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Lista de obras de Takashi Sugimura

A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP.

artículo científico publicado en 2002

Analysis of HPRT and supF mutations caused by pierisin-1, a guanine specific ADP-ribosylating toxin derived from the cabbage butterfly

artículo científico publicado en 2003

Analysis of an RNA adduct formed from aminophenylnorharman

artículo científico publicado en 2009

Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines

artículo científico publicado en 2010

Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly

artículo científico publicado en 2002

Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice

artículo científico publicado en 2003

Carcinogenicity of Food Mutagens

artículo científico publicado en 1996

Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats

artículo científico publicado en 2004

Causal relationship between the loss of RUNX3 expression and gastric cancer

scientific journal article

Characterization of Dysplastic Aberrant Crypt Foci in the Rat Colon Induced by 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine ⬇️

artículo científico publicado el 1 de octubre de 2003

Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, against PhIP-induced mammary carcinogenesis.

artículo científico publicado en 2002

Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection.

artículo científico publicado en 2004

Cloning of the 5' upstream region of the rat p16 gene and its role in silencing

artículo científico publicado en 2002

Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice

artículo científico publicado en 2003

Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.

artículo científico publicado en 2003

Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice

artículo científico publicado en 2005

Decreased expression of the seven ARP2/3 complex genes in human gastric cancers

artículo científico publicado en 2004

Decreased fidelity in replicating CpG methylation patterns in cancer cells.

artículo científico publicado en 2005

Demonstration of Cytotoxicity against Wasps by Pierisin-1: A Possible Defense Factor in the Cabbage White Butterfly ⬇️

artículo científico publicado el 23 de abril de 2013

Destruction of quadruplex by proteins, and its biological implications in replication and telomere maintenance ⬇️

artículo científico publicado el 1 de enero de 2003

Detection of aminophenylnorharman, a possible endogenous mutagenic and carcinogenic compound, in human urine samples

artículo científico publicado en 2007

Detection of endogenous DNA adducts, O-carboxymethyl-2'-deoxyguanosine and 3-ethanesulfonic acid-2'-deoxycytidine, in the rat stomach after duodenal reflux

artículo científico publicado en 2008

Developmental stage-specific expression and tissue distribution of pierisin-1, a guanine-specific ADP-ribosylating toxin, in Pieris rapae

artículo científico publicado en 2004

Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays

artículo científico

Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat.

artículo científico publicado en 2003

Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats

artículo científico publicado en 2005

Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae

artículo científico publicado en 2008

Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand.

artículo científico publicado en 2003

Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet ⬇️

artículo científico publicado el 1 de enero de 2002

Enhanced thyroid carcinogenicity of N-nitrosobis(2-oxopropyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model of type II diabetes mellitus

artículo científico publicado en 2007

Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl)amine-treated hamsters by high-fat diet.

artículo científico publicado en 2011

Enhancement of colon carcinogenesis by prostaglandin E2 administration

artículo científico publicado en 2003

Enzymatic properties of pierisin-1 and its N-terminal domain, a guanine-specific ADP-ribosyltransferase from the cabbage butterfly

artículo científico publicado en 2004

Establishment of a detection system for demethylating agents using an endogenous promoter CpG island.

artículo científico publicado en 2004

Etiology-specific gene expression profiles in rat mammary carcinomas.

artículo científico publicado en 2002

Fidelity of the methylation pattern and its variation in the genome.

artículo científico publicado en 2003

Food and cancer

artículo científico publicado en 2002

Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers--possible mechanistic differences from microsatellite instability in cancer cells

artículo científico publicado en 2002

Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation.

artículo científico publicado en 2004

Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors

artículo científico publicado en 2005

Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems

artículo científico publicado en 2009

Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays.

artículo científico publicado en 2003

Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

artículo científico publicado en 2004

Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish

artículo científico publicado en 2004

High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk.

artículo científico publicado en 2006

High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-Ay mice.

artículo científico publicado en 2010

Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers

artículo científico publicado en 2006

Identification of 20 genes aberrantly methylated in human breast cancers

artículo científico publicado en 2005

Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers

artículo científico publicado en 2004

Identification of a new mutagenic polychlorinated biphenyl derivative in the Waka River, Wakayama, Japan, showing activation of an aryl hydrocarbon receptor-dependent transcription

artículo científico publicado en 2002

Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline

artículo científico publicado en 2004

Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly

artículo científico publicado en 2003

Identification of silencing of nine genes in human gastric cancers.

artículo científico publicado en 2002

Imaging study of pancreatic ductal adenocarcinomas in Syrian hamsters using X-ray micro-computed tomography (CT).

artículo científico publicado en 2010

Improvement of hyperlipidemia by indomethacin in Min mice

artículo científico

In vitro and in vivo formation of aminophenylnorharman from norharman and aniline

artículo científico publicado en 2002

Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor.

artículo científico publicado en 2008

Induction of glandular stomach cancers in Helicobacter pylori-infected Mongolian gerbils by 1-nitrosoindole-3-acetonitrile

artículo científico publicado en 2011

Induction of intestinal tumors and lymphomas in C57BL/6N mice by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

artículo científico publicado en 2002

Induction of multinucleated cells and apoptosis in the PC-3 prostate cancer cell line by low concentrations of polyethylene glycol 1000.

artículo científico publicado en 2008

Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea

artículo científico publicado en 2006

Inhibition of intestinal polyp formation by pitavastatin, a HMG-CoA reductase inhibitor

artículo científico publicado en 2011

Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis

artículo científico publicado en 2002

Insertional mutation of the Attractin gene in the black tremor hamster

artículo científico publicado en 2002

Involvement of nucleotide excision repair (NER) system in repair of mono ADP-ribosylated dG adducts produced by pierisin-1, a cytotoxic protein from cabbage butterfly

artículo científico publicado en 2005

Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

artículo científico publicado en 2002

Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.

artículo científico publicado en 2006

LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1

scientific journal article

LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo

artículo científico publicado en 2004

Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged.

artículo científico publicado en 2005

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

article

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

artículo científico publicado en 2007

Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice.

artículo científico publicado en 2011

Lysyl oxidase is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers.

artículo científico publicado en 2004

Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins

artículo científico publicado en 2006

Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers

artículo científico publicado en 2003

Modification of the 32P-postlabeling method to detect a single adduct species as a single spot

scientific article published on 01 January 2005

Modification of the ³²P-postlabeling method to detect a single adduct species as a single spot

artículo científico publicado en 2014

Molecular cloning of apoptosis-inducing Pierisin-like proteins, from two species of white butterfly, Pieris melete and Aporia crataegi

artículo científico publicado en 2009

Molecular evidence of the involvement of the nucleotide excision repair (NER) system in the repair of the mono(ADP-ribosyl)ated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from the cabbage butterfly.

artículo científico publicado en 2007

Mono(ADP-ribosyl)ation of DNA by apoptosis-inducing protein, pierisin

scientific article published on 01 January 2002

Mono(ADP-ribosyl)ation of the N2 amino groups of guanine residues in DNA by pierisin-2, from the cabbage butterfly, Pieris brassicae

artículo científico publicado en 2004

Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis

artículo científico publicado en 2007

Nucleotide sequence and chromosomal localization of the gene for pierisin-1, a DNA ADP-ribosylating protein, in the cabbage butterfly Pieris rapae ⬇️

artículo científico publicado el 12 de enero de 2012

Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.

artículo científico publicado en 2008

Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice.

artículo científico publicado en 2009

Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent

artículo científico publicado en 2005

Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice

artículo científico publicado en 2005

Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts

artículo científico publicado en 2005

Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane

artículo científico publicado en 2003

Past victories, uncertainty, and reflections on the present and progress in the future

artículo científico publicado en 1998

Periodic analysis of urethane-induced pulmonary tumors in living A/J mice by respiration-gated X-ray microcomputed tomography

artículo científico publicado en 2008

Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers

artículo científico publicado en 2004

Persistence of pierisin-1 activities in the adult cabbage white butterfly, Pieris rapae, during storage after killing

artículo científico publicado en 2007

Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism

artículo científico publicado en 2007

Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice

scientific journal article

Poly(ADP‐ribose) and carcinogenesis ⬇️

artículo científico publicado el 1 de diciembre de 2003

Possible involvement of hyperlipidemia in increasing risk of colorectal tumor development in human familial adenomatous polyposis

artículo científico publicado en 2006

Preventive effects of Cladosiphon fucoidan against Helicobacter pylori infection in Mongolian gerbils

scientific article published on 01 February 2003

Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility

scientific journal article

Promoter hypermethylation and post-transcriptional mechanisms for reduced BRCA1 immunoreactivity in sporadic human breast cancers

artículo científico publicado en 2002

Promoter methylation profiling of 30 genes in human malignant melanoma.

artículo científico publicado en 2004

Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil.

artículo científico publicado en 2008

Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis

artículo científico publicado en 2005

Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development

artículo científico publicado en 2004

Purification and molecular cloning of a DNA ADP-ribosylating protein, CARP-1, from the edible clam Meretrix lamarckii

artículo científico publicado en 2006

Reduced Brca1 protein expression in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinomas

artículo científico publicado en 2002

Reduced expression of GNA11 and silencing of MCT1 in human breast cancers

artículo científico publicado en 2003

Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers

artículo científico publicado en 2002

Reply to Letter from Dr. Tokudome.

artículo científico publicado en 1989

Report of the 16th International Symposium of the Foundation for Promotion of Cancer Research: Recent advances in pancreatic cancer

artículo científico publicado en 2003

Report of the fifteenth international symposium of the foundation for promotion of cancer research: new horizons in the diagnosis and treatment of hematological malignancies based on molecular genetic features

artículo científico publicado en 2002

Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age.

artículo científico publicado en 2009

SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis

artículo científico publicado en 2007

STRUCTURE AND CHEMICAL SYNTHESIS OF ME-IQ, A POTENT MUTAGEN ISOLATED FROM BROILED FISH

article

STRUCTURE OF A POTENT MUTAGEN ISOLATED FROM FRIED BEEF

Silencing of the thrombomodulin gene in human malignant melanoma

artículo científico publicado en 2005

Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis?

artículo científico publicado en 2002

Spontaneous mutations in the Helicobacter pylori rpsL gene

artículo científico publicado en 2003

Structure of DNA adduct formed with aminophenylnorharman, being responsible for the comutagenic action of norharman with aniline

artículo científico publicado en 2002

Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates

artículo científico publicado en 2005

Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats

artículo científico publicado en 2002

Suppression of Helicobacter pylori-induced gastritis by green tea extract in Mongolian gerbils.

artículo científico publicado en 2003

Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor gamma

artículo científico publicado en 2007

Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac

scientific article published on 01 October 2006

Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist

artículo científico publicado en 2005

Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats.

artículo científico publicado en 2006

Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells.

artículo científico publicado en 2002

Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis

artículo científico publicado en 2005

Suppressive effects of garlic extract on Helicobacter pylori-induced gastritis in Mongolian gerbils

artículo científico publicado en 2002

Takashi Tsuruo

artículo científico publicado en 2009

The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions

artículo científico publicado en 2002

The principles of cancer treatment--changes in chemotherapy

artículo científico publicado en 2002

Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells

scientific journal article

Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus

scientific article published on 23 July 2009

Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1.

artículo científico publicado en 2002

Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers.

artículo científico publicado en 2005

Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas

artículo científico publicado en 2005

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