Lista de obras - Margaret Frame - Dominio Público Uruguay

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

artículo científico publicado en 2010

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.

artículo científico publicado en 2015

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

artículo científico publicado en 2022

A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model

artículo científico publicado en 2008

A tal(in) of cell spreading

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

artículo científico publicado en 2015

AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins

artículo científico publicado en 2006

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

artículo científico publicado en 2016

Advances in Rho-dependent actin regulation and oncogenic transformation ⬇️

artículo científico publicado el 1 de febrero de 2002

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

artículo científico publicado en 2017

An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells

artículo científico publicado en 2007

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

scientific article published on 04 December 2011

CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion

artículo científico publicado en 2011

Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.

artículo científico publicado en 2006

Calpain: a role in cell transformation and migration

artículo científico publicado en 2002

Cellular functions of the ADF/cofilin family at a glance

artículo científico publicado en 2016

Characterisation of a nucleo-adhesome

artículo científico publicado en 2022

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

artículo científico publicado en 2007

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery

artículo científico publicado en 2012

Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling

artículo científico publicado en 2006

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

artículo científico publicado en 2010

Diversity of matriptase expression level and function in breast cancer.

artículo científico publicado en 2012

E-cadherin-integrin crosstalk in cancer invasion and metastasis

artículo científico publicado en 2013

Endosomal trafficking of Src tyrosine kinase

artículo científico publicado en 2008

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

artículo científico publicado en 2010

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

artículo científico publicado en 2014

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis

artículo científico publicado en 2004

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells

artículo científico publicado en 2014

FAK and talin: who is taking whom to the integrin engagement party?

artículo científico publicado en 2012

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells

artículo científico publicado en 2011

FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy

artículo científico publicado en 2016

FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling

artículo científico publicado en 2015

FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis.

artículo científico publicado en 2007

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

artículo científico publicado en 2004

Focal adhesion kinase as a potential target in oncology

artículo científico publicado en 2003

Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo

artículo científico publicado en 2012

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

artículo científico publicado en 2007

Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly

artículo científico publicado en 2008

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

artículo científico publicado en 2010

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

artículo científico publicado en 2017

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

scientific journal article

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib

artículo científico publicado en 2006

In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy

artículo científico publicado en 2015

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

artículo científico publicado en 2013

Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression.

artículo científico publicado en 2008

Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.

artículo científico publicado en 2013

Kindlin1 regulates microtubule function to ensure normal mitosis

artículo científico publicado en 2016

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

artículo científico publicado en 2010

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

artículo científico publicado en 2007

Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.

artículo científico publicado en 2011

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

artículo científico publicado en 2009

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

artículo científico publicado en 2016

N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes

artículo científico publicado en 2005

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation

artículo científico publicado en 2008

Newest findings on the oldest oncogene; how activated src does it

artículo científico publicado en 2004

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth

artículo científico publicado en 2017

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

artículo científico publicado en 2015

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

artículo científico publicado en 2021

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma

artículo científico publicado en 2014

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

artículo científico publicado en 2010

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

artículo científico publicado en 2009

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

artículo científico publicado en 2016

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

artículo científico publicado en 2009

Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function

artículo científico publicado en 2004

RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane

artículo científico publicado en 2004

Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1

artículo científico publicado en 2011

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

artículo científico publicado en 2011

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

artículo científico publicado en 2004

Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition

artículo científico publicado en 2004

Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

artículo científico publicado en 2005

Src and focal adhesion kinase as therapeutic targets in cancer

scientific article published on 22 July 2008

Src in cancer: deregulation and consequences for cell behaviour

artículo científico publicado en 2002

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors

artículo científico publicado en 2007

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells

artículo científico publicado en 2012

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex

artículo científico publicado en 2006

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging

artículo científico publicado en 2011

Structural basis of Focal Adhesion Kinase activation on lipid membranes

artículo científico publicado en 2020

The FERM domain: organizing the structure and function of FAK.

artículo científico publicado en 2010

The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells

artículo científico publicado en 2009

The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration

artículo científico publicado en 2014

The ROCKs on which tumour cells thrive

artículo científico publicado en 2016

The SRC-induced mesenchymal state in late-stage colon cancer cells

artículo científico publicado en 2005

The calpain system and cancer.

artículo científico publicado en 2011

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements

scientific journal article

The multi-FERM-domain-containing protein FrmA is required for turnover of paxillin-adhesion sites during cell migration of Dictyostelium

artículo científico publicado en 2008

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

artículo científico publicado en 2011

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

artículo científico publicado en 2005

Translation Microscopy (TRAM) for super-resolution imaging

artículo científico publicado en 2016

Two-color photoactivatable probe for selective tracking of proteins and cells

artículo científico publicado en 2010

Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane

artículo científico publicado en 2010

V-SRC informs integrin signalling

artículo científico publicado en 2013

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging.

artículo científico publicado en 2009

c-Src drives intestinal regeneration and transformation

artículo científico publicado en 2014

mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion

artículo científico publicado en 2010

p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism.

artículo científico publicado en 2007

p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation.

artículo científico publicado en 2010

p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy

artículo científico publicado en 2015

v-Src's hold over actin and cell adhesions

artículo científico publicado en 2002

Lista de obras de Margaret Frame

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model

A tal(in) of cell spreading

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

Advances in Rho-dependent actin regulation and oncogenic transformation ⬇️

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

CD24 interacts with and promotes the activity of c-src within lipid rafts in breast cancer cells, thereby increasing integrin-dependent adhesion

Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.

Calpain: a role in cell transformation and migration

Cellular functions of the ADF/cofilin family at a glance

Characterisation of a nucleo-adhesome

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery

Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

Diversity of matriptase expression level and function in breast cancer.

E-cadherin-integrin crosstalk in cancer invasion and metastasis

Endosomal trafficking of Src tyrosine kinase

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells

FAK and talin: who is taking whom to the integrin engagement party?

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells

FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy

FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling

FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis.

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

Focal adhesion kinase as a potential target in oncology

Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib

In vivo imaging of the tumor and its associated microenvironment using combined CARS / 2-photon microscopy

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression.

Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.

Kindlin1 regulates microtubule function to ensure normal mitosis

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation

Newest findings on the oldest oncogene; how activated src does it

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth

Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development

Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function

RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane

Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition

Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition

Src and focal adhesion kinase as therapeutic targets in cancer

Src in cancer: deregulation and consequences for cell behaviour

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging

Structural basis of Focal Adhesion Kinase activation on lipid membranes

The FERM domain: organizing the structure and function of FAK.

The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells