structure–Activity Relationship Studies in the Ligand-Binding Domain of the Glucocorticoid Receptor-α ⬇️

Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.

Scaffold hopping in de novo design. Ligand generation in the absence of receptor information.

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping

Structure-activity relationships in non-ligand binding pocket (non-LBP) diarylhydrazide antiandrogens.

Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II.

Study of E/Z isomerization in a series of novel non-ligand binding pocket androgen receptor antagonists.

Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.

Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents

Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe.

Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators.

Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones.

Synthesis, structure-activity relationships and antagonistic effects in human MCF-7 breast cancer cells of flexible estrogen receptor modulators.

The effect of tightly bound water molecules on the structural interpretation of ligand-derived pharmacophore models.

The vascular targeting agent combretastatin-A4 and a novel cis-Restricted {beta}-Lactam Analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance.

Theoretical studies of parent 1-, 2-, 3-pyrazolines and their methylated derivatives

Unbiasing scoring functions: a new normalization and rescoring strategy

Virtual screening of the estrogen receptor.