"Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".
artículo científico publicado en 2014
'Flooding' of the lungs and severe dyspnea in a patient with bronchoalveolar carcinoma
scientific article published on 01 March 2010
2',3'-dideoxyinosine (ddI): its chemical stability and cyclodextrin complexation in aqueous media
scientific article published on 01 June 1993
2-Hydroxypropyl-beta-cyclodextrin extracts 2-phenylphenol from silicone tubing
artículo científico publicado en 2004
32P-postlabeling assay for the quantification of the major platinum-DNA adducts
artículo científico publicado en 1999
A Phase 1 Dose-Escalation Study of Low-Dose Metronomic Treatment With Novel Oral Paclitaxel Formulations in Combination With Ritonavir in Patients With Advanced Solid Tumors
artículo científico publicado en 2020
A Phase I Dose Escalation Study of Once-Weekly Oral Administration of Docetaxel as ModraDoc001 Capsule or ModraDoc006 Tablet in Combination with Ritonavir
scientific article published on 19 June 2019
A Phase I and pharmacological study of the platinum polymer AP5280 given as an intravenous infusion once every 3 weeks in patients with solid tumors
scientific article published on 01 May 2004
A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent.
artículo científico publicado en 2004
A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development
artículo científico publicado en 2019
A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia
scientific article published on 01 February 2020
A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum.
artículo científico publicado en 2012
A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion
artículo científico publicado en 2001
A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy
artículo científico publicado en 2018
A cost analysis study of the implementation of fixed-dosing of monoclonal antibodies in the Netherlands Cancer Institute
scientific article published on 10 September 2020
A dose-dependent delayed hypersensitivity reaction to acetaminophen after repeated acetaminophen intoxications
scientific article published on 01 July 1998
A dose-escalation study of bi-daily once weekly oral docetaxel either as ModraDoc001 or ModraDoc006 combined with ritonavir
artículo científico publicado en 2017
A dose-escalation study of indisulam in combination with capecitabine (Xeloda) in patients with solid tumours
artículo científico publicado en 2008
A kinetic study of the chemical stability of the antimetastatic ruthenium complex NAMI-A.
artículo científico publicado en 2002
A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2010
A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide
artículo científico publicado en 2001
A model of hypertension and proteinuria in cancer patients treated with the anti-angiogenic drug E7080
artículo científico publicado en 2010
A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.
artículo científico publicado en 2004
A multi-gram-scale stereoselective synthesis of Z -endoxifen
scholarly article by Lech-Gustav Milroy published in May 2018
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma
artículo científico publicado en 2010
A novel self-microemulsifying formulation of paclitaxel for oral administration to patients with advanced cancer
artículo científico publicado en 2006
A phase 0 clinical trial of novel candidate extended-release formulations of capecitabine
artículo científico publicado en 2016
A phase 1 comparative pharmacokinetic and cardiac safety study of two intravenous formulations of CO-101 in patients with advanced solid tumors
artículo científico publicado en 2013
A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin
artículo científico publicado en 2002
A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies
artículo científico publicado en 2002
A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours
artículo científico publicado en 2012
A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors
artículo científico publicado en 2002
A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients
scientific article published on 01 June 2007
A poor-quality generic drug for the treatment of visceral leishmaniasis: a case report and appeal
artículo científico publicado en 2012
A population pharmacokinetic model for Cremophor EL using nonlinear mixed-effect modeling: model building and validation.
artículo científico publicado en 2002
A population pharmacokinetic model for paclitaxel in the presence of a novel P-gp modulator, Zosuquidar Trihydrochloride (LY335979)
artículo científico publicado en 2003
A prospective case series of women with estrogen receptor-positive breast cancer: levels of tamoxifen metabolites in controlled ovarian stimulation with high-dose tamoxifen
artículo científico publicado en 2013
A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer
artículo científico publicado en 2004
A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors
artículo científico publicado en 2006
A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices
artículo científico publicado en 2020
A semi-physiological population pharmacokinetic model describing the non-linear disposition of indisulam
artículo científico publicado en 2006
A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma
artículo científico publicado en 2010
A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry
artículo científico publicado en 2008
A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry
scientific article published on 31 August 2011
A simple and safe method for 131I radiolabeling of rituximab for myeloablative high-dose radioimmunotherapy
artículo científico publicado en 2009
A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry
artículo científico publicado en 2006
A simple and sensitive assay for the quantitative analysis of rivastigmine and its metabolite NAP 226-90 in human EDTA plasma using coupled liquid chromatography and tandem mass spectrometry
artículo científico publicado en 2006
A systematic study on the chemical stability of mitomycin A and mitomycin B
artículo científico publicado en 1986
A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry
artículo científico publicado en 2009
ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation
scientific article published on 30 January 2019
ABCB1 Attenuates the Brain Penetration of the PARP Inhibitor AZD2461
artículo científico publicado en 2018
ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
artículo científico publicado en 2015
ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients
artículo científico publicado en 2006
ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy
artículo científico publicado en 2014
ABCC2, ABCC3, and ABCB1, but not CYP3A, Protect against Trabectedin-Mediated Hepatotoxicity
artículo científico publicado en 2009
ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors
artículo científico publicado en 2017
Abcc4 together with abcb1 and abcg2 form a robust cooperative drug efflux system that restricts the brain entry of camptothecin analogues
artículo científico publicado en 2013
Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents
artículo científico publicado en 2010
Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity
artículo científico publicado en 2009
Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry
artículo científico publicado en 2006
Accuracy, feasibility, and clinical impact of prospective Bayesian pharmacokinetically guided dosing of cyclophosphamide, thiotepa, and carboplatin in high-dose chemotherapy
artículo científico publicado en 2005
Acute poisoning after oral intake of a toluene-containing paint thinner
artículo científico publicado en 2002
Age-Associated Hematological Toxicity in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Docetaxel in Clinical Practice
artículo científico publicado en 2019
Allometric scaling of pegylated liposomal anticancer drugs
artículo científico publicado en 2011
Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency
artículo científico publicado en 2008
Amyloid beta protein and tau in cerebrospinal fluid and plasma as biomarkers for dementia: a review of recent literature
artículo científico publicado en 2008
An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential.
artículo científico publicado en 2018
An Antiestrogenic Activity Score for tamoxifen and its metabolites is associated with breast cancer outcome.
artículo científico publicado en 2016
An LC-MS/MS method for quantification of the active abiraterone metabolite Δ(4)-abiraterone (D4A) in human plasma
artículo científico publicado en 2017
An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients
artículo científico publicado en 2002
An integrated pharmacokinetic model for the influence of CYP3A4 expression on the in vivo disposition of lopinavir and its modulation by ritonavir
artículo científico publicado en 2010
An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment
scientific article published on 03 September 2008
Analysis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Its Phase I and Phase II Metabolites in Mouse Urine Using LC–UV–MS–MS
Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction
scientific article published on 01 June 1998
Analysis of diacetylmorphine, caffeine, and degradation products after volatilization of pharmaceutical heroin for inhalation
artículo científico publicado en 2006
Analysis of ifosforamide mustard, the active metabolite of ifosfamide, in plasma
artículo científico publicado en 1996
Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography
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artículo científico publicado el 19 de mayo de 1995
Antidrug Antibody Formation in Oncology: Clinical Relevance and Challenges
artículo científico publicado en 2016
Antiviral activity of HIV type 1 protease inhibitors nelfinavir and indinavir in vivo is not influenced by P-glycoprotein activity on CD4+ T cells.
artículo científico publicado en 2007
Application of PET/CT in the development of novel anticancer drugs
artículo científico publicado en 2008
Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.
artículo científico publicado en 2009
Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.
artículo científico publicado en 2008
Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates
artículo científico publicado en 2011
Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism
artículo científico publicado en 2005
Are adverse events of nevirapine and efavirenz related to plasma concentrations?
artículo científico publicado en 2005
Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir
artículo científico publicado en 2003
Assessment of performance of manufacturing procedures in a unit for production of investigational anticancer agents, using a mixed effects analysis
artículo científico publicado en 2007
Automated synthesis and quality control of [99mTc]Tc-PSMA for radioguided surgery (in a [68Ga]Ga-PSMA workflow)
artículo científico publicado en 2020
BRAF Mutations as Predictive Biomarker for Response to Anti-EGFR Monoclonal Antibodies
artículo científico publicado en 2017
Baclofen overdose treated with continuous venovenous hemofiltration
artículo científico publicado en 2015
Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.
artículo científico publicado en 2004
Bayesian pharmacokinetics of lithium after an acute self-intoxication and subsequent haemodialysis: a case report
artículo científico publicado en 2002
Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
artículo científico publicado en 2013
Bevacizumab
artículo científico publicado en 2010
Bevacizumab combined with docetaxel, oxaliplatin, and capecitabine, followed by maintenance with capecitabine and bevacizumab, as first-line treatment of patients with advanced HER2-negative gastric cancer: A multicenter phase 2 study.
artículo científico publicado en 2016
Bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug LL-D49194 alpha 1
scientific article published on 01 January 1989
Bio-analysis of N-(deacetyl-O-4-vinblastoyl-23)-L-ethyl isoleucinate, methane sulphonate (VileE) by high-performance liquid chromatography with fluorescence detection
scientific article published on 01 January 1990
Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction
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artículo científico publicado el 15 de agosto de 1997
Bio-analysis of vinorelbine by high-performance liquid chromatography with fluorescence detection
artículo científico publicado en 1992
Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry
scientific article published on 10 September 2019
Bioanalysis of aplidine, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography after derivatization with trans-4-hydrazino-2-stilbazole
artículo científico publicado en 1999
Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry
scientific article published on 11 May 2018
Bioanalysis of m-iodobenzylguanidine in plasma by high-performance liquid chromatography after derivatization with benzoin
artículo científico publicado en 1999
Bioanalysis of the investigational anti-tumour drug 5,10-dideaza-5,6,7,8-tetrahydrofolic acid by high-performance liquid chromatography with ultraviolet detection
artículo científico publicado el 15 de abril de 1992
Bioanalysis of the novel peptide anticancer drug kahalalide F in human plasma by h.p.l.c. under basic conditions coupled with positive turbo-ionspray tandem mass spectrometry.
artículo científico publicado en 2002
Bioanalysis of thiocoraline, a new marine antitumoral depsipeptide, in plasma by high-performance liquid chromatography and fluorescence detection
artículo científico publicado en 1999
Bioanalytical Issues in Patient-Friendly Sampling Methods for Therapeutic Drug Monitoring: Focus on Antiretroviral Drugs
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artículo científico publicado el 1 de octubre de 2009
Bioanalytical LC-MS/MS validation of therapeutic drug monitoring assays in oncology
artículo científico publicado en 2019
Bioanalytical aspects of clinical mass balance studies in oncology
artículo científico
Bioanalytical assay for the new-generation ROS1/TRK/ALK inhibitor repotrectinib in mouse plasma and tissue homogenate using liquid chromatography-tandem mass spectrometry
scientific article published on 01 April 2020
Bioanalytical assay for the novel TRK inhibitor selitrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry
scientific article published on 27 May 2019
Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry.
artículo científico publicado en 2018
Bioanalytical liquid chromatography-tandem mass spectrometric assay for the quantification of the ALK inhibitors alectinib, brigatinib and lorlatinib in plasma and mouse tissue homogenates
scientific article published on 19 August 2018
Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence
artículo científico publicado en 2020
Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review
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artículo científico publicado el 15 de octubre de 2010
Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies
artículo científico publicado en 2009
Bioavailability of oral etoposide in gastric cancer
artículo científico publicado en 1994
Biodetermination of N-(deacetyl-O-4-vinblastoyl-23)-L-tryptophan, a metabolite of vintriptol, by high-performance liquid chromatography with fluorescence detection
scientific article published on 01 February 1992
Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer.
artículo científico publicado en 2013
Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).
artículo científico publicado en 2009
Blood-brain barrier and chemotherapeutic treatment of brain tumors
artículo científico publicado en 2006
Bottom-up sample preparation for the LC-MS/MS quantification of anti-cancer monoclonal antibodies in bio matrices
scientific article published on 25 September 2020
Brain Accumulation of Ponatinib and Its Active Metabolite, N-Desmethyl Ponatinib, Is Limited by P-Glycoprotein (P-GP/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2).
artículo científico publicado en 2017
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment
artículo científico publicado en 2009
Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)
scientific article published on 05 June 2019
Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
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artículo científico publicado el 7 de abril de 2011
Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2).
artículo científico publicado en 2015
Brain accumulation of tivozanib is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) in mice
scientific article published on 28 March 2020
Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1).
artículo científico publicado en 2015
Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) restrict oral availability and brain accumulation of the PARP inhibitor rucaparib (AG-014699).
artículo científico publicado en 2014
Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation
artículo científico publicado en 2017
Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation
artículo científico publicado en 2010
Buparlisib is a brain penetrable pan-PI3K inhibitor
artículo científico publicado en 2018
CD20 antigen imaging with ¹²⁴I-rituximab PET/CT in patients with rheumatoid arthritis
artículo científico publicado en 2011
CMET-12. TUMOR CELL DETECTION BY IMMUNOFLOW CYTOMETRY AND BRAF MUTATION ANALYSIS IN CEREBROSPINAL FLUID OF MELANOMA PATIENTS WITH SUSPECTED LEPTOMENINGEAL METASTASES.
artículo científico publicado en 2017
CRC/EORTC/NCI Joint Formulation Working Party: experiences in the formulation of investigational cytotoxic drugs
artículo científico publicado en 1995
CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity
scientific article published on 01 May 2007
Cannulation of the jugular vein in mice
artículo científico publicado en 2005
Capecitabine induces severe angina-like chest pain
artículo científico publicado en 2004
Carbamazepine induces bioactivation of cyclophosphamide and thiotepa
artículo científico publicado en 2008
Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?
artículo científico publicado en 2008
Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice
scientific article published on 12 April 2006
Case series of acute hepatitis in a non-selected group of HIV-infected patients on nevirapine-containing antiretroviral treatment
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artículo científico publicado el 17 de octubre de 2003
Cellular and clinical pharmacology of the taxanes docetaxel and paclitaxel--a review
artículo científico
Changes in under-treatment after comprehensive geriatric assessment: an observational study
artículo científico publicado en 2010
Characterization and identification of suspected counterfeit miltefosine capsules
scientific article published on 18 January 2012
Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor
artículo científico publicado en 2010
Characterizing the non-linear pharmacokinetics of miltefosine in paediatric visceral leishmaniasis patients from Eastern Africa
artículo científico publicado en 2020
Chemical and enzymatic stability of a cyclic depsipeptide, the novel, marine-derived, anti-cancer agent kahalalide F.
artículo científico publicado en 2001
Chemical stability of suramin in commonly used infusion fluids
Chemical stability of the new antitumour agent intoplicine in infusion fluids
artículo científico publicado en 1993
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option
artículo científico publicado en 2014
Chromatographic analysis of the enantiomers of ifosfamide and some of its metabolites in plasma and urine
scientific article published on 01 March 1997
Chromatographic bioanalytical assays for targeted covalent kinase inhibitors and their metabolites
artículo científico publicado en 2020
Chronic hepatotoxicity after long-term antiretroviral treatment including nevirapine
artículo científico publicado en 2005
Ciprofloxacin strongly inhibits clozapine metabolism: two case reports
artículo científico publicado en 2009
Circulating epithelial tumor cell analysis in CSF in patients with leptomeningeal metastases
scientific article published on 06 January 2020
Circulating tumor cells as pharmacodynamic biomarker in early clinical oncological trials
scientific article published on 17 May 2011
Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
artículo científico publicado en 2001
Clinical Pharmacokinetics and Pharmacodynamics of Pazopanib: Towards Optimized Dosing
artículo científico publicado en 2017
Clinical Pharmacokinetics of Systemically Administered Antileishmanial Drugs.
artículo científico publicado en 2017
Clinical Pharmacokinetics of Vemurafenib in BRAF-Mutated Melanoma Patients
artículo científico publicado en 2016
Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function
artículo científico publicado en 2006
Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors
artículo científico publicado en 2008
Clinical evaluation of the determination of plasma concentrations of darunavir, etravirine, raltegravir and ritonavir in dried blood spot samples
artículo científico publicado en 2011
Clinical experience with aurora kinase inhibitors: a review
scientific article published on 14 August 2009
Clinical pharmacokinetics of an amorphous solid dispersion tablet of elacridar
artículo científico publicado en 2016
Clinical pharmacokinetics of camptothecin topoisomerase I inhibitors
scientific article published on 01 August 1998
Clinical pharmacokinetics of cyclophosphamide
artículo científico publicado en 2005
Clinical pharmacokinetics of therapeutic monoclonal antibodies
artículo científico publicado en 2010
Clinical pharmacokinetics of topotecan
artículo científico publicado en 1996
Clinical pharmacokinetics, pharmacodynamics and metabolism of the novel matrix metalloproteinase inhibitor ABT-518
artículo científico publicado en 2002
Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study
artículo científico publicado en 2002
Clinical proteomics in breast cancer: a review
artículo científico publicado en 2008
Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry
artículo científico publicado en 2006
Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data
artículo científico publicado en 2015
Clinical research on antiangiogenic therapy
artículo científico publicado en 1998
Clinical trial simulations in paediatric oncology: A feasibility study from the Innovative Therapies for Children with Cancer Consortium.
artículo científico publicado en 2017
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients
artículo científico publicado en 2001
Co-administration of cyclosporin enables oral therapy with paclitaxel
article by J M Meerum Terwogt et al published 1 July 1998 in The Lancet
Co-trimoxazole and stavudine interference in a high-performance liquid chromatographic analysis for didanosine in human plasma
scientific article published on 01 December 1998
Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel
artículo científico publicado en 2001
Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.
artículo científico publicado en 2009
Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer
artículo científico publicado en 2008
Combined dapsone and clofazimine intoxication
artículo científico publicado en 1996
Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.
artículo científico publicado en 2013
Combining Isotopic Tracer Techniques to Increase Efficiency of Clinical Pharmacokinetic Trials in Oncology
artículo científico publicado en 2020
Commentary: Substandard medicines are the priority for neglected tropical diseases
artículo científico publicado en 2012
Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein
artículo científico publicado en 1999
Comparing the old and new generation SELDI-TOF MS: implications for serum protein profiling
artículo científico publicado en 2008
Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spectrometry data
artículo científico publicado en 2008
Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction.
artículo científico publicado en 2008
Compatibility and stability of Imexon in infusion devices and its in vitro biocompatibility
artículo científico publicado en 2005
Compatibility and stability of aplidine, a novel marine-derived depsipeptide antitumor agent, in infusion devices, and its hemolytic and precipitation potential upon i.v. administration
artículo científico publicado en 1999
Compatibility and stability of the novel anti-cancer agent C1311 in infusion devices and its in vitro biocompatibility
artículo científico publicado en 2005
Complement activation by PEGylated liposomes containing prednisolone
artículo científico publicado en 2013
Complexation study of the anticancer agent EO-9 with 2-hydroxypropyl-beta-cyclodextrin
artículo científico publicado en 2008
Concentrations of Erlotinib in Tumor Tissue and Plasma in Non-Small-Cell Lung Cancer Patients After Neoadjuvant Therapy.
artículo científico publicado en 2014
Concise drug review: azacitidine and decitabine
artículo científico publicado en 2013
Concise drug review: pazopanib and axitinib
artículo científico publicado en 2012
Concise overview of the clinical pharmacokinetics of dideoxynucleoside antiretroviral agents
artículo científico publicado en 1995
Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein).
artículo científico publicado en 2007
Concomitant intake of abiraterone acetate and food to increase pharmacokinetic exposure: real life data from a therapeutic drug monitoring programme
artículo científico publicado en 2020
Contraindications for anticoagulation in older patients with atrial fibrillation; a narrative review
artículo científico publicado en 2010
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
artículo científico publicado en 2015
Correction of peripheral blood mononuclear cell cytosolic protein for hemoglobin contamination
artículo científico publicado en 2013
Correction to: Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients
artículo científico publicado en 2017
Correction to: Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization
artículo científico publicado en 2020
Corrigendum to "Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine" [J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 893-894 (2012) 92-100]
artículo científico publicado en 2016
Corrigendum to "Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy".
artículo científico publicado en 2015
Cost-effectiveness of monitoring endoxifen levels in breast cancer patients adjuvantly treated with tamoxifen.
artículo científico publicado en 2018
Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression
artículo científico publicado en 2009
Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol) and carboplatin in non-small cell lung cancer patients
artículo científico publicado en 2000
Crizotinib-induced fatal fulminant liver failure
artículo científico publicado en 2015
Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa).
artículo científico publicado en 2005
Cyclodextrin as membrane protectant in spray-drying and freeze-drying of PEGylated liposomes
artículo científico publicado en 2012
Cyclosporine-induced anaphylaxis
scientific article published on 01 July 2000
Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes
scientific article published on 15 July 2019
Cytoreductive surgery and intraoperative hyperthermic intraperitoneal chemotherapy with paclitaxel: a clinical and pharmacokinetic study
artículo científico publicado en 2008
Cytotoxicity of the organic ruthenium anticancer drug Nami-A is correlated with DNA binding in four different human tumor cell lines
artículo científico publicado en 2004
DNA repair mechanisms involved in gemcitabine cytotoxicity and in the interaction between gemcitabine and cisplatin
artículo científico publicado en 2003
DNA tattoo vaccination: effect on plasmid purity and transfection efficiency of different topoisoforms
artículo científico publicado en 2009
DNA vaccination in oncology: current status, opportunities and perspectives
artículo científico publicado en 2010
DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis
artículo científico publicado en 2018
DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update
artículo científico publicado en 2017
Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study.
artículo científico publicado en 2012
Degradation kinetics of antagonist [Arg6, D-Trp7,9, MePhe8]-substance P [6-11] in aqueous solutions
scientific article published in 1995
Degradation kinetics of aplidine, a new marine antitumoural cyclic peptide, in aqueous solution.
artículo científico publicado en 2001
Degradation kinetics of three gonadorelin analogues: developing a method for calculating epimerization parameters
artículo científico publicado en 1998
Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?
artículo científico publicado en 2011
Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation.
artículo científico publicado en 2014
Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error
artículo científico publicado en 2014
Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk
artículo científico publicado en 2008
Detection of breast cancer by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry tissue and serum protein profiling
artículo científico publicado en 2009
Detection of single nucleotide polymorphisms in the ABCG2 gene in a Dutch population
artículo científico publicado en 2005
Determinants of the elimination of methotrexate and 7-hydroxy-methotrexate following high-dose infusional therapy to cancer patients.
artículo científico publicado en 2006
Determination of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of 3'-azido-3'-deoxythymidine, in human plasma by ion-pair high-performance liquid chromatography
artículo científico publicado en 1993
Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection
artículo científico publicado en 2002
Determination of N,N',N"-triethylenethiophosphoramide and its active metabolite N,N',N"-triethylenephosphoramide in plasma and urine using capillary gas chromatography
scientific article published on 01 November 1998
Determination of NVP-BEZ235, a dual PI3K and mTOR inhibitor, in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography with fluorescence detection
artículo científico publicado en 2012
Determination of Platinum Originating from Carboplatin in Human Urine and Canine Excretion Products by Inductively Coupled Plasma Mass Spectrometry
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artículo científico publicado el 1 de abril de 2011
Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma
artículo científico publicado en 1993
Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography
artículo científico publicado en 1998
Determination of ifosfamide, 2- and 3-dechloroethyifosfamide using gas chromatography with nitrogen-phosphorus or mass spectrometry detection
scientific article published on 01 October 2000
Determination of imatinib mesylate and its main metabolite (CGP74588) in human plasma and murine specimens by ion-pairing reversed-phase high-performance liquid chromatography
artículo científico publicado en 2007
Determination of intoplicine, a new antitumour drug, in human faeces by normal-phase high-performance liquid chromatography with fluorescence detection
artículo científico publicado en 1993
Determination of intoplicine, a new antitumour drug, in human whole blood and plasma by normal-phase high-performance liquid chromatography with fluorescence detection
scientific article published on 01 May 1993
Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry
artículo científico publicado en 2005
Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase high-performance liquid chromatography
artículo científico publicado en 1995
Determination of pamidronate in urine by ion-pair liquid chromatography after derivatization with 1-naphthylisothiocyanate
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artículo científico publicado el 15 de agosto de 1997
Determination of platinum originating from carboplatin in canine sebum and cerumen by inductively coupled plasma mass spectrometry
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artículo científico publicado el 17 de septiembre de 2010
Determination of platinum surface contamination in veterinary and human oncology centres using inductively coupled plasma mass spectrometry
artículo científico publicado en 2013
Determination of polyoxyethyleneglycerol triricinoleate 35 (Cremophor EL) in plasma by pre-column derivatization and reversed-phase high-performance liquid chromatography
scientific article published on 01 June 1996
Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry
artículo científico publicado en 2007
Determination of saquinavir in human plasma, saliva, and cerebrospinal fluid by ion-pair high-performance liquid chromatography with ultraviolet detection
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artículo científico publicado el 26 de septiembre de 1997
Determination of stavudine, a new antiretroviral agent, in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection
artículo científico publicado el 23 de diciembre de 1992
Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient
scientific article published on 01 October 2011
Determination of tamoxifen and endoxifen in dried blood spots using LC-MS/MS and the effect of coated DBS cards on recovery and matrix effects.
artículo científico publicado en 2014
Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose
scientific article published on 19 May 2020
Determination of the absolute oral bioavailability of niraparib by simultaneous administration of a 14C-microtracer and therapeutic dose in cancer patients.
artículo científico publicado en 2017
Determination of topotecan in human and mouse plasma and in mouse tissue homogenates by reversed-phase high-performance liquid chromatography
artículo científico publicado en 2007
Determination of total platinum in plasma and plasma ultrafiltrate, from subjects dosed with the platinum-containing N-(2-hydroxypropyl)methacrylamide copolymer AP5280, by use of graphite-furnace Zeeman atomic-absorption spectrometry
scientific article published on 06 June 2002
Deuterodiacetylmorphine as a marker for use of illicit heroin by addicts in a heroin-assisted treatment program
artículo científico publicado en 2005
Development and Validation of an LC-MS/MS Method for the Simultaneous Quantification of Abiraterone, Enzalutamide, and Their Major Metabolites in Human Plasma
artículo científico publicado en 2017
Development and clinical validation of an LC-MS/MS method for the quantification of pazopanib in DBS
artículo científico publicado en 2015
Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices
artículo científico publicado en 2012
Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine
artículo científico publicado en 2012
Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures
artículo científico publicado en 2013
Development and validation of a UPLC-MS/MS method with a broad linear dynamic range for the quantification of morphine, morphine-3-glucuronide and morphine-6-glucuronide in mouse plasma and tissue homogenates
artículo científico publicado en 2020
Development and validation of a bioanalytical method for the quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib in human and mouse matrices using liquid chromatography-tandem mass spectrometry
scientific article published on 17 June 2019
Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of Dexamphetamine in human plasma.
artículo científico publicado en 2017
Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying olaparib in human plasma.
artículo científico publicado en 2013
Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay quantifying vemurafenib in human plasma.
artículo científico publicado en 2013
Development and validation of a liquid chromatography-tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs
artículo científico publicado en 2017
Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma
artículo científico publicado en 2019
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in
artículo científico publicado en 2010
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of lurbinectedin in human plasma and urine
artículo científico publicado en 2018
Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285 x HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form
artículo científico publicado en 2003
Development and validation of a method to determine the unbound paclitaxel fraction in human plasma
artículo científico publicado en 2004
Development and validation of a population pharmacokinetic model for ritonavir used as a booster or as an antiviral agent in HIV-1-infected patients
artículo científico publicado en 2005
Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.
artículo científico publicado en 2009
Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2011
Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.
artículo científico publicado en 2008
Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography-tandem mass spectrometry
artículo científico publicado en 2006
Development and validation of a quantitative method for thymidine phosphorylase activity in peripheral blood mononuclear cells
article
Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma.
artículo científico publicado en 2016
Development and validation of an LC-MS/MS method for the quantification of imatinib and imatinib-d8 in human plasma for the support of an absolute bioavailability microdose trial
scientific article published on 01 April 2020
Development and validation of an LC-MS/MS method for the quantitative analysis of milciclib in human and mouse plasma, mouse tissue homogenates and tissue culture medium
artículo científico publicado en 2020
Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium
scientific article published on 18 July 2019
Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form
artículo científico publicado en 2005
Development and validation of an UPLC-MS/MS method for the therapeutic drug monitoring of oral anti-hormonal drugs in oncology
artículo científico publicado en 2019
Development and validation of an anion-exchange LC-UV method for the quantification and purity determination of the DNA plasmid pDERMATT.
artículo científico publicado en 2008
Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2007
Development and validation of an assay for the simultaneous determination of zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma using liquid chromatography-tandem mass spectrometry
artículo científico publicado en 2013
Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.
artículo científico publicado en 2009
Development and validation of an integrated LC-MS/MS assay for therapeutic drug monitoring of five PARP-inhibitors
scientific article published on 06 December 2019
Development and validation of limited sampling strategies for prediction of the systemic exposure to the novel anticancer agent E7070 (N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide).
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artículo científico publicado en 2002
Development of a LC method for pharmaceutical quality control of the antimetastatic ruthenium complex NAMI-A.
artículo científico publicado en 2003
Development of a Pharmacokinetic Model to Describe the Complex Pharmacokinetics of Pazopanib in Cancer Patients
artículo científico publicado en 2016
Development of a Tumour Growth Inhibition Model to Elucidate the Effects of Ritonavir on Intratumoural Metabolism and Anti-tumour Effect of Docetaxel in a Mouse Model for Hereditary Breast Cancer
artículo científico publicado en 2015
Development of an LC-MS/MS assay for the quantitative determination of the intracellular 5-fluorouracil nucleotides responsible for the anticancer effect of 5-fluorouracil.
artículo científico publicado en 2015
Development of an extended-release formulation of capecitabine making use of in vitro-in vivo correlation modelling.
artículo científico publicado en 2013
Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule
artículo científico publicado en 2002
Development of an oral solid dispersion formulation for use in low-dose metronomic chemotherapy of paclitaxel
artículo científico publicado en 2012
Development of farnesyl transferase inhibitors: a review
artículo científico publicado en 2005
Development of luciferase tagged brain tumour models in mice for chemotherapy intervention studies
artículo científico publicado en 2006
Development of pharmaceutical heroin preparations for medical co-prescription to opioid dependent patients
artículo científico publicado en 2005
Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-meth
article
Dexrazoxane in anthracycline induced cardiotoxicity and extravasation
artículo científico publicado en 2010
Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment
artículo científico publicado en 2011
Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics
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artículo científico publicado el 31 de enero de 2011
Discontinuation of rivastigmine in routine clinical practice
artículo científico publicado en 2005
Discrepancies in reported drug use in geriatric outpatients: relevance to adverse events and drug-drug interactions
scientific article published on 01 April 2009
Disease Progression/Clinical Outcome Model for Castration-Resistant Prostate Cancer in Patients Treated With Eribulin
artículo científico publicado en 2015
Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors.
artículo científico publicado en 2012
Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.
artículo científico publicado en 2009
Do geriatric outpatients adhere to medication changes advised after assessment? An exploratory pilot study
artículo científico publicado en 2009
Docetaxel in 253 previously treated patients with progressive locally advanced or metastatic breast cancer: results of a compassionate use program in The Netherlands
artículo científico publicado en 2000
Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?
artículo científico publicado en 2019
Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors.
artículo científico publicado en 2009
Dose-finding and pharmacological study of ifosfamide in combination with paclitaxel and carboplatin in resistant small-cell lung cancer
artículo científico publicado en 2001
Dose-finding phase I clinical and pharmacokinetic study of orally administered irinotecan in patients with advanced solid tumors.
artículo científico publicado en 2006
Dried Blood Spot Self-Sampling at Home for the Individualization of Tamoxifen Treatment: A Feasibility Study
artículo científico publicado en 2015
Drug Interaction of Fluvoxamine and Fluoxetine with Nevirapine in HIV-1-Infected Individuals
artículo científico publicado en 2003
Drug interactions between antiretroviral drugs and comedicated agents
artículo científico publicado en 2003
Drug interactions in oncology
artículo científico publicado en 2004
Drug interactions with zidovudine
scientific article published on 01 April 1993
Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis
artículo científico publicado en 2004
Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance.
artículo científico publicado en 2008
Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2.
artículo científico publicado en 2013
Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine
artículo científico publicado en 2011
E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer
artículo científico publicado en 2002
Early diagnostic protein biomarkers for breast cancer: how far have we come?
artículo científico publicado en 2011
Effect of Chinese herbs on CYP3A4 activity and expression in vitro
artículo científico publicado en 2013
Effect of cisplatin-containing chemotherapy on lithium serum concentrations
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artículo científico publicado el 1 de abril de 1992
Effect of cyclodextrins on the chemical stability of mitomycins in alkaline solution
artículo científico publicado en 1991
Effect of heat treatment of potentially infected blood samples on therapeutic drug monitoring of selected drugs
artículo científico publicado en 1993
Effect of inhibition of the FGFR-MAPK signaling pathway on the development of ocular toxicities
artículo científico
Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools
artículo científico publicado en 2004
Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice
artículo científico publicado en 2008
Effect of the drug transporters ABCG2, Abcg2, ABCB1 and ABCC2 on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA.
artículo científico publicado en 2013
Effectiveness and safety of reduced-dose fluoropyrimidine therapy in patients carrying the DPYD*2A variant: A matched pair analysis
artículo científico publicado en 2019
Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen
artículo científico publicado en 2015
Effects of co-medicated drugs on cyclophosphamide bioactivation in human liver microsomes
artículo científico publicado en 2005
Effects of cyclosporine a on single-dose pharmacokinetics of intravenous itraconazole in patients with hematologic malignancies
artículo científico publicado en 2008
Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir
artículo científico publicado en 2010
Efficacy and tolerability of a high loading dose (25,000 IU weekly) vitamin D3 supplementation in obese children with vitamin D insufficiency/deficiency
artículo científico publicado en 2014
Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice
artículo científico publicado en 2004
Efficacy, Tolerance, and Plasma Levels of Abiraterone and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer With a Hepatic Transplant
artículo científico publicado en 2019
Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.
artículo científico publicado en 2009
Encorafenib, binimetinib and cetuximab combined therapy for patients with BRAFV600E mutant metastatic colorectal cancer
scientific article published on 01 February 2020
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833
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artículo científico publicado el 1 de enero de 1997
Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOqui
artículo científico publicado en 2008
Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors
artículo científico publicado en 2019
Enrichment of Circulating Endothelial Cells by CD34 Microbeads Followed by Enumeration Using Flow Cytometry
artículo científico publicado en 2017
Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.
artículo científico publicado en 2001
Enzymatic digestion as a tool for the LC-MS/MS quantification of large peptides in biological matrices: measurement of chymotryptic fragments from the HIV-1 fusion inhibitor enfuvirtide and its metabolite M-20 in human plasma
artículo científico publicado en 2007
Enzyme linked immunosorbent assay for the quantification of nivolumab and pembrolizumab in human serum and cerebrospinal fluid
artículo científico publicado en 2018
EpCAM-based assays for epithelial tumor cell detection in cerebrospinal fluid
artículo científico publicado en 2017
EpCAM-based flow cytometry in cerebrospinal fluid greatly improves diagnostic accuracy of leptomeningeal metastases from epithelial tumors
artículo científico publicado en 2015
Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution
scientific article published on 01 January 1990
Eribulin mesylate pharmacokinetics in patients with solid tumors receiving repeated oral ketoconazole
artículo científico publicado en 2012
Etoposide phosphate, the water soluble prodrug of etoposide
artículo científico publicado en 1996
Etoposide, leucovorin, 5-fluorouracil (ELF) combination chemotherapy for advanced gastric cancer: experience with two treatment schedules incorporating intravenous or oral etoposide
artículo científico publicado en 1994
Evaluation of a pharmacology-driven dosing algorithm of 3-weekly paclitaxel using therapeutic drug monitoring: a pharmacokinetic-pharmacodynamic simulation study
artículo científico publicado en 2012
Evaluation of formulas using the serum creatinine level to calculate the optimal dosage of carboplatin.
artículo científico publicado en 1996
Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer
artículo científico publicado en 2010
Evaluation of human plasma protein binding of trabectedin (Yondelis, ET-743).
artículo científico publicado en 2009
Evaluation of pharmacotherapy in geriatric patients after performing complete geriatric assessment at a diagnostic day clinic
artículo científico publicado en 2006
Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM.
artículo científico publicado en 2000
Evaluation of the bioequivalence of tablets and capsules containing the novel anticancer agent R115777 (Zarnestra) in patients with advanced solid tumors
artículo científico publicado en 2002
Evaluation of α2-Integrin Expression as a Biomarker for Tumor Growth Inhibition for the Investigational Integrin Inhibitor E7820 in Preclinical and Clinical Studies
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artículo científico publicado el 9 de marzo de 2011
Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment.
artículo científico publicado en 2015
Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study
scientific article published on 15 November 2019
Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer
artículo científico publicado en 2019
Exposure-response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer
artículo científico publicado en 2019
Exposure-response analyses of anaplastic lymphoma kinase inhibitors crizotinib and alectinib in non-small-cell lung cancer patients
artículo científico publicado en 2020
Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization
artículo científico publicado en 2017
Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice
artículo científico publicado en 2008
Extrahepatic metabolism of ibrutinib
artículo científico publicado en 2020
Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin
artículo científico publicado en 2002
Facile small scale synthesis of nucleoside 5'-phosphate mixtures
artículo científico publicado en 2010
Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure
artículo científico publicado en 2014
Fast and Adequate Liquid Chromatography-Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring
artículo científico publicado en 2017
Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reve
scientific article published on 01 January 2007
Fast and straightforward method for the quantification of pazopanib in human plasma using LC-MS/MS.
artículo científico publicado en 2017
Fatal interstitial lung disease associated with high erlotinib and metabolite levels. A case report and a review of the literature
artículo científico publicado en 2011
Fixed Dosing of Monoclonal Antibodies in Oncology
artículo científico publicado en 2017
Flat dosing of carboplatin is justified in adult patients with normal renal function.
artículo científico publicado en 2006
Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers
artículo científico publicado en 2018
From mouse to man: predictions of human pharmacokinetics of orally administered docetaxel from preclinical studies
artículo científico publicado en 2011
Fully automated high-performance liquid chromatographic method for the determination of carzelesin (U-80,244) and metabolites (U-76,073 and U-76,074) in human plasma
artículo científico publicado en 1994
GMP production of pDERMATT for vaccination against melanoma in a phase I clinical trial
artículo científico publicado en 2008
Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine
scientific article published on 01 December 1992
Gas chromatographic determination of ifosfamide in microvolumes of urine and plasma
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artículo científico publicado el 15 de noviembre de 1991
Gastric bypass may promote weight loss in overweight partners
artículo científico publicado en 2015
Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer
scientific article published on 01 July 1999
Gene polymorphisms, pharmacokinetics, and hematological toxicity in advanced non-small-cell lung cancer patients receiving cisplatin/gemcitabine
artículo científico publicado en 2011
Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer
artículo científico publicado en 2006
Genetically modified mouse models for oral drug absorption and disposition
artículo científico publicado en 2013
Germline TYMS genotype is highly predictive in patients with metastatic gastrointestinal malignancies receiving capecitabine-based chemotherapy
artículo científico publicado en 2015
Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: a prospective clinical study
artículo científico publicado en 2011
HAART, or just mini-HAART?
artículo científico publicado en 2001
HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53
artículo científico publicado en 2015
Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.
artículo científico publicado en 2008
Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters
artículo científico publicado en 2010
Hepatotoxicity and metabolism of trabectedin: a literature review.
artículo científico publicado en 2005
Hepatotoxicity following nevirapine-containing regimens in HIV-1-infected individuals
artículo científico publicado en 2002
Herb-drug interactions in oncology
artículo científico publicado en 2014
Herb-drug interactions in oncology: focus on mechanisms of induction
artículo científico publicado en 2006
Heroin-assisted treatment in the Netherlands: History, findings, and international context
artículo científico publicado en 2010
High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy
artículo científico publicado en 2006
High prevalence of vitamin D insufficiency/deficiency in Dutch multi-ethnic obese children
artículo científico publicado en 2015
High-Tech Drugs in Creaky Formulations
artículo científico publicado en 2017
High-grade glioma mouse models and their applicability for preclinical testing
artículo científico publicado en 2009
High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma.
artículo científico publicado en 2001
High-performance liquid chromatographic analysis of the anticancer drug irinotecan (CPT-11) and its active metabolite SN-38 in human plasma
artículo científico publicado en 2003
High-performance liquid chromatographic analysis of the antitumour drug camptothecin and its lactone ring-opened form in rat plasma
artículo científico publicado en 1993
High-performance liquid chromatographic analysis of the investigational anticancer drug 9-aminocamptothecin, as the lactone form and as the total of the lactone and the hydroxycarboxylate forms, in micro-volumes of human plasma
scientific article published on 01 September 1998
High-performance liquid chromatographic analysis of the new antitumour drug N-benzoylstaurosporine (CGP 41 251) and four potential metabolites in micro-volumes of plasma
artículo científico publicado en 1995
High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma
scientific article published on 01 January 1990
High-performance liquid chromatographic bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug vintriptol
scientific article published on 01 August 1990
High-performance liquid chromatographic bio-analysis of PSC 833 in human and murine plasma
scientific article published on 01 November 1998
High-performance liquid chromatographic bioanalysis of anthracycline cytostatic drugs
artículo científico publicado en 1988
High-performance liquid chromatographic determination of m-iodobenzylguanidine in urine of cancer patients
scientific article published on 01 December 1993
High-performance liquid chromatographic determination of ritonavir in human plasma, cerebrospinal fluid and saliva.
artículo científico publicado en 1998
High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes
artículo científico publicado en 1998
High-performance liquid chromatographic determination of vinblastine, 4-O-deacetylvinblastine and the potential metabolise 4-O-deacetylvinblastine-3-oic acid in biological fluids
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artículo científico publicado el 16 de agosto de 1991
High-performance liquid chromatographic method for the analysis of 10-ethyl-10-deaza-aminopterin and metabolites in plasma
scientific article published on 01 July 1990
High-performance liquid chromatographic procedures for the quantitative determination of paclitaxel (Taxol) in human urine
artículo científico publicado en 1995
High-performance liquid chromatography analysis of a novel small-molecule, anti-cancer drug, Palomid 529, in human and mouse plasma and in mouse tissue homogenates
scientific article published on 29 October 2011
High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature
artículo científico publicado en 2010
Highly sensitive UPLC-MS/MS method for the quantification of paromomycin in human plasma
artículo científico publicado en 2020
Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites
artículo científico publicado en 2013
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel
scientific article published on 03 June 2014
Human mass balance study and metabolite profiling of 14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer
artículo científico publicado en 2017
Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.
artículo científico publicado en 2007
Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.
artículo científico publicado en 2005
Hypersensitivity reactions to etoposide
artículo científico publicado en 1996
Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor.
artículo científico publicado en 2009
Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry
artículo científico publicado en 2010
Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry
artículo científico publicado en 2006
Identification of two new serum protein profiles for renal cell carcinoma.
artículo científico publicado en 2009
Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study
scientific article published on 07 January 2019
Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) gene dosage on plasma pharmacokinetics and brain accumulation of dasatinib, sorafenib, and sunitinib
artículo científico publicado en 2013
Impact of age on exposure to oral antiandrogen therapies in clinical practice
artículo científico publicado en 2018
Importance of highly selective LC-MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen
artículo científico publicado en 2012
Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2.
artículo científico publicado en 2018
Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde
artículo científico publicado en 1999
Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein
artículo científico publicado en 2004
Improved pharmacodynamic assay for dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells
artículo científico publicado en 2015
Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview
artículo científico publicado en 2002
Improving colorectal cancer management: the potential of proteomics
artículo científico publicado en 2008
Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity - Ready for clinical practice?
artículo científico publicado en 2016
Improving the solubility of nilotinib through novel spray-dried solid dispersions.
artículo científico publicado en 2017
In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS
artículo científico publicado en 2000
In vitro characterization of the biotransformation of thiocoraline, a novel marine anti-cancer drug
artículo científico publicado en 2004
In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug
artículo científico publicado en 2006
In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug
artículo científico publicado en 2007
In vitro hemolysis and buffer capacity studies with the novel marine anticancer agent kahalalide F and its reconstitution vehicle cremophor EL/ethanol
artículo científico publicado en 2001
In vitro pharmacokinetic study of the novel anticancer agent E7070: red blood cell and plasma protein binding in human blood
artículo científico publicado en 2003
In vitro transport of gimatecan (7-t-butoxyiminomethylcamptothecin) by breast cancer resistance protein, P-glycoprotein, and multidrug resistance protein 2.
artículo científico publicado en 2007
In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction
artículo científico publicado en 2005
In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide
artículo científico publicado en 1998
Incidence and risk factors for nevirapine-associated rash
artículo científico publicado en 2003
Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study
artículo científico publicado en 2014
Inclusion complexation of doxorubicin and daunorubicin with cyclodextrins
artículo científico publicado en 1990
Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses
artículo científico publicado en 2015
Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar
artículo científico publicado en 2013
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
artículo científico publicado en 2002
Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.
artículo científico publicado en 2003
Increased risk of severe fluoropyrimidine-associated toxicity in patients carrying a G to C substitution in the first 28-bp tandem repeat of the thymidylate synthase 2R allele.
artículo científico publicado en 2015
Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance
artículo científico publicado en 2013
Increasing thyroid-stimulating hormone is associated with impaired glucose metabolism in euthyroid obese children and adolescents
artículo científico publicado en 2013
Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel
artículo científico publicado en 2010
Individualised cancer chemotherapy: strategies and performance of prospective studies on therapeutic drug monitoring with dose adaptation: a review
artículo científico publicado en 2005
Individualized dosing of fluoropyrimidine-based chemotherapy to prevent severe fluoropyrimidine-related toxicity - What are the options?
scientific article published on 05 October 2020
Individualized dosing of oral targeted therapies in oncology is crucial in the era of precision medicine
artículo científico publicado en 2019
Inducing synthetic lethality using PARP inhibitors
artículo científico publicado en 2010
Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin
scientific article published on 03 April 2008
Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs
artículo científico publicado en 2013
Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment
artículo científico publicado en 1998
Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide
artículo científico publicado en 2008
Influence of sample storage duration on serum protein profiles assessed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS).
artículo científico publicado en 2009
Influence of variations in sample handling on SELDI-TOF MS serum protein profiles for colorectal cancer
artículo científico publicado en 2008
Inherent formulation issues of kinase inhibitors
artículo científico publicado en 2016
Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam
artículo científico publicado en 2009
Inhibitors of mTOR.
artículo científico publicado en 2010
Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction
artículo científico publicado en 2004
Integrated Simulation Framework for Toxicity, Dose Intensity, Disease Progression, and Cost Effectiveness for Castration-Resistant Prostate Cancer Treatment With Eribulin
artículo científico publicado en 2015
Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.
artículo científico publicado en 2015
Interactions of serum albumin, valproic acid and carbamazepine with the pharmacokinetics of phenytoin in cancer patients.
artículo científico publicado en 2006
Intermittent fasting during Ramadan causes a transient increase in total, LDL, and HDL cholesterols and hs-CRP in ethnic obese adolescents.
artículo científico publicado en 2014
Intoxication with trazodone caused by dirty facsimile machine
artículo científico publicado en 2009
Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action
artículo científico publicado en 2020
Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients
artículo científico publicado en 2010
Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides
artículo científico publicado en 2018
Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review.
artículo científico publicado en 2019
Intraperitoneal chemotherapy with taxanes for ovarian cancer with peritoneal dissemination
artículo científico publicado en 2006
Intraperitoneal-administered carboplatin in patients with ovarian cancer; influence of a dwell-time on toxicity and response
scientific article published on 01 February 1994
Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel
artículo científico publicado en 2009
Inventory of oral anticancer agents: Pharmaceutical formulation aspects with focus on the solid dispersion technique
artículo científico publicado en 2016
Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.
artículo científico publicado en 2011
Is Bodyweight-Based Dosing Truly Better Than Flat Dosing for Panitumumab? [Letter]
artículo científico publicado en 2020
Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma?
artículo científico publicado en 2012
Is fluorouracil-induced severe toxicity in DPYD*2A individuals related to sex or to treatment regimen?
artículo científico publicado en 2008
Isocratic ion-exchange chromatographic assay for the nucleotide gemcitabine triphosphate in human white blood cells
artículo científico publicado en 2002
Isolation, purification and biological activity of major docetaxel metabolites from human feces.
artículo científico publicado en 1996
Isolation, purification, and biological activity of mono- and dihydroxylated paclitaxel metabolites from human feces
artículo científico
Itraconazole as an alternative for ritonavir liquid formulation when combined with saquinavir
scientific article published on 01 January 2000
Itraconazole solution: summary of pharmacokinetic features and review of activity in the treatment of fluconazole-resistant oral candidosis in HIV-infected persons
artículo científico publicado en 2002
Kinetics and mechanism of the degradation of 1a-acetylmitomycin C in aqueous solution.
artículo científico publicado en 1993
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism
artículo científico publicado en 2007
LC-MS/MS assay for the quantification of testosterone, dihydrotestosterone, androstenedione, cortisol and prednisone in plasma from castrated prostate cancer patients treated with abiraterone acetate or enzalutamide
artículo científico publicado en 2019
LC-UV method development and validation for the investigational anticancer agent imexon and identification of its degradation products
artículo científico publicado en 2005
Lack of tumor uptake of 131-I labeled rituximab in a patient with a CD20 positive lymphoma lesion
artículo científico publicado en 2012
Lapatinib for advanced or metastatic breast cancer
artículo científico publicado en 2012
Lethal morphine intoxication in a patient with a sickle cell crisis and renal impairment: case report and a review of the literature
artículo científico publicado en 2010
Lethal toxicity of uracil/tegafur in the treatment of sigmoid carcinoma
artículo científico publicado en 2006
Letter to the editor regarding "A prospective, controlled study of the botanical compound mixture LCS101 for chemotherapy-induced hematological complications in breast cancer" by Yaal-Hahoshen et al. (The Oncologist 2011;16:1197-1202).
artículo científico publicado en 2012
Limited sampling models for topotecan pharmacokinetics
artículo científico publicado en 1994
Limited-sampling models for anticancer agents
artículo científico publicado en 1994
Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?
scientific article published on 02 July 2009
Liposomal drug formulations in the treatment of rheumatoid arthritis
artículo científico publicado en 2011
Liquid chromatographic assay for simultaneous determination of abacavir and mycophenolic acid in human plasma using dual spectrophotometric detection
artículo científico publicado en 2001
Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde
artículo científico publicado en 2003
Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole.
artículo científico publicado en 2004
Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma
artículo científico publicado en 2006
Liquid chromatographic assay for the protease inhibitor atazanavir in plasma
artículo científico publicado en 2006
Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome
artículo científico publicado en 2010
Liquid chromatographic-mass spectrometric determination of the novel, recently identified thioTEPA metabolite, thioTEPA-mercapturate, in urine
scientific article published on 01 September 1999
Liquid chromatography-mass spectrometry for the quantitative bioanalysis of anticancer drugs
artículo científico publicado en 2005
Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis
artículo científico publicado en 2010
Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma
artículo científico publicado en 2008
Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma
artículo científico publicado en 2016
Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates
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artículo científico publicado el 21 de agosto de 2010
Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite
artículo científico publicado en 2008
Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma
artículo científico publicado en 2012
Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma
artículo científico publicado en 2012
Liquid chromatography-tandem mass spectrometric assay for the PARP inhibitor rucaparib in plasma
artículo científico publicado en 2013
Liquid chromatography-tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma
artículo científico publicado en 2011
Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate.
artículo científico publicado en 2015
Liquid chromatography-tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma
artículo científico publicado en 2016
Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma
artículo científico publicado en 2012
Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes
artículo científico publicado en 2006
Liquid chromatography-tandem mass spectrometric assay for the cyclin-dependent kinase inhibitor AT7519 in mouse plasma
artículo científico publicado en 2013
Liquid chromatography-tandem mass spectrometric assay for the light sensitive survivin suppressant sepantronium bromide (YM155) in mouse plasma
artículo científico publicado en 2014
Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma
artículo científico publicado en 2009
Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma
artículo científico publicado en 2014
Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma.
artículo científico publicado en 2013
Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma.
artículo científico publicado en 2012
Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma
artículo científico publicado en 2007
Liquid chromatography-tandem mass spectrometric assay for the quantification of galunisertib in human plasma and the application in a pre-clinical study
scientific article published on 21 May 2019
Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction
artículo científico publicado en 2017
Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies.
artículo científico publicado en 2015
Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction
artículo científico publicado en 2016
Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasm
artículo científico publicado en 2016
Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the tyrosine kinase inhibitor pazopanib in human plasma
artículo científico publicado en 2012
Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium
artículo científico publicado en 2007
Liquid chromatography-tandem mass spectrometry assay for the EGFR inhibitor pelitinib in plasma.
artículo científico publicado en 2013
Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine
artículo científico publicado en 2016
Liquid chromatography-tandem mass spectrometry assay to quantify plitidepsin in human plasma, whole blood and urine
artículo científico publicado en 2017
Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH4 with biomarker potential in human plasma and serum
artículo científico publicado en 2008
Lithium pharmacokinetics during cisplatin-based chemotherapy: a case report
artículo científico publicado en 1994
Long term stability of lyophilized plasmid DNA pDERMATT.
artículo científico publicado en 2013
Long-term platinum retention after treatment with cisplatin and oxaliplatin
artículo científico publicado en 2008
Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube cancer.
artículo científico publicado en 2015
Low nevirapine plasma concentrations predict virological failure in an unselected HIV-1-infected population
artículo científico publicado en 2003
Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir
artículo científico publicado en 2002
Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response
artículo científico publicado en 2014
MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid
artículo científico publicado en 2005
Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis.
artículo científico publicado en 2018
Malignant effusions contain lysophosphatidic acid (LPA)-like activity
artículo científico publicado en 1998
Malnourished Malawian patients presenting with large Wilms tumours have a decreased vincristine clearance rate
artículo científico publicado en 2010
Management of hot flashes in patients who have breast cancer with venlafaxine and clonidine: a randomized, double-blind, placebo-controlled trial
artículo científico publicado en 2011
Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.
artículo científico publicado en 2014
Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer
scientific article published on 11 October 2019
Mass balance studies, with a focus on anticancer drugs.
artículo científico publicado en 2006
Mass balance study of [¹⁴C]eribulin in patients with advanced solid tumors
scientific article published on 31 October 2011
Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs
artículo científico publicado en 2010
Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions
artículo científico publicado en 2004
Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
scientific article published on 01 September 2011
Metabolism and disposition of the anticancer quinolone derivative vosaroxin, a novel inhibitor of topoisomerase II.
artículo científico publicado en 2017
Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration
artículo científico publicado en 2000
Metabolism of docetaxel in mice
artículo científico publicado en 2005
Metabolism of paclitaxel in mice
artículo científico publicado en 2003
Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer
artículo científico publicado en 2006
Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine
artículo científico publicado en 2012
Metabolite profiling of the multiple tyrosine kinase inhibitor lenvatinib: a cross-species comparison
artículo científico publicado en 2016
Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin
artículo científico publicado en 2018
Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2012
Methylnaltrexone
artículo científico publicado en 2009
Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.
artículo científico publicado en 2005
Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes
artículo científico publicado en 2007
Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction
artículo científico publicado en 2013
Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis
artículo científico publicado en 2012
Model-based evaluation and optimization of cardiac monitoring protocols for adjuvant treatment of breast cancer with trastuzumab
artículo científico publicado en 2012
Model-based treatment optimization of a novel VEGFR inhibitor
artículo científico publicado en 2012
Model‐Based Evaluation of Similarity in Pharmacokinetics of Two Formulations of the Blood‐Derived Plasma Product C1 Esterase Inhibitor
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artículo científico publicado el 1 de febrero de 2012
Modulation of oral drug bioavailability: from preclinical mechanism to therapeutic application
artículo científico publicado en 2005
Modulation of the blood-brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours?
artículo científico publicado en 2004
Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin
artículo científico publicado en 2001
Molecular Imaging of ABCB1/ABCG2 Inhibition at the Human Blood Brain Barrier using Elacridar and 11C-Erlotinib PET.
artículo científico publicado en 2017
Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry
artículo científico publicado en 2007
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs
artículo científico publicado en 2002
Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics
artículo científico publicado en 2006
Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides
artículo científico publicado en 2007
Multiparameter Flow Cytometry Assay for Quantification of Immune Cell Subsets, PD-1 Expression Levels and PD-1 Receptor Occupancy by Nivolumab and Pembrolizumab
artículo científico publicado en 2019
Neoadjuvant Systemic Treatment of Primary Angiosarcoma
scientific article published on 12 August 2020
Nevirapine and efavirenz pharmacokinetics and covariate analysis in the 2NN study.
artículo científico publicado en 2005
Nevirapine plus didanosine: once or twice daily combination?
scientific article published on 01 September 2000
New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine
artículo científico publicado en 2008
No pharmacokinetic drug-drug interaction between nevirapine and paclitaxel
artículo científico publicado en 2005
No relation between docetaxel administration route and high-grade diarrhea incidence
artículo científico publicado en 2020
Novel clinical trial designs for innovative therapies
scientific article published on 24 December 2008
Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers
scientific article published on 24 June 2006
Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor
artículo científico publicado en 2008
O-glucuronidation, a newly identified metabolic pathway for topotecan and N-desmethyl topotecan
scientific article published on 01 August 1998
OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation
artículo científico publicado en 2020
Ocular complications of the acquired immunodeficiency syndrome. Focus on the treatment of cytomegalovirus retinitis with ganciclovir and foscarnet
artículo científico publicado en 1993
Optimal dosing of miltefosine in children and adults with visceral leishmaniasis
artículo científico publicado en 2012
Optimization of intradermal vaccination by DNA tattooing in human skin
artículo científico publicado en 2009
Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel
artículo científico publicado en 2014
Optimizing drug development of anti-cancer drugs in children using modelling and simulation
artículo científico publicado en 2013
Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis
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artículo científico publicado el 2 de abril de 2011
Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study
artículo científico publicado en 2008
Oral anticancer drugs: mechanisms of low bioavailability and strategies for improvement.
artículo científico
Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar
artículo científico publicado en 2012
Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093).
artículo científico publicado en 2004
Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation
artículo científico publicado en 2014
Oral coadministration of elacridar and ritonavir enhances brain accumulation and oral availability of the novel ALK/ROS1 inhibitor lorlatinib
artículo científico publicado en 2019
Oral delivery of taxanes
artículo científico publicado en 2001
Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors
artículo científico publicado en 2009
Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice
artículo científico publicado en 2012
P glycoprotein in human immunodeficiency virus type 1 infection and therapy
artículo científico publicado en 2004
P-Glycoprotein (ABCB1) Transports the Primary Active Tamoxifen Metabolites Endoxifen and 4-Hydroxytamoxifen and Restricts Their Brain Penetration
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artículo científico publicado el 4 de marzo de 2011
P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability
scientific article published on 10 October 2018
P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib
artículo científico publicado en 2012
P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554)
scientific article published on 20 November 2019
P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice
artículo científico publicado en 2017
P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice
scientific article published on 12 December 2018
P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.
artículo científico publicado en 2013
P-glycoprotein (MDR1/ABCB1) controls brain accumulation and intestinal disposition of the novel TGF-β signaling pathway inhibitor galunisertib
scientific article published on 15 July 2019
P-glycoprotein (MDR1/ABCB1) restricts brain accumulation and Cytochrome P450-3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.
artículo científico publicado en 2018
P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide
artículo científico publicado en 2009
P-glycoprotein Limits Ribociclib Brain Exposure and CYP3A4 Restricts Its Oral Bioavailability
artículo científico publicado en 2019
P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.
artículo científico publicado en 2003
P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability
artículo científico publicado en 2018
P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib.
artículo científico publicado en 2015
P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecan
artículo científico publicado en 2007
P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel
article by Jeroen J M A Hendrikx et al published 14 November 2012 in International Journal of Cancer
P-glycoprotein limits oral availability, brain penetration, and toxicity of an anionic drug, the antibiotic salinomycin
artículo científico publicado en 2008
P-glycoprotein system as a determinant of drug interactions: the case of digoxin-verapamil
artículo científico publicado en 1999
P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice
artículo científico publicado en 2015
P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.
artículo científico publicado en 2014
P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine
artículo científico publicado en 2012
P-gp and taxanes
artículo científico publicado en 2014
P04.91 ABC-drug efflux transporters at the blood-brain barrier limit the efficacy of treatment against primary and secondary brain tumors
PARP Inhibitors in the Treatment of Triple-Negative Breast Cancer
artículo científico publicado en 2017
PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models.
artículo científico publicado en 2016
PK/PD model of indisulam and capecitabine: interaction causes excessive myelosuppression
scientific article published on 12 September 2007
PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors
artículo científico publicado en 2012
PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line
artículo científico publicado en 2009
Paclitaxel in self-micro emulsifying formulations: oral bioavailability study in mice
artículo científico publicado en 2010
Palliative effect of metaiodobenzylguanidine in metastatic carcinoid tumors
artículo científico publicado en 1996
Part 1: background, methodology, and clinical adoption of pharmacogenetics
artículo científico publicado en 2011
Part 2: pharmacogenetic variability in drug transport and phase I anticancer drug metabolism
artículo científico publicado en 2011
Part 3: Pharmacogenetic variability in phase II anticancer drug metabolism
artículo científico publicado en 2011
Part 4: pharmacogenetic variability in anticancer pharmacodynamic drug effects
artículo científico publicado en 2011
Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines
artículo científico publicado en 2016
Pemetrexed pathway-associated germline polymorphisms: a useful tool for treatment individualization?
artículo científico publicado en 2010
Penetration of 3'-Amino-3'-Deoxythymidine, a Cytotoxic Metabolite of Zidovudine, Into the Cerebrospinal Fluid of HIV-1-Infected Patients
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artículo científico publicado el 1 de junio de 1997
Penetration of idarubicin into malignant brain tumor tissue.
artículo científico publicado en 1999
Penetration of zidovudine into the cerebrospinal fluid of patients infected with HIV
artículo científico publicado en 1993
Performance of methods for handling missing categorical covariate data in population pharmacokinetic analyses
artículo científico publicado en 2012
Persistent neuropathy after treatment with cisplatin and oxaliplatin
artículo científico publicado en 2009
Personalized medicine in oncology: a personal view with myths and facts
scientific article published on August 2010
Pharmaceutical development and preliminary clinical testing of an oral solid dispersion formulation of docetaxel (ModraDoc001)
artículo científico publicado en 2011
Pharmaceutical development of a lyophilised dosage form for the investigational anticancer agent Imexon using dimethyl sulfoxide as solubilising and stabilising agent
artículo científico publicado en 2005
Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur
scientific article published on 01 March 1997
Pharmaceutical development of a parenteral formulation of the novel anti-tumor agent carzelesin (U-80,244)
artículo científico publicado en 1994
Pharmaceutical development of a parenteral lyophilised dosage form for the novel anticancer agent C1311.
artículo científico publicado en 2005
Pharmaceutical development of a parenteral lyophilised formulation of the investigational anticancer agent ES-285.HCl.
artículo científico publicado en 2005
Pharmaceutical development of a parenteral lyophilized formulation of the novel antitumor agent aplidine.
artículo científico publicado en 2000
Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies
artículo científico publicado en 2016
Pharmaceutical development of an intravenous dosage form of diacetylmorphine hydrochloride.
artículo científico publicado en 2004
Pharmaceutical development of an oral tablet formulation containing a spray dried amorphous solid dispersion of docetaxel or paclitaxel
artículo científico publicado en 2016
Pharmaceutical heroin for inhalation: thermal analysis and recovery experiments after volatilisation
artículo científico publicado en 2005
Pharmaceutical quality control of the investigational polymer-conjugated platinum anticancer agent AP 5280
artículo científico publicado en 2003
Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells
artículo científico publicado en 2013
Pharmacodynamic biomarkers in model-based drug development in oncology
scientific article published on February 2011
Pharmacodynamic modeling of adverse effects of anti-cancer drug treatment
artículo científico publicado en 2016
Pharmacodynamics and pharmacokinetics of oral topotecan in patients with advanced solid tumours and impaired renal function
artículo científico publicado en 2015
Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population
artículo científico publicado en 2006
Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel
scientific article published on 01 October 2006
Pharmacogenetic screening of the gene deletion and duplications of CYP2D6.
artículo científico publicado en 2007
Pharmacogenetic variants associated with outcome in patients with advanced gastric cancer treated with fluoropyrimidine and platinum-based triplet combinations: a pooled analysis of three prospective studies.
artículo científico publicado en 2016
Pharmacokinetic Optimization of Everolimus Dosing in Oncology: A Randomized Crossover Trial
artículo científico publicado en 2017
Pharmacokinetic Parameters of Nevirapine and Efavirenz in Relation to Antiretroviral Efficacy
artículo científico publicado en 2006
Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology
artículo científico publicado en 2020
Pharmacokinetic comparison of two methods of heroin smoking: 'chasing the dragon' versus the use of a heating device
artículo científico publicado en 2005
Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol
artículo científico publicado en 2004
Pharmacokinetic evaluation of three oral formulations of docetaxel boosted with ritonavir: two single-drug formulations vs. a fixed-dose combination tablet
artículo científico publicado en 2013
Pharmacokinetic individualisation of zidovudine therapy. Current state of pharmacokinetic-pharmacodynamic relationships
artículo científico publicado en 1996
Pharmacokinetic study of docetaxel in intraoperative hyperthermic i.p. chemotherapy for ovarian cancer
artículo científico publicado en 2003
Pharmacokinetic variability of zidovudine in HIV-infected individuals: subgroup analysis and drug interactions
scientific article published on 01 December 1994
Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours
artículo científico publicado en 2014
Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas.
artículo científico publicado en 2014
Pharmacokinetics and excretion of (14)C-omacetaxine in patients with advanced solid tumors
artículo científico publicado en 2016
Pharmacokinetics and excretion of 14C-Plitidepsin in patients with advanced cancer.
artículo científico publicado en 2017
Pharmacokinetics and excretion of 14C-bendamustine in patients with relapsed or refractory malignancy
artículo científico publicado en 2013
Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion
scientific article published on 01 January 2000
Pharmacokinetics and metabolism of the staurosporine analogue CGP 41 251 in mice
scientific article published on 01 January 1999
Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients
artículo científico publicado en 2006
Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.
artículo científico publicado en 2000
Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks
artículo científico publicado en 1995
Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature
artículo científico publicado en 2006
Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis
scientific article published on 20 November 2019
Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer
artículo científico publicado en 2016
Pharmacokinetics of Sustained-Release Oral Dexamphetamine Sulfate in Cocaine and Heroin-Dependent Patients.
artículo científico publicado en 2018
Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen
artículo científico publicado en 2009
Pharmacokinetics of eribulin mesylate in patients with solid tumors and hepatic impairment
artículo científico publicado en 2012
Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin
artículo científico publicado en 2013
Pharmacokinetics of gemcitabine and metabolites in a patient with double-sided nephrectomy: a case report and review of the literature
artículo científico publicado en 2009
Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients.
artículo científico publicado en 2008
Pharmacokinetics of nevirapine: once-daily versus twice-daily dosing in the 2NN study.
artículo científico publicado en 2005
Pharmacokinetics of oral cyclosporin A when co-administered to enhance the absorption of orally administered docetaxel
artículo científico publicado en 2001
Pharmacokinetics of oseltamivir carboxylate in critically ill patients: each patient is unique
artículo científico publicado en 2013
Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion
artículo científico publicado en 1999
Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre
artículo científico publicado en 1997
Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients
artículo científico publicado en 1993
Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthracycline therapy treated with a 3-hour paclitaxel infusion: a European Cancer Centre (ECC) trial.
artículo científico publicado en 1995
Pharmacokinetics of sunitinib in an obese patient with a GIST.
artículo científico publicado en 2009
Pharmacokinetics of zidovudine and acetaminophen in a patient on chronic acetaminophen therapy
artículo científico publicado en 1994
Pharmacologic study of 3-hour 135 mg M-2 paclitaxel in platinum pretreated patients with advanced ovarian cancer
artículo científico publicado en 1998
Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.
artículo científico publicado en 2006
Pharmacotherapy of Hospitalised HIV-Infected Patients in a General Hospital during 1990, 1997 and 2001.
artículo científico
Phase 1 study of combination treatment with PTK 787/ZK 222584 and cetuximab for patients with advanced solid tumors: safety, pharmacokinetics, pharmacodynamics analysis
artículo científico publicado en 2010
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer
scientific article published on 09 March 2020
Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction
artículo científico publicado en 2015
Phase I Study of Afatinib and Selumetinib in Patients with KRAS-Mutated Colorectal, Non-Small Cell Lung, and Pancreatic Cancer
artículo científico publicado en 2020
Phase I and pharmacokinetic study of E7070, a novel chloroindolyl sulfonamide cell-cycle inhibitor, administered as a one-hour infusion every three weeks in patients with advanced cancer
artículo científico publicado en 2002
Phase I and pharmacokinetic study of SPI-77, a liposomal encapsulated dosage form of cisplatin
artículo científico publicado en 2002
Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours
artículo científico publicado en 2003
Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumors
artículo científico publicado en 1999
Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies
artículo científico publicado en 2011
Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours
artículo científico publicado en 2006
Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumors
scientific article published on 01 June 1999
Phase I and pharmacokinetic study of oral paclitaxel
artículo científico publicado en 2000
Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks
artículo científico publicado en 2004
Phase I and pharmacokinetic trial of AP5346, a DACH-platinum-polymer conjugate, administered weekly for three out of every 4 weeks to advanced solid tumor patients
artículo científico publicado en 2007
Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor
scientific article published on 01 September 1993
Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer
artículo científico publicado en 1999
Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer
artículo científico publicado en 1997
Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer
artículo científico publicado en 1998
Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours
artículo científico publicado en 2005
Phase I and pharmacological trial of lapatinib in combination with gemcitabine in patients with advanced breast cancer
artículo científico publicado en 2015
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel
artículo científico publicado en 2001
Phase I clinical and pharmacokinetic study of kahalalide F in patients with advanced androgen refractory prostate cancer.
artículo científico publicado en 2005
Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion
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artículo científico publicado el 1 de julio de 1995
Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer
artículo científico publicado en 2005
Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer
artículo científico publicado en 2002
Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer.
artículo científico publicado en 2013
Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors
artículo científico publicado en 2009
Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer
artículo científico publicado en 2007
Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.
artículo científico publicado en 2008
Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin/fluorouracil/leucovorin (FOLFOX4) in patients with solid tumors
artículo científico publicado en 2007
Phase I pharmacological study of continuous chronomodulated capecitabine treatment
scientific article published on 07 May 2020
Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors
artículo científico publicado en 2011
Phase I study of an oral formulation of irinotecan administered daily for 14 days every 3 weeks in patients with advanced solid tumours
artículo científico publicado en 2004
Phase I study of continuous olaparib capsule dosing in combination with carboplatin and/or paclitaxel (Part 1)
scientific article published on 30 October 2019
Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2)
scientific article published on 21 October 2019
Phase I study of lapatinib plus trametinib in patients with KRAS-mutant colorectal, non-small cell lung, and pancreatic cancer
scientific article published on 09 April 2020
Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023.
artículo científico publicado en 2012
Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy
artículo científico publicado en 2014
Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months
artículo científico publicado en 2016
Phase II and pharmacologic study of weekly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer
artículo científico publicado en 2002
Phase II and pharmacological study of oral docetaxel plus cyclosporin A in anthracycline pre-treated metastatic breast cancer
artículo científico publicado en 2014
Phase II and pharmacological study of oral paclitaxel (Paxoral) plus ciclosporin in anthracycline-pretreated metastatic breast cancer
artículo científico publicado en 2006
Phase II study of the combination carboplatin and paclitaxel in patients with ovarian cancer
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artículo científico publicado el 1 de abril de 1997
Phenytoin alters the disposition of topotecan and N-desmethyl topotecan in a patient with medulloblastoma.
artículo científico publicado en 1998
Photophobia in a patient with high indinavir plasma concentrations
artículo científico publicado en 2003
Photostability profiles of the experimental antimetastatic ruthenium complex NAMI-A.
artículo científico publicado en 2002
Pilot Study to Predict Pharmacokinetics of a Therapeutic Gemcitabine Dose From a Microdose
artículo científico publicado en 2020
Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.
artículo científico
Plasma Levels of Enzalutamide and Its Main Metabolites in a Patient With Metastatic Castration-resistant Prostate Cancer Undergoing Hemodialysis
artículo científico publicado en 2018
Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care
artículo científico publicado en 2014
Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinleucinol in mice as determined by high-performance liquid chromatography
artículo científico publicado en 1994
Plasma pharmacokinetics, tissue disposition, excretion and metabolism of vinorelbine in mice as determined by high performance liquid chromatography
scientific article published on 01 May 1993
Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa
artículo científico publicado en 2008
Population PKPD of paclitaxel and carboplatin in ovarian cancer patients: A study by the EORTC-PAMM-NDDG.
artículo científico publicado en 2007
Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine
artículo científico publicado en 2021
Population Pharmacokinetics of MCLA-128, a HER2/HER3 Bispecific Monoclonal Antibody, in Patients with Solid Tumors
artículo científico publicado en 2020
Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.
artículo científico publicado en 2002
Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin
artículo científico publicado en 2008
Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen
artículo científico publicado en 2014
Population pharmacokinetic-pharmacodynamic analysis for eribulin mesilate-associated neutropenia
artículo científico publicado en 2013
Population pharmacokinetic-pharmacodynamic analysis of trastuzumab-associated cardiotoxicity
artículo científico publicado en 2011
Population pharmacokinetics and pharmacodynamics for treatment optimization in clinical oncology
artículo científico publicado en 2008
Population pharmacokinetics and pharmacodynamics of doxorubicin and cyclophosphamide in breast cancer patients: a study by the EORTC-PAMM-NDDG.
artículo científico publicado en 2007
Population pharmacokinetics and pharmacodynamics of mitomycin during intraoperative hyperthermic intraperitoneal chemotherapy
artículo científico publicado en 2004
Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development
artículo científico publicado en 2007
Population pharmacokinetics and pharmacokinetic-pharmacodynamic relationships of the novel anticancer agent E7070 in four phase I studies
artículo científico publicado en 2002
Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine
artículo científico publicado en 2005
Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin
artículo científico publicado en 2005
Population pharmacokinetics of efavirenz in an unselected cohort of HIV-1-infected individuals
artículo científico publicado en 2005
Population pharmacokinetics of heroin and its major metabolites.
artículo científico publicado en 2006
Population pharmacokinetics of ifosfamide and its dechloroethylated and hydroxylated metabolites in children with malignant disease: a sparse sampling approach
artículo científico publicado en 2001
Population pharmacokinetics of indinavir alone and in combination with ritonavir in HIV-1-infected patients
artículo científico publicado en 2005
Population pharmacokinetics of intravenously and orally administered docetaxel with or without co-administration of ritonavir in patients with advanced cancer
artículo científico publicado en 2010
Population pharmacokinetics of itraconazole in Thai HIV-1-infected persons
artículo científico publicado en 2003
Population pharmacokinetics of lopinavir in combination with ritonavir in HIV-1-infected patients
artículo científico publicado en 2005
Population pharmacokinetics of nevirapine in an unselected cohort of HIV-1-infected individuals
artículo científico publicado en 2002
Population pharmacokinetics of nevirapine in an unselected cohort of HIV-1-infected individuals.
artículo científico publicado en 2002
Population pharmacokinetics of orally administered paclitaxel formulated in Cremophor EL
artículo científico publicado en 2005
Population pharmacokinetics of the novel anticancer agent E7070 during four phase I studies: model building and validation
artículo científico publicado en 2002
Population pharmacokinetics of the novel anticancer agent KRN7000.
artículo científico publicado en 2002
Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy
artículo científico publicado en 2001
Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer
artículo científico publicado en 2011
Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
artículo científico publicado en 2017
Practical guidelines for therapeutic drug monitoring of anticancer tyrosine kinase inhibitors: focus on the pharmacokinetic targets
artículo científico
Practical guidelines to interpret plasma concentrations of antiretroviral drugs
artículo científico publicado en 2004
Preclinical pharmacokinetics of paclitaxel and docetaxel
artículo científico publicado en 1998
Predictive Value of Microdose Pharmacokinetics
artículo científico publicado en 2019
Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies.
artículo científico publicado en 2010
Preparation and stability testing of a hydrogel for topical analgesia
artículo científico publicado en 1995
Prescription error resulting in valproic acid intoxication
artículo científico publicado en 2004
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity
artículo científico publicado en 2017
Prevalence of xerostomia and its relationship with underlying diseases, medication, and nutrition: a descriptive observational study.
artículo científico publicado en 2013
Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review
artículo científico publicado en 2014
Process characterisation, optimisation and validation of production of diacetylmorphine/caffeine sachets: a design of experiments approach
artículo científico publicado en 2004
Prognostic factors for the clinical effectiveness of fluconazole in the treatment of oral candidiasis in HIV-1-infected individuals
artículo científico publicado en 2002
Progress in the development of alternative pharmaceutical formulations of taxanes
artículo científico publicado en 2001
Prolonged exposure to tenofovir monotherapy 1 month after treatment discontinuation because of tenofovir-related renal failure
artículo científico publicado en 2009
Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy
artículo científico publicado en 2008
Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers
artículo científico publicado en 2016
PropAngio study protocol: a neoadjuvant trial on the efficacy of propranolol monotherapy in cutaneous angiosarcoma-a proof of principle study
scientific article published on 10 September 2020
Propofol extravasation in a breast cancer patient
artículo científico publicado en 2008
Protein versus DNA as a marker for peripheral blood mononuclear cell counting
artículo científico publicado en 2009
Purity determinations in the bulk drug of the novel indoloquinone antitumor agent EO9
artículo científico publicado en 1996
Qualitative aspects of the degradation of mitomycins in alkaline solution
scientific article published on 01 January 1985
Quantification of 11 Therapeutic Kinase Inhibitors in Human Plasma for Therapeutic Drug Monitoring Using Liquid Chromatography Coupled With Tandem Mass Spectrometry
artículo científico publicado en 2016
Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry
scientific article published on 16 February 2019
Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2009
Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry
artículo científico publicado en 2013
Quantification of docetaxel and its metabolites in human plasma by liquid chromatography/tandem mass spectrometry
artículo científico publicado en 2013
Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry
artículo científico publicado en 2008
Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors
scientific article published on 01 April 2006
Quantification of miltefosine in peripheral blood mononuclear cells by high-performance liquid chromatography-tandem mass spectrometry
artículo científico publicado en 2015
Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography
artículo científico publicado en 1995
Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry
artículo científico publicado en 2008
Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring
artículo científico publicado en 2013
Quantification of taxanes in biological matrices: a review of bioanalytical assays and recommendations for development of new assays
artículo científico
Quantification of the HIV-integrase inhibitor raltegravir and detection of its main metabolite in human plasma, dried blood spots and peripheral blood mononuclear cell lysate by means of high-performance liquid chromatography tandem mass spectrometr
artículo científico publicado en 2008
Quantification of the pharmacokinetic-toxicodynamic relationship of oral docetaxel co-administered with ritonavir
artículo científico publicado en 2020
Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods
scientific article published on 01 April 1999
Quantification of vosaroxin and its metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine using high-performance liquid chromatography-tandem mass spectrometry.
artículo científico publicado en 2016
Quantifying vemurafenib in dried blood spots using high-performance LC-MS/MS
artículo científico publicado en 2014
Quantitative LC-MS/MS analysis of 5-hydroxymethyl-2'-deoxyuridine to monitor the biological activity of J-binding protein
scientific article published on 29 August 2020
Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2004
Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry
artículo científico publicado en 2006
Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2005
Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
artículo científico publicado en 2006
Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection
artículo científico publicado en 2004
Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2005
Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry
artículo científico publicado en 2007
Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry
artículo científico publicado en 2007
Quantitative assay for six potential breast cancer biomarker peptides in human serum by liquid chromatography coupled to tandem mass spectrometry
scientific article published on 18 January 2010
Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry
scientific article published on 26 July 2008
Quantitative bioanalytical assay for the selective RET inhibitors selpercatinib and pralsetinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry
artículo científico publicado en 2020
Quantitative bioanalytical assay for the tropomyosin receptor kinase inhibitor larotrectinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry
artículo científico publicado en 2018
Quantitative determination of (-)-2'-deoxy-3'-thiacytidine (lamivudine) in human plasma, saliva and cerebrospinal fluid by high-performance liquid chromatography with ultraviolet detection.
artículo científico publicado en 1998
Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
artículo científico publicado en 1998
Quantitative determination of abacavir (1592U89), a novel nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection
scientific article published on 01 December 1999
Quantitative determination of azacitidine triphosphate in peripheral blood mononuclear cells using liquid chromatography coupled with high-resolution mass spectrometry.
artículo científico publicado en 2013
Quantitative determination of capecitabine and its six metabolites in human plasma using liquid chromatography coupled to electrospray tandem mass spectrometry
artículo científico publicado en 2012
Quantitative determination of efavirenz (DMP 266), a novel non-nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection
scientific article published on 01 October 1999
Quantitative determination of erlotinib and O-desmethyl erlotinib in human EDTA plasma and lung tumor tissue
artículo científico publicado en 2012
Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
artículo científico publicado en 2012
Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spe
artículo científico publicado en 2004
Quantitative effect of gender, age, liver function, and body size on the population pharmacokinetics of Paclitaxel in patients with solid tumors
artículo científico publicado en 2006
RNA-Sequencing of Tumor-Educated Platelets, a Novel Biomarker for Blood-Based Sarcoma Diagnostics
artículo científico publicado en 2020
RT-PCR detection of respiratory pathogens in newborn children admitted to a neonatal medium care unit
artículo científico publicado en 2012
Race is not associated with nevirapine pharmacokinetics
artículo científico publicado en 2004
Radiochemical purity of iodine-131 labelled metaiodobenzylguanidine infusion fluids: a report from clinical practice
scientific article published on 01 July 1993
Radiochemical stability during infusion of 131I-labelled metaiodobenzylguanidine for therapeutic use
artículo científico publicado en 1993
Randomized phase I and pharmacological study of weekly or 2-weekly gemcitabine and cisplatin in advanced non-small cell lung cancer
artículo científico publicado en 2002
Randomized phase I clinical and pharmacologic study of weekly versus twice-weekly dose-intensive cisplatin and gemcitabine in patients with advanced non-small cell lung cancer
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artículo científico publicado el 1 de septiembre de 2003
Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies
artículo científico publicado en 2010
Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity
artículo científico publicado en 2007
Rapid determination of nevirapine in human plasma by ion-pair reversed-phase high-performance liquid chromatography with ultraviolet detection
artículo científico publicado en 1998
Rapid esterase-sensitive breakdown of polysorbate 80 and its impact on the plasma pharmacokinetics of docetaxel and metabolites in mice
scientific article published on 01 October 1999
Rapid quantification of delavirdine, a novel non-nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with fluorescence detection
artículo científico publicado en 1999
Reasons for undertreatment with oral anticoagulants in frail geriatric outpatients with atrial fibrillation: a prospective, descriptive study
artículo científico publicado en 2010
Recent developments in the chromatographic bioanalysis of approved kinase inhibitor drugs in oncology.
artículo científico publicado en 2016
Reconstitution of recombinant interleukin-2 (rIL-2): a comparative study of various rIL-2 muteins
scientific article published on 01 January 1993
Reduced liver uptake of arterially infused melphalan during retrograde rat liver perfusion with unaffected liver tumor uptake
artículo científico publicado en 2002
Regulatory aspects of human radiolabeled mass balance studies in oncology: concise review
artículo científico publicado en 2016
Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin
artículo científico publicado en 2008
Relationship between cisplatin administration and the development of ototoxicity
artículo científico publicado en 2006
Relationship between exposure and toxicity in high-dose chemotherapy with cyclophosphamide, thiotepa and carboplatin
artículo científico publicado en 2002
Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer
artículo científico publicado en 2011
Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence
scientific article published on 18 June 2019
Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients.
artículo científico publicado en 2013
Renal excretion of iodine-131 labelled meta-iodobenzylguanidine and metabolites after therapeutic doses in patients suffering from different neural crest-derived tumours
artículo científico publicado en 1997
Renal excretion of meta-iodobenzylguanidine after therapeutic doses in cancer patients and its relation to dose and creatinine clearance
scientific article published on 01 September 1995
Renal function, body surface area, and age are associated with risk of early-onset fluoropyrimidine-associated toxicity in patients treated with capecitabine-based anticancer regimens in daily clinical care
artículo científico publicado en 2016
Reply to Arya and Agarwal
artículo científico publicado en 2013
Reply to T. Magnes et al.
artículo científico publicado en 2016
Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.
artículo científico publicado en 2010
Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method
artículo científico publicado en 2009
Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment
artículo científico publicado en 2018
Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics
artículo científico publicado en 2014
Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies
artículo científico publicado en 2014
Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages
artículo científico publicado en 2010
Ritonavir inhibits intratumoral docetaxel metabolism and enhances docetaxel antitumor activity in an immunocompetent mouse breast cancer model
artículo científico publicado en 2015
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan
scientific article published on 01 October 2000
Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity
artículo científico publicado en 2016
SELDI-TOF MS serum protein profiles in breast cancer: assessment of robustness and validity
artículo científico publicado en 2006
Safety and pharmacology of gemcitabine and capecitabine in patients with advanced pancreatico-biliary cancer and hepatic dysfunction.
artículo científico publicado en 2013
Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study
artículo científico publicado en 2007
Sampling technique from central venous catheters proves critical for pharmacokinetic studies
artículo científico publicado en 1999
Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes
artículo científico publicado en 2006
Screening for illicit heroin use in patients in a heroin-assisted treatment program.
artículo científico publicado en 2006
Screening for polymorphisms in the PXR gene in a Dutch population.
artículo científico publicado en 2006
Search for breast cancer biomarkers in fractionated serum samples by protein profiling with SELDI-TOF MS.
artículo científico publicado en 2012
Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.
artículo científico publicado en 2001
Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study
artículo científico publicado en 2011
Selected new developments in oncology
artículo científico publicado en 2010
Selective high-performance liquid chromatographic assay for itraconazole and hydroxyitraconazole in plasma from human immunodeficiency virus-infected patients
artículo científico publicado en 2002
Semi-automatic liquid chromatographic analysis of olpadronate in urine and serum using derivatization with (9-fluorenylmethyl)chloroformate
scientific article published on 01 February 2000
Semi-automatic liquid chromatographic analysis of pamidronate in serum and citrate plasma after derivatization with 1-naphthylisothiocyanate.
artículo científico publicado en 1998
Semi-automatic liquid chromatographic analysis of pamidronate in urine after derivatization with 1-naphthylisothiocyanate
artículo científico publicado en 1999
Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam
artículo científico publicado en 2005
Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy
artículo científico publicado en 2014
Sensitive isocratic high-performance liquid chromatographic determination of a novel indoloquinone cytotoxic drug (EO9) in human plasma and urine
artículo científico publicado en 1993
Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH4-derived putative biomarker peptides in clinical serum samples
artículo científico publicado en 2010
Sensitive method for plasma and tumor Ko143 quantification using reversed-phase high-performance liquid chromatography and fluorescence detection
artículo científico publicado en 2012
Serum beta-HCG and CA-125 as tumor markers in a patient with osteosarcoma: case report
artículo científico publicado en 2011
Serum degradome markers for the detection of breast cancer
artículo científico publicado en 2010
Serum protein profiling for diagnosis of breast cancer using SELDI-TOF MS.
artículo científico publicado en 2009
Serum proteomics and disease-specific biomarkers of patients with advanced gastric cancer
artículo científico publicado en 2010
Severe cannabinoid intoxication in a patient with non-small-cell lung cancer
scientific article published on 01 January 2012
Severe encephalopathy and polyneuropathy induced by dichloroacetate.
artículo científico publicado en 2010
Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.
artículo científico publicado en 2014
Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity
artículo científico publicado en 2009
Should non-nucleoside reverse transcriptase inhibitors be combined?
artículo científico publicado en 2005
Significant induction of cyclophosphamide and thiotepa metabolism by phenytoin
artículo científico publicado en 2005
Sildenafil is not a useful modulator of ABCB1 and ABCG2 mediated drug resistance in vivo
artículo científico publicado en 2013
Simple and rapid method for the simultaneous determination of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma using liquid chromatography
artículo científico publicado en 2003
Simple and selective determination of the cyclophosphamide metabolite phosphoramide mustard in human plasma using high-performance liquid chromatography
scientific article published on 01 August 2000
Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection
artículo científico publicado en 2004
Simple high‐performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue
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artículo científico publicado el 1 de octubre de 2003
Simultaneous determination of AZD1152 (prodrug) and AZD1152-hydroxyquinazoline pyrazol anilide by reversed phase liquid chromatography
artículo científico publicado en 2009
Simultaneous determination of N,N',N"-triethylenethiophosphoramide, cyclophosphamide and some of their metabolites in plasma using capillary gas chromatography
artículo científico publicado en 1998
Simultaneous integrated boost-intensity modulated radiation therapy with concomitant capecitabine and mitomycin C for locally advanced anal carcinoma: a phase 1 study.
artículo científico publicado en 2013
Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure-response relationships
artículo científico publicado en 2018
Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2009
Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS)
scientific article published on 25 April 2007
Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospr
artículo científico publicado en 2004
Simultaneous quantification of dabrafenib and trametinib in human plasma using high-performance liquid chromatography-tandem mass spectrometry
artículo científico publicado en 2016
Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2010
Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry
artículo científico publicado en 2004
Simultaneous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir and saquinavir in human plasma by ion-pair high-performance liquid chromatography with ultraviolet detection
artículo científico publicado en 1998
Skin tissue sample collection, sample homogenization, and analyte extraction strategies for liquid chromatographic mass spectrometry quantification of pharmaceutical compounds
artículo científico publicado en 2020
Slow dissolution behaviour of amorphous capecitabine
artículo científico publicado en 2012
Solubility and bioavailability improvement of pazopanib hydrochloride
scientific article published on 19 April 2018
Sorption of thiotepa to polyurethane catheter causes falsely elevated plasma levels
artículo científico publicado en 2003
Sparse sampling design for therapeutic drug monitoring of sequentially administered cyclophosphamide, thiotepa, and carboplatin (CTC).
artículo científico publicado en 2005
Specific Investigation of Sample Handling Effects on Protease Activities and Absolute Serum Concentrations of Various Putative Peptidome Cancer Biomarkers
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artículo científico publicado el 30 de septiembre de 2010
Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer
scientific article published on 22 August 2006
Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy.
artículo científico publicado en 2014
Stable Isotopically Labeled Intravenous Microdose Pharmacokinetic Trials as a Tool to Assess Absolute Bioavailability: Feasibility and Paradigm to Apply for Protein Kinase Inhibitors in Oncology
artículo científico publicado en 2020
Stable and sensitive method for the simultaneous determination of N5-methyltetrahydrofolate, leucovorin, methotrexate and 7-hydroxymethotrexate in biological fluids
scientific article published on 01 March 1989
Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?
artículo científico publicado en 2005
Standard-dose tegafur-uracil (UFT) is not a safe alternative in partial dihydropyrimidine dehydrogenase-deficient patients
artículo científico publicado en 2013
Strategies to target drugs to gliomas and CNS metastases of solid tumors
artículo científico
Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry
artículo científico publicado en 2005
Study on didanosine concentrations in cerebrospinal fluid. Implications for the treatment and prevention of AIDS dementia complex
artículo científico publicado en 1995
Subtherapeutic antiretroviral plasma concentrations in routine clinical outpatient HIV care
artículo científico publicado en 2003
Successful intraperitoneal suramin treatment of peritoneal mesothelioma
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artículo científico publicado el 1 de agosto de 1997
Survival after massive ecstasy overdose
artículo científico publicado en 1998
Symptoms and treatment in cancer therapy-induced early menopause
artículo científico publicado en 2006
Synthetic vehicles for DNA vaccination
artículo científico publicado en 2010
Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation.
artículo científico publicado en 2019
Systematic review of biomarkers to monitor therapeutic response in leishmaniasis
artículo científico publicado en 2015
Tailored Tamoxifen Treatment for Breast Cancer Patients: A Perspective
artículo científico
Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care
scientific article published on 05 January 2014
Tandem mass spectrometry of small-molecule signal transduction inhibitors: Accurate-m/z data to adapt structure proposals of product ions
artículo científico publicado en 2020
Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.
artículo científico publicado en 2013
Taxanes: a new class of antitumor agents.
artículo científico publicado en 1995
Taxanes: old drugs, new oral formulations
artículo científico publicado en 2013
The G2 checkpoint-a node-based molecular switch
artículo científico publicado en 2017
The Use of Dried Blood Spots for Pharmacokinetic Monitoring of Vemurafenib Treatment in Melanoma Patients.
artículo científico publicado en 2016
The absolute quantification of eight inter‐α‐trypsin inhibitor heavy chain 4 (ITIH4)‐derived peptides in serum from breast cancer patients
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artículo científico publicado el 1 de diciembre de 2010
The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research
artículo científico publicado en 2008
The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS
artículo científico publicado en 2012
The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.
artículo científico publicado en 2009
The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.
artículo científico publicado en 2009
The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry
artículo científico publicado en 2009
The biological and clinical role of drug transporters at the intestinal barrier
artículo científico publicado en 2008
The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients
artículo científico publicado en 2001
The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity
scientific article published on 10 July 2019
The effect of Echinacea purpurea on the pharmacokinetics of docetaxel
artículo científico publicado en 2013
The effect of P-glycoprotein and cytochrome P450 3a on the oral bioavailability of vinorelbine in mice
artículo científico publicado en 2005
The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib
artículo científico publicado en 2008
The effect of St John's wort on the pharmacokinetics of docetaxel
artículo científico publicado en 2014
The effect of complementary and alternative medicines on CYP3A4-mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel
artículo científico publicado en 2014
The effect of fluconazole on ritonavir and saquinavir pharmacokinetics in HIV-1-infected individuals
artículo científico publicado en 2001
The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors
artículo científico publicado en 2004
The effect of grape seed extract on the pharmacokinetics of dextromethorphan in healthy volunteers.
artículo científico publicado en 2013
The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate
artículo científico publicado en 2006
The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models
artículo científico publicado en 2006
The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome
scientific article published on 31 August 2013
The effects of sulfur-containing compounds and gemcitabine on the binding of cisplatin to plasma proteins and DNA determined by inductively coupled plasma mass spectrometry and high performance liquid chromatography-inductively coupled plasma mass s
artículo científico publicado en 2008
The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors
artículo científico publicado en 2017
The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma
scientific article published on 01 November 1996
The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases
artículo científico publicado en 2018
The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.
artículo científico publicado en 2014
The influence of P170-glycoprotein modulators on the efficacy and the distribution of vincristine as well as on MDR1 expression in BRO/mdr1.1 human melanoma xenografts
artículo científico publicado en 1999
The influence of formulation excipients on the stability of the novel antitumor agent carzelesin (U-80,244)
scientific article published on 01 November 1995
The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice
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artículo científico publicado el 7 de noviembre de 2003
The intravenous to oral switch of taxanes: strategies and current clinical developments
artículo científico publicado en 2020
The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.
artículo científico publicado en 2016
The pharmacokinetics of nelfinavir in HIV-1-infected children
artículo científico publicado en 2002
The pharmacokinetics of reduced folates after intraperitoneal and intravenous administration of racemic [6S,R]-folinic acid
scientific article published on 01 January 1994
The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog
artículo científico publicado el 1 de octubre de 1997
The pharmacokinetics of ¹²⁴I-rituximab in patients with rheumatoid arthritis
artículo científico publicado en 2011
The pharmacokinetics of ¹³¹I-rituximab in a patient with CD20 positive non-Hodgkin Lymphoma: evaluation of the effect of radioiodination on the biological properties of rituximab
artículo científico publicado en 2011
The pharmacological role of P-glycoprotein in the intestinal epithelium
artículo científico publicado en 1998
The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patients
artículo científico publicado en 2004
The preparation of radiolabeled monoclonal antibodies for human use.
artículo científico publicado en 2009
The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry
artículo científico publicado en 2005
The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice
artículo científico publicado en 2000
The steady-state plasma pharmacokinetics of indinavir alone and in combination with a low dose of ritonavir in twice daily dosing regimens in HIV-1-infected individuals
scientific article published on 01 October 1999
The toxicity of radiotherapy following high-dose chemotherapy with peripheral blood stem cell support in high-risk breast cancer: a preliminary analysis
scientific article published on 01 August 1996
The use of combinations of monoclonal antibodies in clinical oncology
artículo científico
The use of the Calvert formula to determine the optimal carboplatin dosage
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artículo científico publicado el 1 de enero de 1995
Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology
artículo científico publicado en 2019
Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy
artículo científico publicado en 2018
Therapeutic drug monitoring in cancer--are we missing a trick?
artículo científico publicado en 2014
Therapeutic drug monitoring of antiretroviral drugs at home using dried blood spots: a proof-of-concept study
artículo científico publicado en 2012
Therapeutic drug monitoring of imatinib in patients with gastrointestinal stromal tumours - Results from daily clinical practice
artículo científico publicado en 2020
Therapeutic drug monitoring of non-anticancer drugs in cancer patients.
artículo científico publicado en 2004
Therapeutic drug monitoring of phenytoin in patients with the acquired immunodeficiency syndrome
artículo científico publicado en 1994
Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real-world cohort study: does age matter?
artículo científico publicado en 2018
Thermal stability study of crystalline and novel spray-dried amorphous nilotinib hydrochloride
artículo científico publicado en 2017
Three spectroscopic techniques evaluated as a tool to study the effects of iodination of monoclonal antibodies, exemplified by rituximab
scientific article published on 20 May 2011
Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography
scientific article published on 01 January 1993
Tissue distribution, metabolism and excretion of paclitaxel in mice
artículo científico publicado en 1996
Topoisomerase I inhibitors in the treatment of gastrointestinal cancer: from intravenous to oral administration
artículo científico publicado en 2004
Topoisomerase I levels in white blood cells of patients with ovarian cancer treated with paclitaxel-cisplatin-topotecan in a phase I study
artículo científico publicado en 2002
Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study
scientific article published on 01 January 1999
Toxicokinetics of a dipyridamole (Persantin) intoxication: case report
artículo científico publicado en 2010
Toxicological analysis of azide and cyanide for azide intoxications using gas chromatography
scientific article published on 22 October 2020
Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype
artículo científico publicado en 2007
Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.
artículo científico publicado en 2005
Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose
artículo científico publicado en 2018
Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine.
artículo científico publicado en 2012
Transplacental transfer of anthracyclines, vinblastine, and 4-hydroxy-cyclophosphamide in a baboon model
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artículo científico publicado el 17 de septiembre de 2010
Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone
artículo científico publicado en 2008
Transport of topoisomerase I inhibitors by the breast cancer resistance protein. Potential clinical implications
artículo científico publicado en 2000
Transposon leads to contamination of clinical pDNA vaccine.
artículo científico publicado en 2013
Trastuzumab
scientific article published on 31 May 2011
Trastuzumab and bevacizumab combined with docetaxel, oxaliplatin and capecitabine as first-line treatment of advanced HER2-positive gastric cancer: a multicenter phase II study.
artículo científico publicado en 2015
Treatment Individualization in Colorectal Cancer
artículo científico publicado en 2015
Treatment of hypertension in an elderly outpatient population in the Netherlands
artículo científico publicado en 2009
Treatment of older patients with immune checkpoint inhibitors in routine clinical care as compared to inclusion in pivotal registration trials
Treatment of ovarian cancer using intraperitoneal chemotherapy with taxanes: from laboratory bench to bedside
artículo científico publicado en 2006
Tubulin, BRCA1, ERCC1, Abraxas, RAP80 mRNA expression, p53/p21 immunohistochemistry and clinical outcome in patients with advanced non small-cell lung cancer receiving first-line platinum-gemcitabine chemotherapy.
artículo científico publicado en 2011
Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up
artículo científico publicado en 2020
Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models
artículo científico publicado en 2009
Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents
artículo científico publicado en 2009
Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152).
artículo científico publicado en 2011
Ultra-sensitive LC-MS/MS method for the quantification of gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma for a microdose clinical trial.
artículo científico publicado en 2017
Universal access to quality medicines: prioritisation of a-priori solutions
scientific article published on 01 November 2012
Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.
artículo científico publicado en 2015
Urinary and fecal excretion of topotecan in patients with malignant solid tumours
artículo científico publicado en 2002
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
artículo científico publicado en 2005
Use of chloroquine in reducing mother to child transmission of HIV-1 during breastfeeding
article
Use of dried blood spots for the determination of plasma concentrations of nevirapine and efavirenz
artículo científico publicado en 2012
Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen
artículo científico publicado en 2014
Use of leftovers of monoclonal antibody products after partial extraction - A microbiological safety study
scientific article published on 02 June 2019
Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry
artículo científico publicado en 2007
Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tan
artículo científico publicado en 2009
Validated method for the determination of platinum from a liposomal source (SPI-77) in human plasma using graphite furnace Zeeman atomic absorption spectrometry
scientific article published on 01 February 2000
Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection.
artículo científico publicado en 2016
Validation and clinical application of an LC-MS/MS method for the quantification of everolimus using volumetric absorptive microsampling
artículo científico publicado en 2018
Validation of SELDI-TOF MS serum protein profiles for renal cell carcinoma in new populations
artículo científico publicado en 2007
Validation of a limited sampling model for carboplatin in a high-dose chemotherapy combination
artículo científico publicado en 1994
Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar
artículo científico publicado en 2016
Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular-signal-regulated kinase and DNA in circulating tumor cells
artículo científico publicado en 2012
Validation of a quantitative assay for human neutrophil peptide-1, -2, and -3 in human plasma and serum by liquid chromatography coupled to tandem mass spectrometry
artículo científico publicado en 2010
Validation of high-performance liquid chromatography-tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices
artículo científico publicado en 2011
Validation of high-performance liquid chromatography-tandem mass spectrometry assays quantifying omacetaxine mepesuccinate and its 4'‑des-methyl and cephalotaxine metabolites in human plasma and urine.
artículo científico publicado en 2015
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo
artículo científico publicado en 2005
Validation of previously identified serum biomarkers for breast cancer with SELDI-TOF MS: a case control study
artículo científico publicado en 2009
Validation of serum amyloid α as an independent biomarker for progression-free and overall survival in metastatic renal cell cancer patients.
artículo científico publicado en 2012
Variability in bioavailability of small molecular tyrosine kinase inhibitors
artículo científico
Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter s
scientific article published on 15 September 2017
Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic/pharmacodynamic study.
artículo científico publicado en 2017
Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples.
artículo científico publicado en 2016
Vorinostat in patients with resistant BRAFV600E mutated advanced melanoma: a proof of concept study
artículo científico publicado en 2020
Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer
artículo científico publicado en 2003
Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin
artículo científico publicado en 2003
[Concomitant use of proton pump inhibitors and systemic corticosteroids]
artículo científico publicado en 2013
[Demethylating medication in myelodysplastic syndrome]
scientific article published on 01 January 2012
[Hyperglycaemia during treatment with everolimus].
artículo científico publicado en 2014
[Prevention of severe toxicity from capecitabine, 5-fluorouracil and tegafur by screening for DPD-deficiency]
artículo científico publicado en 2012