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Lista de obras de Pertti Neuvonen

A mechanistic, model-based approach to safety assessment in clinical development

artículo científico publicado en 2012

A randomized clinical trial of histamine 2 receptor antagonism in treatment-resistant schizophrenia

artículo científico publicado en 2013

A semiphysiological population pharmacokinetic model for dynamic inhibition of liver and gut wall cytochrome P450 3A by voriconazole

artículo científico publicado en 2013

ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.

artículo científico publicado en 2009

Acetaminophen improves analgesia but does not reduce opioid requirement after major spine surgery in children and adolescents

artículo científico publicado en 2012

Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast Cancer-Which Factors Matter?

artículo científico publicado en 2017

Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response

artículo científico publicado en 2012

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe

artículo científico publicado en 2009

Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo

artículo científico publicado en 2008

Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism

artículo científico publicado en 2007

Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine

artículo científico publicado en 2009

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .

artículo científico publicado en 2017

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

artículo científico publicado en 2016

Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

artículo científico publicado en 2019

Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide

artículo científico publicado en 2005

Comparison of ropivacaine 2 mg ml(-1) and prilocaine 5 mg ml(-1) for i.v. regional anaesthesia in outpatient surgery

artículo científico publicado en 2006

Cyclosporine markedly raises the plasma concentrations of repaglinide

artículo científico publicado en 2005

Dexmedetomidine inhibits gastric emptying and oro-caecal transit in healthy volunteers

artículo científico publicado en 2011

Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin

artículo científico publicado en 2007

Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

artículo científico publicado en 2008

Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection.

artículo científico publicado en 2011

Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses

artículo científico publicado en 2011

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

artículo científico publicado en 2006

Drug interactions with oral antidiabetic agents: pharmacokinetic mechanisms and clinical implications

artículo científico publicado en 2012

Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren

artículo científico publicado en 2010

Effect of Terbinafine and Voriconazole on the Pharmacokinetics of the Antidepressant Venlafaxine

artículo científico publicado en 2007

Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

artículo científico publicado en 2015

Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine

artículo científico publicado en 2005

Effect of fluconazole on the pharmacokinetics and pharmacodynamics of nateglinide

artículo científico publicado en 2003

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects

artículo científico publicado en 2005

Effect of grapefruit juice on the bioactivation of prasugrel

artículo científico publicado en 2015

Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans

artículo científico publicado en 2012

Effect of rifampicin on the pharmacokinetics of pioglitazone

artículo científico publicado en 2006

Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone

artículo científico publicado en 2009

Effect of timing and route of methylprednisolone administration during pediatric cardiac surgical procedures

artículo científico publicado en 2014

Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl

artículo científico publicado en 2007

Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam

artículo científico publicado en 2006

Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects

artículo científico publicado en 2006

Effect of voriconazole on the pharmacokinetics of diclofenac

artículo científico publicado en 2007

Effect of withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotic agents on cognition in older adults

artículo científico publicado en 2013

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects

artículo científico publicado en 2017

Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide

artículo científico publicado en 2007

Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam--probes of CYP2C9, CYP1A2, and CYP3A4.

artículo científico publicado en 2007

Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism

artículo científico publicado en 2008

Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine

artículo científico publicado en 2007

Effects of grapefruit juice on the absorption of levothyroxine

artículo científico publicado en 2005

Effects of grapefruit juice on the pharmacokinetics of acebutolol

artículo científico publicado en 2005

Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone

artículo científico publicado en 2010

Effects of orange juice on the pharmacokinetics of atenolol

artículo científico publicado en 2005

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

scientific article published on 06 January 2015

Effects of the antifungals voriconazole and fluconazole on the pharmacokinetics of s-(+)- and R-(-)-Ibuprofen

artículo científico publicado en 2006

Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone

artículo científico publicado en 2004

Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine

artículo científico publicado en 2011

Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone

artículo científico publicado en 2010

Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations

Frequencies of single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in a Finnish population

article

Gemfibrozil Is a Strong Inactivator of CYP2C8 in Very Small Multiple Doses

scientific article published on 01 May 2012

Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.

artículo científico publicado en 2013

Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast

artículo científico publicado en 2010

Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings

artículo científico publicado en 2011

Gestational age and birth weight effects on plasma clearance of fentanyl in newborn infants

artículo científico publicado en 2000

Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes

artículo científico publicado en 2002

Grapefruit juice enhances the exposure to oral oxycodone

artículo científico publicado en 2010

Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren

artículo científico publicado en 2010

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

artículo científico publicado en 2013

Handgrip strength and balance in older adults following withdrawal from long-term use of temazepam, zopiclone or zolpidem as hypnotics

artículo científico publicado en 2014

High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma

artículo científico publicado en 2010

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

artículo científico publicado en 2004

High-Dose Methylprednisolone Has No Benefit Over Moderate Dose for the Correction of Tetralogy of Fallot

artículo científico publicado en 2016

In vitro and in vivo entrapment of bupivacaine by lipid dispersions

artículo científico publicado en 2012

In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors

artículo científico publicado en 2014

In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions

artículo científico publicado en 2008

Increased incidence of Merkel cell carcinoma among younger statin users

artículo científico publicado en 2012

Infections and possible vaccine-drug interactions

scientific article published on 08 May 2014

Inhibition of Cytochrome P450 3A by Clarithromycin Uniformly Affects the Pharmacokinetics and Pharmacodynamics of Oxycodone in Young and Elderly Volunteers

artículo científico publicado en 2011

Intravenous Lipid Emulsion Entraps Amitriptyline into Plasma and Can Lower its Brain Concentration - An Experimental Intoxication Study in Pigs

artículo científico publicado en 2013

Intravenous lipid emulsion only minimally influences bupivacaine and mepivacaine distribution in plasma and does not enhance recovery from intoxication in pigs

artículo científico publicado en 2011

Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs

artículo científico publicado en 2010

Intravenous oxycodone for pain relief in the first stage of labour--maternal pharmacokinetics and neonatal exposure

artículo científico publicado en 2012

Itraconazole Increases Ibrutinib Exposure 10-Fold and Reduces Interindividual Variation-A Potentially Beneficial Drug-Drug Interaction

scientific article published on 29 November 2019

Itraconazole, a P-Glycoprotein and CYP3A4 Inhibitor, Markedly Raises the Plasma Concentrations and Enhances the Renin-Inhibiting Effect of Aliskiren

scholarly article by Tuija Tapaninen et al published March 2011 in The Journal of Clinical Pharmacology

Itraconazole, gemfibrozil and their combination markedly raise the plasma concentrations of loperamide

article published in 2006

Lipid Rescue - Efficacy and Safety Still Unproven

artículo científico publicado en 2016

Local infiltration analgesia with levobupivacaine compared with intrathecal morphine in total hip arthroplasty patients

artículo científico publicado en 2012

Long-term persistence of withdrawal of temazepam, zopiclone, and zolpidem in older adults: a 3-year follow-up study.

artículo científico publicado en 2018

Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans

scientific article published on 02 March 2011

Melatonin for sedative withdrawal in older patients with primary insomnia: a randomized double-blind placebo-controlled trial

artículo científico publicado en 2014

Methylprednisolone Exposure in Pediatric Renal Transplant Patients

artículo científico publicado en 2006

Methylprednisolone in neonatal cardiac surgery: reduced inflammation without improved clinical outcome

artículo científico publicado en 2013

Miconazole oral gel increases exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4.

artículo científico publicado en 2010

Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone

Morphine clearance and effects in newborn infants in relation to gestational age.

artículo científico publicado en 2000

No Antidotal Effect of Intravenous Lipid Emulsion in Experimental Amitriptyline Intoxication Despite Significant Entrapment of Amitriptyline

scientific article published on 18 November 2011

No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin

artículo científico publicado en 2009

No significant effect of SLCO1B1 polymorphism on the pharmacokinetics of rosiglitazone and pioglitazone

artículo científico publicado en 2007

No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid

Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib

artículo científico publicado en 2008

Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren

artículo científico publicado en 2011

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

artículo científico publicado en 2011

Out-of-hospital administration of activated charcoal by emergency medical services

scientific article published on 01 February 2005

Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic study

artículo científico publicado en 2011

Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir

artículo científico publicado en 2010

Pharmacokinetics of intravenous N -acetylcysteine in pre-term new-born infants

artículo científico publicado en 1999

Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide

artículo científico publicado en 2006

Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole

artículo científico publicado en 2002

Plasma levels of bupivacaine and its metabolites after subacromial infusions in concentrations 2.5 or 5.0 mg/ml

artículo científico publicado en 2010

Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate

artículo científico publicado en 2008

Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates.

artículo científico publicado en 2012

Propofol versus alfentanil to prevent movement responses during uterine curettage

artículo científico publicado en 2007

Re: Pergolizzi et al. 2011: Exposure to potential CYP450 pharmacokinetic drug-drug interactions

artículo científico publicado en 2012

Reduced benzodiazepine tolerance, but increased flumazenil-precipitated withdrawal in AMPA-receptor GluR-A subunit-deficient mice

artículo científico publicado en 2008

Reevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant Concentrations

scientific article published on 02 February 2011

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects

artículo científico publicado en 2016

Rifampicin has a profound effect on the pharmacokinetics of oral S-ketamine and less on intravenous S-ketamine

artículo científico publicado en 2012

Rifampicin is only a weak inducer of CYP1A2-mediated presystemic and systemic metabolism: studies with tizanidine and caffeine

artículo científico publicado en 2006

Rifampicin markedly decreases the exposure to oral and intravenous tramadol

artículo científico publicado en 2012

Rifampicin reduces plasma concentrations of celiprolol

artículo científico publicado en 2003

Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren

artículo científico publicado en 2010

Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

artículo científico publicado en 2005

Rofecoxib Is a Potent, Metabolism-Dependent Inhibitor of CYP1A2: Implications for in Vitro Prediction of Drug Interactions

artículo científico publicado en 2006

Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects

artículo científico publicado en 2006

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions

artículo científico

Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters.

artículo científico publicado en 2016

S-ketamine concentrations are greatly increased by grapefruit juice

artículo científico publicado en 2012

SLCO1B1 polymorphism and oral antidiabetic drugs

artículo científico publicado en 2010

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

artículo científico publicado en 2006

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren

artículo científico publicado en 2013

Semimechanistic Population Pharmacokinetic Model to Predict the Drug-Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers

artículo científico publicado en 2018

Shift of statin use towards the elderly in 1995-2005: a nation-wide register study in Finland

artículo científico publicado en 2008

Sotalol, unlike the other beta-blockers, increases the QTc interval and risk of torsades de pointes ventricular tachycardia in severe poisonings

artículo científico publicado en 2019

St John's wort greatly decreases the plasma concentrations of oral S-ketamine

artículo científico publicado en 2011

St John's wort greatly reduces the concentrations of oral oxycodone

artículo científico publicado en 2010

Statins and hip fracture prevention--a population based cohort study in women

artículo científico publicado en 2012

Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial

artículo científico publicado en 2017

Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide

artículo científico publicado en 2006

The CYP2C8 inhibitor gemfibrozil does not affect the pharmacokinetics of zafirlukast

artículo científico publicado en 2010

The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone

artículo científico publicado en 2006

The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects

artículo científico publicado en 2004

The analgesic concentration of oxycodone with co-administration of paracetamol -- a dose-finding study in adult patients undergoing laparoscopic cholecystectomy

artículo científico publicado en 2012

The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range

artículo científico publicado en 2008

The role of concentration--effect relationships in the QTc interval prolongation: case sotalol

artículo científico publicado en 2015

Tolfenamic acid is a potent CYP1A2 inhibitor in vitro but does not interact in vivo: correction for protein binding is needed for data interpretation

artículo científico publicado en 2007

Towards safer and more predictable drug treatment--reflections from studies of the First BCPT Prize awardee

artículo científico

UDP-glucuronosyltransferase (UGT) polymorphisms affect atorvastatin lactonization in vitro and in vivo

artículo científico publicado en 2009

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification.

artículo científico publicado en 2013

Voriconazole and fluconazole increase the exposure to oral diazepam

artículo científico publicado en 2007

Voriconazole drastically increases exposure to oral oxycodone

artículo científico publicado en 2008

Voriconazole greatly increases the exposure to oral buprenorphine

artículo científico publicado en 2018

Voriconazole increases while itraconazole decreases plasma meloxicam concentrations

artículo científico publicado en 2008

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

artículo científico publicado en 2016

Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life

artículo científico publicado en 2006

Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia

article published in 2018

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