Filtros de búsqueda

Lista de obras de Aarón Ciechanover

"Covalent affinity" purification of ubiquitin-activating enzyme ⬇️

artículo científico publicado el 10 de marzo de 1982

A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.

artículo científico publicado en 1988

A conversation with Aaron Ciechanover. Interview by Ushma S. Neill

artículo científico publicado en 2013

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. 1978.

artículo científico publicado en 2012

A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1

artículo científico publicado en 2003

A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.

artículo científico publicado en 1998

A path toward understanding neurodegeneration

artículo científico publicado en 2016

ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor

artículo científico publicado en 2009

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

artículo científico publicado en 1980

ATP-stimulated degradation of endogenous proteins in cell free extracts of BHK 21/C13 fibroblasts A key role for the proteinase, macropain, in the ubiquitin-dependent degradation of short-lived proteins ⬇️

artículo científico publicado el 4 de marzo de 1991

Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system ⬇️

artículo científico publicado el 1 de febrero de 1981

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

artículo científico publicado en 2016

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

artículo científico publicado en 2015

An interview with Aaron Ciechanover

artículo científico publicado en 2013

Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells.

artículo científico publicado en 1986

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

artículo científico publicado en 1998

Basic Medical Research Award. The ubiquitin system

artículo científico publicado en 2000

Caspase activation inhibits proteasome function during apoptosis

artículo científico publicado en 2004

Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes.

artículo científico publicado en 1980

Characterization of ubiquitin genes and -transcripts and demonstration of a ubiquitin-conjugating system in Entamoeba histolytica

artículo científico publicado en 1996

Climate change and the integrity of science

artículo científico publicado en 2010

Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system

artículo científico publicado en 1994

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

artículo científico publicado en 2001

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown ⬇️

artículo científico publicado el 10 de julio de 1983

De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains

scientific article published on 10 June 2019

Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium

artículo científico publicado en 2004

Degradation of MYCN oncoprotein by the ubiquitin system

artículo científico publicado el 1 de enero de 1991

Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination

artículo científico publicado en 1999

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

artículo científico publicado en 2015

Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding

artículo científico publicado en 1998

Degradation of nuclear oncoproteins by the ubiquitin system in vitro ⬇️

artículo científico publicado el 1 de enero de 1991

Degradation of ornithine decarboxylase by the mammalian and yeast 26S proteasome complexes requires all the components of the protease

artículo científico publicado en 1995

Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent

artículo científico publicado en 1989

Degradation of ornithine decarboxylase in reticulocyte lysate is ATP-dependent but ubiquitin-independent

artículo científico publicado en 1989

Degradation of proteins by the ubiquitin-mediated proteolytic pathway

scientific article published on March 1990

Degradation of proteins with acetylated amino termini by the ubiquitin system

scientific article published on 01 June 1989

Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue

artículo científico publicado en 2000

Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination

artículo científico publicado en 2004

Degradation of the epstein-barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue

artículo científico publicado en 2000

Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes

artículo científico publicado en 1995

Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2

scientific article published on 01 April 1994

Degradation of tyrosine aminotransferase (TAT) via the ubiquitin-proteasome pathway

scientific article published on 01 March 1997

Degradation of ubiquitin: the fate of the cellular reaper

artículo científico publicado en 2010

Determinants of nuclear and cytoplasmic ubiquitin-mediated degradation of MyoD.

artículo científico publicado en 2002

Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system

artículo científico publicado en 2000

Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles

artículo científico publicado en 2019

Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-κB1 Target SerpinE1 in Aggressive Glioblastoma Tumors

artículo científico publicado en 2020

Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing

scientific journal article

E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1

artículo científico publicado en 2005

E2A protein degradation by the ubiquitin-proteasome system is stage-dependent during muscle differentiation

artículo científico publicado en 2006

Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts ⬇️

artículo científico publicado el 8 de noviembre de 1976

Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by CDD.

artículo científico publicado en 2005

Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.

artículo científico publicado en 2017

Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53.

artículo científico publicado en 2011

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

artículo científico publicado en 2014

Excess of the NF-ĸB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms

artículo científico publicado en 2020

FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination

artículo científico publicado en 2011

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

artículo científico publicado en 2001

Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5.

artículo científico publicado en 2012

Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition

artículo científico publicado en 2018

Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition

scientific article published on 01 September 2017

Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition.

artículo científico publicado en 2016

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

artículo científico publicado en 2009

HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth

artículo científico publicado en 2014

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

artículo científico publicado en 2003

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

artículo científico publicado en 2014

How are substrates recognized by the ubiquitin-mediated proteolytic system?

artículo científico publicado en 1989

Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs.

artículo científico publicado en 1994

Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein

artículo científico publicado en 2007

Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system

artículo científico publicado en 2006

Identification of UBact, a ubiquitin-like protein, along with other homologous components of a conjugation system and the proteasome in different gram-negative bacteria

artículo científico publicado en 2017

Identification of a region within the ubiquitin-activating enzyme required for nuclear targeting and phosphorylation

artículo científico publicado en 1997

Identification of proteins regulated by the proteasome following induction of endoplasmic reticulum stress

scientific article published on 18 July 2019

Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown ⬇️

artículo científico publicado el 25 de febrero de 1981

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha

artículo científico publicado en 1999

Immune defects caused by mutations in the ubiquitin system

artículo científico publicado en 2017

Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins ⬇️

artículo científico publicado el 10 de diciembre de 1982

Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells ⬇️

artículo científico publicado el 15 de junio de 1992

Immunoelectron microscopic localization of ubiquitin in hepatoma cells.

artículo científico publicado en 1988

Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton

artículo científico publicado en 1993

In vivo interactions of MyoD, Id1, and E2A proteins determined by acceptor photobleaching fluorescence resonance energy transfer

artículo científico publicado en 2008

Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes

artículo científico publicado en 2002

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

artículo científico publicado en 1997

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

artículo científico publicado en 1997

Innate and Adaptive Immunity: The 2011 Nobel Prize in Physiology or Medicine ⬇️

artículo científico publicado el 1 de diciembre de 2011

Interview with Aaron Ciechanover

artículo científico publicado en 2009

Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting ⬇️

artículo científico publicado el 31 de enero de 2012

Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004.

artículo científico publicado en 2007

Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting ⬇️

artículo científico publicado el 8 de febrero de 2013

Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

artículo científico publicado en 2017

Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin–proteasome system and onto human diseases and drug targeting ⬇️

artículo científico publicado el 22 de marzo de 2011

Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

artículo científico publicado en 2010

Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

artículo científico publicado en 2012

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

artículo científico publicado en 2005

Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture).

artículo científico publicado en 2005

Intracellular transport of transferrin- and asialoorosomucoid-colloidal gold conjugates to lysosomes after receptor-mediated endocytosis

artículo científico publicado en 1985

Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer

artículo científico publicado en 2003

Isolation, characterization, and partial purification of a novel ubiquitin-protein ligase, E3. Targeting of protein substrates via multiple and distinct recognition signals and conjugating enzymes

scientific article published on 01 January 1996

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

artículo científico publicado en 2008

KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth

artículo científico publicado en 2015

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

artículo científico publicado en 1983

Loss of adhesion of erythrocyte precursors to fibronectin during erythroid differentiation

artículo científico publicado en 1985

Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation

scientific article published on 01 January 1985

Mammalian reticulocytes lose adhesion to fibronectin during maturation to erythrocytes

artículo científico publicado en 1985

Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase

artículo científico publicado en 2004

Mechanisms of Intracellular Protein Breakdown ⬇️

artículo científico publicado el 1 de enero de 1982

Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.

artículo científico publicado en 2001

Modes of regulation of ubiquitin-mediated protein degradation

artículo científico publicado en 2000

Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor

artículo científico publicado en 2009

Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor

artículo científico publicado en 2011

Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS

artículo científico publicado en 2012

Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins

artículo científico publicado en 2013

Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.

artículo científico publicado en 2016

Modulation of the cell cycle regulating transcription factor E2F1 pathway by the proteasome following amino acid starvation

artículo científico publicado en 2019

Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

artículo científico publicado en 1991

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

artículo científico publicado en 2018

Monitoring stress-induced autophagic engulfment and degradation of the 26S proteasome in mammalian cells

artículo científico publicado en 2019

Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal

artículo científico publicado en 2017

Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation

artículo científico publicado en 2014

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice

artículo científico publicado en 1999

N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis

artículo científico publicado en 2018

N-terminal ubiquitination

artículo científico publicado en 2005

N-terminal ubiquitination: more protein substrates join in.

artículo científico publicado en 2004

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1

artículo científico publicado en 2012

Narrative review: protein degradation and human diseases: the ubiquitin connection

artículo científico publicado en 2006

Non-canonical ubiquitin-based signals for proteasomal degradation ⬇️

artículo científico publicado el 1 de febrero de 2012

Nonenzymatic polyubiquitination of expressed proteins

artículo científico publicado en 2014

Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent

artículo científico publicado en 1994

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination

artículo científico publicado en 2016

On the involvement of calpains in the degradation of the tumor suppressor protein p53

artículo científico publicado en 1997

On the linkage between the ubiquitin-proteasome system and the mitochondria

artículo científico publicado en 2016

On the wings of imagination

artículo científico publicado en 2011

Oxidative stress-related increase in ubiquitination in early coronary atherogenesis

artículo científico publicado en 2003

PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins

artículo científico publicado en 2011

Personalized medicine: the road ahead

artículo científico publicado en 2012

Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia

artículo científico publicado en 2007

Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2

artículo científico publicado en 2011

Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase

artículo científico publicado en 1990

Post-translational modification profiling - A novel tool for mapping the protein modification landscape in cancer

artículo científico publicado en 2016

Processing of p105 is inhibited by docking of p50 active subunits to the ankyrin repeat domain, and inhibition is alleviated by signaling via the carboxyl-terminal phosphorylation/ ubiquitin-ligase binding domain

artículo científico publicado en 2001

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

artículo científico publicado en 1980

Proteasome phase separation: a novel layer of quality control

artículo científico publicado en 2020

Protein Quality Control by Molecular Chaperones in Neurodegeneration

artículo científico publicado en 2017

Protein synthesis elongation factor EF-1 alpha is an isopeptidase essential for ubiquitin-dependent degradation of certain proteolytic substrates

artículo científico publicado en 1996

Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu

artículo científico publicado en 1994

Purification and characterization of a novel protein that is required for degradation of N-alpha-acetylated proteins by the ubiquitin system ⬇️

artículo científico publicado el 15 de octubre de 1991

Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates

artículo científico publicado en 1994

Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway

artículo científico publicado en 1988

Purification, characterization, and rapid inactivation of thermolabile ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.

artículo científico publicado en 1989

RING1B ubiquitination and stability are regulated by ARF.

artículo científico publicado en 2012

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

artículo científico publicado en 2002

Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway

artículo científico publicado en 2017

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

artículo científico publicado en 1997

Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways

artículo científico publicado en 2007

Regulation of the Polycomb protein RING1B ubiquitination by USP7.

artículo científico publicado en 2010

Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome

artículo científico publicado en 2010

Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation

artículo científico publicado en 2005

Regulation of the ubiquitin-mediated proteolytic pathway: role of the substrate alpha-NH2 group and of transfer RNA.

artículo científico publicado en 1987

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

artículo científico publicado en 2011

Rescue of the complex temperature-sensitive phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitin-activating enzyme cDNA.

artículo científico publicado en 1994

Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP ⬇️

artículo científico publicado el 1 de julio de 1979

Response to health in the Occupied Palestinian Territory ⬇️

artículo científico publicado el 29 de octubre de 2011

Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.

artículo científico publicado en 1998

Role of arginine-tRNA in protein degradation by the ubiquitin pathway

artículo científico publicado en 1987

Role of the ubiquitin ligase KPC1 in NF-κB activation and tumor suppression

scholarly article by Yelena Kravtsova-Ivantsiv et al published 22 February 2016 in Journal of analytical science & technology

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

artículo científico publicado en 2000

Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects

artículo científico publicado en 2020

Sorting and recycling of cell surface receptors and endocytosed ligands: The asialoglycoprotein and transferrin receptors ⬇️

artículo científico publicado el 1 de enero de 1983

Stress-induced alterations in autophagic pathway: relationship to ubiquitin system ⬇️

artículo científico publicado el 1 de abril de 1992

Stress-induced polyubiquitination of proteasomal ubiquitin receptors targets the proteolytic complex for autophagic degradation

artículo científico publicado en 2017

Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain

artículo científico publicado en 1999

Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system

artículo científico publicado en 2011

Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

artículo científico publicado en 2013

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

artículo científico publicado en 2009

The 2008 Lindau Nobel Laureate Meeting: Aaron Ciechanover, Chemistry 2004.

artículo científico publicado en 2009

The 26 S proteasome: from basic mechanisms to drug targeting

artículo científico publicado en 2009

The 26S proteasome of the yeast Saccharomyces cerevisiae

scientific article published on 01 November 1994

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

artículo científico publicado en 2008

The N-Degron Pathway Mediates ER-phagy

artículo científico publicado en 2019

The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system

artículo científico publicado en 2008

The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105.

artículo científico publicado en 2002

The Polycomb Protein Ring1B Generates Self Atypical Mixed Ubiquitin Chains Required for Its In Vitro Histone H2A Ligase Activity

artículo científico publicado en 2006

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

artículo científico publicado en 2017

The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors ⬇️

artículo científico publicado el 1 de enero de 1983

The complexity of recognition of ubiquitinated substrates by the 26S proteasome

artículo científico

The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.

artículo científico publicado en 2018

The eye lens has an active ubiquitin-protein conjugation system.

artículo científico publicado en 1986

The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death

artículo científico publicado en 2016

The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore

artículo científico publicado en 2012

The nuclear ubiquitin-proteasome system degrades MyoD.

artículo científico publicado en 2001

The p105 NF-ĸB precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation

scientific article published on 12 September 2020

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

artículo científico publicado en 2011

The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation

artículo científico publicado en 2012

The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2.

artículo científico publicado en 2016

The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue

artículo científico publicado en 2004

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

artículo científico publicado en 1996

The ubiquitin pathway for the degradation of intracellular proteins

artículo científico publicado en 1986

The ubiquitin proteasome system and its involvement in cell death pathways

scientific article published on 01 January 2010

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

artículo científico publicado en 2003

The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting

artículo científico publicado en 2003

The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting

artículo científico publicado en 2006

The ubiquitin proteolytic system: from an idea to the patient bed.

artículo científico publicado en 2006

The ubiquitin system

artículo científico publicado en 1998

The ubiquitin system for protein degradation

artículo científico publicado el 1 de enero de 1992

The ubiquitin system: from basic mechanisms to the patient bed.

artículo científico publicado en 2004

The ubiquitin system: historical perspective

artículo científico publicado en 2010

The ubiquitin system: pathogenesis of human diseases and drug targeting

artículo científico publicado en 2004

The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent manner

artículo científico publicado en 1996

The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress

artículo científico publicado el 1 de enero de 1991

The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins.

artículo científico publicado en 1991

The ubiquitin-dependent proteolytic pathway: specificity of recognition of the proteolytic substrates

artículo científico publicado en 1989

The ubiquitin-mediated proteolytic pathway

artículo científico publicado en 1993

The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation ⬇️

artículo científico publicado el 1 de enero de 1984

The ubiquitin-mediated proteolytic pathway: enzymology and mechanisms of recognition of the proteolytic substrates

artículo científico publicado en 1990

The ubiquitin-mediated proteolytic pathway: mechanisms of action and cellular physiology

artículo científico publicado en 1994

The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins.

artículo científico publicado en 1994

The ubiquitin-mediated proteolytic pathway: mode of action and clinical implications

artículo científico publicado en 2000

The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators

artículo científico publicado en 1995

The ubiquitin-mediated system for intracellular protein degradation

artículo científico publicado en 1991

The ubiquitin-proteasome pathway and pathogenesis of human diseases

artículo científico publicado en 1999

The ubiquitin-proteasome pathway: on protein death and cell life

artículo científico publicado en 1998

The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death

artículo científico publicado en 1998

The ubiquitin-proteasome proteolytic pathway

artículo científico publicado en 1994

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

artículo científico publicado en 2002

The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression

artículo científico publicado en 2015

The ubiquitin-proteasome system and autophagy: Coordinated and independent activities

artículo científico publicado en 2016

The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extended

artículo científico publicado en 2004

The ubiquitin-proteasome system--micro target for macro intervention?

artículo científico publicado en 2005

The ubiquitin-proteasome system: A potential therapeutic target for heart failure

artículo científico publicado en 2017

The ubiquitin-proteasome system: the relationship between protein degradation and human diseases

artículo científico publicado el 1 de diciembre de 2001

Tracing the history of the ubiquitin proteolytic system: the pioneering article

artículo científico publicado en 2009

Trafficking of the transferrin receptor

artículo científico publicado el 1 de enero de 1991

Transfer RNA is an essential component of the ubiquitin- and ATP-dependent proteolytic system

artículo científico publicado en 1985

Transfer RNA is required for conjugation of ubiquitin to selective substrates of the ubiquitin- and ATP-dependent proteolytic system

artículo científico publicado en 1986

Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis

artículo científico publicado en 2006

Ubiquitin as a central cellular regulator

artículo científico publicado en 2004

Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases

artículo científico publicado en 2013

Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation

scientific article published on 06 July 2009

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85 ⬇️

artículo científico publicado el 1 de mayo de 1984

Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target.

artículo científico publicado en 2007

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

artículo científico publicado en 1999

Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.

artículo científico publicado en 2004

Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles ⬇️

artículo científico publicado el 1 de julio de 1992

Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70

scientific article published on 01 April 1997

Ubiquitin-mediated degradation of cellular proteins in health and disease

artículo científico publicado en 2002

Ubiquitin-mediated degradation of cellular proteins: why destruction is essential for construction, and how it got from the test tube to the patient's bed.

artículo científico publicado en 2001

Ubiquitin-mediated degradation of tyrosine aminotransferase (TAT) in vitro and in vivo

artículo científico publicado en 1997

Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation

artículo científico publicado en 1995

Ubiquitin-mediated protein modification and degradation

artículo científico publicado el 1 de noviembre de 1992

Ubiquitin-mediated proteolysis: biological regulation via destruction

artículo científico publicado en 2000

Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells

artículo científico publicado en 2008

Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation

artículo científico publicado en 2005

Ubiquitination and degradation of proteins

scientific article published on 01 January 2011

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

artículo científico publicado en 2011

Ubiquitination of specific mitochondrial matrix proteins

artículo científico publicado en 2016

Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions

artículo científico publicado en 2009

c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination

artículo científico publicado en 2001

p62 at the crossroad of the ubiquitin-proteasome system and autophagy

artículo científico publicado en 2016

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.

artículo científico publicado en 2016

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

artículo científico publicado en 2017

pH and the recycling of transferrin during receptor-mediated endocytosis

artículo científico publicado en 1983

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda