Lista de obras - Andres Merits - Dominio Público Uruguay

A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells.

artículo científico publicado en 2018

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach

artículo científico publicado en 2017

A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents

artículo científico publicado en 2018

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

artículo científico publicado en 2016

A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice

artículo científico publicado en 2012

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

article published in the Proceedings of the National Academy of Sciences of the United States of America

Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products.

artículo científico publicado en 2016

Antigenic Variation of East/Central/South African and Asian Chikungunya Virus Genotypes in Neutralization by Immune Sera

artículo científico publicado en 2016

Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs

artículo científico publicado en 2010

Antiviral activity of silymarin against chikungunya virus

artículo científico publicado en 2015

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus

artículo científico publicado en 2017

Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection

artículo científico publicado en 2015

Biochemical and Genetic Evidence for Interactions between Potato A Potyvirus-Encoded Proteins P1 and P3 and Proteins of the Putative Replication Complex

article

Biological, Serological, and Molecular Differences Among Isolates of Potato A Potyvirus

article by M Rajamäki et al published April 1998 in Phytopathology

Cell-to-Cell Spread of the RNA Interference Response Suppresses Semliki Forest Virus (SFV) Infection of Mosquito Cell Cultures and Cannot Be Antagonized by SFV

artículo científico publicado en 2009

Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication

artículo científico publicado en 2014

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells ⬇️

artículo científico publicado en 2017

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

artículo científico publicado en 2017

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.

artículo científico publicado en 2016

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo.

artículo científico publicado en 2013

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

artículo científico publicado en 2017

Cis-acting sequences and secondary structures in untranslated regions of duck Tembusu virus RNA are important for cap-independent translation and viral proliferation

artículo científico publicado en 2020

Comparison of the complete sequences of five different isolates of Potato virus A (PVA), genus Potyvirus.

artículo científico publicado en 1999

Comparison of the nucleotide sequences of the 3'-terminal regions of one aphid and two non-aphid transmissible isolates of potato A potyvirus

artículo científico publicado en 1996

Complex formation between hepatitis C virus NS2 and NS3 proteins

artículo científico publicado en 2005

Construction, properties, and potential application of infectious plasmids containing Semliki Forest virus full-length cDNA with an inserted intron

artículo científico publicado en 2007

Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences

artículo científico publicado en 2013

Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2.

artículo científico publicado en 2016

Cross-utilisation of template RNAs by alphavirus replicases

scientific article published on 04 September 2020

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

artículo científico publicado en 2022

DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost

artículo científico publicado en 2018

Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection

artículo científico publicado en 2017

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

artículo científico publicado en 2018

Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

scientific article published on 28 August 2019

Design and Validation of Novel Chikungunya Virus Protease Inhibitors

artículo científico publicado en 2016

Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.

artículo científico publicado en 2016

Detection of Persistent Chikungunya Virus RNA but not Infectious Virus in Experimental Vertical Transmission in Aedes aegypti from Malaysia

artículo científico publicado en 2015

Development of a luciferase-based system for the detection of ZnT8 autoantibodies

artículo científico publicado en 2014

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

artículo científico publicado en 2017

Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research ⬇️

artículo científico publicado en 2017

Expanding the activity spectrum of antiviral agents

scientific article published on 10 April 2019

Fingolimod treatment abrogates chikungunya virus–induced arthralgia

artículo científico publicado en 2017

Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity

artículo científico publicado en 2014

Glycosylation of phytepsin and expression of dad1 , dad2 and ost1 during onset of cell death in germinating barley scutella

artículo científico publicado en 2000

ICTV Virus Taxonomy Profile: Togaviridae.

artículo científico publicado en 2018

Identification of Alphavirus Inhibitors by Using Virus-Based Assays and a Chikungunya Replicon Cell Line

artículo científico publicado en 2011

Identification of Natural Molecular Determinants of Ross River Virus Type I Interferon Modulation

artículo científico publicado en 2020

Identification of a Novel Function of theAlphavirusCapping Apparatus

artículo científico publicado en 2000

Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis

artículo científico publicado en 2006

Identification of the genome-linked protein in virions of Potato virus A, with comparison to other members in genus Potyvirus.

artículo científico publicado en 2001

Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking

artículo científico

Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.

artículo científico publicado en 2016

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

artículo científico publicado en 2011

Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus

artículo científico publicado en 2007

Inter-domain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

artículo científico publicado en 2020

Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations

artículo científico publicado en 2014

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018

artículo científico publicado en 2019

Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein

artículo científico publicado en 2011

Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus

artículo científico publicado en 2013

Modulation of Aire regulates the expression of tissue-restricted antigens

scientific journal article

Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.

artículo científico publicado en 2008

Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease

artículo científico publicado en 2006

Mouse macrophage innate immune response to Chikungunya virus infection

artículo científico publicado en 2012

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

artículo científico publicado en 2019

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus.

artículo científico publicado en 2018

Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design

artículo científico publicado en 2017

Mutations at the palmitoylation site of non-structural protein nsP1 of Semliki Forest virus attenuate virus replication and cause accumulation of compensatory mutations

artículo científico publicado en 2007

Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2

artículo científico publicado en 2015

Mutations in the nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest virus

artículo científico publicado en 2008

Neurons and oligodendrocytes in the mouse brain differ in their ability to replicate Semliki Forest virus

artículo científico publicado en 2008

Novel activities of safe-in-human broad-spectrum antiviral agents.

artículo científico publicado en 2018

Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice

artículo científico publicado en 2013

Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region

artículo científico publicado en 2009

Novel vectors expressing anti-apoptotic protein Bcl-2 to study cell death in Semliki Forest virus-infected cells

artículo científico publicado en 2007

Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells

artículo científico publicado en 2011

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments

artículo científico publicado en 2016

Palmitoylated cysteines in Chikungunya virus nsP1 are critical for targeting to cholesterol-rich plasma membrane microdomains with functional consequences for viral genome replication

artículo científico publicado en 2020

Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

artículo científico publicado en 2017

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 ⬇️

artículo científico publicado en 2018

Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus

artículo científico publicado en 2012

Poly(A) Addition Site Mapping and Polyadenylation Signal Analysis in a Plant Circovirus Replication-Related Gene

artículo científico publicado en 1995

Polypurine (A)-rich sequences promote cross-kingdom conservation of internal ribosome entry

artículo científico publicado en 2002

Presentation overrides specificity: probing the plasticity of alphaviral proteolytic activity through mutational analysis

artículo científico publicado en 2013

Prime-boost immunization strategies against Chikungunya virus

artículo científico publicado en 2014

Properly folded nonstructural polyprotein directs the semliki forest virus replication complex to the endosomal compartment

artículo científico publicado en 2003

Properties and use of novel replication-competent vectors based on Semliki Forest virus

artículo científico publicado en 2009

Properties of non-structural protein 1 of Semliki Forest virus and its interference with virus replication

artículo científico publicado en 2008

RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication

artículo científico publicado en 2013

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications

artículo científico publicado en 2015

Regulation of -1 ribosomal frameshifting directed by cocksfoot mottle sobemovirus genome

artículo científico publicado en 2000

Regulation of the sequential processing of Semliki Forest virus replicase polyprotein

artículo científico publicado en 2003

Reverse genetic system, genetically stable reporter viruses and packaged subgenomic replicon based on a Brazilian Zika virus isolate

artículo científico publicado en 2017

Role of the Amphipathic Peptide of Semliki Forest Virus Replicase Protein nsP1 in Membrane Association and Virus Replication

artículo científico publicado en 2007

SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts ⬇️

artículo científico

SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy ⬇️

artículo científico publicado en 2017

Safe and Effective Treatment of Experimental Neuroblastoma and Glioblastoma Using Systemically Delivered Triple MicroRNA-Detargeted Oncolytic Semliki Forest Virus

artículo científico publicado en 2016

Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots

artículo científico publicado en 2021

Semliki Forest virus strongly reduces mosquito host defence signaling

artículo científico publicado en 2008

Semliki forest virus-induced endoplasmic reticulum stress accelerates apoptotic death of mammalian cells

artículo científico publicado en 2010

Sensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein Processing

scientific article published on 17 March 2020

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection

artículo científico publicado en 2012

Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells

artículo científico publicado en 2018

Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication

artículo científico publicado en 2015

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

scientific article published on 18 April 2019

Synthesis and biological activity of bimorpholine and its carbanucleoside

artículo científico publicado en 2011

Synthesis of novel acyclic nucleoside analogues with anti-retroviral activity

artículo científico publicado en 2010

The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling

artículo científico publicado en 2016

The Dimeric Peptide (KKYRYHLKPF)2K Shows Broad-Spectrum Antiviral Activity by Inhibiting Different Steps of Chikungunya and Zika Virus Infection

artículo científico publicado en 2023

The first nonmammalian pegivirus demonstrates efficient in vitro replication and high lymphotropism

scientific article published on 05 August 2020

The host DHX9 DExH Box helicase is recruited to Chikungunya virus replication complexes for optimal genomic RNA translation

artículo científico publicado en 2018

The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication

artículo científico publicado en 2014

The infection of mammalian and insect cells with SFV bearing nsP1 palmitoylation mutations

artículo científico publicado en 2010

The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation

artículo científico publicado en 2004

The type I interferon system protects mice from Semliki Forest virus by preventing widespread virus dissemination in extraneural tissues, but does not mediate the restricted replication of avirulent virus in central nervous system neurons

artículo científico publicado en 2007

Therapeutics and vaccines against chikungunya virus

artículo científico

Timeliness of proteolytic events is prerequisite for efficient functioning of the alphaviral replicase.

artículo científico publicado en 2018

Transfection of infectious RNA and DNA/RNA layered vectors of semliki forest virus by the cell-penetrating peptide based reagent PepFect6.

artículo científico publicado en 2013

Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses

artículo científico publicado en 2015

Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development

artículo científico publicado en 2014

Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein

artículo científico publicado en 2016

Viperin restricts chikungunya virus replication and pathology

artículo científico publicado en 2012

Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion

artículo científico publicado en 2015

Virus replicon particle based Chikungunya virus neutralization assay using Gaussia luciferase as readout

artículo científico publicado en 2013

Virus-Specific mRNA Capping Enzyme Encoded by Hepatitis E Virus

Virus-specific mRNA capping enzyme encoded by hepatitis E virus

artículo científico publicado en 2001

Lista de obras de Andres Merits

A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells.

A Sensitive Method for Detecting Zika Virus Antigen in Patients' Whole-Blood Specimens as an Alternative Diagnostic Approach

A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Antibacterial activity of the nitrovinylfuran G1 (Furvina) and its conversion products.

Antigenic Variation of East/Central/South African and Asian Chikungunya Virus Genotypes in Neutralization by Immune Sera

Antiviral RNA interference responses induced by Semliki Forest virus infection of mosquito cells: characterization, origin, and frequency-dependent functions of virus-derived small interfering RNAs

Antiviral activity of silymarin against chikungunya virus

Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus

Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection

Biochemical and Genetic Evidence for Interactions between Potato A Potyvirus-Encoded Proteins P1 and P3 and Proteins of the Putative Replication Complex

Biological, Serological, and Molecular Differences Among Isolates of Potato A Potyvirus

Cell-to-Cell Spread of the RNA Interference Response Suppresses Semliki Forest Virus (SFV) Infection of Mosquito Cell Cultures and Cannot Be Antagonized by SFV

Characterization of Aedes aegypti innate-immune pathways that limit Chikungunya virus replication

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells ⬇️

Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.

Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo.

Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen

Cis-acting sequences and secondary structures in untranslated regions of duck Tembusu virus RNA are important for cap-independent translation and viral proliferation

Comparison of the complete sequences of five different isolates of Potato virus A (PVA), genus Potyvirus.

Comparison of the nucleotide sequences of the 3'-terminal regions of one aphid and two non-aphid transmissible isolates of potato A potyvirus

Complex formation between hepatitis C virus NS2 and NS3 proteins

Construction, properties, and potential application of infectious plasmids containing Semliki Forest virus full-length cDNA with an inserted intron

Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences

Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2.

Cross-utilisation of template RNAs by alphavirus replicases

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

DNA-launched RNA replicon vaccines induce potent anti-Ebolavirus immune responses that can be further improved by a recombinant MVA boost

Deciphering the potential of baicalin as an antiviral agent for Chikungunya virus infection

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

Design and Validation of Novel Chikungunya Virus Protease Inhibitors

Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Detection of Persistent Chikungunya Virus RNA but not Infectious Virus in Experimental Vertical Transmission in Aedes aegypti from Malaysia

Development of a luciferase-based system for the detection of ZnT8 autoantibodies

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research ⬇️

Expanding the activity spectrum of antiviral agents

Fingolimod treatment abrogates chikungunya virus–induced arthralgia

Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity

Glycosylation of phytepsin and expression of dad1 , dad2 and ost1 during onset of cell death in germinating barley scutella

ICTV Virus Taxonomy Profile: Togaviridae.

Identification of Alphavirus Inhibitors by Using Virus-Based Assays and a Chikungunya Replicon Cell Line

Identification of Natural Molecular Determinants of Ross River Virus Type I Interferon Modulation

Identification of a Novel Function of theAlphavirusCapping Apparatus

Identification of mutations causing temperature-sensitive defects in Semliki Forest virus RNA synthesis

Identification of the genome-linked protein in virions of Potato virus A, with comparison to other members in genus Potyvirus.

Imipramine Inhibits Chikungunya Virus Replication in Human Skin Fibroblasts through Interference with Intracellular Cholesterol Trafficking

Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus

Inter-domain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

Kinetic and phenotypic analysis of CD8+ T cell responses after priming with alphavirus replicons and homologous or heterologous booster immunizations

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018

Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein

Magnetic fractionation and proteomic dissection of cellular organelles occupied by the late replication complexes of Semliki Forest virus

Modulation of Aire regulates the expression of tissue-restricted antigens

Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.

Molecular determinants of substrate specificity for Semliki Forest virus nonstructural protease

Mouse macrophage innate immune response to Chikungunya virus infection

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus.

Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design

Mutations at the palmitoylation site of non-structural protein nsP1 of Semliki Forest virus attenuate virus replication and cause accumulation of compensatory mutations

Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2

Mutations in the nuclear localization signal of nsP2 influencing RNA synthesis, protein expression and cytotoxicity of Semliki Forest virus

Neurons and oligodendrocytes in the mouse brain differ in their ability to replicate Semliki Forest virus

Novel activities of safe-in-human broad-spectrum antiviral agents.

Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice

Novel functions of the alphavirus nonstructural protein nsP3 C-terminal region

Novel vectors expressing anti-apoptotic protein Bcl-2 to study cell death in Semliki Forest virus-infected cells

Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells

Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments

Palmitoylated cysteines in Chikungunya virus nsP1 are critical for targeting to cholesterol-rich plasma membrane microdomains with functional consequences for viral genome replication

Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 ⬇️