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Lista de obras de Kristian Helin

A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

artículo científico publicado en 2019

A New Role for the Polycomb Group Protein Ezh1 in Promoting Transcription

artículo científico publicado en 2012

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

artículo científico publicado en 1992

A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene.

artículo científico publicado en 1995

A dual program for translation regulation in cellular proliferation and differentiation

artículo científico publicado en 2014

A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation

artículo científico publicado en 2010

A model for transmission of the H3K27me3 epigenetic mark

artículo científico publicado en 2008

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

artículo científico publicado en 2016

A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

artículo científico publicado en 2004

A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1

scientific journal article

A role for the transcription factor HEY1 in glioblastoma

artículo científico publicado en 2008

A screen identifies the oncogenic micro-RNA miR-378a-5p as a negative regulator of oncogene-induced senescence

artículo científico publicado en 2014

A single amino acid substitution is sufficient to modify the mitogenic properties of the epidermal growth factor receptor to resemble that of gp185erbB-2

artículo científico publicado en 1992

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

artículo científico publicado en 2001

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors

artículo científico publicado en 2009

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.

artículo científico publicado en 2018

Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein

artículo científico publicado en 1999

Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity

scientific article published on 10 December 2018

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

artículo científico publicado en 2004

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

artículo científico publicado en 1995

An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene

artículo científico publicado en 1995

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1

artículo científico publicado en 1993

Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus

artículo científico publicado en 2008

Apaf-1 is a transcriptional target for E2F and p53

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

artículo científico publicado en 1997

Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes

artículo científico publicado en 2011

BLUEPRINT to decode the epigenetic signature written in blood.

artículo científico publicado en 2012

BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers

artículo científico publicado en 2019

Bricks & Mortar

scientific article published in Nature

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

artículo científico publicado en 2007

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

artículo científico publicado en 1999

CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression

artículo científico publicado en 2013

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site

artículo científico publicado en 1995

Cell cycle, differentiation and disease

artículo científico publicado en 2013

Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

artículo científico publicado en 2000

Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

artículo científico publicado en 1998

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription

artículo científico publicado en 2005

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

artículo científico publicado en 2010

Chromatin proteins and modifications as drug targets

artículo científico publicado en 2013

Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells

artículo científico publicado en 2011

Chromatin repressive complexes in stem cells, development, and cancer

artículo científico publicado en 2014

Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

artículo científico publicado en 2021

Concurrent neutral endopeptidase and ACE inhibition in experimental heart failure: renal and hormonal effects

artículo científico publicado en 1993

Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS.

artículo científico publicado en 2005

Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development ⬇️

artículo científico publicado en 2016

Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2

artículo científico publicado en 2008

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

artículo científico publicado en 1997

DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function

artículo científico publicado en 2008

DNA methylation: TET proteins-guardians of CpG islands?

artículo científico publicado en 2011

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

artículo científico publicado en 2016

DcE2F, a functional plant E2F-like transcriptional activator from Daucus carota

artículo científico publicado en 2000

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

artículo científico publicado en 2005

Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

artículo científico publicado en 1996

E2F Family Members Are Differentially Regulated by Reversible Acetylation

scientific article published in Journal of Biological Chemistry

E2F activates late-G1 events but cannot replace E1A in inducing S phase in terminally differentiated skeletal muscle cells

artículo científico publicado en 1999

E2F target genes: unraveling the biology

artículo científico publicado en 2004

E2F-1-induced p53-independent apoptosis in transgenic mice.

artículo científico publicado en 1998

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

artículo científico publicado en 1998

E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer

artículo científico publicado en 2006

E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression

artículo científico publicado en 2000

E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells

artículo científico publicado en 2007

E2F1 is crucial for E2F-dependent apoptosis

artículo científico publicado en 2005

E2F1-mediated transcriptional inhibition of the plasminogen activator inhibitor type 1 gene

artículo científico publicado en 2001

E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

artículo científico publicado en 2003

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

artículo científico

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice

artículo científico publicado en 2017

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

artículo científico publicado en 2017

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

artículo científico publicado en 2003

Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5.

artículo científico publicado en 2015

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation

artículo científico publicado en 2018

Epigenetic control of embryonic stem cell fate

artículo científico publicado en 2010

Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2.

artículo científico publicado en 2009

Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.

artículo científico publicado en 2015

Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation

artículo científico publicado en 2013

FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

scientific article published on 16 February 2014

Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer

artículo científico publicado en 2014

G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter.

artículo científico publicado en 1994

Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication

artículo científico publicado en 2013

Geminin: a major DNA replication safeguard in higher eukaryotes

artículo científico publicado en 2004

Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide

artículo científico publicado en 2014

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

artículo científico publicado en 2006

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

scientific article published on 05 July 2013

H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans

artículo científico publicado en 2015

H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway

artículo científico publicado en 2022

HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases

artículo científico publicado en 2018

HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity

artículo científico publicado en 2006

Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein

artículo científico publicado en 1994

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

artículo científico publicado en 1993

Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation

artículo científico publicado en 2013

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

scientific article published on 01 December 2019

Histone demethylases in development and disease ⬇️

artículo científico publicado el 20 de septiembre de 2010

Histone lysine demethylases as targets for anticancer therapy

artículo científico publicado en 2013

Histone methyltransferases in cancer

artículo científico publicado en 2010

Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase

artículo científico publicado en 2008

Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F

artículo científico publicado en 2007

Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis

artículo científico publicado en 2004

Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins

artículo científico publicado en 2012

Identification of catechols as histone-lysine demethylase inhibitors

artículo científico publicado en 2012

Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary

artículo científico publicado en 2020

Identification of target genes of the p16INK4A-pRB-E2F pathway.

artículo científico publicado en 2003

Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

artículo científico publicado en 1993

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

artículo científico publicado en 1997

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization ⬇️

artículo científico publicado el 1 de septiembre de 1997

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

artículo científico publicado en 1993

Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy

artículo científico publicado en 2013

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

artículo científico publicado en 1993

Inhibition of demethylases by GSK-J1/J4.

artículo científico publicado en 2014

Inhibition of in vitro myogenic differentiation by cellular transcription factor E2F1.

artículo científico publicado en 1995

Inhibitors of histone demethylases

scientific article published on February 2011

Isolation and characterization of DUSP11, a novel p53 target gene

artículo científico publicado en 2009

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

artículo científico publicado en 2010

Jarid1b targets genes regulating development and is involved in neural differentiation

artículo científico publicado en 2011

Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome

scientific article published on 01 January 2014

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

artículo científico publicado en 2016

Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells

artículo científico publicado en 2016

KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes

scientific article published on 30 March 2020

Loss of Geminin induces rereplication in the presence of functional p53

artículo científico publicado en 2004

Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways

artículo científico publicado en 2004

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

artículo científico publicado en 2015

Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinoma

artículo científico publicado en 1997

MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma

artículo científico publicado en 2011

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

artículo científico publicado en 2001

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer

artículo científico publicado en 2016

Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development

artículo científico publicado en 2017

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

artículo científico publicado en 2002

Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms

artículo científico publicado en 2005

Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones

artículo científico publicado en 2014

Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation

scientific article published on 01 April 2019

Molecular mechanisms and potential functions of histone demethylases

artículo científico

Molecular mechanisms and potential functions of histone demethylases

Molecular mechanisms in gliomagenesis

artículo científico publicado en 2005

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors ⬇️

artículo científico publicado el 25 de abril de 1992

Mutant FOXL2C134W highjacks SMAD4 and SMAD2/3 to drive adult granulosa cell tumors

artículo científico publicado en 2020

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

artículo científico publicado en 2009

NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling

artículo científico publicado en 2010

NPAT expression is regulated by E2F and is essential for cell cycle progression

artículo científico publicado en 2003

Naturally death-resistant precursor cells revealed as the origin of retinoblastoma

artículo científico publicado en 2004

Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity

scientific article published on 11 September 2019

Nucleocytoplasmic shuttling of transcription factors

artículo científico publicado en 2000

Nucleophosmin is required for DNA integrity and p19Arf protein stability

scientific journal article

OVCA1: emerging as a bona fide tumor suppressor

artículo científico publicado en 2004

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression

artículo científico publicado en 2016

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

artículo científico publicado en 2019

PR-DUB maintains expression of critical genes through FOXK1/2 and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination

artículo científico publicado en 2020

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

artículo científico publicado en 2014

PRMT5 inhibition modulates E2F1 methylation and gene regulatory networks leading to therapeutic efficacy in JAK2V617F mutant MPN

artículo científico publicado en 2020

PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia

scientific article published on 14 October 2019

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

artículo científico publicado en 2013

Phosphorylation of a specific cdk site in E2F-1 affects its electrophoretic mobility and promotes pRB-binding in vitro

artículo científico

Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

artículo científico publicado en 1999

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.

artículo científico publicado en 2013

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

artículo científico publicado en 2008

Polycomb complexes act redundantly to repress genomic repeats and genes

artículo científico publicado en 2010

Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation

artículo científico publicado en 2010

Polycomb group protein-mediated repression of transcription

artículo científico publicado en 2010

Polycomb group proteins in cell cycle progression and cancer.

artículo científico publicado en 2004

Polycomb group proteins: navigators of lineage pathways led astray in cancer

artículo científico publicado en 2009

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

artículo científico publicado en 2014

Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins

artículo científico publicado en 1994

Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS.

artículo científico publicado en 2013

Profiling cancer

artículo científico publicado en 2003

Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF

scientific article published on 01 December 2019

Quantification of differential transcription factor activity and multiomics-based classification into activators and repressors: diffTF

Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36

artículo científico publicado en 2010

RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3

artículo científico publicado en 2007

RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo

artículo científico publicado en 2015

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

artículo científico publicado en 2013

Reduced hepatic tumor incidence in cyclin G1-deficient mice

artículo científico publicado en 2003

Regional tumour glutamine supply affects chromatin and cell identity

artículo científico publicado en 2016

Regulation of cell proliferation by the E2F transcription factors ⬇️

artículo científico publicado el 1 de febrero de 1998

Regulation of stem cell differentiation by histone methyltransferases and demethylases

artículo científico publicado en 2008

Revolution in the Polycomb hierarchy

artículo científico publicado en 2014

Role of TET enzymes in DNA methylation, development, and cancer

artículo científico publicado en 2016

Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer

artículo científico publicado en 2016

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

artículo científico publicado en 2007

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation ⬇️

artículo científico publicado en 2011

SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance

artículo científico publicado en 2015

Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

artículo científico publicado en 2012

Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

artículo científico publicado en 2002

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

artículo científico publicado en 2004

Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation

artículo científico publicado en 2016

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

scientific journal article

TET1: an epigenetic guardian of lymphomagenesis

artículo científico publicado en 2015

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

artículo científico publicado en 2019

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

artículo científico publicado en 2014

TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis

artículo científico publicado en 2021

Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells

artículo científico publicado en 2013

Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells

artículo científico publicado en 2012

The E2F family: specific functions and overlapping interests

artículo científico publicado en 2004

The E2F transcription factors: key regulators of cell proliferation

artículo científico publicado en 2000

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

artículo científico publicado en 2009

The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma

artículo científico publicado en 2011

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

scientific article published on 21 August 2019

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis

scientific article published on 28 July 2019

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

artículo científico publicado en 2007

The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity

artículo científico publicado en 2021

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation

article

The biological activity of the human epidermal growth factor receptor is positively regulated by its C-terminal tyrosines

artículo científico publicado en 1991

The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

scientific article published on 27 March 2019

The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development

artículo científico publicado en 2014

The emerging functions of histone demethylases

artículo científico publicado en 2008

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3

artículo científico publicado en 2013

The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal in mice

artículo científico publicado en 2015

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase

artículo científico publicado en 2018

The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia

artículo científico publicado en 2013

The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner

artículo científico publicado en 2014

The histone methyltransferase SET8 is required for S-phase progression

artículo científico publicado en 2007

The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors

artículo científico publicado en 2011

The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence

artículo científico publicado en 2015

The p53 tumour suppressor protein

artículo científico publicado en 2000

The polycomb group protein Suz12 is required for embryonic stem cell differentiation

artículo científico publicado en 2007

The polycomb repressive complex 2 is a potential target of SUMO modifications

artículo científico publicado en 2008

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

artículo científico publicado en 1998

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

artículo científico publicado en 2006

The regulation of APAF1 expression during development and tumourigenesis

artículo científico publicado en 2002

The retinoblastoma protein as a transcriptional repressor

artículo científico publicado en 1993

The role of p53 and pRB in apoptosis and cancer

artículo científico publicado en 2002

The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1.

artículo científico publicado en 2009

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

artículo científico publicado en 2005

Transcriptional regulation by Polycomb group proteins

artículo científico

Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.

artículo científico publicado en 1988

Transmembrane signalling at the epidermal growth factor receptor. Positive regulation by the C-terminal phosphotyrosine residues

artículo científico publicado en 1991

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

artículo científico publicado en 2015

Tumor suppressors: from genes to function and possible therapies

article

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

artículo científico publicado en 2007

Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells

artículo científico publicado en 2013

Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells

artículo científico publicado en 2013

ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells

artículo científico publicado en 2016

[Basic stem cell biology and cancer]

artículo científico publicado en 2010

erbB-2 autophosphorylation is required for mitogenic action and high-affinity substrate coupling.

artículo científico publicado en 1992

p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression

artículo científico publicado en 1997

shRNA screening identifies JMJD1C as being required for leukemia maintenance

artículo científico publicado en 2014

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