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Lista de obras de Matthias Gaestel

1 H NMR spectroscopy reveals that mouse Hsp25 has a flexible C-terminal extension of 18 amino acids

artículo científico publicado en 1995

3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways

artículo científico publicado en 1996

A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium

artículo científico publicado en 2016

A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis

artículo científico publicado en 2004

A theoretical approach to cluster formation in biological membranes.

artículo científico publicado en 1984

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

artículo científico publicado en 2012

Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients

artículo científico publicado en 2001

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons

artículo científico publicado en 2005

Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor

article

Adenosine increases calcium sensitivity via receptor-independent activation of the p38/MK2 pathway in mesenteric arteries

artículo científico publicado en 2007

Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization

scientific article published on 01 February 2003

Alpha A-crystallin confers cellular thermoresistance

artículo científico publicado en 1994

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2

scientific article published on 01 June 2019

Analysis of chaperone properties of small Hsp's

artículo científico publicado en 2000

Analysis of properties of small heat shock protein Hsp25 in MAPK-activated protein kinase 2 (MK2)-deficient cells: MK2-dependent insolubilization of Hsp25 oligomers correlates with susceptibility to stress

artículo científico publicado en 2006

Analysis of small Hsp phosphorylation

artículo científico publicado en 2000

Analysis of the Interaction of Small Heat Shock Proteins with Unfolding Proteins

artículo científico publicado en 2003

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death

artículo científico publicado en 1998

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFα- and hydrogen peroxide-induced cell death

article

Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling

artículo científico publicado en 2012

Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

artículo científico publicado en 1997

Biological monitoring of non-thermal effects of mobile phone radiation: recent approaches and challenges

scientific article published on August 2010

Bispecific antibody-producing hybrid hybridomas selected by a fluorescence activated cell sorter

artículo científico publicado en 1987

Blockade of MK2 is protective in inflammation-associated colorectal cancer development.

artículo científico publicado en 2015

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

artículo científico publicado en 1997

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

artículo científico publicado en 2006

Characterisation of cell-type-specific responses in the liver towards IL-1β by a mathematical model for the p38MAPK/MK2 pathway

article

Characterization of a novel MK3 splice variant from murine ventricular myocardium

scientific article published on 04 June 2010

Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5

scientific journal article

Characterization of the expression and regulation of MK5 in the murine ventricular myocardium

artículo científico publicado en 2010

Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.

artículo científico publicado en 1994

Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK

artículo científico publicado en 2015

Comparison of the homologous carboxy-terminal domain and tail of alpha-crystallin and small heat shock protein.

artículo científico publicado en 1993

Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif

scientific journal article

Cooperative and distinct functions of MK2 and MK3 in the regulation of the macrophage transcriptional response to lipopolysaccharide

scientific article published on 30 July 2019

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

scientific article published on 26 August 2013

Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation

artículo científico publicado en 2010

Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis

artículo científico publicado en 2013

Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2.

artículo científico publicado en 2002

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

scientific article published on 30 September 2013

Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury.

artículo científico publicado en 2014

Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy

artículo científico publicado en 2008

Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase ⬇️

artículo científico publicado el 25 de octubre de 1992

Development and tissue-specific distribution of mouse small heat shock protein hsp25.

artículo científico publicado en 1993

Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1

scientific article published in Journal of Biological Chemistry

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

artículo científico publicado en 2015

Dimer structure as a minimum cooperative subunit of small heat-shock proteins

artículo científico publicado en 1995

Distinct cellular functions of MK2.

artículo científico publicado en 2002

Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulat

artículo científico publicado en 2011

Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands

article

EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction

artículo científico publicado en 2017

Editorial: Emerging Functions of Septins

artículo científico publicado en 2017

Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination

artículo científico publicado en 2003

Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production

scientific journal article

Erratum to: 'Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice'.

artículo científico publicado en 2016

Evidence for a hsp25-specific mechanism involved in transcriptional activation by heat shock

artículo científico publicado en 1998

Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration

artículo científico publicado en 2014

Expression of heat shock protein 25,000 in rat uterus during pregnancy and pseudopregnancy

scientific article published on 01 June 1996

Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture

artículo científico publicado en 2016

FRET-based detection of different conformations of MK2.

artículo científico publicado en 2001

Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

scientific article published on 01 March 2019

GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis

artículo científico publicado en 2016

Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis

artículo científico publicado en 2006

Generation of antibodies against human hsp27 and murine hsp25 by immunization with a chimeric small heat shock protein

artículo científico publicado el 1 de enero de 1991

Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis

artículo científico publicado en 2014

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

artículo científico publicado en 2002

Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3

scientific article published on 01 March 2019

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

HDM2 phosphorylation by MAPKAP kinase 2.

artículo científico publicado en 2005

Heat shock protein 27 is a substrate of cGMP-dependent protein kinase in intact human platelets: phosphorylation-induced actin polymerization caused by HSP27 mutants

artículo científico publicado en 2001

Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade

artículo científico publicado en 1996

Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways

artículo científico publicado en 2005

IFN-gamma regulation in anti-CD4 antibody-induced T cell unresponsiveness

artículo científico publicado en 2004

IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification

artículo científico publicado en 2017

IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.

artículo científico publicado en 2018

IL-33-activated murine mast cells control the dichotomy between RORγt+ and Helios+ Tregs via the MK2/3-mediated IL-6 production in vitro

scientific article published on 30 July 2019

Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins

artículo científico publicado en 1992

Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction

artículo científico publicado en 2002

Identification of the phosphorylation sites of the murine small heat shock protein hsp25 ⬇️

artículo científico publicado el 5 de agosto de 1991

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance

artículo científico publicado en 2002

Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction

artículo científico publicado en 1999

Increased expression of heat-shock protein 27 kDa in Alzheimer disease: a preliminary study

artículo científico publicado en 1993

Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs

artículo científico publicado en 2002

Interleukin (IL)-6 signaling leads to phosphorylation of the small heat shock protein (Hsp)27 through activation of the MAP kinase and MAPKAP kinase 2 pathway in monocytes and monocytic leukemia cells.

artículo científico publicado en 1995

Interleukin-1-induced intracellular signaling pathways converge in the activation of mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 and the subsequent phosphorylation of the 27-kilodalton heat shock

artículo científico publicado en 1994

Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology.

artículo científico publicado en 2001

Interleukin-3 and granulocyte-macrophage colony-stimulating factor induce activation of the MAPKAP kinase 2 resulting in in vitro serine phosphorylation of the small heat shock protein (Hsp 27).

artículo científico publicado en 1994

Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?

artículo científico publicado en 2002

LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP

artículo científico publicado en 2013

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression

artículo científico publicado en 2015

Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis

artículo científico publicado en 2007

Lateral lipid distribution and phase transition in phosphatidylethanolamine/phosphatidylserine vesicles. A cross-linking study.

artículo científico publicado en 1983

Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation

artículo científico publicado en 1998

MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.

artículo científico publicado en 2010

MAP-Kinase Activated Protein Kinase 2 Links Endothelial Activation and Monocyte/macrophage Recruitment in Arteriogenesis

artículo científico publicado en 2015

MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.

artículo científico publicado en 2008

MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges

artículo científico publicado en 2015

MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease

artículo científico publicado en 2006

MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages

artículo científico publicado en 2009

MAPKAP kinase 2 (MK2)-dependent and -independent models of blister formation in pemphigus vulgaris

artículo científico publicado en 2013

MAPKAP kinase 2 is activated by heat shock and TNF-alpha: in vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade

artículo científico publicado en 1995

MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

scientific journal article

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

scientific journal article

MAPKAP kinase 2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus infections

artículo científico publicado en 2015

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

article

MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

artículo científico publicado en 2006

MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection

artículo científico publicado en 2014

MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells

artículo científico publicado en 2009

MAPKAP kinases - MKs - two's company, three's a crowd

artículo científico publicado en 2006

MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin

artículo científico publicado en 2010

MAPKAPK-2 Signaling Is Critical for Cutaneous Wound Healing

MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia

artículo científico publicado en 2009

MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization

scientific article published in 2007

MK2 Deletion in Mice Prevents Diabetes-Induced Perturbations in Lipid Metabolism and Cardiac Dysfunction.

artículo científico publicado en 2015

MK2 and Fas receptor contribute to the severity of CNS demyelination

artículo científico publicado en 2014

MK2 and MK3--a pair of isoenzymes?

artículo científico publicado en 2008

MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation

artículo científico publicado en 2007

MK2 regulates the early stages of skin tumor promotion.

artículo científico publicado en 2009

MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

scientific journal article

MK2-TNF-Signaling Comes Full Circle

artículo científico publicado en 2017

MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation

artículo científico publicado en 2016

MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart

artículo científico publicado en 2017

MK5 haplodeficiency decreases collagen deposition and scar size during post-myocardial infarction wound repair

artículo científico publicado en 2019

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury

artículo científico publicado en 2009

Mitogen-Activated Protein Kinase 2 Signaling Shapes Macrophage Plasticity in Aggregatibacter actinomycetemcomitans-Induced Bone Loss

artículo científico publicado en 2016

Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover

artículo científico publicado en 2013

Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice

artículo científico publicado en 2002

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) contributes to secondary damage after spinal cord injury.

artículo científico publicado en 2010

Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice

artículo científico publicado en 2014

Mitogen-activated protein kinase-activated protein kinase 2 in angiotensin II-induced inflammation and hypertension: regulation of oxidative stress

artículo científico publicado en 2010

Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3

artículo científico publicado en 2014

Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells.

artículo científico publicado en 2015

Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

artículo científico publicado en 2006

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

artículo científico publicado en 2002

Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function

artículo científico publicado en 2013

Modulation of HSP27 alters hypoxia-induced endothelial permeability and related signaling pathways

artículo científico publicado en 2009

Molecular chaperones in signal transduction.

artículo científico publicado en 2006

Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosa

artículo científico publicado en 1989

Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins

artículo científico publicado en 1989

Molecular mechanisms of phosphorylation-regulated TTP (tristetraprolin) action and screening for further TTP-interacting proteins

artículo científico publicado en 2010

Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.

artículo científico publicado en 2011

Mouse Hsp25, a small heat shock protein

article

Mouse Hsp25, a small shock protein. The role of its C-terminal extension in oligomerization and chaperone action

artículo científico publicado en 2000

Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation

artículo científico publicado en 2009

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway

artículo científico publicado en 2009

Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries.

artículo científico publicado en 2015

Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice

artículo científico publicado en 2016

Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.

artículo científico publicado en 2015

Over-expression of the small heat-shock protein, hsp25, inhibits growth of Ehrlich ascites tumor cells

artículo científico publicado en 1992

P38 Mitogen Activated Protein Kinase Regulates Endothelial VCAM-1 Expression at the Post-transcriptional Level

article

P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity

artículo científico publicado en 2004

PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype

artículo científico publicado en 1997

Peptides as signaling inhibitors for mammalian MAP kinase cascades

artículo científico publicado en 2009

Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2-mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25.

artículo científico publicado en 1998

Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

artículo científico publicado en 2006

Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription

artículo científico publicado en 2020

Preoperative Treatment of Rectal Cancer with Radiation, Chemotherapy and Hyperthermia: Analysis of Treatment Efficacy and Heat-Shock Response

article

Production and characterization of four monoclonal antibodies specific for human interferon-alpha-1 and -alpha-2.

artículo científico publicado en 1989

Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy

artículo científico publicado en 2019

Protein Kinases as Substrates for SAPKs

Protein kinases as small molecule inhibitor targets in inflammation.

artículo científico publicado en 2007

RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.

artículo científico publicado en 2009

Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice.

artículo científico publicado en 2008

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

artículo científico publicado en 1999

Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade

artículo científico publicado en 2007

Regulation of vimentin intermediate filaments in endothelial cells by hypoxia

artículo científico publicado en 2010

Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell

artículo científico publicado en 2004

Role of p38alpha Map kinase in Type I interferon signaling

artículo científico publicado en 2003

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

artículo científico publicado en 2008

SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition

artículo científico publicado en 2011

SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development

artículo científico publicado en 2019

Scaffolding by ERK3 regulates MK5 in development

scientific journal article

Selective NMR Experiments on Macromolecules: Implementation and Analysis of QUIET-NOESY.

artículo científico publicado en 1998

Sep(t)arate or not – how some cells take septin-independent routes through cytokinesis

artículo científico publicado en 2015

Septins: Active GTPases or just GTP-binding proteins?

Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations

artículo científico publicado en 2015

Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines

artículo científico

Simple preparative two-step purification of interleukin-2 from culture medium of lectin stimulated normal human lymphocytes

article

Small heat shock proteins are molecular chaperones.

artículo científico publicado en 1993

Small heat-shock protein family: function in health and disease.

artículo científico publicado en 1998

Small-molecule protein and lipid kinase inhibitors in inflammation and specific models for their evaluation

artículo científico publicado en 2012

Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.

artículo científico publicado en 2007

Specificity of signaling from MAPKs to MAPKAPKs: kinases' tango nuevo

artículo científico publicado en 2008

Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes

artículo científico publicado en 2010

Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance

artículo científico publicado en 1994

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis

artículo científico publicado en 2016

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway

artículo científico publicado en 1999

Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner

scientific journal article

Structural and functional homology between periplasmic bacterial molecular chaperones and small heat shock proteins

artículo científico publicado en 1995

Structure and organisation of a murine gene encoding small heat-shock protein Hsp25.

artículo científico publicado en 1993

Supramolecular structure of the recombinant murine small heat shock protein hsp25

scientific article published on 01 August 1991

Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice

article by Kumaravelu Jagavelu et al published 26 November 2007 in Circulation Research

T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K

artículo científico publicado en 2018

TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

scientific article published on 30 August 2019

TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.

artículo científico publicado en 2005

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

artículo científico publicado en 2014

TPL2 meets p38MAPK: emergence of a novel positive feedback loop in inflammation

artículo científico publicado en 2016

TRIF Signaling Stimulates Translation of TNF- mRNA via Prolonged Activation of MK2

Targeting innate immunity protein kinase signalling in inflammation

artículo científico publicado en 2009

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

artículo científico publicado en 2016

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

artículo científico publicado en 2016

The 5'-untranslated region of p23 mRNA from the Ehrlich ascites tumor is involved in translation control of the growth related protein p23

artículo científico publicado el 1 de enero de 1991

The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells

artículo científico publicado en 2020

The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.

artículo científico publicado en 1993

The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis

artículo científico publicado en 2015

The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

scientific journal article

The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning

artículo científico publicado en 2019

The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility

artículo científico publicado en 2014

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

artículo científico publicado en 2011

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

artículo científico publicado en 2016

The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3

scientific article published on 16 September 2019

The anti-cancer drug cisplatin induces H25 in Ehrlich ascites tumor cells by a mechanism different from transcriptional stimulation influencing predominantly H25 translation.

artículo científico publicado en 1996

The dynamics of Hsp25 quaternary structure. Structure and function of different oligomeric species

artículo científico publicado en 1999

The effect of the intersubunit disulfide bond on the structural and functional properties of the small heat shock protein Hsp25.

artículo científico publicado en 1998

The electric potential across the erythrocyte membrane: a mathematical model

artículo científico publicado el 1 de enero de 1981

The electric potential profile across the erythrocyte membrane

artículo científico publicado en 1982

The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

artículo científico publicado en 2012

The growth-related protein P23 of the Ehrlich ascites tumor: translational control, cloning and primary structure

artículo científico publicado en 1989

The influence of Ca2+ on the lateral lipid distribution and phase transition in phosphatidylethanolamine/phosphatidylserine vesicles

artículo científico publicado en 1984

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

artículo científico publicado en 2006

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

artículo científico publicado en 1999

The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages

artículo científico publicado en 2009

The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.

artículo científico publicado en 2010

The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells.

artículo científico publicado en 2017

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation

artículo científico publicado en 2012

The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research

artículo científico publicado en 2015

The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.

artículo científico publicado en 1997

The role of mammalian MAPK signaling in regulation of cytokine mRNA stability and translation

artículo científico publicado en 2014

The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-alpha pathway of systemic and cutaneous inflammation

artículo científico publicado en 2009

The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest

artículo científico publicado en 2012

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

artículo científico publicado en 2015

Thiol/disulfide exchange between small heat shock protein 25 and glutathione

artículo científico publicado en 1998

To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function

artículo científico publicado en 2017

Transcript levels for extracellular matrix proteins are altered in MK5-deficient cardiac ventricular fibroblasts

scientific article published on 16 May 2019

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

artículo científico publicado en 2015

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages

artículo científico publicado en 2020

Tumour necrosis factor-α plays a significant role in the Aldara-induced skin inflammation in mice.

artículo científico publicado en 2015

Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation

artículo científico publicado en 2007

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation

artículo científico publicado en 2007

Use of fluorescence-activated cell sorting to select hybrid hybridomas producing bispecific monoclonal antibodies

scientific article published on 01 January 1987

What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition

artículo científico

ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation

artículo científico publicado en 2016

[28] Purification and characterization of small heat shock proteins

artículo científico publicado en 1998

cDNA sequence coding for a translationally controlled human tumor protein

artículo científico publicado en 1989

p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins

artículo científico publicado en 2010

p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells

artículo científico publicado en 2020

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

scientific journal article

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

artículo científico publicado en 2017

p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex

artículo científico publicado en 2014

p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin

artículo científico publicado en 2013

sHsp-phosphorylation: enzymes, signaling pathways and functional implications

artículo científico publicado en 2002

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

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