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Lista de obras de Kang-Yell Choi

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

artículo científico publicado en 2020

A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog

scientific article published on 19 February 2020

A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer

scientific article published in Scientific Reports

A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both β-Catenin and RAS

scientific article published on 08 April 2019

A mutant KRAS-induced factor REG4 promotes cancer stem cell properties via Wnt/β-catenin signaling

artículo científico publicado en 2019

A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

scholarly article by Sang-Kyu Lee published in November 2018

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

scientific journal article

APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer

artículo científico publicado en 2020

Activation of protein kinase C by 1-beta-D-arabinofuranosylcytosine conjugates of phospholipid.

artículo científico publicado en 2004

Akt is involved in the inhibition of cell proliferation by EGF.

artículo científico publicado en 2007

Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin.

artículo científico publicado en 2007

Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway

scientific journal article

Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation

artículo científico publicado en 2004

CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation

artículo científico publicado en 2013

CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

artículo científico publicado en 2019

CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation

artículo científico publicado en 2015

Caffeic acid phenethyl ester downregulates phospholipase D1 via direct binding and inhibition of NFκB transactivation

artículo científico publicado en 2013

Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: effect of p53.

artículo científico publicado en 2006

Co‐treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis ⬇️

artículo científico publicado el 1 de junio de 2012

Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5.

artículo científico publicado en 2016

Design, synthesis and biological evaluation of novel aliphatic amido/sulfonamido-quaternary ammonium salts as antitumor agents ⬇️

artículo científico publicado el 1 de febrero de 2013

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer

scientific article published on 26 May 2020

Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells

artículo científico publicado en 2002

Discovery of a small-molecule inhibitor of Dvl-CXXC5 interaction by computational approaches

artículo científico publicado en 2018

Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells

artículo científico publicado en 2004

Drosophila extracellular signal-regulated kinase involves the insulin-mediated proliferation of Schneider cells

artículo científico publicado en 2002

EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation

artículo científico publicado en 2007

ERK activation is involved in tooth development via FGF10 signaling.

artículo científico publicado en 2009

Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/β-catenin pathway activation

artículo científico publicado en 2015

Feature genes of hepatitis B virus-positive hepatocellular carcinoma, established by its molecular discrimination approach using prediction analysis of microarray

artículo científico publicado en 2004

H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation

artículo científico publicado en 2009

Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling ⬇️

artículo científico publicado el 21 de septiembre de 2012

House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/Akt pathway

artículo científico publicado en 2013

Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice

artículo científico publicado en 2014

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

artículo científico publicado en 2018

Identification of small-molecule compounds targeting the dishevelled PDZ domain by virtual screening and binding studies.

artículo científico publicado en 2016

Indirubin-3'-oxime reverses bone loss in ovariectomized and hindlimb-unloaded mice via activation of the Wnt/β-catenin signaling

artículo científico publicado en 2014

Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway

artículo científico publicado en 2019

Indirubin-3'-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice

artículo científico publicado en 2014

Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells

artículo científico publicado en 2014

Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway

artículo científico publicado en 2018

Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis

artículo científico publicado en 2009

Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis

artículo científico publicado en 2018

Isolation and Maintenance of Cortical Neural Progenitor Cells In Vitro ⬇️

artículo científico publicado el 1 de enero de 2013

Isolation and characterization of a Drosophila homologue of mitogen-activated protein kinase phosphatase-3 which has a high substrate specificity towards extracellular-signal-regulated kinase ⬇️

artículo científico publicado el 1 de enero de 2002

K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

artículo científico publicado en 2015

KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.

artículo científico publicado en 2012

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

artículo científico publicado en 2016

MEK1/2 Inhibitors AS703026 and AZD6244 May Be Potential Therapies for KRAS Mutated Colorectal Cancer That Is Resistant to EGFR Monoclonal Antibody Therapy ⬇️

artículo científico publicado el 30 de noviembre de 2010

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment

artículo científico publicado en 2022

MicroRNA-320a and microRNA-4496 attenuate Helicobacter pylori cytotoxin-associated gene A (CagA)-induced cancer-initiating potential and chemoresistance by targeting β-catenin and ATP-binding cassette, subfamily G, member 2.

artículo científico publicado en 2016

N-Formyl-Methionyl-Leucyl-Phenylalanine (fMLP) Promotes Osteoblast Differentiation via the N-Formyl Peptide Receptor 1-mediated Signaling Pathway in Human Mesenchymal Stem Cells from Bone Marrow ⬇️

artículo científico publicado el 3 de marzo de 2011

N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation ⬇️

artículo científico publicado el 15 de agosto de 2011

NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway

artículo científico publicado en 2008

PLD1 and PLD2 differentially regulate the balance of macrophage polarization in inflammation and tissue injury

artículo científico publicado en 2020

Persicaria hydropiper (L.) Spach and its Flavonoid Components, Isoquercitrin and Isorhamnetin, Activate the Wnt/β‐catenin Pathway and Inhibit Adipocyte Differentiation of 3T3‐L1 Cells ⬇️

artículo científico publicado el 17 de marzo de 2011

Phospholipase D Meets Wnt Signaling: A New Target for Cancer Therapy ⬇️

artículo científico publicado el 11 de enero de 2011

Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells ⬇️

artículo científico publicado el 30 de agosto de 2013

Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells

artículo científico publicado en 2016

Phospholipase D1 Has a Pivotal Role in Interleukin-1β-Driven Chronic Autoimmune Arthritis through Regulation of NF-κB, Hypoxia-Inducible Factor 1α, and FoxO3a ⬇️

artículo científico publicado el 20 de mayo de 2013

Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/β-Catenin and PI3K/Akt Signaling

artículo científico publicado en 2017

Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis

artículo científico publicado en 2010

Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability

artículo científico publicado en 2014

Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity

artículo científico publicado en 2015

Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing

artículo científico publicado en 2016

Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1.

artículo científico publicado en 2009

Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis ⬇️

artículo científico publicado el 10 de abril de 2012

Rebamipide attenuates Helicobacter pylori CagA-induced self-renewal capacity via modulation of β-catenin signaling axis in gastric cancer-initiating cells

artículo científico publicado en 2016

Regulation of Drosophila MKP-3 by Drosophila ERK.

artículo científico

Response

artículo científico publicado en 2014

Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development

artículo científico publicado en 2016

Retinyl retinoate induces hyaluronan production and less irritation than other retinoids

artículo científico publicado en 2010

Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling.

artículo científico publicado en 2014

Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer

scientific article published on 29 July 2016

Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy

artículo científico publicado en 2016

Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

scientific article published on 06 March 2020

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation

artículo científico publicado en 2016

Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells

artículo científico publicado en 2017

Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer

artículo científico publicado en 2014

Sur8 mediates tumorigenesis and metastasis in colorectal cancer

scientific article published on 29 July 2016

Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling.

artículo científico

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

artículo científico publicado en 2015

Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis

artículo científico publicado en 2017

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells

artículo científico publicado en 2015

Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway

artículo científico

Temporal cDNA microarray analysis of gene expression in human hepatocellular carcinoma upon radiation exposure.

artículo científico publicado en 2006

The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing

artículo científico publicado en 2015

The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc

artículo científico publicado en 2003

The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.

artículo científico publicado en 2015

Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK

artículo científico publicado en 2005

Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells

artículo científico publicado en 2002

Valproic Acid Induces Cutaneous Wound Healing In Vivo and Enhances Keratinocyte Motility ⬇️

artículo científico publicado el 7 de noviembre de 2012

Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells ⬇️

artículo científico publicado el 10 de abril de 2012

Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway

artículo científico publicado en 2008

WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

artículo científico publicado en 2019

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

artículo científico publicado en 2019

Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/beta-catenin and protein kinase Calpha.

artículo científico publicado en 2008

beta-Catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances

artículo científico publicado en 2005

β-Catenin-RAS interaction serves as a molecular switch for RAS degradation via GSK3β

artículo científico publicado en 2018

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