Lista de obras - Titia Sixma - Dominio Público Uruguay

"4D Biology for health and disease" workshop report

artículo científico

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme

artículo científico publicado en 2016

A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit

artículo científico publicado en 2012

A genomic and functional inventory of deubiquitinating enzymes

artículo científico publicado en 2005

A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

artículo científico publicado en 2001

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

artículo científico publicado en 2007

ARP/wARP and molecular replacement: the next generation

artículo científico

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

artículo científico publicado en 2004

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors

artículo científico publicado en 2011

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

artículo científico publicado en 2003

Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors

scientific article published on 01 January 2006

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins

artículo científico publicado en 2018

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

artículo científico publicado en 2012

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

artículo científico publicado en 2013

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

artículo científico publicado en 2016

Chemical Trapping of the Dynamic MutS-MutL Complex Formed in DNA Mismatch Repair in Escherichia coli ⬇️

artículo científico publicado el 15 de marzo de 2011

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin

artículo científico publicado en 2010

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies

artículo científico publicado en 2006

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

artículo científico publicado en 2005

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

artículo científico publicado en 2001

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system

artículo científico publicado en 1997

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

artículo científico publicado en 2005

Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

artículo científico publicado en 2000

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

artículo científico publicado en 1997

DNA mismatch repair: MutS structures bound to mismatches.

artículo científico publicado en 2001

Dimeric -Cobratoxin X-ray Structure: LOCALIZATION OF INTERMOLECULAR DISULFIDES AND POSSIBLE MODE OF BINDING TO NICOTINIC ACETYLCHOLINE RECEPTORS

artículo científico publicado en 2012

Divide and conquer: the E2 active site

scientific article published on 01 June 2006

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

artículo científico publicado en 2006

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

artículo científico publicado en 2011

Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein

artículo científico publicado en 2008

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases

artículo científico publicado en 2011

Erratum: The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

artículo científico publicado en 2014

Eukaryotic expression: developments for structural proteomics.

artículo científico publicado en 2006

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

artículo científico publicado en 2006

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis

artículo científico publicado en 2011

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

artículo científico publicado en 2007

Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT)

artículo científico publicado en 1994

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

artículo científico publicado en 2015

Histone ubiquitination in the DNA damage response

artículo científico publicado en 2017

Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks

artículo científico publicado en 2011

Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner

artículo científico publicado en 2008

Identification of cross-linked peptides for protein interaction studies using mass spectrometry and 18O labeling

scientific article published on 01 September 2002

Insight in nAChR subtype selectivity from AChBP crystal structures.

artículo científico publicado en 2009

Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor

artículo científico publicado en 2009

Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo ⬇️

artículo científico publicado el 15 de diciembre de 1992

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

artículo científico publicado en 2015

Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis.

artículo científico publicado en 2012

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

artículo científico publicado en 2019

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells

artículo científico publicado en 2016

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography ⬇️

artículo científico publicado el 6 de febrero de 1992

Layers of DUB regulation.

artículo científico

Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.

artículo científico publicado en 2014

Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS

artículo científico publicado en 2010

Make them, break them, and catch them: studying rare ubiquitin chains.

artículo científico publicado en 2015

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

artículo científico publicado en 2015

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase

artículo científico publicado en 2011

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.

artículo científico publicado en 2015

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.

artículo científico publicado en 2011

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

artículo científico publicado en 2004

Nicotinic receptor structure emerging slowly

artículo científico publicado en 2007

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation

artículo científico publicado en 2007

Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes.

artículo científico publicado en 2010

Preparation of sumoylated substrates for biochemical analysis.

artículo científico publicado en 2009

Protein engineering: making ubiquitin specific

artículo científico publicado en 2013

Protein-protein interactions regulate Ubl conjugation

artículo científico publicado en 2007

Proteomic analysis identifies novel binding partners of BAP1

artículo científico publicado en 2021

Quantitative analysis of USP activity in vitro

artículo científico publicado en 2019

RBR E3-ligases at work

artículo científico

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

artículo científico publicado en 2012

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

artículo científico publicado en 2012

Regulation of USP7: A High Incidence of E3 Complexes.

artículo científico publicado en 2017

SUMO assay with peptide arrays on solid support: insights into SUMO target sites.

artículo científico publicado en 2008

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

Sharp kinking of a coiled-coil in MutS allows DNA binding and release

artículo científico publicado en 2019

Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein

artículo científico publicado en 2012

Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate binding site

artículo científico publicado en 2020

Structural analysis of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA.

artículo científico publicado en 2004

Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair.

artículo científico publicado en 2009

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein

artículo científico publicado en 1997

Structural basis of specific H2A K13/K15 ubiquitination by RNF168

scientific article published on 15 April 2019

Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

artículo científico publicado en 2006

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

artículo científico publicado en 2006

Structure and function of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor

artículo científico publicado en 2003

Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery

artículo científico publicado en 2015

Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role

artículo científico publicado en 2016

Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution

artículo científico publicado en 1994

Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates

artículo científico publicado en 2003

Symmetry and asymmetry of the RING-RING dimer of Rad18

artículo científico publicado en 2011

Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements.

artículo científico publicado en 2013

The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor

artículo científico publicado en 2002

The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

artículo científico publicado en 2014

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

artículo científico publicado en 2011

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

artículo científico publicado en 2012

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

scientific journal article

The alternating ATPase domains of MutS control DNA mismatch repair

artículo científico publicado en 2003

The conserved molecular machinery in DNA mismatch repair enzyme structures

artículo científico publicado en 2016

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

artículo científico publicado en 2000

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

artículo científico publicado en 2014

The role of UBL domains in ubiquitin-specific proteases

artículo científico publicado en 2012

The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente

artículo científico publicado en 2014

The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains

artículo científico publicado en 2009

The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair

artículo científico publicado en 2019

Touch, act and go: landing and operating on nucleosomes

artículo científico

Transient transfection coupled to baculovirus infection for rapid protein expression screening in insect cells

artículo científico publicado en 2012

USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling.

artículo científico publicado en 2017

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.

artículo científico publicado en 2018

Ubc9 sumoylation regulates SUMO target discrimination

artículo científico publicado en 2008

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain ⬇️

artículo científico publicado en 2011

Use of Single-Cysteine Variants for Trapping Transient States in DNA Mismatch Repair

scientific article published on 22 May 2017

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis

artículo científico publicado en 2009

Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation

artículo científico publicado en 2013

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

artículo científico publicado en 2008

Variations on the ABC

artículo científico publicado en 2005

Variety in the USP deubiquitinase catalytic mechanism

artículo científico publicado en 2024

X-ray studies reveal lanthanide binding sites at the A/B5 interface of E. coli heat labile enterotoxin

artículo científico publicado el 3 de febrero de 1992

ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability.

artículo científico publicado en 2018

wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models

artículo científico publicado en 1997

Lista de obras de Titia Sixma

"4D Biology for health and disease" workshop report

A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme

A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit

A genomic and functional inventory of deubiquitinating enzymes

A glia-derived acetylcholine-binding protein that modulates synaptic transmission.

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

ARP/wARP and molecular replacement: the next generation

ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes.

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors

Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins

Active site alanine substitutions can convert deubiquitinating enzymes into avid ubiquitin-binding domains

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

BAP1/ASXL1 recruitment and activation for H2A deubiquitination.

Chemical Trapping of the Dynamic MutS-MutL Complex Formed in DNA Mismatch Repair in Escherichia coli ⬇️

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA.

DNA mismatch repair: MutS structures bound to mismatches.

Dimeric -Cobratoxin X-ray Structure: LOCALIZATION OF INTERMOLECULAR DISULFIDES AND POSSIBLE MODE OF BINDING TO NICOTINIC ACETYLCHOLINE RECEPTORS

Divide and conquer: the E2 active site

Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair.

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein

Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases

Erratum: The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

Eukaryotic expression: developments for structural proteomics.

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis

Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT)

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

Histone ubiquitination in the DNA damage response

Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks

Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner

Identification of cross-linked peptides for protein interaction studies using mass spectrometry and 18O labeling

Insight in nAChR subtype selectivity from AChBP crystal structures.

Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor

Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo ⬇️

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis.

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography ⬇️

Layers of DUB regulation.

Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways.

Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS

Make them, break them, and catch them: studying rare ubiquitin chains.

Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.

Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

Nicotinic receptor structure emerging slowly

Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation

Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes.

Preparation of sumoylated substrates for biochemical analysis.

Protein engineering: making ubiquitin specific

Protein-protein interactions regulate Ubl conjugation

Proteomic analysis identifies novel binding partners of BAP1

Quantitative analysis of USP activity in vitro

RBR E3-ligases at work

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Regulation of USP7: A High Incidence of E3 Complexes.

SUMO assay with peptide arrays on solid support: insights into SUMO target sites.

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

Sharp kinking of a coiled-coil in MutS allows DNA binding and release

Structural Characterization of Binding Mode of Smoking Cessation Drugs to Nicotinic Acetylcholine Receptors through Study of Ligand Complexes with Acetylcholine-binding Protein

Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate binding site

Structural analysis of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA.

Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair.