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Lista de obras de Laura Machesky

"Wunder" F-BAR domains: going from pits to vesicles

artículo científico publicado en 2007

A RAC-GEF network critical for early intestinal tumourigenesis

artículo científico publicado en 2021

A Rac1-independent role for P-Rex1 in melanoblasts

artículo científico publicado en 2014

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

artículo científico publicado en 2010

Actin dynamics at sites of extracellular matrix degradation.

artículo científico publicado en 2006

Actin dynamics at the leading edge: from simple machinery to complex networks.

scientific article published on September 2009

Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor

scientific journal article

Actin on trafficking: could actin guide directed receptor transport?

artículo científico publicado en 2012

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis ⬇️

artículo científico publicado en 2011

Actin-based protrusions: promoters or inhibitors of cancer invasion?

artículo científico publicado en 2009

Actin-bundling proteins in cancer progression at a glance ⬇️

artículo científico publicado el 1 de marzo de 2012

Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism

artículo científico publicado en 2012

Alan Hall 1952-2015.

artículo científico publicado en 2015

Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication

artículo científico publicado en 2004

Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression

artículo científico publicado en 2005

Arp2/3 complex activity in filopodia of spreading cells.

artículo científico publicado en 2008

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3

artículo científico publicado en 2011

Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis

artículo científico publicado en 2006

Biophysical approaches for investigation of the cytoskeleton. A special issue stemming from research presented at the 2012 ECF meeting: a FEBS/EMBO workshop lecture course in Pécs, Hungary

artículo científico publicado en 2013

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

artículo científico publicado en 2016

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors

scientific article published on 23 July 2019

Cell structure and dynamics

artículo científico publicado en 2003

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

artículo científico publicado en 2020

Cells Assemble Invadopodia-Like Structures and Invade into Matrigel in a Matrix Metalloprotease Dependent Manner in the Circular Invasion Assay ⬇️

artículo científico publicado el 8 de febrero de 2012

Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties

artículo científico publicado en 2007

Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche

scientific article published in 2022

Congenital myopathies: diseases of the actin cytoskeleton.

artículo científico publicado en 2004

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin

artículo científico publicado en 2017

Correction: Lineage Tracing of Pf4-Cre Marks Hematopoietic Stem Cells and Their Progeny.

artículo científico publicado en 2013

CrkL directs ASAP1 to peripheral focal adhesions.

artículo científico publicado en 2003

Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment

artículo científico publicado en 2013

Cytokinesis: IQGAPs find a function ⬇️

artículo científico publicado el 12 de marzo de 1998

Deadly actin collapse by disulfidptosis

artículo científico publicado en 2023

Development of a cost effective automated platform to produce human liver spheroids for basic and applied research

scientific article published on 02 October 2020

Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RAR alpha and calcium-dependent signaling

artículo científico publicado en 2002

Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells

artículo científico publicado en 2003

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

artículo científico publicado en 2018

Fascin 1 is dispensable for developmental and tumour angiogenesis

artículo científico publicado en 2013

Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation

artículo científico publicado en 2013

Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma

article

Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes

artículo científico publicado en 2014

Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain

artículo científico publicado en 2013

Fascin1 in carcinomas: Its regulation and prognostic value

artículo científico publicado en 2014

Fascin: Invasive filopodia promoting metastasis

artículo científico publicado en 2010

Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation

scientific article published on 02 December 2020

Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis

artículo científico publicado en 2011

Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex

artículo científico publicado en 2012

Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion

artículo científico publicado en 2008

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

artículo científico publicado en 2019

Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5.

artículo científico publicado en 2003

Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5. T.H. Millard, B. Behrendt, S. Launay, K. Fütterer, L.M. Machesky, Cell Motil.Cytoskeleton (2003) 54(1):81-90

Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53.

artículo científico publicado en 2008

Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis

artículo científico publicado en 2003

In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis

artículo científico publicado en 2013

Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2

artículo científico publicado en 2005

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.

artículo científico publicado en 2006

Invasion by Force: The C. elegans Anchor Cell Leads the Way

scientific article published on 01 February 2019

Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.

artículo científico publicado en 2005

Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models

artículo científico publicado en 2003

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

artículo científico publicado en 2010

Lamellipodia and filopodia in metastasis and invasion

artículo científico publicado en 2008

Laura Machesky: actin opens the way.

artículo científico publicado en 2014

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

artículo científico publicado en 2015

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny

artículo científico publicado en 2012

Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton

artículo científico publicado en 2003

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.

artículo científico publicado en 2018

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

artículo científico publicado en 2012

Loss of reelin expression in breast cancer is epigenetically controlled and associated with poor prognosis

artículo científico publicado en 2010

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour

artículo científico publicado en 2016

MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta

artículo científico publicado en 2003

MIM: a multifunctional scaffold protein

artículo científico publicado en 2007

MRL proteins: leading Ena/VASP to Ras GTPases

artículo científico publicado en 2004

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

artículo científico publicado en 2013

Melanoblasts Populate the Mouse Choroid Earlier in Development Than Previously Described

artículo científico publicado en 2020

Melanoblasts on the move: Rac1 sets the pace

artículo científico publicado en 2012

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

artículo científico publicado en 2014

Membrane binding properties of IRSp53-missing in metastasis domain (IMD) protein.

artículo científico publicado en 2013

Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment

artículo científico publicado en 2003

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

artículo científico

Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1

artículo científico publicado en 2012

Myopathy mutations in alpha-skeletal-muscle actin cause a range of molecular defects.

artículo científico publicado en 2004

Myopathy-causing actin mutations promote defects in serum-response factor signalling

artículo científico publicado en 2010

N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

scientific article published on 24 October 2019

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

artículo científico publicado en 2012

N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts

artículo científico publicado en 2006

N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelination

artículo científico publicado en 2007

Overflow in science and its implications for trust.

artículo científico publicado en 2015

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

artículo científico publicado en 2011

Phenotypes induced by NM causing alpha-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes

artículo científico publicado en 2009

Phenotypes of myopathy-related actin mutants in differentiated C2C12 myotubes

artículo científico publicado en 2007

Phenotypic analysis of Myo10 knockout (Myo10) mice lacking full-length (motorized) but not brain-specific headless myosin X

artículo científico publicado en 2019

Platelet lamellipodium formation is not required for thrombus formation and stability

artículo científico publicado en 2019

Podosomes in adhesion, migration, mechanosensing and matrix remodeling.

artículo científico publicado en 2013

Polarised cell migration: intrinsic and extrinsic drivers

artículo científico publicado en 2014

Predicting cell shapes in melanomas.

artículo científico publicado en 2013

Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation

artículo científico publicado en 2012

Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering

scientific article published in 2019

Rab5 and rac team up in cell motility

artículo científico publicado en 2008

Rac1 cycling fast in melanoma with P29S.

artículo científico publicado en 2013

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

artículo científico publicado en 2011

Rac1 in the driver’s seat for melanoma

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

artículo científico publicado en 2005

Regulation of WASP: PIP2 Pipped by Toca-1?

artículo científico publicado en 2004

Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis

artículo científico publicado en 2002

SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods

artículo científico publicado en 2012

Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.

artículo científico publicado en 2012

Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown

artículo científico publicado en 2020

Sharks' teeth and dunes

scientific article published in Nature

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex

artículo científico publicado en 2004

Simulation of melanoblast displacements reveals new features of developmental migration.

artículo científico publicado en 2018

Single-sample image-fusion upsampling of fluorescence lifetime images

artículo científico publicado en 2024

So far, yet so close: α-Catenin dimers help migrating cells get together.

artículo científico publicado en 2017

Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells

artículo científico publicado en 2005

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

artículo científico publicado en 2009

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex

artículo científico publicado en 2006

Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1

artículo científico publicado en 2020

Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

artículo científico publicado en 2005

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

scholarly article by Stuart Francis et al published 15 April 2019 in Bioorganic & Medicinal Chemistry Letters

Studies on the actin-binding protein HS1 in platelets

artículo científico publicado en 2007

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

artículo científico publicado en 2011

The Arp2/3 complex is critical for colonisation of the mouse skin by melanoblasts

artículo científico publicado en 2020

The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology.

artículo científico publicado en 2010

The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice

artículo científico publicado en 2020

The WASP-Arp2/3 pathway: genetic insights

artículo científico publicado en 2004

The WAVE Regulatory Complex Is Required to Balance Protrusion and Adhesion in Migration

artículo científico publicado en 2020

The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation

artículo científico publicado en 2016

The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion

artículo científico publicado en 2010

The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces

scientific article published on 22 September 2020

The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis

artículo científico publicado en 2020

The liver metastatic niche: modelling the extracellular matrix in metastasis

artículo científico publicado en 2021

The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis

artículo científico publicado en 2007

The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis

artículo científico publicado en 2020

Tissue engineering the cancer microenvironment-challenges and opportunities

scientific article published on 08 November 2018

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo

artículo científico publicado en 2012

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

artículo científico publicado en 2017

Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages

artículo científico publicado en 2014

WASP Restricts Active Rac to Maintain Cells' Front-Rear Polarization

scientific article published on 27 November 2019

WAVE/Scars in platelets

artículo científico publicado en 2005

WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion

artículo científico publicado en 2016

WIP is necessary for matrix invasion by breast cancer cells.

artículo científico publicado en 2014

WIP: WASP-interacting proteins at invadopodia and podosomes.

artículo científico

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