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Lista de obras de David Tuveson

5th International Symposium on Focused Ultrasound: North Bethesda, MD, USA. 28 August- 1 September 2016.

artículo científico publicado en 2016

A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth

scientific article published on 01 May 2019

A framework for advancing our understanding of cancer-associated fibroblasts

scientific article published on 24 January 2020

A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules

artículo científico publicado en 2015

A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy

artículo científico publicado en 2011

A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel

artículo científico publicado en 2008

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma ⬇️

artículo científico publicado en 2018

ADAM8 as a drug target in pancreatic cancer.

artículo científico publicado en 2015

ATP citrate lyase inhibition can suppress tumor cell growth

artículo científico publicado en 2005

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.

artículo científico publicado en 2014

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

artículo científico publicado en 2003

Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening

An shRNA silencing a non-toxic transgene reduces nutrient consumption and increases production of adenoviral vectors in a novel packaging cell

artículo científico publicado en 2009

Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer

artículo científico publicado en 2013

Augmenting NF-κB in poor-risk CLL: A general paradigm for other cancers?

artículo científico publicado en 2015

Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

artículo científico publicado en 2020

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

artículo científico publicado en 2015

BRAF as a potential therapeutic target in melanoma and other malignancies

artículo científico publicado en 2003

BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model

artículo científico publicado en 2015

Bioactivation of Napabucasin Triggers Reactive Oxygen Species-Mediated Cancer Cell Death

artículo científico publicado en 2019

C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

artículo científico publicado en 2009

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

artículo científico publicado en 2011

CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer

artículo científico publicado en 2013

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

artículo científico publicado en 2020

Cancer modeling meets human organoid technology

artículo científico publicado en 2019

Cancer: Double trouble for tumours.

artículo científico publicado en 2017

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice

artículo científico publicado en 2011

Challenges and Opportunities in Modeling Pancreatic Cancer

artículo científico publicado en 2017

Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions

artículo científico publicado en 2012

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

artículo científico publicado en 2004

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

scientific article published on 22 May 2016

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

scientific article published on 13 June 2019

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

artículo científico publicado en 2011

Deciphering cancer fibroblasts

artículo científico publicado en 2018

Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

artículo científico publicado en 2015

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

artículo científico publicado en 2006

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia.

artículo científico publicado en 2013

Deploying mouse models of pancreatic cancer for chemoprevention studies

artículo científico publicado en 2010

Detecting and diagnosing ampullary neoplasms

artículo científico publicado en 2004

Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials

artículo científico publicado en 2011

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.

artículo científico publicado en 2017

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

artículo científico publicado en 2020

Dynamic changes during the treatment of pancreatic cancer

artículo científico publicado en 2018

Dynamics of the immune reaction to pancreatic cancer from inception to invasion

artículo científico publicado en 2007

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

artículo científico publicado en 2002

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

artículo científico publicado en 2013

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

artículo científico publicado en 2004

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

artículo científico publicado en 2017

Erratum: Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

artículo científico publicado en 2016

Erratum: Corrigendum: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

artículo científico publicado en 2013

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

artículo científico publicado en 2011

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways

artículo científico publicado en 2007

Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series

scientific article published on 04 June 2020

Fibroblast heterogeneity in the cancer wound

artículo científico publicado en 2014

Finding and killing the CRABs of pancreatic cancer.

artículo científico publicado en 2009

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

artículo científico publicado en 2012

Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells

artículo científico publicado en 2016

Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens

Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens

Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma

article

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer ⬇️

artículo científico publicado el 4 de noviembre de 2010

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

scientific article published on 01 October 2019

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

artículo científico publicado en 2012

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

artículo científico publicado en 2018

ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity

artículo científico publicado en 2020

Identification of Resistance Pathways Specific to Malignancy Using Organoid Models of Pancreatic Cancer

scientific article published on 06 September 2019

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma.

scientific article published on 17 February 2015

Immigration in science

scientific article published on 01 November 2020

Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.

artículo científico publicado en 2014

In search of an early warning system for pancreatic cancer

scientific article published on 01 January 2003

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

artículo científico publicado en 2011

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

artículo científico publicado en 2014

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

artículo científico publicado en 2009

Kras in Organoids

artículo científico publicado en 2018

Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas

artículo científico publicado en 2007

K‐Ras‐Driven Pancreatic Cancer Mouse Model for Anticancer Inhibitor Analyses

artículo científico publicado en 2008

MAX-ing out MYC: a novel small molecule inhibitor against MYC-dependent tumors

artículo científico publicado en 2014

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model

artículo científico publicado en 2015

Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer

artículo científico publicado en 2018

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.

artículo científico publicado en 2016

Maximizing mouse cancer models

artículo científico publicado en 2007

Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development.

artículo científico publicado en 2005

Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma

artículo científico publicado en 2006

Model organoids provide new research opportunities for ductal pancreatic cancer

artículo científico publicado en 2015

Modeling pancreatic cancer with organoids

artículo científico publicado en 2016

Modelling oncogenic Ras/Raf signalling in the mouse.

artículo científico publicado en 2009

Mouse Models of Pancreatic Ductal Adenocarcinoma

artículo científico

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors

artículo científico publicado en 2005

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

artículo científico publicado en 2004

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

artículo científico publicado en 2016

Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells

scientific article published on 28 June 2019

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

artículo científico publicado en 2011

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

artículo científico publicado en 2019

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

scientific article published on 03 May 2019

Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

article

Organoid models for translational pancreatic cancer research

artículo científico publicado en 2019

PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk.

artículo científico publicado en 2017

Pancreatic cancer

article

Pancreatic cancer foiled by a switch of tumour subtype

journal article; published in Nature on 2018-05-14

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

artículo científico publicado en 2012

Pancreatic cancer in mice and man: the Penn Workshop 2004

artículo científico publicado en 2006

Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.

artículo científico publicado en 2006

Perspectives on the role of Wnt biology in cancer

scientific article published on 09 July 2019

Pharmacokinetics and pharmacodynamics of new drugs for pancreatic cancer

scientific article published on 05 July 2019

Physiological analysis of oncogenic K-ras

artículo científico publicado en 2006

Preclinical models of pancreatic ductal adenocarcinoma

artículo científico publicado en 2015

Predictive in vivo animal models and translation to clinical trials

artículo científico

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

scientific article published on 04 September 2019

Quid pro Quo: A Tumor is Not Alone

artículo científico publicado en 2017

RAS in cellular transformation and senescence

scientific article published on September 2009

ROS in Cancer: The Burning Question

artículo científico publicado en 2017

ROS in translation: Chink in the armor

artículo científico publicado en 2016

Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization

scientific article published on 22 February 2017

Ras redux: rethinking how and where Ras acts.

artículo científico publicado en 2003

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

artículo científico publicado en 2018

Recapitulating human cancer in a mouse.

artículo científico publicado en 2013

Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma

artículo científico publicado en 2017

Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

artículo científico publicado en 2007

Restoration of p53 function leads to tumour regression in vivo

artículo científico publicado en 2007

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression

artículo científico publicado en 2011

RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells

artículo científico publicado en 2013

Roadmap for the Emerging Field of Cancer Neuroscience

scientific article published on 01 April 2020

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

artículo científico publicado en 2011

SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice

artículo científico publicado en 2013

Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids

artículo científico publicado en 2020

Soils and Seeds That Initiate Pancreatic Cancer Metastasis

artículo científico publicado en 2017

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo

artículo científico publicado en 2006

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

artículo científico publicado en 2003

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

artículo científico publicado en 2007

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

scientific article published on 24 April 2020

Stromal biology and therapy in pancreatic cancer.

artículo científico publicado en 2010

Stromal biology and therapy in pancreatic cancer: a changing paradigm

artículo científico

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

artículo científico publicado en 2018

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy for personalized cancer treatment

artículo científico publicado en 2018

Suppression of BRAF(V599E) in human melanoma abrogates transformation ⬇️

artículo científico publicado el 1 de septiembre de 2003

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

artículo científico publicado en 2010

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

artículo científico publicado en 2015

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

artículo científico publicado en 2013

Targeting oncogene dependence and resistance

artículo científico publicado en 2003

Technologically advanced cancer modeling in mice

artículo científico publicado en 2002

The RAS and YAP1 dance, who is leading?

artículo científico publicado en 2014

The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression.

artículo científico publicado en 2007

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.

artículo científico publicado en 2015

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

artículo científico publicado en 2012

The differential effects of mutant p53 alleles on advanced murine lung cancer

artículo científico publicado en 2005

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice

artículo científico publicado en 2019

The promise and perils of antioxidants for cancer patients

artículo científico publicado en 2014

The use of GEM models for experimental cancer therapeutics

artículo científico publicado en 2008

The use of targeted mouse models for preclinical testing of novel cancer therapeutics.

artículo científico publicado en 2006

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

scientific article published on 13 January 2020

Transcriptional Regulation by Nrf2.

artículo científico publicado en 2017

Translational medicine: Cancer lessons from mice to humans

scientific article published in Nature

Twist induces an epithelial-mesenchymal transition to facilitate tumor metastasis

artículo científico publicado en 2004

Understanding metastasis in pancreatic cancer: a call for new clinical approaches

scientific article published on 01 January 2012

Untangling the genetics from the epigenetics in pancreatic cancer metastasis

artículo científico publicado en 2017

VAV1: a new target in pancreatic cancer?

artículo científico publicado en 2005

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy

artículo científico publicado en 2014

Waging war against pancreatic cancer: an interview with David Tuveson

artículo científico publicado en 2017

What we have learned about pancreatic cancer from mouse models.

artículo científico

nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

artículo científico publicado en 2012

p53 mutations change phosphatidylinositol acyl chain composition

artículo científico publicado en 2014

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