Lista de obras - Steven Rosenberg - Dominio Público Uruguay

'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations.

artículo científico publicado en 2017

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.

scientific article published on 20 October 2013

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

artículo científico publicado en 2016

A High-avidity WT1-reactive T-Cell Receptor Mediates Recognition of Peptide and Processed Antigen but not Naturally Occurring WT1-positive Tumor Cells

artículo científico publicado en 2016

A Phase I study of an HLA-DPB1*0401-restricted T cell receptor targeting MAGE-A3 for patients with metastatic cancers

artículo científico publicado en 2015

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers

artículo científico publicado en 2018

A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma

artículo científico publicado en 2016

A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Effect of Nystatin on the Development of Oral Irritation in Patients Receiving High-Dose Intravenous Interleukin-2

A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies.

artículo científico publicado en 2016

A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.

artículo científico publicado en 2010

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

artículo científico publicado en 2009

A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas

artículo científico publicado en 2010

A highly recurrent RPS27 5'UTR mutation in melanoma

artículo científico publicado en 2014

A large scale method of separating multiple lymphokines secreted by the murine EL-4 thymoma

scientific article published on 01 January 1985

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes

artículo científico publicado en 1996

A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2

artículo científico publicado en 1986

A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer.

artículo científico publicado en 2014

A novel murine T-cell receptor targeting NY-ESO-1.

artículo científico publicado en 2014

A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma

artículo científico publicado en 2002

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

artículo científico publicado en 2006

A pilot study of antiangiogenic therapy with bevacizumab and thalidomide in patients with metastatic renal cell carcinoma

artículo científico publicado en 2004

A pilot study of the combination of interleukin-2-based immunotherapy and radiation therapy

artículo científico publicado el 1 de noviembre de 1992

A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response

artículo científico publicado en 2014

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

artículo científico publicado en 1987

A prospective analysis of positron emission tomography and conventional imaging for detection of stage IV metastatic melanoma in patients undergoing metastasectomy

artículo científico publicado en 2004

A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy

artículo científico publicado en 1994

A prospective, randomized, double-blind, placebo-controlled trial evaluating the effect of nystatin on the development of oral irritation in patients receiving high-dose intravenous interleukin-2

artículo científico publicado en 2001

A randomized double-blinded comparison of the antiemetic efficacy of ondansetron and droperidol in patients receiving high-dose interleukin-2.

artículo científico publicado en 1994

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

artículo científico publicado en 2003

A simple and effective method to generate lentiviral vectors for ex vivo gene delivery to mature human peripheral blood lymphocytes

artículo científico publicado en 2012

A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors

artículo científico publicado en 2010

A summary of the results of a review of 405 patients with non-Hodgkin's lymphoma at Stanford University ⬇️

artículo científico publicado el 1 de marzo de 1975

A tumor-infiltrating lymphocyte from a melanoma metastasis with decreased expression of melanoma differentiation antigens recognizes MAGE-12.

artículo científico publicado en 2000

Acquired erythropoietin responsiveness of interleukin-2-dependent T lymphocytes retrovirally transduced with genes encoding chimeric erythropoietin/interleukin-2 receptors ⬇️

artículo científico publicado el 15 de septiembre de 1995

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

artículo científico publicado en 2005

Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma

artículo científico publicado en 1991

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo

artículo científico publicado en 2007

Adoptive Cell Therapy--Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors.

artículo científico

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression ⬇️

artículo científico publicado el 15 de agosto de 2011

Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.

artículo científico publicado en 2008

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

artículo científico publicado en 2008

Adoptive cell therapy for the treatment of patients with metastatic melanoma

artículo científico publicado en 2009

Adoptive cell therapy: genetic modification to redirect effector cell specificity.

artículo científico publicado en 2010

Adoptive cell transfer as personalized immunotherapy for human cancer

artículo científico publicado en 2015

Adoptive cell transfer for patients with metastatic melanoma: the potential and promise of cancer immunotherapy.

artículo científico publicado en 2013

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

artículo científico publicado en 2005

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

artículo científico publicado en 2008

Adoptive immunotherapy for cancer: building on success

artículo científico publicado en 2006

Adoptive immunotherapy for cancer: harnessing the T cell response

artículo científico publicado en 2012

Adoptive immunotherapy of a newly induced sarcoma: immunologic characteristics of effector cells

scientific article published on 01 October 1985

Adoptive immunotherapy of a syngeneic murine leukemia with a tumor-specific cytotoxic T cell clone and recombinant human interleukin 2: correlation with clonal IL 2 receptor expression

artículo científico publicado en 1986

Adoptive immunotherapy of established syngeneic solid tumors: role of T lymphoid subpopulations

scientific article published on 01 April 1984

Adoptive immunotherapy of murine hepatic metastases with lymphokine activated killer (LAK) cells and recombinant interleukin 2 (RIL 2) can mediate the regression of both immunogenic and nonimmunogenic sarcomas and an adenocarcinoma

artículo científico publicado en 1985

Adoptive immunotherapy of renal cell carcinoma: studies from the Surgery Branch, National Cancer Institute

artículo científico publicado en 1993

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

artículo científico publicado en 2008

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

artículo científico publicado en 2010

Adoptive transfer of tumor infiltrating lymphocytes for metastatic cervical cancer

artículo científico publicado en 2013

Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion

artículo científico publicado en 2006

Adoptive-cell-transfer therapy for the treatment of patients with cancer

artículo científico publicado en 2003

Adoptively Transferred Tumor-Infiltrating Lymphocytes Can Cure Established Metastatic Tumor in Mice and Persist Long-Term In Vivo as Functional Memory T Lymphocytes ⬇️

artículo científico publicado el 1 de diciembre de 1991

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

artículo científico publicado en 2009

Adoptively transferred tumor-infiltrating T cells target somatic cancer mutations in a human papillomavirus+ cancer patient with complete tumor regression

artículo científico publicado en 2015

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

artículo científico publicado en 2014

Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease

artículo científico publicado en 2016

Altered CD8(+) T-cell responses when immunizing with multiepitope peptide vaccines

artículo científico publicado en 2006

Alternating chemotherapy and irradiation in the treatment of advanced Hodgkin's disease ⬇️

artículo científico publicado el 1 de febrero de 1979

An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors.

artículo científico publicado en 2017

An antigenic peptide produced by reverse splicing and double asparagine deamidation ⬇️

artículo científico publicado el 13 de junio de 2011

An improved method for growing murine tumor-infiltrating lymphocytes with in vivo antitumor activity

artículo científico publicado en 1990

An ongoing prospective randomized comparison of interleukin-2 regimens for the treatment of metastatic renal cell cancer

artículo científico publicado el 1 de diciembre de 1997

Analysis of cytokine secretion by melanoma-specific CD4+ T lymphocytes

artículo científico publicado en 1995

Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in situ lesions.

artículo científico publicado en 1996

Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

artículo científico publicado en 2005

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

artículo científico publicado en 2011

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

artículo científico publicado en 2009

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

artículo científico publicado en 2009

Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer

artículo científico publicado en 2010

Antibody-dependent cellular cytotoxicity mediated by murine lymphocytes activated in recombinant interleukin 2

artículo científico publicado en 1987

Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

scientific article published on 29 January 2020

Antigen-specific tumor vaccines. Development and characterization of recombinant adenoviruses encoding MART1 or gp100 for cancer therapy.

artículo científico publicado en 1996

Antitumor effects in mice of the intravenous injection of attenuated Salmonella typhimurium

artículo científico publicado en 2002

Antitumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: successful immunotherapy of established pulmonary metastases from weakly immunogenic and nonimmunogenic murine tumors of three district histological types

artículo científico publicado en 1986

Antitumor efficacy of lymphokine-activated killer cells and recombinant interleukin-2 in vivo: survival benefit and mechanisms of tumor escape in mice undergoing immunotherapy.

artículo científico publicado en 1986

Assessment of Ovarian Function After Preparative Chemotherapy and Total Body Radiation for Adoptive Cell Therapy ⬇️

artículo científico publicado el 1 de mayo de 2011

Audiovestibular Dysfunction Associated with Adoptive Cell Immunotherapy for Melanoma ⬇️

artículo científico publicado el 17 de mayo de 2012

Augmentation of antitumor efficacy by the combination of recombinant tumor necrosis factor and chemotherapeutic agents in vivo

scientific article published on 01 July 1989

Augmented lymphocyte expansion from solid tumors with engineered cells for costimulatory enhancement ⬇️

artículo científico publicado en 2011

Author Correction: Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

artículo científico publicado en 2019

Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

artículo científico publicado en 2019

Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4.

artículo científico publicado en 2005

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells ⬇️

artículo científico publicado el 8 de diciembre de 2011

BRAF Inhibition: Bridge or Boost to T-cell Therapy?

scientific article published on 01 March 2019

Bcl-2 overexpression enhances tumor-specific T-cell survival

artículo científico publicado en 2005

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

artículo científico publicado en 2004

Biological and antitumor effects of recombinant human macrophage colony-stimulating factor in mice

artículo científico publicado en 1991

Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.

artículo científico publicado en 2010

CARs on track in the clinic

artículo científico publicado en 2011

CD4+ T-cells from mice immunized to syngeneic sarcomas recognize distinct, non-shared tumor antigens

artículo científico publicado en 1994

CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma ⬇️

artículo científico publicado el 28 de julio de 2010

CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.

artículo científico publicado en 2005

CEPP(B): an effective and well-tolerated regimen in poor-risk, aggressive non-Hodgkin's lymphoma

artículo científico publicado en 1990

CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma ⬇️

artículo científico publicado el 23 de enero de 2012

CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.

artículo científico publicado en 2006

Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells ⬇️

artículo científico publicado el 15 de octubre de 1997

Cancer immunotherapy

artículo científico publicado en 2008

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer

scientific article published in Science

Cancer immunotherapy using interleukin-2 and interleukin-2-activated lymphocytes

artículo científico publicado en 1986

Cancer immunotherapy: moving beyond current vaccines

artículo científico publicado en 2004

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

artículo científico publicado en 2002

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

artículo científico publicado en 2003

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

artículo científico publicado en 2013

Cancer regression in patients after transfer of genetically engineered lymphocytes

artículo científico publicado en 2006

Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes

scholarly article

Cell transfer therapy for cancer: lessons from sequential treatments of a patient with metastatic melanoma

artículo científico publicado en 2003

Cellular immunotherapy of cancer

scientific article published on 01 February 1990

Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice ⬇️

artículo científico publicado el 15 de abril de 1992

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

artículo científico publicado en 2005

Characterization of Lymphocytes Infiltrating Human Breast Cancer, Specific Immune Reactivity Detected by Measuring Cytokine Secretion ⬇️

artículo científico publicado el 1 de julio de 1992

Characterization of Postsplenectomy Bacteremia among Patients with and without Lymphoma ⬇️

artículo científico publicado el 13 de julio de 1972

Characterization of T-cell Receptors Directed Against HLA-A01-restricted and C07-restricted Epitopes of MAGE-A3 and MAGE-A12 ⬇️

artículo científico publicado el 1 de noviembre de 2012

Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer.

artículo científico publicado en 2017

Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells

artículo científico publicado en 2009

Characterization of human tumor cell lines transduced with the cDNA encoding either tumor necrosis factor alpha (TNF-a) or interleukin-2 (IL-2).

artículo científico publicado en 1993

Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen.

artículo científico publicado en 1995

Characterization of the lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with phytohemagglutinin

artículo científico publicado en 1983

Chemotherapy of the non-Hodgkin's lymphomas: the Stanford experience

artículo científico publicado el 1 de septiembre de 1977

Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor

artículo científico publicado en 2014

Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum ⬇️

artículo científico publicado el 10 de abril de 2012

Circulating Tumor DNA as an Early Indicator of Response to T-cell Transfer Immunotherapy in Metastatic Melanoma

artículo científico publicado en 2016

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

artículo científico publicado en 2015

Clinical and surgical (laparotomy) evaluation of patients with non-Hodgkin's lymphomas

scientific article published on 01 September 1977

Clinical scale rapid expansion of lymphocytes for adoptive cell transfer therapy in the WAVE® bioreactor

artículo científico publicado en 2012

Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma.

artículo científico publicado en 2014

Clinical trials in the non-Hodgkin's lymphomata at Stanford University experimental design and preliminary results ⬇️

artículo científico publicado el 1 de marzo de 1975

Clinical trials with IL-2

scientific article published on 01 November 1986

Clinical-scale lentiviral vector transduction of PBL for TCR gene therapy and potential for expression in less-differentiated cells

artículo científico publicado en 2008

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

artículo científico publicado en 2013

Combination chemotherapy and radiotherapy for Hodgkin's disease ⬇️

artículo científico publicado el 1 de diciembre de 1972

Combination cytokine immunotherapy with tumor necrosis factor alpha, interleukin 2, and alpha-interferon and its synergistic antitumor effects in mice

artículo científico publicado en 1989

Combination therapy with interferon-gamma and interleukin-2 for the treatment of metastatic melanoma

artículo científico publicado en 1996

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma

article

Combined effects of chemotherapy and interleukin 2 in the therapy of mice with advanced pulmonary tumors

artículo científico publicado en 1988

Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells.

artículo científico publicado en 2017

Combined modality therapy in malignant lymphomas

artículo científico publicado el 1 de septiembre de 1977

Combined modality therapy of Hodgkin's disease.A report on the stanford trials ⬇️

artículo científico publicado el 1 de agosto de 1978

Common expression of melanoma tumor-associated antigens recognized by human tumor infiltrating lymphocytes: analysis by human lymphocyte antigen restriction

artículo científico publicado en 1991

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma ⬇️

artículo científico publicado el 24 de septiembre de 2012

Comparative studies of the long-term growth of lymphocytes from tumor infiltrates, tumor-draining lymph nodes, and peripheral blood by repeated in vitro stimulation with autologous tumor

artículo científico publicado en 1990

Comparison between conventional salvage therapy and high-dose therapy with autografting for recurrent or refractory Hodgkin's disease

artículo científico publicado en 1997

Comparison of common gamma-chain cytokines, interleukin-2, interleukin-7, and interleukin-15 for the in vitro generation of human tumor-reactive T lymphocytes for adoptive cell transfer therapy

artículo científico publicado en 2006

Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.

artículo científico publicado en 2015

Computed tomography, lymphography, and staging laparotomy: correlations in initial staging of Hodgkin disease

scientific article published on 01 July 1984

Considerations for the Clinical Application of Chimeric Antigen Receptor T Cells: Observations from aRecombinant DNA Advisory Committee SymposiumHeld June 15, 2010 ⬇️

artículo científico publicado el 1 de mayo de 2011

Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor

artículo científico publicado en 2009

Continuous intravenous administration of live genetically modified salmonella typhimurium in patients with metastatic melanoma

artículo científico publicado en 2003

Correlates of response to IL-2 therapy in patients treated for metastatic renal cancer and melanoma.

artículo científico publicado en 1996

Curative intravenous adoptive immunotherapy of Meth A murine sarcoma. A histologic and immunohistochemical assessment.

artículo científico publicado en 1985

Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy

artículo científico publicado en 2004

Cytokine regulation of tumor necrosis factor-alpha and -beta (lymphotoxin)-messenger RNA expression in human peripheral blood mononuclear cells

artículo científico publicado en 1990

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene

artículo científico publicado en 2007

Cytokines alter target cell susceptibility to lysis. II. Evaluation of tumor infiltrating lymphocytes

artículo científico publicado en 1989

Cytokines alter target cell susceptibility to lysis: I. Evaluation of non-major histocompatibility complex-restricted effectors reveals differential effects on natural and lymphokine-activated killing

artículo científico publicado en 1990

Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis

article

Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer

artículo científico publicado en 2005

Decrease in interleukin 2-induced vascular leakage in the lungs of mice by administration of recombinant interleukin 1 alpha in vivo

scientific article published on 01 February 1989

Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee

artículo científico publicado en 2020

Delata-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation

artículo científico publicado en 1979

Delayed reactions to contrast media after interleukin-2 immunotherapy

artículo científico publicado el 1 de abril de 1992

Dendritic Cells Retrovirally Transduced with a Model Antigen Gene Are Therapeutically Effective against Established Pulmonary Metastases ⬇️

artículo científico publicado el 20 de octubre de 1997

Determinants of successful CD8+ T-cell adoptive immunotherapy for large established tumors in mice

artículo científico publicado en 2011

Development of Human Anti-Murine T-Cell Receptor Antibodies in Both Responding and Nonresponding Patients Enrolled in TCR Gene Therapy Trials ⬇️

artículo científico publicado el 1 de diciembre de 2010

Development of a T cell receptor targeting an HLA-A*0201 restricted epitope from the cancer-testis antigen SSX2 for adoptive immunotherapy of cancer

artículo científico publicado en 2014

Development of an automated closed system for generation of human lymphokine-activated killer (LAK) cells for use in adoptive immunotherapy

artículo científico publicado en 1987

Development of long-term cell lines and lymphoid clones reactive against murine and human tumors: a new approach to the adoptive immunotherapy of cancer

scientific article published on 01 August 1982

Differences in the effects of host suppression on the adoptive immunotherapy of subcutaneous and visceral tumors

scientific article published on 01 July 1986

Different adjuvanticity of incomplete freund's adjuvant derived from beef or vegetable components in melanoma patients immunized with a peptide vaccine.

artículo científico publicado en 2010

Differential Anti-MART-1/MelanA CTL Activity in Peripheral Blood of HLA-A2 Melanoma Patients in Comparison to Healthy Donors

Differential anti-MART-1/MelanA CTL activity in peripheral blood of HLA-A2 melanoma patients in comparison to healthy donors: evidence of in vivo priming by tumor cells

scientific article published on 01 July 1996

Discovery and characterization of an immunogenic neoantigen in a patient with metastatic triple negative breast cancer.

artículo científico publicado en 2015

Disseminated human malignant melanoma in congenitally immune-deficient (bg/nu/xid) mice

artículo científico publicado en 1991

Diversity of mutated antigen recognition by tumor infiltrating lymphocytes from patients with metastatic melanoma

artículo científico publicado en 2015

Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

artículo científico publicado en 2013

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

artículo científico publicado en 2016

Durable Complete Response from Metastatic Melanoma after Transfer of Autologous T Cells Recognizing 10 Mutated Tumor Antigens

artículo científico publicado en 2016

Durable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing 10 mutated tumor antigens.

artículo científico publicado en 2015

Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

artículo científico publicado en 2011

EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss.

scientific article published on 18 December 2013

Effect of anti-B16 melanoma monoclonal antibody on established murine B16 melanoma liver metastases

artículo científico publicado en 1987

Effect of combined therapy with lymphokine-activated killer cells, interleukin 2 and specific monoclonal antibody on established B16 melanoma lung metastases.

artículo científico publicado en 1988

Effect of corticosteroid on the antitumor activity of lymphokine-activated killer cells and interleukin 2 in mice

scientific article published on 01 November 1986

Effect of hydration on plasma-methotrexate levels

artículo científico publicado el 1 de octubre de 1977

Effect of immunotherapy with allogeneic lymphokine-activated killer cells and recombinant interleukin 2 on established pulmonary and hepatic metastases in mice

artículo científico publicado en 1986

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity

artículo científico publicado en 2008

Effects of high-dose methotrexate and vincristine on ovarian and testicular functions in patients undergoing postoperative adjuvant treatment of osteosarcoma

artículo científico publicado en 1981

Effects of murine tumor class I major histocompatibility complex expression on antitumor activity of tumor-infiltrating lymphocytes

artículo científico publicado en 1990

Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma

scientific article published on 01 December 1981

Efficacy of adjuvant radiation therapy in the treatment of soft tissue sarcoma of the extremity: 20-year follow-up of a randomized prospective trial

artículo científico publicado en 2014

Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.

artículo científico publicado en 2014

Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity

artículo científico publicado en 1999

Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome

scientific article published on 01 March 1988

Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.

artículo científico publicado en 2018

Engineering improved T cell receptors using an alanine-scan guided T cell display selection system ⬇️

artículo científico publicado el 13 de marzo de 2013

Engineering the immune response to "self" for effective cancer immunotherapy

artículo científico publicado en 2014

Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

artículo científico publicado en 2007

Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

artículo científico publicado en 2006

Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy

artículo científico publicado en 2018

Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models

scientific article published on 01 January 2020

Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T cell receptor following a rapid expansion

artículo científico publicado en 2010

Enrichment of CD8+ cells from melanoma tumor-infiltrating lymphocyte cultures reveals tumor reactivity for use in adoptive cell therapy.

artículo científico publicado en 2010

Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4

artículo científico publicado en 2006

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19 ⬇️

artículo científico publicado el 28 de julio de 2010

Eradication of a disseminated syngeneic mouse lymphoma by systemic adoptive transfer of immune lymphocytes and its dependence upon a host component(s).

artículo científico publicado en 1985

Evaluation of computed tomography in the detection of pulmonary metastases.A prospective study ⬇️

artículo científico publicado el 1 de marzo de 1979

Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma

artículo científico publicado en 2006

Evaluation of γ-Retroviral Vectors That Mediate the Inducible Expression of IL-12 for Clinical Application ⬇️

artículo científico publicado el 1 de junio de 2012

Evidence for an orderly progression in the spread of Hodgkin's disease

artículo científico

Evidence that lymphokine-activated killer cells and natural killer cells are distinct based on an analysis of congenitally immunodeficient mice

scientific article published on 01 November 1985

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

scientific article published on 21 March 2019

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

artículo científico publicado en 2011

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

artículo científico publicado en 2011

Expansion and characterization of T cells transduced with a chimeric receptor against ovarian cancer

artículo científico publicado en 2000

Expansion of human tumor infiltrating lymphocytes for use in immunotherapy trials

artículo científico publicado en 1987

Experimental and clinical studies with intraoperative radiotherapy

scientific article published on 01 September 1983

Expression of MAGE-A and NY-ESO-1 in Primary and Metastatic Cancers

artículo científico publicado en 2016

Expression of New York esophageal squamous cell carcinoma-1 in primary and metastatic melanoma.

artículo científico publicado en 2013

Expression of a "self-"antigen by human tumor cells enhances tumor antigen-specific CD4(+) T-cell function.

artículo científico publicado en 2002

Expression profiling of TCR-engineered T cells demonstrates overexpression of multiple inhibitory receptors in persisting lymphocytes ⬇️

artículo científico publicado el 16 de julio de 2013

Extended-field radiation therapy in Hodgkin's disease. A progress report.

artículo científico publicado en 1968

Extended-field radical radiotherapy in advanced Hodgkin's disease: short-term results of 2 randomized clinical trials

scientific article published on 01 June 1966

Extralymphatic Hodgkin's disease. Prognosis and response to therapy.

artículo científico publicado en 1981

Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling

artículo científico publicado en 2007

Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2

artículo científico publicado en 1986

Extremity soft tissue sarcomas: analysis of prognostic variables in 300 cases and evaluation of tumor necrosis as a factor in stratifying higher-grade sarcomas

artículo científico publicado en 1989

FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions

artículo científico publicado en 2008

Factors predicting survival in adults with stage I and II large-cell lymphoma treated with primary radiation therapy

artículo científico publicado en 1986

Female Reproductive Potential after Treatment for Hodgkin's Disease ⬇️

artículo científico publicado el 4 de junio de 1981

Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes

artículo científico publicado en 2002

Frequent mutations in the MITF pathway in melanoma

artículo científico publicado en 2009

Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens

artículo científico publicado en 1999

Functional dissociation between local and systemic immune response during anti-melanoma peptide vaccination

scientific article published on 01 October 1998

Functional heterogeneity of vaccine-induced CD8(+) T cells

artículo científico publicado en 2002

Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy

artículo científico publicado en 2013

Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice ⬇️

artículo científico publicado el 11 de octubre de 2010

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

artículo científico publicado en 2009

Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction

artículo científico publicado en 1990

Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

artículo científico publicado en 2006

Generation from tumor-bearing mice of lymphocytes with in vivo therapeutic efficacy

artículo científico publicado en 1987

Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine design.

artículo científico publicado en 2002

Generation of long-term T-lymphoid cell lines with specific cytotoxic reactivity for a syngeneic murine lymphoma

artículo científico publicado en 1982

Generation of lytic and proliferative lymphoid clones to syngeneic tumor: in vitro and in vivo studies

scientific article published on 01 May 1984

Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients

artículo científico publicado en 2003

Generation of tumor-specific CTLs from melanoma patients by using peripheral blood stimulated with allogeneic melanoma tumor cell lines. Fine specificity and MART-1 melanoma antigen recognition.

artículo científico publicado en 1995

Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

artículo científico publicado en 2011

Genetic inference of immune responsiveness of melanoma cancer patients to TIL therapy

artículo científico publicado en 2013

Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells

artículo científico publicado en 2005

HLA association with response and toxicity in melanoma patients treated with interleukin 2-based immunotherapy

artículo científico publicado en 1992

Helper T cells infiltrating human renal cell carcinomas have the phenotype of activated memory-like T lymphocytes

scientific article published on 01 January 1995

Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients.

artículo científico publicado en 1987

Hematologic neoplasia in patients treated for Hodgkin's disease

artículo científico publicado el 8 de diciembre de 1977

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells

artículo científico publicado en 2007

Hemodynamic effects of the administration of tumor-infiltrating lymphocytes to cancer patients.

artículo científico publicado en 1993

Heterogeneity of lymphokine-activated killer cells induced by IL-2. Separate lymphoid subpopulations lyse tumor, allogeneic blasts, and modified syngeneic blasts

artículo científico publicado en 1988

High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy.

artículo científico publicado en 1999

High efficiency TCR gene transfer into primary human lymphocytes affords avid recognition of melanoma tumor antigen glycoprotein 100 and does not alter the recognition of autologous melanoma antigens

artículo científico publicado en 2003

High frequency CD8+PD-1+ TCR clonotypes isolated from fresh melanomas display anti-tumor activity

artículo científico publicado en 2015

High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

artículo científico publicado en 2007

High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D

artículo científico publicado en 2020

High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.

artículo científico publicado en 2008

High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial

artículo científico publicado en 2001

High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

artículo científico publicado en 2005

Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting

artículo científico publicado en 2013

Hodgkin's disease, stages I and II occurring below the diaphragm ⬇️

artículo científico publicado el 1 de mayo de 1979

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene

artículo científico publicado en 1994

Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy.

artículo científico publicado en 2010

Human lymphokine-activated killer cells: further isolation and characterization of the precursor and effector cell

artículo científico publicado en 1987

Human melanoma antigens recognized by T lymphocytes

artículo científico publicado en 1996

Human melanoma metastases demonstrate nonstochastic site-specific antigen heterogeneity that correlates with T-cell infiltration

artículo científico publicado en 2014

Human tumor infiltrating lymphocytes. Analysis of lymphokine mRNA expression and relevance to cancer immunotherapy

artículo científico publicado en 1989

Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules

artículo científico publicado en 2003

IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain

artículo científico publicado en 2010

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.

artículo científico publicado en 2011

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

artículo científico publicado en 2004

IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

artículo científico publicado en 2005

IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells

artículo científico publicado en 2007

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

artículo científico publicado en 2008

IL-2-based immunotherapy alters circulating neutrophil Fc receptor expression and chemotaxis

scientific article published on 01 May 1990

IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes

artículo científico publicado en 1989

IL-4 regulation of murine lymphokine-activated killer activity in vitro. Effects on the IL-2-induced expansion, cytotoxicity, and phenotype of lymphokine-activated killer effectors

artículo científico publicado en 1989

IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans

artículo científico publicado en 1989

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

artículo científico publicado en 2006

Identification and characterization of a tumor infiltrating CD56(+)/CD16 (-) NK cell subset with specificity for pancreatic and prostate cancer cell lines.

artículo científico publicado en 2010

Identification of BING-4 cancer antigen translated from an alternative open reading frame of a gene in the extended MHC class II region using lymphocytes from a patient with a durable complete regression following immunotherapy

artículo científico publicado en 2002

Identification of MART-1-specific T-cell receptors: T cells utilizing distinct T-cell receptor variable and joining regions recognize the same tumor epitope ⬇️

artículo científico publicado el 15 de octubre de 1994

Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer

artículo científico publicado en 2019

Identification of a colorectal tumor-associated antigen (COA-1) recognized by CD4(+) T lymphocytes ⬇️

artículo científico publicado el 15 de octubre de 2003

Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes

artículo científico publicado en 1995

Identification of a new shared HLA-A2.1 restricted epitope from the melanoma antigen tyrosinase

artículo científico publicado en 2001

Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2)

artículo científico publicado en 1998

Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

artículo científico publicado en 1995

Identification of cellular mechanisms operational in vivo during the regression of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin 2

artículo científico publicado en 1987

Identification of endogenous HLA-A2-restricted reactivity against shared melanoma antigens in patients using the quantitative real-time polymerase chain reaction

artículo científico publicado en 2002

Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression

artículo científico publicado en 2004

Identification of mutation-specific tumor infiltrating lymphocytes from metastatic ovarian cancer

artículo científico publicado en 2015

Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.

artículo científico publicado en 1987

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes

artículo científico publicado en 1994

Identification of tumor-regression antigens in melanoma.

artículo científico publicado en 1996

Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma

artículo científico publicado en 1997

Identification of unique murine tumor associated antigens by tumor infiltrating lymphocytes using tumor specific secretion of interferon-gamma and tumor necrosis factor

artículo científico publicado en 1991

Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

artículo científico publicado en 2020

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

artículo científico publicado en 2018

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

artículo científico publicado en 2013

Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides

artículo científico publicado en 1996

Immunization of HLA-A0201 and/or HLA-DPbeta104 patients with metastatic melanoma using epitopes from the NY-ESO-1 antigen

artículo científico publicado en 2004

Immunization of patients with melanoma peptide vaccines: immunologic assessment using the ELISPOT assay

scientific article published on 01 September 1998

Immunization of patients with metastatic melanoma using both class I- and class II-restricted peptides from melanoma-associated antigens

artículo científico publicado en 2003

Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase

artículo científico publicado en 2004

Immunogenicity of somatic mutations in human gastrointestinal cancers.

artículo científico publicado en 2015

Immunohistochemical correlates of response to recombinant interleukin-2-based immunotherapy in humans

artículo científico publicado en 1989

Immunohistologic responses within dermal metastatic melanoma lesions of patients treated with a synthetic peptide vaccine

artículo científico publicado en 2000

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

artículo científico publicado en 2019

Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

artículo científico publicado en 2020

Immunoselection of a human melanoma resistant to specific lysis by autologous tumor-infiltrating lymphocytes. Possible mechanisms for immunotherapeutic failures

artículo científico publicado en 1990

Immunotherapy for Metastatic Solid Cancers ⬇️

artículo científico publicado el 1 de enero de 2011

Immunotherapy of cancer with lymphokine-activated killer cells and recombinant interleukin-2

artículo científico publicado en 1985

Immunotherapy of murine sarcomas using lymphokine activated killer cells: optimization of the schedule and route of administration of recombinant interleukin-2

scientific article published on 01 June 1986

Immunotherapy: The path to win the war on cancer?

artículo científico publicado en 2015

Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells

artículo científico publicado en 2020

Impact of a recombinant fowlpox vaccine on the efficacy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient with metastatic melanoma

artículo científico publicado en 2009

Impact of salvage treatment on initial relapses in patients with Hodgkin disease, stages I-III ⬇️

artículo científico publicado el 1 de mayo de 1978

Improved gene transfer into human lymphocytes using retroviruses with the gibbon ape leukemia virus envelope

artículo científico publicado en 1996

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues

artículo científico publicado en 1996

Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment ⬇️

artículo científico publicado el 1 de febrero de 2011

In search of an effective antiemetic: a nusring staff participates in marijuana research

artículo científico publicado en 1980

In vitro and in vivo antitumor properties of a T-cell clone generated from murine tumor-infiltrating lymphocytes

artículo científico publicado en 1990

In vitro differentiation of T-cells capable of mediating the regression of established syngeneic tumors in mice

scientific article published on 01 March 1987

In vitro growth of cytotoxic human lymphocytes. II. Use of T cell growth factor (TCGF) to clone human T cells

scientific article published on 01 June 1980

In vitro growth of cytotoxic human lymphocytes. III. The preparation of lectin-free T cell growth factor (TCGF) and an analysis of its activity

artículo científico publicado en 1981

In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors.

artículo científico publicado en 1980

In vitro growth of murine T cells. VI. Accelerated skin graft rejection caused by adoptively transferred cells expanded in T cell growth factor

artículo científico publicado en 1981

In vitro sensitization and expansion with viable tumor cells and interleukin 2 in the generation of specific therapeutic effector cells

artículo científico publicado en 1986

In vivo administration of interferon alpha and interleukin 2 induces proliferation of lymphoid cells in the organs of mice

artículo científico publicado en 1990

In vivo administration of purified Jurkat-derived interleukin 2 in mice

artículo científico publicado en 1984

In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.

artículo científico publicado en 1985

In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2.

artículo científico publicado en 1985

In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration

artículo científico publicado en 1987

In vivo administration of recombinant macrophage colony-stimulating factor induces macrophage-mediated antibody-dependent cytotoxicity of tumor cells

artículo científico publicado el 1 de agosto de 1992

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes

scientific article published on 01 August 1995

In vivo antitumor activity of tumor-infiltrating lymphocytes expanded in recombinant interleukin-2.

artículo científico publicado en 1987

In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice

artículo científico publicado en 1989

In vivo proliferation of adoptively transferred tumor-infiltrating lymphocytes in mice

scientific article published on 01 April 1991

Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma

artículo científico publicado en 2005

Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.

artículo científico publicado en 2003

Inability to mediate prolonged reduction of regulatory T Cells after transfer of autologous CD25-depleted PBMC and interleukin-2 after lymphodepleting chemotherapy

artículo científico publicado en 2007

Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

artículo científico publicado en 2006

Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells

artículo científico publicado en 2010

Increased vaccine-specific T cell frequency after peptide-based vaccination correlates with increased susceptibility to in vitro stimulation but does not lead to tumor regression

scientific article published on 01 December 1999

Individual cultures of melanoma tumor infiltrating lymphocytes possess distinct patterns of reactivity with mutated antigens identified by whole exome sequencing of autologous tumors

article

Induction of CD4+ Th1 lymphocytes that recognize known and novel class II MHC restricted epitopes from the melanoma antigen gp100 by stimulation with recombinant protein

artículo científico publicado en 2004

Induction of antibody-dependent cellular cytotoxicity in vivo by IFN-alpha and its antitumor efficacy against established B16 melanoma liver metastases when combined with specific anti-B16 monoclonal antibody

artículo científico publicado en 1990

Induction of endogenous cytokine-mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients.

artículo científico publicado en 1989

Induction of melanoma reactive T cells by stimulator cells expressing melanoma epitope-major histocompatibility complex class I fusion proteins

artículo científico publicado en 1997

Initial relapse in previously treated Hodgkin's disease—II retrograde transdiaphragmatic extension ⬇️

artículo científico publicado el 1 de septiembre de 1977

Initial relapses in previously treated Hodgkin's disease. I. Results of second treatment

artículo científico publicado el 1 de junio de 1976

Intercurrent death after Hodgkin disease therapy in radiotherapy and adjuvant MOPP trials

artículo científico publicado en 1988

Interleukin 2 and psoriasis

scientific article published on 01 December 1988

Interleukin 2 expanded tumor-infiltrating lymphocytes in human renal cell cancer: isolation, characterization, and antitumor activity

artículo científico publicado en 1988

Interleukin 4 promotes the growth of tumor-infiltrating lymphocytes cytotoxic for human autologous melanoma

artículo científico publicado en 1988

Interleukin-2 based immunotherapy for metastatic renal cell carcinoma with the kidney in place

artículo científico publicado en 1999

Interleukin-2-transduced lymphocytes grow in an autocrine fashion and remain responsive to antigen.

artículo científico publicado en 1995

Intralymphatic dendritic cell vaccination induces tumor antigen-specific, skin-homing T lymphocytes

artículo científico publicado en 2006

Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma

artículo científico publicado en 2006

Intraperitoneal administration of interleukin-2 in patients with cancer

artículo científico publicado en 1986

Intratumoral LAK cell and interleukin-2 therapy of human gliomas.

artículo científico publicado en 1989

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells.

artículo científico publicado en 2011

Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis

artículo científico publicado en 2007

Irradiation Enhances Human T-cell Function by Upregulating CD70 Expression on Antigen-presenting Cells In Vitro ⬇️

artículo científico publicado el 1 de mayo de 2011

Isolation and Characterization of an HLA-DPB1*04: 01-restricted MAGE-A3 T-Cell Receptor for Cancer Immunotherapy

artículo científico publicado en 2016

Isolation of T cell receptors specifically reactive with mutated tumor associated antigens

artículo científico publicado en 2014

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.

artículo científico publicado en 2016

Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

artículo científico publicado en 2015

LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases

artículo científico publicado en 2017

Lack of retroperitoneal lymphadenopathy predicts survival of patients with metastatic renal cell carcinoma

artículo científico publicado en 2001

Lack of specific gamma-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation

artículo científico publicado en 2009

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

artículo científico publicado en 2017

Large scale production of human lymphokine activated killer cells for use in adoptive immunotherapy

artículo científico publicado en 1986

Large-scale depletion of CD25+ regulatory T cells from patient leukapheresis samples

artículo científico publicado en 2005

Lentiviral vector design for optimal T cell receptor gene expression in the transduction of peripheral blood lymphocytes and tumor-infiltrating lymphocytes

artículo científico publicado en 2009

Levels of peripheral CD4(+)FoxP3(+) regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer ⬇️

artículo científico publicado el 3 de mayo de 2012

Limb-sparing surgery for soft tissue sarcomas: wound related morbidity in patients undergoing wide local excision.

artículo científico publicado en 1987

Liver resection for metastatic melanoma with postoperative tumor-infiltrating lymphocyte therapy.

artículo científico publicado en 2009

Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice.

artículo científico publicado en 2012

Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy

artículo científico publicado en 2017

Long-Term Follow-Up of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy

artículo científico publicado en 2020

Long-term outcome in 87 patients with low-grade soft-tissue sarcoma

artículo científico publicado en 1993

Long-term survival of adoptively transferred tumor-infiltrating lymphocytes in mice.

artículo científico publicado en 1990

Loss of S100 antigenicity in metastatic melanoma

scientific article published on September 2005

Lymphoblastic lymphoma in adults: results of a pilot protocol

artículo científico publicado en 1981

Lymphokine-activated killer (LAK) cell phenomenon. IV. Lysis by LAK cell clones of fresh human tumor cells from autologous and multiple allogeneic tumors

scientific article published on 01 July 1985

Lymphokine-activated killer (LAK) cells. Analysis of factors relevant to the immunotherapy of human cancer

artículo científico publicado en 1985

Lymphokine-activated killer cells: lysis of fresh syngeneic natural killer-resistant murine tumor cells by lymphocytes cultured in interleukin 2.

artículo científico publicado en 1984

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels.

artículo científico publicado en 2017

Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor

artículo científico publicado en 1981

Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins

artículo científico publicado en 1982

Lysis of fresh natural killer-resistant tumor cells by lectin-activated syngeneic and allogeneic murine splenocytes.

artículo científico publicado en 1983

Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens

artículo científico publicado en 1981

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain

artículo científico publicado en 1993

MAGE-A is More Highly Expressed Than NY-ESO-1 in a Systematic Immunohistochemical Analysis of 3668 Cases

artículo científico publicado en 2016

MHC class I-restricted recognition of a melanoma antigen by a human CD4+ tumor infiltrating lymphocyte

artículo científico publicado en 1999

MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro

artículo científico publicado en 2010

MOPP chemotherapy for advanced Hodgkin's disease. Prognostic factors in 81 patients

artículo científico publicado en 1973

Manipulation of oxygen radical-scavenging capacity in mice alters host sensitivity to tumor necrosis factor toxicity but does not interfere with its antitumor efficacy

artículo científico publicado en 1990

Measuring tissue-based biomarkers by immunochromatography coupled with reverse-phase lysate microarray

artículo científico publicado en 2006

Mechanism of action of Cyclosporin A: inhibition of lymphokine secretion studied with antigen-stimulated T cell hybridomas

artículo científico publicado en 1984

Mechanisms of immunologic antitumor therapy: lessons from the laboratory and clinical applications

artículo científico

Mechanistic aspects of successful immunotherapy of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin-2.

artículo científico publicado en 1987

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes

artículo científico publicado en 1994

Melanoma-associated B cells are distinct from peripheral blood-derived B cells, and may serve as a source of tumor-targeting antibodies

artículo científico publicado en 2013

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes

artículo científico publicado en 1996

Melanoma: Why is sentinel lymph node biopsy 'standard of care' for melanoma?

artículo científico publicado en 2014

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy

artículo científico publicado en 2015

Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

artículo científico publicado en 2019

Metabolic and renal effects of interleukin-2 immunotherapy for metastatic cancer.

artículo científico publicado en 1988

Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma.

artículo científico publicado en 2016

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 T cells via TLR4 signaling

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling.

artículo científico publicado en 2007

Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy

artículo científico publicado en 2008

Minimally invasive liver resection to obtain tumor-infiltrating lymphocytes for adoptive cell therapy in patients with metastatic melanoma

artículo científico publicado en 2012

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

artículo científico publicado en 2013

Mobilization of dendritic cell precursors in patients with cancer by flt3 ligand allows the generation of higher yields of cultured dendritic cells

artículo científico publicado en 2002

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.

artículo científico publicado en 2012

Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy

artículo científico publicado en 2006

Modulation of murine tumor major histocompatibility antigens by cytokines in vivo and in vitro

scientific article published on 01 October 1988

Multiple HLA class II-restricted melanocyte differentiation antigens are recognized by tumor-infiltrating lymphocytes from a patient with melanoma

artículo científico publicado en 2002

Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells.

artículo científico publicado en 2014

Murine Autoantibodies to a Cryptic Membrane Antigen: Possible Explanation for Neuraminidase-Induced Increase in Cell Immunogenicity2 ⬇️

artículo científico publicado el 1 de abril de 1974

Murine lymphokine-activated killer (LAK) cells: phenotypic characterization of the precursor and effector cells

artículo científico publicado en 1986

Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.

artículo científico publicado en 2013

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma

artículo científico publicado en 2014

Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma

artículo científico publicado en 2010

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma

artículo científico publicado en 2008

Mutational inactivation of STAG2 causes aneuploidy in human cancer

artículo científico publicado en 2011

Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes

artículo científico publicado en 2012

Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma.

artículo científico publicado en 2012

NIH conference. New approaches to the immunotherapy of cancer using interleukin-2.

artículo científico publicado en 1988

NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis.

artículo científico publicado en 2012

NY-ESO-1 may be a potential target for lung cancer immunotherapy.

artículo científico publicado en 1999

Neoantigen screening identifies broad TP53 mutant immunogenicity in patients with epithelial cancers

artículo científico publicado en 2019

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

artículo científico publicado en 2012

No Initial Therapy for Stage III and IV Non-Hodgkin's Lymphomas of Favorable Histologic Types

artículo científico publicado el 1 de enero de 1979

No correlation between clinical response to CTLA-4 blockade and presence of NY-ESO-1 antibody in patients with metastatic melanoma

article

Non-Hodgkin's lymphomas. 3. Preliminary results of radiotherapy and a proposal for new clinical trials.

artículo científico publicado en 1972

Non-Hodgkin's lymphomas. IV. Clinicopathologic correlation in 405 cases.

artículo científico publicado en 1973

Non-Hodgkin's lymphomas.V. Results of radiotherapy ⬇️

artículo científico publicado el 1 de septiembre de 1973

Normal tissue depresses while tumor tissue enhances human T cell responses in vivo to a novel self/tumor melanoma antigen, OA1

artículo científico publicado en 2003

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

artículo científico publicado en 2015

Novel somatic mutations in heterotrimeric G proteins in melanoma

artículo científico publicado en 2010

Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer

artículo científico publicado en 1985

Occurrence of Non-Hodgkin's Lymphoma after Therapy for Hodgkin's Disease ⬇️

artículo científico publicado el 1 de marzo de 1979

Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma

artículo científico publicado en 2009

Outcomes of Adoptive Cell Transfer With Tumor-infiltrating Lymphocytes for Metastatic Melanoma Patients With and Without Brain Metastases

artículo científico publicado en 2018

Overview of interleukin-2 as an immunotherapeutic agent

artículo científico publicado en 1989

PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

scientific article published on 25 March 2014

Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies

artículo científico publicado en 2014

Paraneoplastic granulocytosis in metastatic melanoma

artículo científico publicado en 2010

Parathyroid hormone-related protein and hypercalcemia in patients with metastatic melanoma: case report and review

artículo científico publicado en 2003

Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration

artículo científico publicado en 2008

Pathologic findings associated with interleukin-2-based immunotherapy for cancer: a postmortem study of 19 patients

artículo científico publicado en 1990

Patterns of relapse and response to retreatment in patients with metastatic melanoma or renal cell carcinoma who responded to interleukin-2-based immunotherapy

artículo científico publicado el 1 de marzo de 1998

Penetration of recombinant interleukin-2 across the blood-cerebrospinal fluid barrier

artículo científico publicado en 1988

Persistence of CTL clones targeting melanocyte differentiation antigens was insufficient to mediate significant melanoma regression in humans

artículo científico publicado en 2014

Persistence of multiple tumor-specific T-cell clones is associated with complete tumor regression in a melanoma patient receiving adoptive cell transfer therapy

artículo científico publicado en 2005

Personalized Cell Transfer Immunotherapy for B-Cell Malignancies and Solid Cancers ⬇️

artículo científico publicado el 1 de noviembre de 2011

Personalized immunotherapy for non-small cell lung cancer through identification of tumor-specific mutations by next generation sequencing and adoptive transfer of tumor infiltrating lymphocytes that recognize neoantigens

artículo científico publicado en 2015

Phase 1 study in patients with metastatic melanoma of immunization with dendritic cells presenting epitopes derived from the melanoma-associated antigens MART-1 and gp100.

artículo científico publicado en 2000

Phase I study of human leukocyte interferon in patients with advanced cancer

artículo científico publicado el 1 de enero de 1983

Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma

artículo científico publicado en 2002

Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy

artículo científico publicado en 2013

Phenotypic and functional maturation of tumor antigen-reactive CD8+ T lymphocytes in patients undergoing multiple course peptide vaccination

artículo científico publicado en 2004

Phenotypic characterization of murine tumor-infiltrating T lymphocytes ⬇️

artículo científico publicado el 15 de marzo de 1991

Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma

scientific article published on 01 May 2019

Prednisone in MOPP chemotherapy for Hodgkin's disease ⬇️

artículo científico publicado el 18 de diciembre de 1976

Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL

scholarly article by John Rossi et al published 23 August 2018 in Blood

Presentation of tumor antigens by dendritic cells genetically modified with viral and nonviral vectors

artículo científico publicado en 2006

Prevention of interleukin-2 withdrawal-induced apoptosis in lymphocytes retrovirally cotransduced with genes encoding an antitumor T-cell receptor and an antiapoptotic protein

artículo científico publicado en 2010

Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine

artículo científico publicado en 2005

Primary human lymphocytes transduced with NY-ESO-1 antigen-specific TCR genes recognize and kill diverse human tumor cell lines

artículo científico publicado en 2005

Production of recombinant MART-1 proteins and specific antiMART-1 polyclonal and monoclonal antibodies: use in the characterization of the human melanoma antigen MART-1.

artículo científico publicado en 1997

Prognostic factors in pathologic stage III Hodgkin's disease

artículo científico publicado en 1982

Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade

artículo científico publicado en 2007

Prospective evaluation of doxorubicin-induced cardiomyopathy resulting from postsurgical adjuvant treatment of patients with soft tissue sarcomas

artículo científico publicado en 1983

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

artículo científico publicado en 2016

Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.

artículo científico publicado en 2002

Prospective study of cardiomyopathy induced by adjuvant doxorubicin therapy in patients with soft-tissue sarcomas

artículo científico publicado en 1986

Prospects for gene-engineered T cell immunotherapy for solid cancers. ⬇️

artículo científico publicado en 2016

Quality of life assessment of patients in extremity sarcoma clinical trials.

artículo científico publicado en 1982

Quantitation of T-cell receptor frequencies by competitive PCR: generation and evaluation of novel TCR subfamily and clone specific competitors

artículo científico publicado en 1999

RANTES secretion by gene-modified tumor cells results in loss of tumorigenicity in vivo: role of immune cell subpopulations

artículo científico publicado en 1996

RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

artículo científico publicado en 2018

Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma.

artículo científico publicado en 2013

Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer

artículo científico publicado en 2003

Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

artículo científico publicado en 2016

Rapid Identification and Evaluation of Neoantigen-reactive T-Cell Receptors From Single Cells

artículo científico publicado en 2020

Rapid production of clinical-grade gammaretroviral vectors in expanded surface roller bottles using a "modified" step-filtration process for clearance of packaging cells

artículo científico publicado en 2010

Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma ⬇️

artículo científico publicado el 24 de septiembre de 2012

Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression

artículo científico publicado en 2008

Recognition of an antigenic peptide derived from tyrosinase-related protein-2 by CTL in the context of HLA-A31 and -A33 ⬇️

artículo científico publicado el 15 de enero de 1998

Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.

artículo científico publicado en 2005

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

artículo científico publicado en 2019

Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides ⬇️

artículo científico publicado el 1 de noviembre de 1995

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression

artículo científico publicado en 1995

Recognition of shared melanoma antigens by human tumor-infiltrating lymphocytes

artículo científico publicado el 1 de octubre de 1992

Recognition of shared melanoma antigens in association with major HLA-A alleles by tumor infiltrating T lymphocytes from 123 patients with melanoma

artículo científico publicado en 2000

Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy

artículo científico publicado en 1994

Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma

artículo científico publicado en 2003

Recombinant interleukin 2 stimulates in vivo proliferation of adoptively transferred lymphokine-activated killer (LAK) cells

artículo científico publicado en 1985

Recurrent inactivating RASA2 mutations in melanoma

artículo científico publicado en 2015

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer

artículo científico publicado en 2014

Relapse after response to interleukin-2-based immunotherapy: patterns of progression and response to retreatment

artículo científico publicado en 1991

Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells

artículo científico publicado en 2008

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

artículo científico publicado en 2005

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

artículo científico publicado en 2012

Results of clinical trials with the administration of interleukin 2 and adoptive immunotherapy with activated cells in patients with cancer

artículo científico publicado en 1986

Retroviral transduction of human dendritic cells with a tumor-associated antigen gene.

artículo científico publicado en 1996

Risk of bowel perforation in patients receiving interleukin-2 after therapy with anti-CTLA 4 monoclonal antibody

artículo científico publicado en 2007

Risk of second cancers after treatment for Hodgkin's disease

artículo científico publicado en 1988

Routine Computer Tomography Imaging for the Detection of Recurrences in High-Risk Melanoma Patients

artículo científico publicado en 2017

Safety and efficacy of high-dose interleukin-2 therapy in patients with brain metastases

artículo científico publicado en 2002

Selection of CD8+PD-1+ lymphocytes in fresh human melanomas enriches for tumor-reactive T cells

artículo científico publicado en 2010

Selection of circulating PD-1+ lymphocytes from cancer patients enriches for tumor-reactive and mutation-specific lymphocytes.

artículo científico publicado en 2015

Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2.

artículo científico publicado en 2006

Selective growth, in vitro and in vivo, of individual T cell clones from tumor-infiltrating lymphocytes obtained from patients with melanoma

artículo científico publicado en 2004

Separation and functional studies of the human lymphokine-activated killer cell.

artículo científico publicado en 1987

Separation and growth of human CD4+ and CD8+ tumor-infiltrating lymphocytes and peripheral blood mononuclear cells by direct positive panning on covalently attached monoclonal antibody-coated flasks

artículo científico publicado en 1990

Serum interleukin-6 levels in metastatic renal cell carcinoma before treatment with interleukin-2 correlates with paraneoplastic syndromes but not patient survival ⬇️

artículo científico publicado el 1 de marzo de 1998

Shared human melanoma antigens. Recognition by tumor-infiltrating lymphocytes in HLA-A2.1-transfected melanomas.

artículo científico publicado en 1992

Simplified Method of the Growth of Human Tumor Infiltrating Lymphocytes in Gas-permeable Flasks to Numbers Needed for Patient Treatment ⬇️

artículo científico publicado el 1 de abril de 2012

Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.

artículo científico publicado en 2013

Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

artículo científico publicado en 2008

Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-cell Persistence Following Adoptive Cell Therapy

scientific article published on 04 September 2019

Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy

artículo científico publicado en 2009

Skin reactions in a subset of patients with stage IV melanoma treated with anti-cytotoxic T-lymphocyte antigen 4 monoclonal antibody as a single agent

article by Samer H Jaber et al published February 2006 in Archives of Dermatology

Soft tissue sarcoma: functional outcome after wide local excision and radiation therapy

artículo científico publicado en 1984

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

artículo científico publicado en 2014

Somatic mutations in MAP3K5 attenuate its proapoptotic function in melanoma through increased binding to thioredoxin

artículo científico publicado en 2014

Specific increase in T cell potency via structure-based design of a T cell receptor for adoptive immunotherapy.

artículo científico publicado en 2014

Specific increase in potency via structure-based design of a TCR.

artículo científico publicado en 2014

Specific release of cytokines by lymphocytes infiltrating human melanomas in response to shared melanoma antigens.

artículo científico publicado en 1993

Specific release of granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and IFN-gamma by human tumor-infiltrating lymphocytes after autologous tumor stimulation

scientific article published on 01 May 1991

Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System.

artículo científico publicado en 2016

Staging laparotomies in unselected previously untreated patients with non-Hodgkin's lymphomas ⬇️

artículo científico publicado el 1 de septiembre de 1973

Staging laparotomy and splenectomy in Hodgkin's disease: analysis of indications and patterns of involvement in 285 consecutive, unselected patients

artículo científico publicado el 1 de mayo de 1973

Status of activation of circulating vaccine-elicited CD8+ T cells

artículo científico publicado en 2000

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

artículo científico publicado en 2020

Stimulation of tumor-reactive T lymphocytes using mixtures of synthetic peptides derived from tumor-associated antigens with diverse MHC binding affinities ⬇️

artículo científico publicado el 1 de mayo de 2003

Structure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicity

artículo científico publicado en 2013

Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice.

artículo científico publicado en 1990

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo

scientific article published on 01 February 1987

Study and characterization of mutated antigen specific T cells isolated from fresh tumor and peripheral lymphocytes in cancer patients

artículo científico publicado en 2015

Successful treatment of melanoma brain metastases with adoptive cell therapy.

artículo científico publicado en 2010

Surgical Staging of Abdominal Involvement in Unselected Patients with Hodgkin's Disease ⬇️

artículo científico publicado el 1 de noviembre de 1970

Surgical management of melanoma brain metastases in patients treated with immunotherapy.

artículo científico publicado en 2011

Survival, persistence, and progressive differentiation of adoptively transferred tumor-reactive T cells associated with tumor regression

artículo científico publicado en 2005

Synergistic antitumor effects of combination immunotherapy with recombinant interleukin-2 and a recombinant hybrid alpha-interferon in the treatment of established murine hepatic metastases.

artículo científico publicado en 1988

Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-alpha

scientific article published on 01 July 1988

Systemic administration of interleukin-2 in humans

artículo científico publicado el 1 de octubre de 1984

Systemic administration of recombinant human interleukin-2 in mice

artículo científico publicado el 1 de octubre de 1984

Systemic administration of recombinant interleukin 2 stimulates in vivo lymphoid cell proliferation in tissues

artículo científico publicado en 1985

Systemic induction of cells mediating antibody-dependent cellular cytotoxicity following administration of interleukin 2

scientific article published on 01 December 1989

T cell receptor affinity and avidity defines antitumor response and autoimmunity in T cell immunotherapy

artículo científico publicado en 2013

T cell responses to Mls determinants are restricted by cross-reactive MHC determinants

scientific article published on 01 April 1985

T cells associated with tumor regression recognize frameshifted products of the CDKN2A tumor suppressor gene locus and a mutated HLA class I gene product

artículo científico publicado en 2004

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

artículo científico publicado en 2014

T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

artículo científico publicado en 2010

T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study

artículo científico publicado en 2019

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.

artículo científico publicado en 2016

T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers

scientific article published on 31 May 2018

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

artículo científico publicado en 2013

T-cell receptor gene therapy of established tumors in a murine melanoma model

artículo científico publicado en 2008

T-cell receptor repertoire in tumor-infiltrating lymphocytes. Analysis of melanoma-specific long-term lines

artículo científico publicado en 1994

T-cell therapy against cancer mutations

artículo científico publicado en 2014

TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells

artículo científico publicado en 2005

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

artículo científico publicado en 2012

Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6

artículo científico publicado en 2015

Technical aspects of lymphokine-activated killer cell production ⬇️

artículo científico publicado el 1 de enero de 1988

Tetramer based approach for efficient identification and isolation of neo-antigen specific CD8 T cells from peripheral blood (PBL) of patients with metastatic cancers

artículo científico publicado en 2015

The GYMSSA trial: a prospective randomized trial comparing gastrectomy, metastasectomy plus systemic therapy versus systemic therapy alone

artículo científico publicado en 2009

The Persistence of Human Peripheral Lymphocytes, Tumor Infiltrating Lymphocytes, and Colon Adenocarcinomas in Immunodeficient Mice ⬇️

artículo científico publicado el 1 de enero de 1992

The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes ⬇️

artículo científico publicado el 28 de julio de 2011

The Use of Melanosomal Proteins in the Immunotherapy of Melanoma ⬇️

artículo científico publicado el 1 de julio de 1998

The Waardenburg syndrome type 4 gene, SOX10, is a novel tumor-associated antigen identified in a patient with a dramatic response to immunotherapy

artículo científico publicado en 2002

The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo

scientific article published on 01 July 1985

The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: direct correlation between reduction of established metastases and cytolytic activity of lymphokine-activated killer cells

scientific article published on 01 May 1986

The concept, evolution and preliminary results of the current Stanford clinical trials for Hodgkin's disease

artículo científico publicado en 1985

The current status and future applications of interleukin 2- and adoptive immunotherapy in cancer treatment

artículo científico publicado en 1988

The development of gene therapy for the treatment of cancer

artículo científico publicado en 1993

The effect of various cytokines on the in vitro induction of antibody-dependent cellular cytotoxicity in murine cells. Enhancement of IL-2-induced antibody-dependent cellular cytotoxicity activity by IL-1 and tumor necrosis factor-alpha

scientific article published on 01 April 1989

The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin's disease: 1962-1984.

artículo científico publicado en 1985

The fate of interleukin-2 after in vivo administration

artículo científico publicado en 1983

The hematologic toxicity of interleukin-2 in patients with metastatic melanoma and renal cell carcinoma

artículo científico publicado en 1995

The in vivo distribution of autologous human and murine lymphoid cells grown in T cell growth factor (TCGF): implications for the adoptive immunotherapy of tumors

artículo científico publicado en 1980

The intronic region of an incompletely spliced gp100 gene transcript encodes an epitope recognized by melanoma-reactive tumor-infiltrating lymphocytes

artículo científico publicado en 1997

The management of stage I--II Hodgkin's disease with irradiation alone or combined modality therapy: the Stanford experience

scientific article published on 01 March 1982

The natural history of initially untreated low-grade non-Hodgkin's lymphomas

artículo científico publicado en 1984

The potential benefits of therapeutic splenectomy for patients with Hodgkin's disease and non-Hodgkin's lymphomas

artículo científico publicado en 1985

The stoichiometric production of IL-2 and IFN-γ mRNA defines memory T cells that can self-renew after adoptive transfer in humans.

artículo científico publicado en 2012

The systemic administration of purified interleukin 2 enhances the ability of sensitized murine lymphocytes to cure a disseminated syngeneic lymphoma

artículo científico publicado en 1984

The treatment of advanced stage favorable histology non-Hodgkin's lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation.

artículo científico publicado en 1981

The treatment of malignant histiocytosis

scientific article published on 01 July 1984

The use of interleukin-6 to generate tumor-infiltrating lymphocytes with enhanced in vivo antitumor activity

artículo científico publicado en 1994

The value of sequential bone marrow biopsy and laparotomy and splenectomy in a series of 127 consecutive untreated patients with non-Hodgkin's lymphoma ⬇️

artículo científico publicado el 1 de marzo de 1975

Third-line chemotherapy for resistant Hodgkin's disease with lomustine, etoposide, and methotrexate.

artículo científico publicado en 1987

Thoracic metastasectomy for adoptive immunotherapy of melanoma: a single-institution experience

artículo científico publicado en 2010

Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation

artículo científico publicado en 2014

Thyroid dysfunction in 281 patients with metastatic melanoma or renal carcinoma treated with interleukin-2 alone

artículo científico publicado en 1995

Toll-like receptors in tumor immunotherapy

artículo científico publicado en 2007

Toward cell transfer immunotherapy against patient-specific mutations in gastrointestinal cancers

artículo científico publicado en 2014

Toxicity of recombinant human interleukin-2 in rats following intravenous infusion

scientific article published on 01 August 1985

Transduction of an HLA-DP4-restricted NY-ESO-1-specific TCR into primary human CD4+ lymphocytes

artículo científico publicado en 2006

Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions

artículo científico publicado en 2005

Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy

artículo científico publicado en 2004

Treating cancer with genetically engineered T cells ⬇️

artículo científico publicado el 12 de junio de 2011

Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3.

artículo científico publicado en 2017

Treatment of advanced Hodgkin's disease with B-CAVE following MOPP failure

artículo científico publicado en 1978

Treatment of advanced Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide (ABVD) after failure of MOPP therapy

artículo científico publicado en 1978

Treatment of advanced non-Hodgkin's lymphomas with favorable histologies: preliminary results of a prospective trial

artículo científico publicado en 1976

Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines

artículo científico publicado en 2008

Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study

artículo científico publicado en 2017

Treatment of refractory non-Hodgkin's lymphomas of unfavorable histology with teniposide, cytarabine, and cisplatin

scientific article published on 01 June 1987

Trends in the safety of high dose bolus interleukin-2 administration in patients with metastatic cancer ⬇️

artículo científico publicado el 15 de agosto de 1998

Tumor Infiltrating Lymphocyte Therapy for Metastatic Melanoma: Analysis of Tumors Resected for TIL ⬇️

artículo científico publicado el 1 de octubre de 2010

Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

artículo científico publicado en 2009

Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma

artículo científico publicado en 2005

Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.

artículo científico publicado en 2003

Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study

artículo científico publicado en 2005

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

artículo científico publicado en 2016

Tumor-infiltrating human CD4+ regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity

artículo científico publicado en 2019

Tumor-infiltrating lymphocytes derived from select B-cell lymphomas secrete granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha in response to autologous tumor stimulation

artículo científico publicado en 1993

Tumor-infiltrating lymphocytes from human ovarian cancer patients recognize autologous tumor in an MHC class II-restricted fashion

artículo científico publicado en 1996

Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma

artículo científico publicado en 2015

Tumor-reactive CD8+ T cells in metastatic gastrointestinal cancer refractory to chemotherapy.

artículo científico publicado en 2013

Tumor-specific CD4+ melanoma tumor-infiltrating lymphocytes

artículo científico publicado en 2012

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts

artículo científico publicado en 2010

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas

artículo científico publicado en 1989

Tumorigenicity and immunogenicity of murine tumor cells expressing an MHC class II molecule with a covalently bound antigenic peptide

artículo científico publicado en 2000

Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers

scientific article published on 04 June 2019

Unique murine tumor-associated antigens identified by tumor infiltrating lymphocytes

artículo científico publicado en 1990

Unique neoantigens expressed by melanomas and common epithelial cancers presented by multiple HLA alleles can be efficiently identified utilizing peptide prediction algorithms

artículo científico publicado en 2015

Upregulation of tumor necrosis factor-alpha production by retrovirally transduced human tumor-infiltrating lymphocytes using trans-retinoic acid

artículo científico publicado en 1994

Use of CD137 up-regulation to identify T cell receptors specifically reactive with mutated tumor associated antigens from tumor infiltrating lymphocytes

artículo científico publicado en 2015

Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens.

artículo científico publicado en 2016

Use of interleukin-7, interleukin-2, and interferon-gamma to propagate CD4+ T cells in culture with maintained antigen specificity

scientific article published on 01 October 1993

Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity ⬇️

artículo científico publicado el 1 de enero de 1998

Use of soluble recombinant TNF receptor to improve detection of TNF secretion in cultures of tumor infiltrating lymphocytes ⬇️

artículo científico publicado el 6 de julio de 1992

Use of standard criteria for assessment of cancer vaccines.

artículo científico publicado en 2005

Use of the piggyBac transposon to create stable packaging cell lines for the production of clinical-grade self-inactivating γ-retroviral vectors

artículo científico publicado en 2014

Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report

scientific article published on 01 December 1988

Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen

artículo científico publicado en 1996

Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy

scientific article published on 01 January 1996

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

artículo científico publicado en 2013

gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma

artículo científico publicado en 2011

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

artículo científico publicado en 2020

Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma ⬇️

artículo científico publicado el 1 de octubre de 2010

Lista de obras de Steven Rosenberg

'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations.

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

A High-avidity WT1-reactive T-Cell Receptor Mediates Recognition of Peptide and Processed Antigen but not Naturally Occurring WT1-positive Tumor Cells

A Phase I study of an HLA-DPB1*0401-restricted T cell receptor targeting MAGE-A3 for patients with metastatic cancers

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers

A Pilot Trial of the Combination of Vemurafenib with Adoptive Cell Therapy in Patients with Metastatic Melanoma

A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Effect of Nystatin on the Development of Oral Irritation in Patients Receiving High-Dose Intravenous Interleukin-2

A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies.

A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer.

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas

A highly recurrent RPS27 5'UTR mutation in melanoma

A large scale method of separating multiple lymphokines secreted by the murine EL-4 thymoma

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes

A new approach to the therapy of cancer based on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2

A novel chimeric antigen receptor against prostate stem cell antigen mediates tumor destruction in a humanized mouse model of pancreatic cancer.

A novel murine T-cell receptor targeting NY-ESO-1.

A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

A pilot study of antiangiogenic therapy with bevacizumab and thalidomide in patients with metastatic renal cell carcinoma

A pilot study of the combination of interleukin-2-based immunotherapy and radiation therapy

A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

A prospective analysis of positron emission tomography and conventional imaging for detection of stage IV metastatic melanoma in patients undergoing metastasectomy

A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy

A prospective, randomized, double-blind, placebo-controlled trial evaluating the effect of nystatin on the development of oral irritation in patients receiving high-dose intravenous interleukin-2

A randomized double-blinded comparison of the antiemetic efficacy of ondansetron and droperidol in patients receiving high-dose interleukin-2.

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

A simple and effective method to generate lentiviral vectors for ex vivo gene delivery to mature human peripheral blood lymphocytes

A simplified method for the clinical-scale generation of central memory-like CD8+ T cells after transduction with lentiviral vectors encoding antitumor antigen T-cell receptors

A summary of the results of a review of 405 patients with non-Hodgkin's lymphoma at Stanford University ⬇️

A tumor-infiltrating lymphocyte from a melanoma metastasis with decreased expression of melanoma differentiation antigens recognizes MAGE-12.

Acquired erythropoietin responsiveness of interleukin-2-dependent T lymphocytes retrovirally transduced with genes encoding chimeric erythropoietin/interleukin-2 receptors ⬇️

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma

Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo

Adoptive Cell Therapy--Tumor-Infiltrating Lymphocytes, T-Cell Receptors, and Chimeric Antigen Receptors.

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression ⬇️

Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2.

Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens

Adoptive cell therapy for the treatment of patients with metastatic melanoma

Adoptive cell therapy: genetic modification to redirect effector cell specificity.

Adoptive cell transfer as personalized immunotherapy for human cancer

Adoptive cell transfer for patients with metastatic melanoma: the potential and promise of cancer immunotherapy.

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

Adoptive immunotherapy for cancer: building on success

Adoptive immunotherapy for cancer: harnessing the T cell response

Adoptive immunotherapy of a newly induced sarcoma: immunologic characteristics of effector cells

Adoptive immunotherapy of a syngeneic murine leukemia with a tumor-specific cytotoxic T cell clone and recombinant human interleukin 2: correlation with clonal IL 2 receptor expression

Adoptive immunotherapy of established syngeneic solid tumors: role of T lymphoid subpopulations

Adoptive immunotherapy of murine hepatic metastases with lymphokine activated killer (LAK) cells and recombinant interleukin 2 (RIL 2) can mediate the regression of both immunogenic and nonimmunogenic sarcomas and an adenocarcinoma

Adoptive immunotherapy of renal cell carcinoma: studies from the Surgery Branch, National Cancer Institute

Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

Adoptive transfer of tumor infiltrating lymphocytes for metastatic cervical cancer

Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion

Adoptive-cell-transfer therapy for the treatment of patients with cancer

Adoptively Transferred Tumor-Infiltrating Lymphocytes Can Cure Established Metastatic Tumor in Mice and Persist Long-Term In Vivo as Functional Memory T Lymphocytes ⬇️

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

Adoptively transferred tumor-infiltrating T cells target somatic cancer mutations in a human papillomavirus+ cancer patient with complete tumor regression

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease

Altered CD8(+) T-cell responses when immunizing with multiepitope peptide vaccines

Alternating chemotherapy and irradiation in the treatment of advanced Hodgkin's disease ⬇️

An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors.

An antigenic peptide produced by reverse splicing and double asparagine deamidation ⬇️

An improved method for growing murine tumor-infiltrating lymphocytes with in vivo antitumor activity

An ongoing prospective randomized comparison of interleukin-2 regimens for the treatment of metastatic renal cell cancer

Analysis of cytokine secretion by melanoma-specific CD4+ T lymphocytes

Analysis of expression of the melanoma-associated antigens MART-1 and gp100 in metastatic melanoma cell lines and in in situ lesions.

Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer

Antibody-dependent cellular cytotoxicity mediated by murine lymphocytes activated in recombinant interleukin 2

Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens

Characterization of T-cell Receptors Directed Against HLA-A01-restricted and C07-restricted Epitopes of MAGE-A3 and MAGE-A12 ⬇️