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Lista de obras de Shizuo Akira

'Toll' gates for future immunotherapy

artículo científico publicado en 2006

5'-Triphosphate RNA is the ligand for RIG-I

artículo científico publicado en 2006

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

artículo científico publicado en 2008

A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

artículo científico publicado en 2015

A Polysaccharide Carrier to Effectively Deliver Native Phosphodiester CpG DNA to Antigen-Presenting Cells

article

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

artículo científico publicado en 2005

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

artículo científico publicado en 2010

A critical role of IL-33 in experimental allergic rhinitis

scholarly article by Yoko Haenuki et al published July 2012 in The Journal of Allergy and Clinical Immunology

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

artículo científico publicado en 2009

A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity

artículo científico publicado en 2011

A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability

artículo científico publicado en 2012

A novel unbiased measure for motif co-occurrence predicts combinatorial regulation of transcription ⬇️

artículo científico publicado el 13 de diciembre de 2012

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.

artículo científico publicado en 2009

A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant

artículo científico publicado en 2009

A20 is a negative regulator of IFN regulatory factor 3 signaling.

artículo científico publicado en 2005

ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling

artículo científico publicado en 2007

Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

artículo científico publicado en 2009

Activation of MDA5 requires higher-order RNA structures generated during virus infection

artículo científico publicado en 2009

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity

artículo científico publicado en 2004

Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses

artículo científico publicado en 2002

Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure

artículo científico publicado en 2010

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice

artículo científico publicado en 2008

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1 ⬇️

artículo científico publicado el 24 de noviembre de 2010

Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes

artículo científico publicado en 2015

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

artículo científico publicado en 2010

Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity ⬇️

artículo científico publicado el 10 de julio de 2012

Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition

artículo científico publicado en 2011

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells

scientific journal article

Apolipoprotein CIII Induces Monocyte Chemoattractant Protein-1 and Interleukin 6 Expression Via Toll-Like Receptor 2 Pathway in Mouse Adipocytes: Retracted ⬇️

artículo científico publicado el 9 de septiembre de 2010

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

artículo científico publicado en 2009

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

artículo científico publicado en 2016

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

scientific journal article

B cells enhance early innate immune responses during bacterial sepsis

artículo científico publicado en 2011

BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway

artículo científico publicado en 2006

Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner

artículo científico publicado en 2009

Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

scientific article published on 18 March 2014

CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation

artículo científico

CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan

artículo científico publicado en 2012

Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 ( Irf2 ) in trypsinogen5 gene transcription ⬇️

artículo científico publicado el 31 de octubre de 2011

Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors

artículo científico publicado en 2007

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

artículo científico publicado en 2013

Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis

artículo científico publicado en 2015

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

artículo científico publicado en 2012

Control of adipose tissue inflammation through TRB1.

artículo científico publicado en 2010

CpG-activated Thy1.2+ dendritic cells protect against lethal Listeria monocytogenes infection

artículo científico publicado en 2005

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation

scientific journal article

Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice

artículo científico publicado en 2012

Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells

artículo científico publicado en 2006

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

scientific journal article

Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling

artículo científico publicado en 2010

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

artículo científico publicado en 2002

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

artículo científico publicado en 2013

DNA released from dying host cells mediates aluminum adjuvant activity

scholarly article by Thomas Marichal et al published 17 July 2011 in Nature Medicine

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

artículo científico publicado en 2017

DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant

artículo científico publicado en 2013

Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans

scientific journal article

Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori

artículo científico publicado en 2007

Deletion of TLR5 results in spontaneous colitis in mice

artículo científico publicado en 2007

Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy

scientific journal article

Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway

artículo científico publicado en 2008

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

artículo científico publicado en 2006

Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides

artículo científico publicado en 2006

Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens

artículo científico publicado en 2003

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

artículo científico publicado en 2006

Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila

artículo científico publicado en 2005

Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis

artículo científico publicado en 2015

Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin

scientific article published on June 2009

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

artículo científico publicado en 2009

Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction

artículo científico publicado en 2008

Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.

artículo científico publicado en 2009

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity

artículo científico publicado en 2010

Emergent genome-wide control in wildtype and genetically mutated lipopolysaccarides-stimulated macrophages

artículo científico publicado en 2009

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency

artículo científico publicado en 2007

Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.

artículo científico publicado en 2018

Erratum: A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

scholarly article published in Nature Immunology

Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest

artículo científico publicado en 2005

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

artículo científico publicado en 2002

Essential role of IPS-1 in innate immune responses against RNA viruses

artículo científico publicado en 2006

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling

artículo científico publicado en 2007

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

artículo científico publicado en 2010

FIP200 regulates targeting of Atg16L1 to the isolation membrane

artículo científico publicado en 2013

Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model ⬇️

artículo científico publicado el 2 de julio de 2013

Genetic analysis of resistance to viral infection

artículo científico publicado en 2007

Glucocorticoids synergize with IL-1beta to induce TLR2 expression via MAP Kinase Phosphatase-1-dependent dual Inhibition of MAPK JNK and p38 in epithelial cells

artículo científico publicado en 2004

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

scientific journal article

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

artículo científico publicado en 2014

Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction ⬇️

artículo científico publicado el 8 de diciembre de 2010

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

artículo científico publicado en 2007

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action ⬇️

artículo científico publicado el 8 de marzo de 2013

Host innate immune receptors and beyond: making sense of microbial infections

artículo científico publicado en 2008

Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression

artículo científico publicado en 2002

IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages

artículo científico publicado en 2003

IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

artículo científico publicado en 2002

IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

artículo científico publicado en 2007

IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus

artículo científico publicado en 2012

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

artículo científico publicado en 2005

Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity

artículo científico publicado en 2009

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

artículo científico publicado en 2007

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

scientific journal article

Immune interventions of human diseases through toll-like receptors

artículo científico publicado en 2009

Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.

artículo científico publicado en 2010

Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling ⬇️

artículo científico publicado el 26 de septiembre de 2010

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

artículo científico publicado en 2006

Impaired autophagy in macrophages promotes inflammatory eye disease

artículo científico publicado en 2016

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice

artículo científico publicado en 2012

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

scientific article published on 16 September 2008

Induction of CXCL5 during inflammation in the rodent lung involves activation of alveolar epithelium

scientific journal article

Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity

scientific journal article

Induction of type I interferon by adenovirus-encoded small RNAs

artículo científico publicado en 2010

Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice

artículo científico publicado en 2010

Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1.

artículo científico publicado en 2010

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

artículo científico publicado en 2005

Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages

artículo científico publicado en 2004

Innate and adaptive immune responses to viral infection and vaccination

artículo científico publicado en 2011

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

scientific journal article

Innate immune control of nucleic acid-based vaccine immunogenicity

artículo científico publicado en 2009

Innate immune recognition of nucleic acids: beyond toll-like receptors

artículo científico publicado en 2005

Innate immune recognition of viral infection

artículo científico publicado en 2006

Innate immune recognition of, and regulation by, DNA.

artículo científico publicado en 2006

Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells

artículo científico publicado en 2013

Innate immune response to viral infection

artículo científico publicado en 2008

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

artículo científico publicado en 2009

Innate immunity

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

artículo científico publicado en 2014

Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.

artículo científico publicado en 2006

Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock

artículo científico publicado en 2012

Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

artículo científico publicado en 2002

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

scientific journal article

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

artículo científico publicado en 2005

Interleukin-18 Facilitates the Early Antimicrobial Host Response to Escherichia coli Peritonitis ⬇️

artículo científico publicado el 1 de octubre de 2003

Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa

artículo científico publicado en 2003

Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway

artículo científico publicado en 2010

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

artículo científico publicado en 2009

Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes

artículo científico publicado en 2007

Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers

artículo científico publicado en 2002

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

artículo científico publicado en 2010

Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway

artículo científico publicado en 2002

Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif

artículo científico publicado en 2008

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

artículo científico publicado en 2008

Leukemia Inhibitory Factor Coordinates the Down-regulation of the Visual Cycle in the Retina and Retinal-pigmented Epithelium ⬇️

artículo científico publicado el 29 de mayo de 2012

Limited role for interleukin-18 in the host protection response to pulmonary infection with Pseudomonas aeruginosa in mice

artículo científico publicado en 2004

Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism

artículo científico publicado en 2012

Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium

artículo científico publicado en 2008

Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4.

artículo científico publicado en 2004

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

artículo científico publicado en 2007

Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway

artículo científico publicado en 2006

Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation

artículo científico publicado en 2013

Manifold mechanisms of Toll-like receptor-ligand recognition

artículo científico publicado en 2005

Manipulation of host innate immune responses by the malaria parasite

artículo científico publicado en 2007

Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice ⬇️

artículo científico publicado el 1 de enero de 2013

Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice

artículo científico publicado en 2011

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

artículo científico publicado en 2009

Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury

artículo científico publicado en 2006

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

scientific journal article

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure ⬇️

artículo científico publicado el 10 de mayo de 2012

Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response

artículo científico publicado en 2017

Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages

artículo científico publicado en 2006

Molecular and cellular mechanisms of DNA vaccines

artículo científico publicado en 2008

MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha

artículo científico publicado en 2004

MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi

artículo científico publicado en 2006

MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis

artículo científico publicado en 2003

MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus

artículo científico publicado en 2007

MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus

artículo científico publicado en 2014

MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection

artículo científico publicado en 2010

MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

artículo científico publicado en 2006

NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

artículo científico publicado en 2007

NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection

artículo científico publicado en 2009

NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA

artículo científico publicado en 2011

Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum

artículo científico publicado en 2005

Negative Regulators in Toll-like Receptor Responses ⬇️

artículo científico publicado el 1 de noviembre de 2010

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

artículo científico publicado en 2006

Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B

artículo científico publicado en 2014

Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1.

artículo científico publicado en 2002

Nitrogen dioxide promotes allergic sensitization to inhaled antigen

artículo científico publicado en 2007

Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

artículo científico publicado en 2014

Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly

artículo científico publicado en 2008

Novel Bacterial Lipoprotein Structures Conserved in Low-GC Content Gram-positive Bacteria Are Recognized by Toll-like Receptor 2 ⬇️

artículo científico publicado el 2 de febrero de 2012

Novel strategies to improve DNA vaccine immunogenicity

artículo científico publicado en 2011

Nucleic acid sensing by T cells initiates Th2 cell differentiation

artículo científico publicado en 2014

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

artículo científico publicado en 2005

Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria

artículo científico publicado en 2014

Oncolytic Reovirus Inhibits Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in a TLR3-Dependent Manner

artículo científico publicado en 2018

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways

artículo científico publicado en 2006

Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha

scientific journal article

PI3K integrates the action of insulin and leptin on hypothalamic neurons

artículo científico publicado en 2005

Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer

artículo científico publicado en 2005

Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88.

artículo científico publicado en 2004

Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane

artículo científico publicado en 2011

Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans

artículo científico publicado en 2010

Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation

artículo científico publicado en 2006

Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation

artículo científico publicado en 2015

Physical and functional interactions between ZIP kinase and UbcH5

artículo científico publicado en 2008

Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis

artículo científico publicado en 2008

Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists

artículo científico publicado en 2010

Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes

artículo científico publicado en 2010

Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway

artículo científico publicado en 2011

Plasmodium products persist in the bone marrow and promote chronic bone loss.

artículo científico publicado en 2017

PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation

artículo científico publicado en 2009

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense ⬇️

artículo científico publicado el 19 de agosto de 2010

Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor

scientific journal article

Potential link between the immune system and metabolism of nucleic acids

artículo científico publicado en 2008

Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC

artículo científico publicado en 2014

Prion pathogenesis in the absence of Toll-like receptor signalling

artículo científico publicado en 2003

Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation

scientific article published on January 2010

Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production

artículo científico publicado en 2013

Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.

scholarly article

Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.

artículo científico publicado en 2006

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

artículo científico publicado en 2010

Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism

scientific journal article

RAE1 ligands for the NKG2D receptor are regulated by STING-dependent DNA sensor pathways in lymphoma

artículo científico publicado en 2014

RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection

artículo científico publicado en 2014

Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype

artículo científico publicado en 2011

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

artículo científico publicado en 2009

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production

artículo científico publicado en 2009

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

scientific journal article

Regulation of Lipopolysaccharide-Induced Translation of Tumor Necrosis Factor-Alpha by the Toll-Like Receptor 4 Adaptor Protein TRAM ⬇️

artículo científico publicado el 14 de abril de 2011

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

artículo científico publicado en 2004

Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.

artículo científico publicado en 2009

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

artículo científico publicado en 2008

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

artículo científico publicado en 2007

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

artículo científico publicado en 2005

Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes

artículo científico publicado en 2009

Retinal cell type-specific prevention of ischemia-induced damages by LPS-TLR4 signaling through microglia

artículo científico publicado en 2013

Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance

artículo científico publicado en 2007

Role of Adrenomedullin in Lyme Disease ⬇️

artículo científico publicado el 4 de octubre de 2010

Role of MyD88 and Toll-like receptors 2 and 4 in the sensing of Parachlamydia acanthamoebae

artículo científico publicado en 2010

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

scientific journal article

Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii

artículo científico publicado en 2014

Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus

artículo científico publicado en 2009

Role of zinc-finger anti-viral protein in host defense against Sindbis virus

artículo científico publicado en 2015

Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA

scientific journal article

Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model

artículo científico publicado en 2015

Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells

artículo científico publicado en 2002

Route to Discovering the Immunogenic Properties of DNA from TLR9 to Cytosolic DNA Sensors

STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury

artículo científico publicado en 2008

Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency

artículo científico publicado en 2016

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

artículo científico publicado en 2005

Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis

artículo científico publicado en 2008

Signaling flux redistribution at toll-like receptor pathway junctions

artículo científico publicado en 2008

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

article

Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan

artículo científico publicado en 2003

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

artículo científico publicado en 2002

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

artículo científico publicado en 2004

Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex

artículo científico publicado en 2005

Stat-3 is required for pulmonary homeostasis during hyperoxia

artículo científico

Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms ⬇️

artículo científico publicado el 1 de octubre de 2003

Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation

artículo científico publicado en 2004

Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

artículo científico publicado en 2016

Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT

artículo científico publicado en 2005

Synthesis and in vitro characterization of antigen-conjugated polysaccharide as a CpG DNA carrier

artículo científico publicado en 2006

Systems biology approaches to toll-like receptor signaling

artículo científico publicado en 2012

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.

artículo científico publicado en 2006

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

artículo científico publicado en 2006

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

artículo científico publicado en 2014

TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis

artículo científico publicado en 2009

TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector

artículo científico publicado en 2015

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

artículo científico publicado en 2008

TLR ignores methylated RNA?

artículo científico publicado en 2005

TLR signaling pathways

artículo científico publicado en 2004

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

artículo científico publicado en 2012

TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming

artículo científico publicado en 2009

TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity

artículo científico publicado en 2008

TLR5 functions as an endocytic receptor to enhance flagellin‐specific adaptive immunity ⬇️

artículo científico publicado el 3 de diciembre de 2010

TLR5-Deficient Mice Lack Basal Inflammatory and Metabolic Defects but Exhibit Impaired CD4 T Cell Responses to a Flagellated Pathogen ⬇️

artículo científico publicado el 30 de marzo de 2011

TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus

artículo científico publicado en 2008

TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

artículo científico publicado en 2010

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

artículo científico publicado en 2015

TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection

artículo científico publicado en 2011

TRAF Family Member-associated NF-κB Activator (TANK) Is a Negative Regulator of Osteoclastogenesis and Bone Formation ⬇️

artículo científico publicado el 6 de julio de 2012

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF

artículo científico publicado en 2005

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway

artículo científico publicado en 2008

TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

artículo científico publicado en 2009

TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses

artículo científico publicado en 2009

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

scientific journal article

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

scientific journal article

TRIF signaling is essential for TLR4-driven IgE class switching

artículo científico publicado en 2014

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

scientific journal article

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

scientific journal article

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

artículo científico publicado en 2009

Targeting dendritic cell signaling to regulate the response to immunization

artículo científico publicado en 2008

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

artículo científico publicado en 2006

Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products

artículo científico publicado en 2009

The Atg5 Atg12 conjugate associates with innate antiviral immune responses

artículo científico publicado en 2007

The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing

scientific journal article

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

artículo científico publicado en 2011

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

artículo científico publicado en 2017

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

artículo científico publicado en 2005

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

artículo científico publicado en 2004

The Second Messenger Phosphatidylinositol-5-Phosphate Facilitates Antiviral Innate Immune Signaling ⬇️

artículo científico publicado el 14 de agosto de 2013

The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation

scientific article published on October 2013

The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling ⬇️

artículo científico publicado el 23 de septiembre de 2011

The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation ⬇️

artículo científico publicado el 29 de noviembre de 2012

The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2

artículo científico publicado en 2009

The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant

artículo científico publicado en 2013

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis

artículo científico publicado en 2007

The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector

artículo científico publicado en 2014

The enzyme Cyp26b1 mediates inhibition of mast cell activation by fibroblasts to maintain skin-barrier homeostasis

artículo científico publicado en 2014

The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation

artículo científico publicado en 2007

The malarial metabolite hemozoin and its potential use as a vaccine adjuvant

artículo científico publicado en 2010

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

artículo científico publicado en 2015

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

artículo científico publicado en 2006

The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria

artículo científico publicado en 2005

The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.

artículo científico publicado en 2011

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

artículo científico publicado en 2003

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection

artículo científico publicado en 2004

The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

artículo científico publicado en 2011

The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

artículo científico publicado en 2010

Therapeutic targeting of Toll-like receptors

Toll or toll-free adjuvant path toward the optimal vaccine development

artículo científico publicado en 2007

Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli

artículo científico publicado en 2005

Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease

artículo científico publicado en 2009

Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection

artículo científico publicado en 2004

Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation

artículo científico publicado en 2008

Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense

artículo científico publicado en 2004

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells

scientific journal article

Toll-like receptor 4 mediates the antitumor host response induced by a 55-kilodalton protein isolated from Aeginetia indica L., a parasitic plant

artículo científico publicado en 2004

Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease

artículo científico publicado en 2008

Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

artículo científico publicado en 2009

Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice

artículo científico publicado en 2006

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

artículo científico publicado en 2005

Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation

artículo científico publicado en 2016

Toll-like receptor 9-dependent activation of myeloid dendritic cells by Deoxynucleic acids from Candida albicans

artículo científico publicado en 2009

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells

artículo científico publicado en 2003

Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity

artículo científico publicado en 2006

Toll-like receptor downstream signaling

artículo científico publicado en 2004

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines

artículo científico publicado en 2008

Toll-like receptor signalling

artículo científico publicado en 2004

Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice

artículo científico publicado en 2003

Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways

scientific journal article

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment

artículo científico publicado en 2006

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3... ⬇️

artículo científico publicado el 15 de octubre de 2003

Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages

artículo científico publicado en 2006

Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen

scientific article published on October 2002

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

artículo científico publicado en 2009

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling

artículo científico publicado en 2009

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice ⬇️

artículo científico publicado el 24 de febrero de 2011

Type I interferon modulates monocyte recruitment and maturation in chronic inflammation

artículo científico publicado en 2009

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

article

Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza ⬇️

artículo científico publicado el 8 de febrero de 2013

Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections

artículo científico publicado en 2011

West Nile virus noncoding subgenomic RNA contributes to viral evasion of the type I interferon-mediated antiviral response

artículo científico publicado en 2012

ZIP kinase triggers apoptosis from nuclear PML oncogenic domains

artículo científico publicado en 2003

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

scientific journal article

Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus

artículo científico publicado en 2013

iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice

artículo científico publicado en 2009

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

artículo científico publicado en 2015

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